DE3883456D1 - Verfahren zur Herstellung von substituierten Indolinonderivaten. - Google Patents
Verfahren zur Herstellung von substituierten Indolinonderivaten.Info
- Publication number
- DE3883456D1 DE3883456D1 DE88305510T DE3883456T DE3883456D1 DE 3883456 D1 DE3883456 D1 DE 3883456D1 DE 88305510 T DE88305510 T DE 88305510T DE 3883456 T DE3883456 T DE 3883456T DE 3883456 D1 DE3883456 D1 DE 3883456D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- indolinone derivatives
- substituted indolinone
- chem
- equivalents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 abstract 2
- 229910021578 Iron(III) chloride Inorganic materials 0.000 abstract 1
- -1 acetyl halide Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002829 reductive effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
- C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878714371A GB8714371D0 (en) | 1987-06-19 | 1987-06-19 | Process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3883456D1 true DE3883456D1 (de) | 1993-09-30 |
| DE3883456T2 DE3883456T2 (de) | 1994-03-17 |
Family
ID=10619198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE88305510T Expired - Lifetime DE3883456T2 (de) | 1987-06-19 | 1988-06-16 | Verfahren zur Herstellung von substituierten Indolinonderivaten. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4997954A (de) |
| EP (1) | EP0300614B1 (de) |
| JP (1) | JPH07596B2 (de) |
| KR (1) | KR0143088B1 (de) |
| CN (1) | CN1019296B (de) |
| AT (1) | ATE93521T1 (de) |
| AU (1) | AU600582B2 (de) |
| CA (1) | CA1326035C (de) |
| CY (1) | CY1951A (de) |
| DE (1) | DE3883456T2 (de) |
| DK (1) | DK169965B1 (de) |
| EG (1) | EG18412A (de) |
| ES (1) | ES2058285T3 (de) |
| FI (1) | FI89264C (de) |
| GB (1) | GB8714371D0 (de) |
| HK (1) | HK1003226A1 (de) |
| HU (4) | HU203723B (de) |
| IE (1) | IE62830B1 (de) |
| IL (1) | IL86736A (de) |
| MY (1) | MY103583A (de) |
| NO (1) | NO172577C (de) |
| NZ (1) | NZ225072A (de) |
| PH (1) | PH24608A (de) |
| PT (1) | PT87770B (de) |
| ZA (1) | ZA884334B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
| MX9304801A (es) * | 1992-08-06 | 1997-06-28 | Warner Lambert Co | 2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales. |
| US5278162A (en) * | 1992-09-18 | 1994-01-11 | The Du Pont Merck Pharmaceutical Company | 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man |
| GB9300309D0 (en) * | 1993-01-08 | 1993-03-03 | Smithkline Beecham Plc | Process |
| US6218421B1 (en) * | 1999-07-01 | 2001-04-17 | Smithkline Beecham P.L.C. | Method of promoting smoking cessation |
| AR030557A1 (es) | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
| WO2002048104A1 (fr) * | 2000-12-14 | 2002-06-20 | Nissan Chemical Industries, Ltd. | Procede de production d'un derive d'indole |
| WO2005074387A2 (en) * | 2003-12-30 | 2005-08-18 | Sun Pharmaceutical Industries Limited | Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride |
| US7378439B2 (en) * | 2004-01-20 | 2008-05-27 | Usv, Ltd. | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride |
| WO2005105741A1 (en) * | 2004-02-11 | 2005-11-10 | Sun Pharmaceutical Industries Limited | Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride |
| WO2005080333A1 (en) * | 2004-02-19 | 2005-09-01 | Torrent Pharmaceuticals Ltd | Process for purification of ropinirole |
