DE69108014D1 - Verfahren zur herstellung von nucleosiden und ihre analogen. - Google Patents

Verfahren zur herstellung von nucleosiden und ihre analogen.

Info

Publication number
DE69108014D1
DE69108014D1 DE69108014T DE69108014T DE69108014D1 DE 69108014 D1 DE69108014 D1 DE 69108014D1 DE 69108014 T DE69108014 T DE 69108014T DE 69108014 T DE69108014 T DE 69108014T DE 69108014 D1 DE69108014 D1 DE 69108014D1
Authority
DE
Germany
Prior art keywords
nucleoside
analogs
cyclonucleoside
cytarabine
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69108014T
Other languages
English (en)
Other versions
DE69108014T2 (de
Inventor
Khashayar Karimian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Pharmachem Inc
Original Assignee
Acic Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA 2012093 external-priority patent/CA2012093C/en
Priority claimed from CA 2012094 external-priority patent/CA2012094C/en
Application filed by Acic Canada Inc filed Critical Acic Canada Inc
Publication of DE69108014D1 publication Critical patent/DE69108014D1/de
Application granted granted Critical
Publication of DE69108014T2 publication Critical patent/DE69108014T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69108014T 1990-03-13 1991-03-13 Verfahren zur herstellung von nucleosiden und ihre analogen. Expired - Fee Related DE69108014T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA 2012093 CA2012093C (en) 1990-03-13 1990-03-13 Process for producing 2,2'-cyclocytidine and analogues thereof
CA 2012094 CA2012094C (en) 1990-03-13 1990-03-13 Process for producing cytarabine and analogues thereof
PCT/CA1991/000077 WO1991013900A1 (en) 1990-03-13 1991-03-13 Process for producing 2,2'-o-cyclonucleosides, nucleosides, and analogs thereof

Publications (2)

Publication Number Publication Date
DE69108014D1 true DE69108014D1 (de) 1995-04-13
DE69108014T2 DE69108014T2 (de) 1995-07-06

Family

ID=25674007

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108014T Expired - Fee Related DE69108014T2 (de) 1990-03-13 1991-03-13 Verfahren zur herstellung von nucleosiden und ihre analogen.

Country Status (8)

Country Link
US (1) US5610292A (de)
EP (1) EP0521923B1 (de)
AT (1) ATE119541T1 (de)
AU (1) AU7473791A (de)
BR (1) BR9106158A (de)
DE (1) DE69108014T2 (de)
HU (1) HUT61566A (de)
WO (1) WO1991013900A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU710074B2 (en) * 1994-06-22 1999-09-16 Proligo Llc Novel method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement
IT1277425B1 (it) 1995-08-03 1997-11-10 Pro Bio Sint Srl Metodo per la preparazione della 1-b-d-arabinofuranosilcitosina
AU747242B2 (en) 1997-01-08 2002-05-09 Proligo Llc Bioconjugation of macromolecules
US7427678B2 (en) 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
CN1263765C (zh) * 2000-04-13 2006-07-12 三井化学株式会社 胞苷衍生物的生产方法
EP2147679B1 (de) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Zusammensetzungen für den Blut-Hirn-Schrankentransport
AU2003210629A1 (en) 2002-01-23 2003-09-02 Proligo, Llc Methods for the integrated synthesis and purification of oligonucleotides
US7615629B2 (en) 2002-12-31 2009-11-10 Sigma-Aldrich Co. Methods and compositions for the tandem synthesis of two or more oligonucleotides on the same solid support
EP1668023A1 (de) * 2003-09-12 2006-06-14 Max-Delbrück-Centrum Für Molekulare Medizin B-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen
CN1300326C (zh) * 2004-12-22 2007-02-14 华南理工大学 酶催化制备阿糖胞苷酯的方法
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
US8404830B2 (en) 2007-07-17 2013-03-26 Somalogic, Inc. Method for generating aptamers with improved off-rates
AU2009223453B2 (en) 2008-03-03 2014-05-01 Tosk, Inc. Methotrexate adjuvants to reduce toxicity and methods for using the same
JP5564517B2 (ja) 2009-02-20 2014-07-30 ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ グルタチオンをベースとする薬物送達システム
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
EP2558586B1 (de) 2010-04-12 2016-10-12 Somalogic, Inc. APTAMERE FÜR ß-NGF UND IHRE VERWENDUNG BEI DER BEHANDLUNG VON DURCH ß-NGF VERMITTELTEN KRANKHEITEN UND LEIDEN
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
SG10202006426QA (en) 2013-11-21 2020-08-28 Somalogic Inc Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652554A (en) * 1982-02-22 1987-03-24 St. Jude Children's Research Hospital Nitro-substituted 1-β-D-arabinofuranosylcytosines
HUT61565A (en) * 1990-03-13 1993-01-28 Acic Canada Inc Process for producing 2,3'-0-cyclocytidine and 1-(beta-d-xylopento-furanosyl)-cytosine derivatives and their analogous compounds, as well as 3'-0-(p-toluenesulfonyl)-cytidine derivatives

Also Published As

Publication number Publication date
ATE119541T1 (de) 1995-03-15
US5610292A (en) 1997-03-11
HUT61566A (en) 1993-01-28
EP0521923B1 (de) 1995-03-08
EP0521923A1 (de) 1993-01-13
BR9106158A (pt) 1993-03-16
AU7473791A (en) 1991-10-10
DE69108014T2 (de) 1995-07-06
HU9202906D0 (en) 1992-11-30
WO1991013900A1 (en) 1991-09-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee