KR870001431B1 - 라니티딘 염산염의 제조방법 - Google Patents

라니티딘 염산염의 제조방법 Download PDF

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Publication number
KR870001431B1
KR870001431B1 KR1019810003689A KR810003689A KR870001431B1 KR 870001431 B1 KR870001431 B1 KR 870001431B1 KR 1019810003689 A KR1019810003689 A KR 1019810003689A KR 810003689 A KR810003689 A KR 810003689A KR 870001431 B1 KR870001431 B1 KR 870001431B1
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KR
South Korea
Prior art keywords
ranitidine hydrochloride
type
ranitidine
hydrochloride
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019810003689A
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English (en)
Korean (ko)
Other versions
KR830007070A (ko
Inventor
레스리 크록키스 데렉
Original Assignee
그랙소 그룹 리밋티드
배리 안토니 뉴삼
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10516407&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR870001431(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 그랙소 그룹 리밋티드, 배리 안토니 뉴삼 filed Critical 그랙소 그룹 리밋티드
Publication of KR830007070A publication Critical patent/KR830007070A/ko
Application granted granted Critical
Publication of KR870001431B1 publication Critical patent/KR870001431B1/ko
Expired legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
KR1019810003689A 1980-10-01 1981-10-01 라니티딘 염산염의 제조방법 Expired KR870001431B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB80/31634 1980-10-01
GB8031634 1980-10-01

Publications (2)

Publication Number Publication Date
KR830007070A KR830007070A (ko) 1983-10-14
KR870001431B1 true KR870001431B1 (ko) 1987-08-06

Family

ID=10516407

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003689A Expired KR870001431B1 (ko) 1980-10-01 1981-10-01 라니티딘 염산염의 제조방법

Country Status (29)

Country Link
US (2) US4521431A (https=)
JP (1) JPS5791983A (https=)
KR (1) KR870001431B1 (https=)
AT (1) AT389696B (https=)
AU (1) AU549119B2 (https=)
BE (1) BE890574A (https=)
CA (1) CA1202638A (https=)
CH (1) CH652122A5 (https=)
CZ (1) CZ280885B6 (https=)
DE (1) DE3139134A1 (https=)
DK (2) DK167794B1 (https=)
ES (1) ES8301954A1 (https=)
FR (1) FR2491067A1 (https=)
GR (1) GR72499B (https=)
HK (1) HK97985A (https=)
IE (1) IE51604B1 (https=)
IL (1) IL63968A (https=)
IT (1) IT1143237B (https=)
KE (1) KE3549A (https=)
LU (1) LU83661A1 (https=)
MY (1) MY8500747A (https=)
NL (1) NL8104482A (https=)
NZ (1) NZ198522A (https=)
PH (2) PH19489A (https=)
PT (1) PT73744B (https=)
SE (1) SE453500B (https=)
SK (1) SK277922B6 (https=)
ZA (1) ZA816809B (https=)
ZW (1) ZW24481A1 (https=)