| EP1568689A1 (de) * | 2004-02-19 | 2005-08-31 | Helm AG | Verfahren zur Herstellung der 2-oxoindol-Derivat, Ropinirole |
| EP1756072A2 (de) * | 2004-04-27 | 2007-02-28 | Wyeth | Reinigung von progesteronrezeptor-modulatoren |
| WO2007110879A2 (en) | 2006-03-29 | 2007-10-04 | Alembic Limited | A process for the purification of ropinirole hydrochloride |
| US20070254941A1 (en) * | 2006-04-21 | 2007-11-01 | Glenmark Pharmaceuticals Limited | Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation |
| CN100457732C (zh) * | 2006-05-25 | 2009-02-04 | 药源药物化学（上海）有限公司 | 罗匹尼罗的制备方法 |
| WO2010023693A2 (en) * | 2008-09-01 | 2010-03-04 | Lupin Limited | Novel controlled release compositions of ropinirole |
| EP2438917B1 (de) * | 2009-05-21 | 2014-09-03 | Hisamitsu Pharmaceutical Co., Inc. | Transdermales präparat |
| EP3640240B1 (de) | 2017-06-16 | 2020-12-09 | Zhejiang Huahai Licheng Pharmaceutical Co., Ltd. | Verfahren zur aufreinigung von ropinirolhydrochlorid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588740A (en) * | 1982-12-07 | 1986-05-13 | Smithkline Beckman Corporation | Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones |
| US4452808A (en) * | 1982-12-07 | 1984-06-05 | Smithkline Beckman Corporation | 4-Aminoalkyl-2(3H)-indolones |
| US4761485A (en) * | 1987-03-11 | 1988-08-02 | Pfizer Inc. | Synthetic method for indol-2(3H)-ones |
-
1987
- 1987-06-19 GB GB878714371A patent/GB8714371D0/en active Pending
-
1988
- 1988-06-13 PH PH37063A patent/PH24608A/en unknown
- 1988-06-13 CA CA000569292A patent/CA1326035C/en not_active Expired - Lifetime
- 1988-06-13 NO NO882588A patent/NO172577C/no not_active IP Right Cessation
- 1988-06-14 IL IL86736A patent/IL86736A/xx not_active IP Right Cessation
- 1988-06-15 US US07/207,351 patent/US4997954A/en not_active Expired - Lifetime
- 1988-06-16 EP EP88305510A patent/EP0300614B1/de not_active Expired - Lifetime
- 1988-06-16 DE DE88305510T patent/DE3883456T2/de not_active Expired - Lifetime
- 1988-06-16 ES ES88305510T patent/ES2058285T3/es not_active Expired - Lifetime
- 1988-06-16 AT AT88305510T patent/ATE93521T1/de not_active IP Right Cessation
- 1988-06-16 CN CN88103732A patent/CN1019296B/zh not_active Expired
- 1988-06-17 FI FI882919A patent/FI89264C/fi active IP Right Grant
- 1988-06-17 HU HU893988A patent/HU203723B/hu not_active IP Right Cessation
- 1988-06-17 NZ NZ225072A patent/NZ225072A/xx unknown
- 1988-06-17 PT PT87770A patent/PT87770B/pt not_active IP Right Cessation
- 1988-06-17 AU AU18119/88A patent/AU600582B2/en not_active Expired
- 1988-06-17 ZA ZA884334A patent/ZA884334B/xx unknown
- 1988-06-17 DK DK334788A patent/DK169965B1/da not_active IP Right Cessation
- 1988-06-17 HU HU883123A patent/HU202200B/hu unknown
- 1988-06-17 KR KR1019880007283A patent/KR0143088B1/ko not_active IP Right Cessation
- 1988-06-17 MY MYPI88000674A patent/MY103583A/en unknown
- 1988-06-17 HU HU911599A patent/HU205339B/hu not_active IP Right Cessation
- 1988-06-17 IE IE183788A patent/IE62830B1/en not_active IP Right Cessation
- 1988-06-17 HU HU906948A patent/HUT55360A/hu unknown
- 1988-06-17 JP JP63151067A patent/JPH07596B2/ja not_active Expired - Lifetime
- 1988-06-19 EG EG342/88A patent/EG18412A/xx active
-
1997
- 1997-05-16 CY CY195197A patent/CY1951A/xx unknown
-
1998
- 1998-03-19 HK HK98102343A patent/HK1003226A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |