ES8603839A1 - Un procedimiento para la preparacion de una hidroxiaminoce- tona - Google Patents
Un procedimiento para la preparacion de una hidroxiaminoce- tonaInfo
- Publication number
- ES8603839A1 ES8603839A1 ES545670A ES545670A ES8603839A1 ES 8603839 A1 ES8603839 A1 ES 8603839A1 ES 545670 A ES545670 A ES 545670A ES 545670 A ES545670 A ES 545670A ES 8603839 A1 ES8603839 A1 ES 8603839A1
- Authority
- ES
- Spain
- Prior art keywords
- imidazol
- dihydro
- pyridoyl
- ones
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/48—Aldehydo radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UNA PIRIDOILIMIDAZOL-2-ONA. CONSISENTE EN: A) REDUCIR UNA DICETO-OXIMA (II) CON HIDROXIDO GASEOSO Y UN CATALIZADOR METALICO COMO PD/C, PARA DAR UNA HIDROXIIMINOCETONA DE FORMULA (III); B) CICLAR LA HIDROXIIMINOCETONA (III) POR REACCION CON UN ION CIANATO PARA OBTENER UNA HIDROXIMETILIMIDAZOL-2-ONA (IV); C) OXIDAR EL PRODUCTO DE B) CON N-CLOROSUCCINIMIDA O DIOXIDO DE MANGANESO, PARA OBTENER LA PIRIDOILIMIDAZOL-2-ONA DE FORMULA (I). SIENDO AR UN GRUPO 2-,3-, O 4-PIRIDILO Y R1 ES HIDROGENO O UN GRUPO ALQUILO DE 1 A 4 C. SE UTILIZAN POR QUE EJERCEN UNA POTENTE ACTIVIDAD CARDIOTONICA, COMO AGENTES TERAPEUTICOS EN EL TRATAMIENTO DE LA INSUFICIENCIA CARDIACA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63585284A | 1984-07-30 | 1984-07-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES545670A0 ES545670A0 (es) | 1986-01-01 |
| ES8603839A1 true ES8603839A1 (es) | 1986-01-01 |
Family
ID=24549382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545670A Expired ES8603839A1 (es) | 1984-07-30 | 1985-07-29 | Un procedimiento para la preparacion de una hidroxiaminoce- tona |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0170214B1 (es) |
| JP (1) | JPH0696573B2 (es) |
| KR (1) | KR910006636B1 (es) |
| AT (1) | ATE46330T1 (es) |
| AU (1) | AU579389B2 (es) |
| CA (1) | CA1262732C (es) |
| DE (1) | DE3572973D1 (es) |
| DK (2) | DK170338B1 (es) |
| ES (1) | ES8603839A1 (es) |
| FI (1) | FI85271C (es) |
| GR (1) | GR851846B (es) |
| HU (2) | HU194553B (es) |
| IE (1) | IE58075B1 (es) |
| IL (1) | IL75902A (es) |
| NO (1) | NO163955C (es) |
| NZ (1) | NZ212870A (es) |
| PH (2) | PH25128A (es) |
| PT (1) | PT80883B (es) |
| ZA (1) | ZA855592B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11209375A (ja) * | 1998-01-23 | 1999-08-03 | Nippon Bayer Agrochem Co Ltd | 複素環置換アルコール誘導体及び農園芸用殺菌剤 |
| DE19858352A1 (de) | 1998-12-17 | 2000-06-21 | Basf Ag | Verfahren zum Herstellen von 2,4-Dimethyl-3,5-bis-alkoxycarbonyl-pyrrol |
| CN103214422B (zh) * | 2013-05-07 | 2015-07-15 | 南通大学 | 一类新型取代胺基咪唑酮衍生物的制备方法及抗癌作用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405628A (en) * | 1981-03-05 | 1983-09-20 | Merrell Dow Pharmaceuticals Inc. | 4-Pyridylimidazolones and method of use |
-
1985
- 1985-07-24 CA CA487359A patent/CA1262732C/en not_active Expired
- 1985-07-24 ZA ZA855592A patent/ZA855592B/xx unknown
- 1985-07-24 IL IL75902A patent/IL75902A/xx not_active IP Right Cessation
- 1985-07-25 GR GR851846A patent/GR851846B/el unknown
- 1985-07-25 NZ NZ212870A patent/NZ212870A/xx unknown
- 1985-07-25 EP EP85109363A patent/EP0170214B1/en not_active Expired
- 1985-07-25 AT AT85109363T patent/ATE46330T1/de not_active IP Right Cessation
- 1985-07-25 DE DE8585109363T patent/DE3572973D1/de not_active Expired
- 1985-07-26 FI FI852923A patent/FI85271C/fi not_active IP Right Cessation
- 1985-07-29 HU HU852858A patent/HU194553B/hu not_active IP Right Cessation
- 1985-07-29 NO NO852995A patent/NO163955C/no not_active IP Right Cessation
- 1985-07-29 PT PT80883A patent/PT80883B/pt not_active IP Right Cessation
- 1985-07-29 HU HU874716A patent/HU196996B/hu not_active IP Right Cessation
- 1985-07-29 KR KR1019850005434A patent/KR910006636B1/ko not_active IP Right Cessation
- 1985-07-29 JP JP60166058A patent/JPH0696573B2/ja not_active Expired - Lifetime
- 1985-07-29 DK DK343985A patent/DK170338B1/da not_active IP Right Cessation
- 1985-07-29 IE IE189385A patent/IE58075B1/en not_active IP Right Cessation
- 1985-07-29 AU AU45539/85A patent/AU579389B2/en not_active Ceased
- 1985-07-29 ES ES545670A patent/ES8603839A1/es not_active Expired
- 1985-07-30 PH PH32581A patent/PH25128A/en unknown
-
1989
- 1989-04-25 PH PH38562A patent/PH25683A/en unknown
-
1990
- 1990-06-01 DK DK137290A patent/DK170163B1/da not_active IP Right Cessation
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