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CA1279328C (en) * 1983-07-15 1991-01-22 Janos Borvendeg Process for preparing basic thioethers and the salts thereof
GB8629781D0 (en) * 1986-12-12 1987-01-21 Glaxo Group Ltd Pharmaceutical compositions
SE8704436D0 (sv) * 1987-11-13 1987-11-13 Pm Konsult Handelsbolag Anvendning av antisekretoriska substanser for nya indikationer
IL90245A (en) * 1988-05-11 1994-04-12 Glaxo Group Ltd Resin adsorbate comprising ranitidine together with a synthetic cation exchange resin, its preparation and pharmaceutical compositions containing it
GB8904182D0 (en) * 1989-02-23 1989-04-05 Glaxo Canada Pharmaceutical compositions
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
US5338871A (en) * 1991-12-20 1994-08-16 Torcan Chemical Ltd. Preparation of form 1 ranitidine hydrochloride
CN1048984C (zh) * 1991-12-20 2000-02-02 多坎化学有限公司 晶形1呋喃硝胺氢氯化物的制备
US5721359A (en) * 1993-03-12 1998-02-24 Pharmacia & Upjohn Company Crystalline ceftiofur free acid
DE4341310A1 (de) * 1993-12-03 1995-06-08 Hexal Pharma Gmbh Tablette oder Kapsel mit einem Gehalt an stabilem Ranitidinhydrochlorid Form 1
US5407687A (en) * 1994-02-22 1995-04-18 Glaxo Inc. Ranitidine solid dosage form
EP0754182A1 (en) * 1994-04-08 1997-01-22 Brantford Chemicals Inc. Form 1 ranitidine hydrochloride with increased density
CA2120874E (en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine
SK282424B6 (sk) 1994-04-15 2002-01-07 Pharmacia + Upjohn Company "S" a "T" kryštalické formy 1-[5-metánsulfónamidoindolyl-2- karbonyl]-4-[3-(1-metyl-etylamino)-2-pyridinyl] piperazínu
IN181698B (https=) * 1994-05-13 1998-09-05 Ranbaxy Lab Ltd
IN181699B (https=) * 1994-05-13 1998-09-05 Ranbaxy Lab Ltd
NZ272054A (en) * 1994-05-13 1996-05-28 Ranbaxy Lab Ltd Process for producing form 1 ranitidine hydrochloride
CN1148849A (zh) * 1994-05-18 1997-04-30 赫彻斯特马里恩鲁斯公司 抗组胺哌啶衍生物，其多晶形物和假同晶物的无水和水合物形式的制备方法
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
ES2122387T3 (es) 1994-06-24 1998-12-16 Ranbaxy Lab Ltd Procedimiento para la preparacion de la forma 1 del clorhidrato de ranitidina.
WO1996016055A1 (en) * 1994-11-18 1996-05-30 Pharmacia & Upjohn Company A new physically stable solid form of a fluoroquinolone
US5538737A (en) * 1994-11-30 1996-07-23 Applied Analytical Industries, Inc. Oral compositions of H2 -antagonists
US5663381A (en) * 1995-04-21 1997-09-02 Hexal Pharmaceuticals, Inc. Process for preparing form 1 ranitidine hydrochloride
US5686588A (en) * 1995-08-16 1997-11-11 Yoo; Seo Hong Amine acid salt compounds and process for the production thereof
WO1997035853A1 (en) * 1996-03-25 1997-10-02 Hoechst Marion Roussel, Inc. Process for the preparation of form 1 ranitidine hydrochloride
ATE196764T1 (de) * 1997-08-08 2000-10-15 Aventis Pharma Gmbh Kristallform von 5-methylisoxazol-4-carbonsäure- (4-trifluormethyl)-anilid
US6287693B1 (en) 1998-02-25 2001-09-11 John Claude Savoir Stable shaped particles of crystalline organic compounds
IT1317858B1 (it) * 2000-02-29 2003-07-15 Pharmexcel S R L Allomorfo del cloridrato dell'isomero z di derivato dialchilamminofurano, procedimento per la sua produzione e composizione
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US20020183553A1 (en) * 2000-10-19 2002-12-05 Ben-Zion Dolitzky Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof
US20060173064A1 (en) * 2001-08-24 2006-08-03 Lippa Arnold S (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders
US6569887B2 (en) * 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
AR040661A1 (es) * 2002-07-26 2005-04-13 Theravance Inc Diclorhidrato cristalino de n-{2-[-((r)-2-hidroxi-2-feniletilamino)fenil]etil}-(r)-2hidroxi-2-(3-formamido-4-hidroxifenil)etilamina, agonista del receptor adrenergico beta 2
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US7166641B2 (en) * 2002-10-02 2007-01-23 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same
PL376604A1 (pl) * 2002-11-08 2006-01-09 Dov Pharmaceuticals, Inc. Polimorfy chlorowodorku bicifadyny
TW200510277A (en) * 2003-05-27 2005-03-16 Theravance Inc Crystalline form of β2-adrenergic receptor agonist
US7384557B2 (en) * 2003-07-14 2008-06-10 Applied Ambient Extraction Process Consultants, Llc Method and apparatus for removing solute from a solid solute-bearing product
TWI328006B (en) * 2003-12-26 2010-08-01 Nissan Chemical Ind Ltd Crystal form of quinoline compound and process for its production
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US20060100263A1 (en) * 2004-11-05 2006-05-11 Anthony Basile Antipyretic compositions and methods
US20060100271A1 (en) * 2004-11-08 2006-05-11 Keith Whitehead Stabilized aqueous ranitidine compositions
NZ592836A (en) 2005-07-27 2013-01-25 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
AU2007309534B2 (en) * 2006-10-20 2012-08-16 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20090069374A1 (en) * 2007-06-06 2009-03-12 Phil Skolnick Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments
TW201011043A (en) * 2008-06-20 2010-03-16 Chugai Pharmaceutical Co Ltd Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives
PL2727912T3 (pl) 2011-06-30 2017-12-29 Toray Industries, Inc. Kryształy pochodnej glicyny i ich zastosowanie farmaceutyczne
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
CN106432149B (zh) * 2015-05-26 2018-04-17 烟台市华文欣欣医药科技有限公司 一种制备治疗胃病的药物盐酸雷尼替丁化合物的方法
CN105030694A (zh) * 2015-08-04 2015-11-11 青岛蓝盛洋医药生物科技有限责任公司 一种治疗胃溃疡的药物盐酸雷尼替丁组合物干混悬剂
CN104971053A (zh) * 2015-08-05 2015-10-14 青岛蓝盛洋医药生物科技有限责任公司 一种治疗消化系统疾病的药物盐酸雷尼替丁组合物片剂
CN105055331A (zh) * 2015-08-31 2015-11-18 青岛蓝盛洋医药生物科技有限责任公司 一种治疗消化性溃疡的药物盐酸雷尼替丁组合物颗粒剂
WO2021079183A1 (en) * 2019-10-21 2021-04-29 Sms Pharmaceuticals Limited Isopropyl alcohol solvent free crystalline ranitidine hydrochloride form-2 which is free of nitrosamine (ndma) impurity

