KR860002111B1 - 9a-아자-9a-호모에티트로마이신 유도체의 제조방법 - Google Patents

9a-아자-9a-호모에티트로마이신 유도체의 제조방법 Download PDF

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Publication number
KR860002111B1
KR860002111B1 KR1019850002453A KR850002453A KR860002111B1 KR 860002111 B1 KR860002111 B1 KR 860002111B1 KR 1019850002453 A KR1019850002453 A KR 1019850002453A KR 850002453 A KR850002453 A KR 850002453A KR 860002111 B1 KR860002111 B1 KR 860002111B1
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KR
South Korea
Prior art keywords
amino
hydrogen
formula
compound
aza
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Expired
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KR1019850002453A
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English (en)
Korean (ko)
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KR850007435A (ko
Inventor
로버트 허스크 제임스
아담 나겔 아더
Original Assignee
화이자 인코포레이티드
윌리암 데이비스 휸
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Priority claimed from US06/600,252 external-priority patent/US4512982A/en
Application filed by 화이자 인코포레이티드, 윌리암 데이비스 휸 filed Critical 화이자 인코포레이티드
Publication of KR850007435A publication Critical patent/KR850007435A/ko
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Publication of KR860002111B1 publication Critical patent/KR860002111B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019850002453A 1984-04-13 1985-04-12 9a-아자-9a-호모에티트로마이신 유도체의 제조방법 Expired KR860002111B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US600252 1984-04-13
US06/600,252 US4512982A (en) 1984-04-13 1984-04-13 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
US06/616,529 US4518590A (en) 1984-04-13 1984-06-04 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US616,529 1984-06-04

Publications (2)

Publication Number Publication Date
KR850007435A KR850007435A (ko) 1985-12-04
KR860002111B1 true KR860002111B1 (ko) 1986-11-26

Family

ID=27083554

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850002453A Expired KR860002111B1 (ko) 1984-04-13 1985-04-12 9a-아자-9a-호모에티트로마이신 유도체의 제조방법

Country Status (19)

Country Link
US (1) US4518590A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0159856B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR860002111B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU549235B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1234805A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3565267D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK164785A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EG (1) EG17459A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (3) ES8607335A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI851449A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR850900B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU195668B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE57739B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL74865A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO161497C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ211769A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH21185A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT80270B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (3) YU62385A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
US4904644A (en) * 1988-08-03 1990-02-27 Schering Corporation Antimicrobial compound isolated from Actinomadura fulva subsp indica
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2062932A1 (en) 1991-03-15 1992-09-16 Robert R. Wilkening 9-deoxo-9(z)-hydroxyiminoerythromycin a and o-derivatives thereof
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
JPH06509326A (ja) * 1991-04-09 1994-10-20 アボツト・ラボラトリーズ 大環式ラクタムプロキネティック剤
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
US5686587A (en) * 1993-05-19 1997-11-11 Pfizer Inc. Intermediate for azithromycin
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
USRE38426E1 (en) * 1995-10-09 2004-02-10 Aventis Pharma S.A. 5-O-deosaminyl 6-O-methyl erythronolide A derivatives, preparation method therefor and use thereof for preparing biologically active materials
EP1313749B1 (en) * 2000-08-23 2005-10-12 Wockhardt Limited Process for preparation of anhydrous azithromycin
MXPA03009786A (es) 2001-04-27 2004-01-29 Pfizer Prod Inc Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-sustituidos.
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003211113B2 (en) 2002-02-15 2007-08-09 Merckle Gmbh Antibiotic conjugates
GB0310992D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
US4180654A (en) * 1978-01-03 1979-12-25 Pfizer Inc. 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor

Also Published As

Publication number Publication date
YU126787A (en) 1988-02-29
AU549235B2 (en) 1986-01-23
PT80270B (pt) 1987-10-20
CA1234805A (en) 1988-04-05
NO161497B (no) 1989-05-16
DE3565267D1 (en) 1988-11-03
YU126887A (en) 1988-02-29
ES551502A0 (es) 1987-05-01
EG17459A (en) 1992-12-30
ES8607335A1 (es) 1986-06-16
KR850007435A (ko) 1985-12-04
HUT37629A (en) 1986-01-23
EP0159856A3 (en) 1986-03-19
ES551503A0 (es) 1987-04-16
EP0159856A2 (en) 1985-10-30
IL74865A (en) 1987-12-31
PT80270A (en) 1985-05-01
IE850912L (en) 1985-10-13
IL74865A0 (en) 1985-07-31
IE57739B1 (en) 1993-03-24
NO161497C (no) 1989-08-23
DK164785D0 (da) 1985-04-12
NZ211769A (en) 1987-10-30
FI851449L (fi) 1985-10-14
FI851449A7 (fi) 1985-10-14
HU195668B (en) 1988-06-28
DK164785A (da) 1985-12-10
NO851466L (no) 1985-10-14
EP0159856B1 (en) 1988-09-28
GR850900B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1985-11-25
AU4107085A (en) 1985-10-17
ES542134A0 (es) 1986-06-16
YU62385A (en) 1988-02-29
PH21185A (en) 1987-08-12
FI851449A0 (fi) 1985-04-11
ES8704965A1 (es) 1987-04-16
US4518590A (en) 1985-05-21
ES8705458A1 (es) 1987-05-01

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