KR840007090A - 3,5-디아라비노시드의 제조방법 - Google Patents

3,5-디아라비노시드의 제조방법 Download PDF

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Publication number
KR840007090A
KR840007090A KR1019830005719A KR830005719A KR840007090A KR 840007090 A KR840007090 A KR 840007090A KR 1019830005719 A KR1019830005719 A KR 1019830005719A KR 830005719 A KR830005719 A KR 830005719A KR 840007090 A KR840007090 A KR 840007090A
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South Korea
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ara
group
monophosphate
dinucleoside
dinucleoside monophosphate
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KR1019830005719A
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English (en)
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와이 바라스키트(외 2) 장
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신 뜨라보
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Priority claimed from FR8220274A external-priority patent/FR2537144A1/fr
Application filed by 신 뜨라보 filed Critical 신 뜨라보
Publication of KR840007090A publication Critical patent/KR840007090A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

내용 없음

Description

3,5-디아라비노시드의 제조방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 아라 A는 9-β-D-아라비노푸라노실-아데닌이고, 아라 C는 1-β-D-아라비노푸라노실-시토신이고, P는 모노포스페이트기인 일반식 아라 A-P-아라 C, 아라 C-P-아라 A 및 A-P-아라 A의 디뉴클레오시드 모노포스페이트를 제조하는 방법에 있어서
  2. 1) 3'-위치에 유리 OH기를 갖는 신톤아데닌과 시토신을 제조하고, 2)5'-위치에 유리 OH기를 갖는 신톤아데닌과 시토신을 제조하고, 3)-2관능성인 산화제의 도웃으로 3'-위치에 유리기를 갖는 신톤을 인산화 시키고, -축합제의 도움으로, 얻어진 디에스테르와 선택된 뉴클레오시드를 축합시키고, -얻어진 화합물을 탈보호시켜서 원하는 2량체를 트리에틸아모늄염의 형태로 얻음으로써, 디뉴클레오시드 모노페이트를 합성하는 것을 특징으로 하는 디뉴클레오시드 모노포스페이트의 제조방법.
  3. 제1항에 있어서, 2관능성 인산화제가 0-클로로페닝 포스포로디클로리데이트인 것을 특징으로 하는 디뉴클레오시드 모노포스페이트의 제조방법.
  4. 제2항에 있어서, 축합제가 1-메시틸렌술포닐-3-니트로-1,2,4-트리아졸인 것을 특징으로 하는 디뉴클레오시드 모노포스페이트의 제조방법.
  5. 제1,2 또는 3항에 있어서, -0-클로로페닐기는 4-니트로벤즈알드옥심과 트리에틸아민의 용액으로 탈보호되고, -벤조일기는 암모니아 수용액에 의하여 제거되고, -모노메톡시트리틸기는 아세트산에 의하여 가수분해되는 것을 특징으로 하는 디뉴클레오시드 모노포스페이트의 제조방법.
  6. 아라 A는 9-β-D-아라비노푸라노실-아데닌이고, 아라 C는 1-β-D-아라비노푸라노실-시토신이고, p는 모노포스페이트인 일반식 아라 A-P-아라 C, 알 C-P-아라 A 및 아라 A-P-아라 A의 디뉴클레오시드 모노포페이트에 있어서, 상기 청구범위 제1항 내지 제4항중 어느 하나의 방법에 의하여 제조된 것을 특징으로 하는, 디뉴클레오시드 모노포스페이트.
  7. 제5항에 있어서, 스페이트기의 성분이 0-클로로페닐기인 것을 특징으로 하는, 디뉴클로오시드 모노포스페이트.
  8. 적당한 부형제와 함께 제5항 또는 제6항에서 규정한 디 뉴클레오시드 모노포스페이트를 함유하는 것을 특징으로 하는 약리적 조성물.
  9. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830005719A 1982-12-03 1983-12-02 3,5-디아라비노시드의 제조방법 KR840007090A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8220274 1982-12-03
FR8220274A FR2537144A1 (fr) 1982-12-03 1982-12-03 3',5'-diarabinosides, leur preparation et leur application en therapeutique
FR8304123 1983-03-14
FR8304123A FR2542744B2 (fr) 1982-12-03 1983-03-14 3',5'-diarabinosides, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
KR840007090A true KR840007090A (ko) 1984-12-05

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ID=26223174

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Application Number Title Priority Date Filing Date
KR1019830005719A KR840007090A (ko) 1982-12-03 1983-12-02 3,5-디아라비노시드의 제조방법

Country Status (13)

Country Link
EP (1) EP0121635A1 (ko)
JP (1) JPS59112998A (ko)
KR (1) KR840007090A (ko)
AU (1) AU2192783A (ko)
DK (1) DK555683A (ko)
ES (1) ES527737A0 (ko)
FI (1) FI834429A (ko)
FR (1) FR2542744B2 (ko)
GR (1) GR79109B (ko)
IL (1) IL70361A0 (ko)
MA (1) MA19965A1 (ko)
NO (1) NO834433L (ko)
PT (1) PT77767B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879700A (en) * 1991-10-15 1999-03-09 Hostetler; Karl Y. Nucleoside analogue phosphates for topical use
US6015573A (en) * 1993-05-12 2000-01-18 Hostetler; Karl Y. Nucleoside phosphate therapy for viral infection
WO1994026273A1 (en) * 1993-05-12 1994-11-24 Hostetler Karl Y Acyclovir derivatives for topical use
US6025335A (en) * 1995-09-21 2000-02-15 Lipitek International, Inc. L-Nucleoside Dimer Compounds and therapeutic uses
GB201317166D0 (en) * 2013-09-27 2013-11-06 Astex Therapeutics Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
DK555683D0 (da) 1983-12-02
FI834429A (fi) 1984-06-04
AU2192783A (en) 1984-06-07
IL70361A0 (en) 1984-03-30
EP0121635A1 (fr) 1984-10-17
PT77767B (fr) 1986-05-30
GR79109B (ko) 1984-10-02
DK555683A (da) 1984-06-04
FI834429A0 (fi) 1983-12-02
FR2542744A2 (fr) 1984-09-21
JPS59112998A (ja) 1984-06-29
FR2542744B2 (fr) 1985-06-14
NO834433L (no) 1984-06-04
ES8406504A1 (es) 1984-08-01
PT77767A (fr) 1984-01-01
ES527737A0 (es) 1984-08-01
MA19965A1 (fr) 1984-07-01

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