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GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
US4233302A (en) * 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE3139134C2 (https=) 1990-04-19
SE8105812L (sv) 1982-04-02
DK436281A (da) 1982-04-02
CH652122A5 (fr) 1985-10-31
CZ280885B6 (cs) 1996-04-17
ZW24481A1 (en) 1983-04-27
BE890574A (fr) 1982-04-01
PH19489A (en) 1986-05-14
CZ403591A3 (en) 1994-01-19
IL63968A (en) 1985-10-31
IT8149407A0 (it) 1981-10-01
HK97985A (en) 1985-12-13
AU7595581A (en) 1982-04-08
JPH0443070B2 (https=) 1992-07-15
ATA422281A (de) 1989-06-15
IL63968A0 (en) 1981-12-31
IE812287L (en) 1982-04-01
US4521431A (en) 1985-06-04
DE3139134A1 (de) 1982-05-19
AT389696B (de) 1990-01-10
FR2491067A1 (fr) 1982-04-02
FR2491067B1 (https=) 1984-09-07
US4672133A (en) 1987-06-09
JPS5791983A (en) 1982-06-08
SE453500B (sv) 1988-02-08
AU549119B2 (en) 1986-01-16
SK403591A3 (en) 1995-08-09
KR830007070A (ko) 1983-10-14
PT73744A (en) 1981-10-01
ES505951A0 (es) 1983-01-01
MY8500747A (en) 1985-12-31
SK277922B6 (en) 1995-08-09
NL8104482A (nl) 1982-05-03
DK167794B1 (da) 1993-12-13
IT1143237B (it) 1986-10-22
DK33792A (da) 1992-03-12
DK167923B1 (da) 1994-01-03
NZ198522A (en) 1985-07-12
PH21761A (en) 1988-02-18
ZA816809B (en) 1983-05-25
KE3549A (en) 1985-08-16
PT73744B (en) 1983-10-31
LU83661A1 (fr) 1983-06-08
CA1202638A (en) 1986-04-01
IE51604B1 (en) 1987-01-21
DK33792D0 (da) 1992-03-12
ES8301954A1 (es) 1983-01-01
GR72499B (https=) 1983-11-15

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