KR860001101A - 1,3-디하이드로-4-피리도일-2h-이미다졸-2-온의 제조방법 - Google Patents

1,3-디하이드로-4-피리도일-2h-이미다졸-2-온의 제조방법 Download PDF

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KR860001101A
KR860001101A KR1019850005434A KR850005434A KR860001101A KR 860001101 A KR860001101 A KR 860001101A KR 1019850005434 A KR1019850005434 A KR 1019850005434A KR 850005434 A KR850005434 A KR 850005434A KR 860001101 A KR860001101 A KR 860001101A
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carbon atoms
diketo
oxime
alkyl group
group
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KR1019850005434A
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KR910006636B1 (ko
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에이. 쉬네틀러 리챠드 (외 1)
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개리 디. 스트리트
메렐 다우 파마슈티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/48—Aldehydo radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

1,3-디하이드로-4-피리도일-2H-이미다졸-2-온의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (20)

  1. 하기 일반식(Ⅱ)의 디케토-옥심을 환원시키고 생서물을 회수함을 특징으로 하는, 하기 일반식(Ⅳ)의 하이드록시아미노케톤의 제조방법.
    상기 식에어, Ar은 2-,3-또는 4-피리딜 그룹이고, R1은 수소 또는 탄소수 1 내지 4의 알킬그룹이다.
  2. 제1항에 있어서, 디케토-옥심을 수소개스와 금속촉매로 환원시키는 방법.
  3. 제1항에 있어서, 디케토-옥심을 수소개스와 탄소상 팔라듐촉매로 환원시키는 방법.
  4. 제2항에 있어서, Ar이 4-피리딜 그룹이고, R1은 수소 또는 탄소수 1 내지 4의 알킬그룹인 방법.
  5. 제4항에 있어서, R1이 에틸그룹인 방법.
  6. 제1항에 있어서, 디케토-옥심을 용해금속으로 환원시키는 방법.
  7. 제1항에 있어서, 디케토-옥심을 아연금속, 포름산 및 메탄설폰산으로 이루어진 혼합물로 환원시키는 방법.
  8. 제6항에 있어서, Ar이 4-피리딜 그룹이고, R1은 탄소수 1 내지 4의 알킬그룹인 방법.
  9. 제8항에 있어서, R1이 에틸그룹인 방법.
  10. 하기 일반식(Ⅳ)의 하이드록시아미노케톤을 알칼리금속 또는 알칼리토금속 시아네이트와 반응시키고 생성물을 회수함을 특징으로 하는, 하기 일반식(Ⅴ)의 하이드록시메틸이미다졸-2-온의 제조방법;
    상기 식에서, Ar이 4-피리딜 그룹이고, R1은 수소 또는 탄소수 1 내지 4의 알킬그룹인 방법.
  11. 제10항에 있어서, 알칼리금속 또는 알칼리토금속시아네이트가 시안산칼륨인 방법.
  12. 제10항에 있어서, Ar이 4-피리딜 그룹이고, R1은 탄소수 1 내지 4의 알킬그룹인 방법.
  13. 제12항에 있어서, R1이 에틸그룹인 방법.
  14. 하기 일반식(Ⅴ)의 하이드록시메틸이미다졸-2-온을 산화시키고 생성물을 회수함을 특징으로 하는, 하기 일반식(Ⅰ)의 피리도일이미다졸-2-온의 제조방법;
    상기 식에서, Ar이 4-피리딜 그룹이고, R1은 수소 또는 탄소수 1 내지 4의 알킬그룹인 방법이다.
  15. 제14항에 있어서, 하이드록시메틸이미다졸-2-온을 N-클로로석신이미드로 산화시키는 방법.
  16. 제14항에 있어서, 하이드록시메틸이미다졸-2-온을 이산화망간으로 산화시키는 방법.
  17. 제14항에 있어서, Ar이 4-피리딜 그룹이고, R1은 수소 또는 탄소수 1 내지 4의 알킬그룹인 방법이다.
  18. 제16항에 있어서, R1이 에틸그룹인 방법.
  19. (a)하기 일반식(Ⅱ)의 디케토-옥심을 환원시켜 하기 일반식(Ⅳ)의 하이드록시아미노케톤을 제조하고, (b)제조된 하이드록시아미노케톤을 시아네이트이온과 반응시켜 폐환시켜 하기 일반식(Ⅴ)의 하이드록시메틸-이미다졸-2-온-을 제조하고 (C)제조된 하이드록시메틸이미다졸-2-온을 산화시켜 하기 일반식(I)의 피리도일이미다졸-2-온을 제조하고 이를 분리시킴을 특징으로 하는, 하기 일반식(Ⅰ)의 피리도일-이미다졸-2-온의 제조방법;
    상기 식에서. Ar이 2-,3-또는 4-피리딜 그룹이고, R1은 수소 또는 탄소수 1 내지 4의 알킬그룹이다.
  20. 제19항에 있어서, 디케토-옥심을, 아연금속, 포름산 및 메탄설폰산으로 이루어진 혼합물로 환원시키고; 하이드록시메틸이미다졸-2-온을 N-클로로석신이미드로 산화시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850005434A 1984-07-30 1985-07-29 I,3-디하이드로-4-피리도일-2h-이미다졸-2-온의 제조방법 KR910006636B1 (ko)

