KR850000073B1 - 5-(2-포르밀-3-히드록시페녹시)펜타노익 산류의 제조방법 - Google Patents

5-(2-포르밀-3-히드록시페녹시)펜타노익 산류의 제조방법 Download PDF

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Publication number
KR850000073B1
KR850000073B1 KR1019800002541A KR800002541A KR850000073B1 KR 850000073 B1 KR850000073 B1 KR 850000073B1 KR 1019800002541 A KR1019800002541 A KR 1019800002541A KR 800002541 A KR800002541 A KR 800002541A KR 850000073 B1 KR850000073 B1 KR 850000073B1
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South Korea
Prior art keywords
formyl
formula
hydroxyphenoxy
acid
compound
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KR1019800002541A
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English (en)
Korean (ko)
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KR830002693A (ko
Inventor
죠프리닌
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더 웰컴 파운데이숀 리미티드
미첼 피터 잭슨
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Publication of KR830002693A publication Critical patent/KR830002693A/ko
Priority to KR1019840001263A priority Critical patent/KR850000072B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/30—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing —CHO groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/74—Unsaturated compounds containing —CHO groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1019800002541A 1979-06-29 1980-06-27 5-(2-포르밀-3-히드록시페녹시)펜타노익 산류의 제조방법 Expired KR850000073B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840001263A KR850000072B1 (ko) 1979-06-29 1984-03-13 5-(2-포르밀-3-히드록시페녹시)펜타노익산류

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7922781 1979-06-29
GB7922781 1979-06-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001263A Division KR850000072B1 (ko) 1979-06-29 1984-03-13 5-(2-포르밀-3-히드록시페녹시)펜타노익산류

Publications (2)

Publication Number Publication Date
KR830002693A KR830002693A (ko) 1983-05-30
KR850000073B1 true KR850000073B1 (ko) 1985-02-18

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ID=10506199

Family Applications (2)

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KR1019800002541A Expired KR850000073B1 (ko) 1979-06-29 1980-06-27 5-(2-포르밀-3-히드록시페녹시)펜타노익 산류의 제조방법
KR1019840001263A Expired KR850000072B1 (ko) 1979-06-29 1984-03-13 5-(2-포르밀-3-히드록시페녹시)펜타노익산류

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KR1019840001263A Expired KR850000072B1 (ko) 1979-06-29 1984-03-13 5-(2-포르밀-3-히드록시페녹시)펜타노익산류

Country Status (18)

Country Link
US (1) US4410537A (https=)
EP (1) EP0022229B1 (https=)
JP (1) JPS5649335A (https=)
KR (2) KR850000073B1 (https=)
AU (1) AU545274B2 (https=)
DE (1) DE3061269D1 (https=)
DK (1) DK159770C (https=)
FI (1) FI71929C (https=)
GB (1) GB2053218B (https=)
GR (1) GR68748B (https=)
HU (1) HU190774B (https=)
IL (1) IL60422A (https=)
IT (1) IT1133025B (https=)
MW (1) MW2380A1 (https=)
OA (1) OA06699A (https=)
ZA (1) ZA803880B (https=)
ZM (1) ZM5780A1 (https=)
ZW (1) ZW14480A1 (https=)

