FI882919A0 - Foerfarande. - Google Patents

Foerfarande.

Info

Publication number
FI882919A0
FI882919A0 FI882919A FI882919A FI882919A0 FI 882919 A0 FI882919 A0 FI 882919A0 FI 882919 A FI882919 A FI 882919A FI 882919 A FI882919 A FI 882919A FI 882919 A0 FI882919 A0 FI 882919A0
Authority
FI
Finland
Prior art keywords
chem
equivalents
iii
compound
foerfarande
Prior art date
Application number
FI882919A
Other languages
English (en)
Other versions
FI882919A (fi
FI89264B (fi
FI89264C (fi
Inventor
Joseph M Fortunak
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of FI882919A0 publication Critical patent/FI882919A0/fi
Publication of FI882919A publication Critical patent/FI882919A/fi
Publication of FI89264B publication Critical patent/FI89264B/fi
Application granted granted Critical
Publication of FI89264C publication Critical patent/FI89264C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
    • C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
FI882919A 1987-06-19 1988-06-17 Foerfarande foer framstaellning av indolinonderivat FI89264C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8714371 1987-06-19
GB878714371A GB8714371D0 (en) 1987-06-19 1987-06-19 Process

Publications (4)

Publication Number Publication Date
FI882919A0 true FI882919A0 (fi) 1988-06-17
FI882919A FI882919A (fi) 1988-12-20
FI89264B FI89264B (fi) 1993-05-31
FI89264C FI89264C (fi) 1993-09-10

Family

ID=10619198

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882919A FI89264C (fi) 1987-06-19 1988-06-17 Foerfarande foer framstaellning av indolinonderivat

Country Status (25)

Country Link
US (1) US4997954A (fi)
EP (1) EP0300614B1 (fi)
JP (1) JPH07596B2 (fi)
KR (1) KR0143088B1 (fi)
CN (1) CN1019296B (fi)
AT (1) ATE93521T1 (fi)
AU (1) AU600582B2 (fi)
CA (1) CA1326035C (fi)
CY (1) CY1951A (fi)
DE (1) DE3883456T2 (fi)
DK (1) DK169965B1 (fi)
EG (1) EG18412A (fi)
ES (1) ES2058285T3 (fi)
FI (1) FI89264C (fi)
GB (1) GB8714371D0 (fi)
HK (1) HK1003226A1 (fi)
HU (4) HU205339B (fi)
IE (1) IE62830B1 (fi)
IL (1) IL86736A (fi)
MY (1) MY103583A (fi)
NO (1) NO172577C (fi)
NZ (1) NZ225072A (fi)
PH (1) PH24608A (fi)
PT (1) PT87770B (fi)
ZA (1) ZA884334B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
MX9304801A (es) * 1992-08-06 1997-06-28 Warner Lambert Co 2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales.
US5278162A (en) * 1992-09-18 1994-01-11 The Du Pont Merck Pharmaceutical Company 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
GB9300309D0 (en) * 1993-01-08 1993-03-03 Smithkline Beecham Plc Process
US6218421B1 (en) * 1999-07-01 2001-04-17 Smithkline Beecham P.L.C. Method of promoting smoking cessation
AR030557A1 (es) 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
AU2002222642A1 (en) * 2000-12-14 2002-06-24 Nissan Chemical Industries Ltd. Method for producing indole derivative
WO2005074387A2 (en) * 2003-12-30 2005-08-18 Sun Pharmaceutical Industries Limited Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride
US7378439B2 (en) * 2004-01-20 2008-05-27 Usv, Ltd. Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
WO2005105741A1 (en) * 2004-02-11 2005-11-10 Sun Pharmaceutical Industries Limited Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride
WO2005080333A1 (en) * 2004-02-19 2005-09-01 Torrent Pharmaceuticals Ltd Process for purification of ropinirole
EP1568689A1 (en) * 2004-02-19 2005-08-31 Helm AG Process for the preparation of the 2-oxoindole derivative, Ropinirole
AU2005237520B2 (en) 2004-04-27 2012-01-19 Wyeth Purification of progesterone receptor modulators
EP2007721B1 (en) 2006-03-29 2011-07-27 Alembic Limited A process for the purification of ropinirole hydrochloride
US20070254941A1 (en) * 2006-04-21 2007-11-01 Glenmark Pharmaceuticals Limited Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation
CN100457732C (zh) * 2006-05-25 2009-02-04 药源药物化学（上海）有限公司 罗匹尼罗的制备方法
US20110195117A1 (en) * 2008-09-01 2011-08-11 Lupin Limited Controlled release compositions of ropinirole
ES2513691T3 (es) * 2009-05-21 2014-10-27 Hisamitsu Pharmaceutical Co., Inc. Preparación transdérmica
CN110621660B (zh) 2017-06-16 2022-06-28 浙江华海立诚药业有限公司 盐酸罗匹尼罗的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US4588740A (en) * 1982-12-07 1986-05-13 Smithkline Beckman Corporation Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
US4761485A (en) * 1987-03-11 1988-08-02 Pfizer Inc. Synthetic method for indol-2(3H)-ones

Also Published As

Publication number Publication date
MY103583A (en) 1993-08-28
CA1326035C (en) 1994-01-11
ATE93521T1 (de) 1993-09-15
NO172577B (no) 1993-05-03
HUT48583A (en) 1989-06-28
IL86736A (en) 1992-03-29
DK334788A (da) 1988-12-20
NZ225072A (en) 1990-05-28
HU205339B (en) 1992-04-28
US4997954A (en) 1991-03-05
ZA884334B (en) 1990-04-25
JPS6419065A (en) 1989-01-23
NO882588D0 (no) 1988-06-13
FI882919A (fi) 1988-12-20
PT87770B (pt) 1992-10-30
HU202200B (en) 1991-02-28
PH24608A (en) 1990-08-17
CN1019296B (zh) 1992-12-02
HK1003226A1 (en) 1998-10-16
DK334788D0 (da) 1988-06-17
KR890000421A (ko) 1989-03-14
DE3883456T2 (de) 1994-03-17
GB8714371D0 (en) 1987-07-22
ES2058285T3 (es) 1994-11-01
IE881837L (en) 1988-12-19
NO882588L (no) 1988-12-20
EP0300614B1 (en) 1993-08-25
DK169965B1 (da) 1995-04-18
AU1811988A (en) 1988-12-22
HU203723B (en) 1991-09-30
EP0300614A1 (en) 1989-01-25
HU911599D0 (en) 1991-11-28
CY1951A (en) 1997-05-16
PT87770A (pt) 1989-05-31
JPH07596B2 (ja) 1995-01-11
CN1030076A (zh) 1989-01-04
DE3883456D1 (de) 1993-09-30
EG18412A (en) 1992-12-30
HUT52043A (en) 1990-06-28
IE62830B1 (en) 1995-03-08
FI89264B (fi) 1993-05-31
FI89264C (fi) 1993-09-10
AU600582B2 (en) 1990-08-16
NO172577C (no) 1993-08-11
KR0143088B1 (ko) 1998-07-15
HUT55360A (en) 1991-05-28

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: SMITH KLINE & FRENCH LABORATORIES LTD.

BB Publication of examined application
FG Patent granted

Owner name: SMITH KLINE & FRENCH LABORATORIES LTD