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US63585284A 1984-07-30 1984-07-30
US635852 1984-07-30

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KR910006636B1 KR910006636B1 (ko) 1991-08-29

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AT (1) ATE46330T1 (ko)
AU (1) AU579389B2 (ko)
CA (1) CA1262732C (ko)
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DK (2) DK170338B1 (ko)
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PH (2) PH25128A (ko)
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JPH11209375A (ja) * 1998-01-23 1999-08-03 Nippon Bayer Agrochem Co Ltd 複素環置換アルコール誘導体及び農園芸用殺菌剤
DE19858352A1 (de) 1998-12-17 2000-06-21 Basf Ag Verfahren zum Herstellen von 2,4-Dimethyl-3,5-bis-alkoxycarbonyl-pyrrol
CN103214422B (zh) * 2013-05-07 2015-07-15 南通大学 一类新型取代胺基咪唑酮衍生物的制备方法及抗癌作用

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US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use

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IL75902A (en) 1988-10-31
ATE46330T1 (de) 1989-09-15
NO163955B (no) 1990-05-07
JPH0696573B2 (ja) 1994-11-30
PT80883A (en) 1985-08-01
DK137290A (da) 1990-06-01
JPS6143167A (ja) 1986-03-01
NZ212870A (en) 1988-10-28
ES8603839A1 (es) 1986-01-01
HUT38334A (en) 1986-05-28
FI85271B (fi) 1991-12-13
NO852995L (no) 1986-01-31
NO163955C (no) 1990-08-15
DK170338B1 (da) 1995-08-07
DK343985A (da) 1986-01-31
ES545670A0 (es) 1986-01-01
DK343985D0 (da) 1985-07-29
PH25683A (en) 1991-09-04
AU579389B2 (en) 1988-11-24
ZA855592B (en) 1986-03-26
HU194553B (en) 1988-02-29
FI852923L (fi) 1986-01-31
CA1262732A (en) 1989-11-07
PT80883B (pt) 1987-09-18
KR910006636B1 (ko) 1991-08-29
AU4553985A (en) 1986-02-06
EP0170214B1 (en) 1989-09-13
IE58075B1 (en) 1993-06-30
FI852923A0 (fi) 1985-07-26
IE851893L (en) 1986-01-30
FI85271C (fi) 1992-03-25
DK137290D0 (da) 1990-06-01
EP0170214A1 (en) 1986-02-05
IL75902A0 (en) 1985-12-31
GR851846B (ko) 1985-12-02
DE3572973D1 (en) 1989-10-19
DK170163B1 (da) 1995-06-06
CA1262732C (en) 1989-11-07
PH25128A (en) 1991-02-19
HU196996B (en) 1989-02-28

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