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ZA818741B (en) * 1980-12-18 1983-07-27 Wellcome Found Pharmaceutical compounds,preparation,use and intermediates therefor and their preparation
GB8606913D0 (en) * 1986-03-20 1986-04-23 Hider R C Treatment of sickle cell disease
US6083522A (en) 1997-01-09 2000-07-04 Neucoll, Inc. Devices for tissue repair and methods for preparation and use thereof
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
RU2300516C2 (ru) * 1999-11-05 2007-06-10 Эмисфере Текнолоджиз, Инк. Соединения феноксикарбоновой кислоты и композиции для доставки активных веществ
MXPA02004092A (es) * 1999-11-05 2003-02-12 Emisphere Tech Inc Compuestos y composiciones de acido fenilaminocarboxilico para administrar agentes activos.
WO2001070663A2 (en) * 2000-03-17 2001-09-27 Corixa Corporation Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
US8236288B2 (en) 2011-01-07 2012-08-07 Skinmedica, Inc. Melanin modification compositions and methods of use
WO2013102142A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
HK1203412A1 (en) * 2011-12-28 2015-10-30 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
AP2015008718A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
EP3919056B1 (en) 2013-03-15 2024-08-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
SG10201802911RA (en) * 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
WO2015027067A2 (en) * 2013-08-23 2015-02-26 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
ES2860648T5 (es) 2014-02-07 2024-11-27 Global Blood Therapeutics Inc Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehído
AU2016229294B2 (en) 2015-03-06 2021-11-04 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
US11020382B2 (en) 2015-12-04 2021-06-01 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
KR20180105685A (ko) * 2016-02-08 2018-09-28 비욘드스프링 파마수티컬스, 인코포레이티드. 투카레솔 또는 이의 유사체를 함유하는 조성물
TWI825524B (zh) 2016-05-12 2023-12-11 美商全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
JP7025416B2 (ja) 2016-06-06 2022-02-24 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 好中球減少症を低減させるための組成物および方法
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
WO2019182938A1 (en) * 2018-03-22 2019-09-26 Virginia Commonwealth University Aromatic aldehydes with sustained and enhanced in vitro and in vivo pharmacologic activity to treat sickle cell disease
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease
HRP20220295T1 (hr) 2018-11-19 2022-05-13 Global Blood Therapeutics, Inc. Spojevi 2-formil-3-hidroksifeniloksimetila koji mogu modulirati hemoglobin
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors
AU2023376662B2 (en) * 2022-11-07 2025-06-05 Children's Hospital Of Philadelphia (Chop) Benzaldehyde compounds with direct polymer destabilizing effects to treat sickle cell disease

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Publication number Priority date Publication date Assignee Title
LU36787A1 (https=) * 1958-04-30
CH543472A (fr) * 1969-01-31 1973-10-31 Orchimed Sa Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques
DE2209128C3 (de) 1971-03-05 1981-10-22 CIBA-GEIGY AG, 4002 Basel Bis-Stilbenverbindungen, Verfahren zu deren Herstellung und deren Verwendung als optische Aufheller
CH550776A (de) 1971-03-05 1974-06-28 Ciba Geigy Ag Herstellung neuer bis-stilbenverbindungen.
GB1511645A (en) * 1974-05-31 1978-05-24 Univ Ife Sickle cell anaemia treatment
US4137309A (en) * 1976-10-14 1979-01-30 The Procter & Gamble Company Therapeutic treatment

Also Published As

Publication number Publication date
IL60422A0 (en) 1980-09-16
HU190774B (en) 1986-11-28
GB2053218B (en) 1984-01-25
KR850000072B1 (ko) 1985-02-18
FI71929B (fi) 1986-11-28
DK159770B (da) 1990-12-03
EP0022229A1 (en) 1981-01-14
ZM5780A1 (en) 1983-11-21
JPS5649335A (en) 1981-05-02
KR840004668A (ko) 1984-10-22
US4410537A (en) 1983-10-18
DK279780A (da) 1980-12-30
ZW14480A1 (en) 1982-03-17
OA06699A (fr) 1982-05-31
DK159770C (da) 1991-04-22
MW2380A1 (en) 1982-03-10
AU5969780A (en) 1981-01-08
AU545274B2 (en) 1985-07-11
FI802052A7 (fi) 1980-12-30
EP0022229B1 (en) 1982-12-08
GR68748B (https=) 1982-02-16
GB2053218A (en) 1981-02-04
KR830002693A (ko) 1983-05-30
FI71929C (fi) 1987-03-09
IL60422A (en) 1984-06-29
IT1133025B (it) 1986-07-09
IT8049108A0 (it) 1980-06-27
JPH0154339B2 (https=) 1989-11-17
DE3061269D1 (en) 1983-01-13
ZA803880B (en) 1982-02-24

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