DE3262887D1 - 1-beta-d-arabinofuranosyl-(e)-5-(2-halogenovinyl) uracil-5'-phosphate, preparation thereof and use thereof - Google Patents

1-beta-d-arabinofuranosyl-(e)-5-(2-halogenovinyl) uracil-5'-phosphate, preparation thereof and use thereof

Info

Publication number
DE3262887D1
DE3262887D1 DE8282108163T DE3262887T DE3262887D1 DE 3262887 D1 DE3262887 D1 DE 3262887D1 DE 8282108163 T DE8282108163 T DE 8282108163T DE 3262887 T DE3262887 T DE 3262887T DE 3262887 D1 DE3262887 D1 DE 3262887D1
Authority
DE
Germany
Prior art keywords
halogenovinyl
arabinofuranosyl
uracil
beta
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282108163T
Other languages
English (en)
Inventor
Shinji Sakata
Haruhiko Machida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15306105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3262887(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Application granted granted Critical
Publication of DE3262887D1 publication Critical patent/DE3262887D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
DE8282108163T 1981-09-09 1982-09-03 1-beta-d-arabinofuranosyl-(e)-5-(2-halogenovinyl) uracil-5'-phosphate, preparation thereof and use thereof Expired DE3262887D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56142045A JPS5843993A (ja) 1981-09-09 1981-09-09 １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Publications (1)

Publication Number Publication Date
DE3262887D1 true DE3262887D1 (en) 1985-05-09

Family

ID=15306105

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282108163T Expired DE3262887D1 (en) 1981-09-09 1982-09-03 1-beta-d-arabinofuranosyl-(e)-5-(2-halogenovinyl) uracil-5'-phosphate, preparation thereof and use thereof

Country Status (12)

Country Link
US (1) US4542210A (de)
EP (1) EP0074101B1 (de)
JP (1) JPS5843993A (de)
KR (1) KR890000762B1 (de)
AT (1) ATE12503T1 (de)
AU (1) AU552353B2 (de)
CA (1) CA1204107A (de)
DE (1) DE3262887D1 (de)
ES (1) ES8308570A1 (de)
GB (1) GB2108964B (de)
MY (1) MY8700826A (de)
SG (1) SG81787G (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
EP0104066B1 (de) * 1982-09-17 1988-08-10 Glaxo Group Limited Derivate von 5-Halovinyl-2'-deoxyuridin
US4658044A (en) * 1983-09-16 1987-04-14 Glaxo Group Limited Intermediates for uracil derivatives
ZA85578B (en) * 1985-01-24 1985-07-22 Neopharmed S.P.A. Acylated derivatives of cytidine-diphosphate-choline,process for their preparation and their therapeutic use
GB8912972D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Therapeutic nucleosides
KR960008669B1 (ko) * 1991-04-24 1996-06-28 야마사 쇼오유 가부시끼가이샤 1-β-D-아라비노푸라노실-(E)-5-(2-할로게노비닐) 우라실 유도체
US5446031A (en) * 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
CA2298681C (en) 1997-08-08 2008-07-08 Newbiotics, Inc. Methods and compositions for overcoming resistance to biologic and chemotherapy
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
AU753155B2 (en) 1998-01-23 2002-10-10 Kiadis Pharma Intellectual Property B.V. Enzyme catalyzed therapeutic agents
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
MXPA02000762A (es) 1999-07-22 2002-08-20 Newbiotics Inc Metodos para tratar tumores resistentes a terapia.
CA2441350A1 (en) * 2001-01-19 2002-07-25 Newbiotics, Inc. Methods to treat autoimmune and inflammatory conditions
EP1569658A4 (de) * 2001-12-20 2007-05-30 Pharmassett Ltd Behandlung einer ebv- und khsv-infektion sowie einer damit zusammenhängenden abnormalen zellproliferation
JP4964473B2 (ja) * 2006-02-10 2012-06-27 アリジェン製薬株式会社 ピリミジンヌクレオシド誘導体及びその塩
US8076302B2 (en) 2007-02-15 2011-12-13 Arigen Pharmaceuticals, Inc. Pyrimidine nucleoside derivatives and salts thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157275A (en) * 1965-07-27 1969-07-02 Takeda Chemical Industries Ltd A Method for the Production of 5'-Ribonucleotide
US3382232A (en) * 1965-08-26 1968-05-07 Takeda Chemical Industries Ltd Method for the production of 5'-ribonucleotide
FR5616M (de) * 1966-07-29 1968-01-15
EP0015584A3 (de) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
GB2060604B (en) * 1979-10-03 1983-11-23 Univ Birmingham And Stichting E15-(2-halogenovinyl)-2'-deoxycytidines
JPS5687599A (en) * 1979-12-19 1981-07-16 Yamasa Shoyu Co Ltd E 55 22halogenovinyl arabinofuranosyluracil and its preparation
JPS5714598A (en) * 1980-06-30 1982-01-25 Yamasa Shoyu Co Ltd 5-substituted-1-beta-d-arabinofuranosyluracil derivative and its preparation
US4383990A (en) * 1980-10-01 1983-05-17 Beecham Group Limited Antiviral agents, their preparation and use
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Also Published As

