CA2012094A1 - Process for producing cytarabine and analogues thereof - Google Patents

Process for producing cytarabine and analogues thereof

Info

Publication number
CA2012094A1
CA2012094A1 CA 2012094 CA2012094A CA2012094A1 CA 2012094 A1 CA2012094 A1 CA 2012094A1 CA 2012094 CA2012094 CA 2012094 CA 2012094 A CA2012094 A CA 2012094A CA 2012094 A1 CA2012094 A1 CA 2012094A1
Authority
CA
Canada
Prior art keywords
cytarabine
producing
analogues
analogue
cyclocytidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2012094
Other languages
French (fr)
Other versions
CA2012094C (en
Inventor
Khashayar Karimian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Pharmachem Inc
Original Assignee
Acic Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA 2012094 priority Critical patent/CA2012094C/en
Application filed by Acic Canada Inc filed Critical Acic Canada Inc
Priority to EP91906244A priority patent/EP0521923B1/en
Priority to DE69108014T priority patent/DE69108014T2/en
Priority to PCT/CA1991/000077 priority patent/WO1991013900A1/en
Priority to AT91906244T priority patent/ATE119541T1/en
Priority to BR919106158A priority patent/BR9106158A/en
Priority to AU74737/91A priority patent/AU7473791A/en
Priority to HU9202906A priority patent/HUT61566A/en
Publication of CA2012094A1 publication Critical patent/CA2012094A1/en
Priority to US08/313,579 priority patent/US5610292A/en
Application granted granted Critical
Publication of CA2012094C publication Critical patent/CA2012094C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Abstract

A novel process for producing cytarabine or a cytarabine analogue comprising the step of reacting 2,2'-cyclocytidine or an analogue thereof with an amine.
Preferably the process is conducted in the presence of an aqueous solvent. Cytarabine is a known antineoplastic and antiviral agent.
CA 2012094 1990-03-13 1990-03-13 Process for producing cytarabine and analogues thereof Expired - Fee Related CA2012094C (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA 2012094 CA2012094C (en) 1990-03-13 1990-03-13 Process for producing cytarabine and analogues thereof
DE69108014T DE69108014T2 (en) 1990-03-13 1991-03-13 METHOD FOR PRODUCING NUCLEOSIDES AND THEIR ANALOGS.
PCT/CA1991/000077 WO1991013900A1 (en) 1990-03-13 1991-03-13 Process for producing 2,2'-o-cyclonucleosides, nucleosides, and analogs thereof
AT91906244T ATE119541T1 (en) 1990-03-13 1991-03-13 METHOD FOR PRODUCING NUCLEOSIDES AND THEIR ANALOGUES.
EP91906244A EP0521923B1 (en) 1990-03-13 1991-03-13 Process for producing nucleosides, and analogs therof
BR919106158A BR9106158A (en) 1990-03-13 1991-03-13 PROCESS TO PRODUCE 2,2'-O-CYCLONUCLEOSIDEOS, NUCLEOSIDEOS AND THEIR ANALOGS
AU74737/91A AU7473791A (en) 1990-03-13 1991-03-13 Process for producing 2,2'-o-cyclonucleosides, nucleosides, and analogs thereof
HU9202906A HUT61566A (en) 1990-03-13 1991-03-13 Process for producing 2,2'-o-cyclonucleosides, nucleosides and their analogous compounds
US08/313,579 US5610292A (en) 1990-03-13 1994-09-27 Process for producing 2,2'-o-cyclonucleosides nucleosides, and analogs thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2012094 CA2012094C (en) 1990-03-13 1990-03-13 Process for producing cytarabine and analogues thereof

Publications (2)

Publication Number Publication Date
CA2012094A1 true CA2012094A1 (en) 1991-09-13
CA2012094C CA2012094C (en) 1996-07-23

Family

ID=4144516

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2012094 Expired - Fee Related CA2012094C (en) 1990-03-13 1990-03-13 Process for producing cytarabine and analogues thereof

Country Status (1)

Country Link
CA (1) CA2012094C (en)

Also Published As

Publication number Publication date
CA2012094C (en) 1996-07-23

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