KR840001589A - 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐) 우라실-5'-인산염 및 그 제조방법 - Google Patents

1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐) 우라실-5'-인산염 및 그 제조방법 Download PDF

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KR840001589A
KR840001589A KR1019820003969A KR820003969A KR840001589A KR 840001589 A KR840001589 A KR 840001589A KR 1019820003969 A KR1019820003969 A KR 1019820003969A KR 820003969 A KR820003969 A KR 820003969A KR 840001589 A KR840001589 A KR 840001589A
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South Korea
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halogenovinyl
uracil
formula
dna virus
arabinofranosyl
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KR1019820003969A
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KR890000762B1 (ko
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신지 사까다 (외 1)
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하마구찌 기헤에
야마사 쇼오유 가부시기가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biotechnology (AREA)
  • Biochemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)

Abstract

내용 없음

Description

1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐) 우라실-5′-인산염 및 그 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (20)

  1. 하기 구조식을 가진 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐) 우라실-5′-인산염 및 그 제조 방법.
  3. 식중, X는 할로겐을 나타낸다.
  4. X가 취소, 염소 및 요오드로 구성된 그루우프에서 선택된 할로겐인 특허청구의 범위 1기재의 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐) 우라실-5′-인산염 및 그 제조 방법.
  5. 하기 구조식(Ⅱ)의 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐) 우라실을 인산화제와 반응시킴에 의하여 5′-위(位)의 히드록실기를 인산화하며, 그리고 선택적으로 상기의 형성된 산을 소망하는 염으로 변환시킴으로써 이루어지는 하기 구조식(Ⅰ)의 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐) 우라실-5′-인산염 또는 약학적으로 받아들일 수 있는 그 염의 제조 방법.
  7. 식중, X는 할로겐을 나타낸다.
  9. 식중, X는 위에서 정의된 것과 동일하다.
  10. 인산화반응이 트리알킬인산염내에서 인산화제로서 포스포러스 옥시클로 라이드의 사용에 의하여 수행되어지는 특허청구의 범위 3기재의 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐) 우라실-5′-인산염의 제조 방법.
  11. 유효량의 하기 구조식(Ⅰ)의 화합물 또는 약적으로 받아들일 수 있는 그 염과 약학적으로 받아들일 수 있는 담체로 이루어지는 항-DNA 바이러스제 조성물.
  13. 식중, X는 할로겐을 나타낸다.
  14. X가 취소, 염소 및 요오드로 구성된 그루우프에서 선택된 할로겐인 특허청구의 범위 5기재의 항-DNA 바이러스제 조성물.
  15. 항-헤르페스 바이러스제인 특허청구의 범위 5 또는 6기재의 항-DNA 바이러스제 조성물.
  16. 항-수두 바이러스제인 특허청구의 범위 5 또는 6기재의 항-DNA 바이러스제 조성물.
  17. 안약형태로된 특허청구의 범위 5기재의 항-DNA 바이러스제 조성물.
  18. 주사약형태로된 특허청구의 범위 5기재의 항-DNA 바이러스제 조성물.
  19. 연고형태로된 특허청구의 범위 5기재의 항-DNA 바이러스제 조성물.
  20. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8203969A 1981-09-09 1982-09-03 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐)우라실-5'-인산의 제조방법 KR890000762B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56142045A JPS5843993A (ja) 1981-09-09 1981-09-09 １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
JP81-142045 1981-09-09

Publications (2)

Publication Number Publication Date
KR840001589A true KR840001589A (ko) 1984-05-07
KR890000762B1 KR890000762B1 (ko) 1989-04-05

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KR8203969A KR890000762B1 (ko) 1981-09-09 1982-09-03 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐)우라실-5'-인산의 제조방법

Country Status (12)

Country Link
US (1) US4542210A (ko)
EP (1) EP0074101B1 (ko)
JP (1) JPS5843993A (ko)
KR (1) KR890000762B1 (ko)
AT (1) ATE12503T1 (ko)
AU (1) AU552353B2 (ko)
CA (1) CA1204107A (ko)
DE (1) DE3262887D1 (ko)
ES (1) ES8308570A1 (ko)
GB (1) GB2108964B (ko)
MY (1) MY8700826A (ko)
SG (1) SG81787G (ko)

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JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
EP0104066B1 (en) * 1982-09-17 1988-08-10 Glaxo Group Limited 5-halovinyl-2'-deoxyuridine derivatives
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GB8912972D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Therapeutic nucleosides
KR960008669B1 (ko) * 1991-04-24 1996-06-28 야마사 쇼오유 가부시끼가이샤 1-β-D-아라비노푸라노실-(E)-5-(2-할로게노비닐) 우라실 유도체
US5446031A (en) * 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
CA2298681C (en) 1997-08-08 2008-07-08 Newbiotics, Inc. Methods and compositions for overcoming resistance to biologic and chemotherapy
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
AU753155B2 (en) 1998-01-23 2002-10-10 Kiadis Pharma Intellectual Property B.V. Enzyme catalyzed therapeutic agents
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
MXPA02000762A (es) 1999-07-22 2002-08-20 Newbiotics Inc Metodos para tratar tumores resistentes a terapia.
CA2441350A1 (en) * 2001-01-19 2002-07-25 Newbiotics, Inc. Methods to treat autoimmune and inflammatory conditions
EP1569658A4 (en) * 2001-12-20 2007-05-30 Pharmassett Ltd TREATMENT OF EPSTEIN-BARR VIRUS, INFECTION WITH KAPOSI-ASSOCIATED SARCOMA HERPESVIRUS AND ABNORMAL CELL PROLIFERATION
JP4964473B2 (ja) * 2006-02-10 2012-06-27 アリジェン製薬株式会社 ピリミジンヌクレオシド誘導体及びその塩
US8076302B2 (en) 2007-02-15 2011-12-13 Arigen Pharmaceuticals, Inc. Pyrimidine nucleoside derivatives and salts thereof

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GB1157275A (en) * 1965-07-27 1969-07-02 Takeda Chemical Industries Ltd A Method for the Production of 5'-Ribonucleotide
US3382232A (en) * 1965-08-26 1968-05-07 Takeda Chemical Industries Ltd Method for the production of 5'-ribonucleotide
FR5616M (ko) * 1966-07-29 1968-01-15
EP0015584A3 (de) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
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EP0074101A1 (en) 1983-03-16
AU552353B2 (en) 1986-05-29
EP0074101B1 (en) 1985-04-03
JPS5843993A (ja) 1983-03-14
DE3262887D1 (en) 1985-05-09
GB2108964A (en) 1983-05-25
CA1204107A (en) 1986-05-06
AU8799682A (en) 1983-03-17
SG81787G (en) 1988-04-15
JPS637559B2 (ko) 1988-02-17
ES515573A0 (es) 1983-09-16
ATE12503T1 (de) 1985-04-15
ES8308570A1 (es) 1983-09-16
US4542210A (en) 1985-09-17
MY8700826A (en) 1987-12-31
KR890000762B1 (ko) 1989-04-05
GB2108964B (en) 1985-04-11

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