Publication number Publication date
EP0074101A1 (de) 1983-03-16
AU552353B2 (en) 1986-05-29
EP0074101B1 (de) 1985-04-03
JPS5843993A (ja) 1983-03-14
GB2108964A (en) 1983-05-25
CA1204107A (en) 1986-05-06
AU8799682A (en) 1983-03-17
SG81787G (en) 1988-04-15
JPS637559B2 (de) 1988-02-17
ES515573A0 (es) 1983-09-16
ATE12503T1 (de) 1985-04-15
ES8308570A1 (es) 1983-09-16
US4542210A (en) 1985-09-17
MY8700826A (en) 1987-12-31
KR890000762B1 (ko) 1989-04-05
KR840001589A (ko) 1984-05-07
GB2108964B (en) 1985-04-11

Similar Documents

Publication Publication Date Title
DE3262887D1 (en) 1-beta-d-arabinofuranosyl-(e)-5-(2-halogenovinyl) uracil-5'-phosphate, preparation thereof and use thereof
ES527954A1 (es) Un procedimiento para preparar isoxazoles
PT77912B (en) Process for the preparation of antiviral compounds namelly 2-amino-4-oxo-5,6,7,8-tetrahydroquinazoline and their application in the treatment of viral infections
NO823836L (no) Fremgangsmaate ved fremstilling av antifibrinolytisk aktive forbindelser.
DE3270118D1 (en) 6-alpha-methyl-prednisolone derivatives, their preparation and utilization
DE3173954D1 (en) Use of adenosin derivatives for the manufacture of psychopharmacons
DE3260540D1 (en) 2-aryl-3,4-diaza-bicyclo(4.n.0)alken-(2)-ones-(5), process for their preparation, and medicines containing these compounds
ES8505518A1 (es) Procedimiento para preparar derivados de aminoacidos
NO159722C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme cykloalifatiske forbindelser.
GB2104890B (en) Pyridinecarbinols, their preparation and fungicides containing them
HUT42770A (en) Process for preparing novel pyrrolo-benzimidazole derivatives, pyrrolo -benzoxazole derivatives and pyrrolo-benzthiazole derivatives and pharmaceutical compositions comprising the same
ES511365A0 (es) "procedimiento de preparacion de derivados de fenetanolamina".
ZA821785B (en) Novel soluble n2 substituted derivatives of 2,4-diamino 5-benzyl pyrimidine, process for their preparation and medicaments containing them
IL62599A (en) 3-benzyl-3-phenyltetrahydroimidazothiazol-3-ol and-thiazolopyrimidin-3-ol derivatives,their preparation and pharmaceutical compositions containing them
IL59424A (en) 1,3,4-oxadiazolylmethylthiol phosphates,their manufacture and pesticidal compositions containing them
GB1554841A (en) 2,4 - dichlorophenyl - imidazolyl - ethan - ones and -ols a process for their preparation and their use as medicaments
DE3060236D1 (en) Thiazole derivatives, their preparation and medicaments containing them
ES8308335A1 (es) Un procedimiento para la preparacion de nuevos derivados de desoxiuridina.
YU211180A (en) Process for preparing 2-(2-chloro-4-cyclopropyl-phenylimino)-imidazolidine
IL78748A0 (en) Phosphorimidates,their preparation and their use as pesticides
IL80373A (en) Bisthiophosphate derivatives,their preparation and pesticidal compositions containing them

Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee