KR840006239A - 1-페닐-2(1h,3h)-인돌온의 제조방법 - Google Patents

1-페닐-2(1h,3h)-인돌온의 제조방법 Download PDF

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Publication number
KR840006239A
KR840006239A KR1019830004396A KR830004396A KR840006239A KR 840006239 A KR840006239 A KR 840006239A KR 1019830004396 A KR1019830004396 A KR 1019830004396A KR 830004396 A KR830004396 A KR 830004396A KR 840006239 A KR840006239 A KR 840006239A
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KR
South Korea
Prior art keywords
phenyl
methyl
hydrogen
preparing
indoleone
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KR1019830004396A
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English (en)
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KR860001270B1 (ko
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랄프 호워드 해리
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윌리암 데이비스 휜
화이자 인코포레이티드
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Publication of KR840006239A publication Critical patent/KR840006239A/ko
Priority to KR1019860005907A priority Critical patent/KR860001272B1/ko
Priority to KR1019860005906A priority patent/KR860001271B1/ko
Priority to KR1019860005908A priority patent/KR860001297B1/ko
Application granted granted Critical
Publication of KR860001270B1 publication Critical patent/KR860001270B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

1-페닐-2(1H,3H)-인돌온유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 일반식(III)의 인돌온을, 0내지 30℃에서 POCl3와의 반응에 의해 활성화시킨 일반식(II)의 아미드와반응시킴을 특징으로 하여 일반식(I)의 화합물을 제조하는 방법.
    상기식에서 A2및 B1은 함께 1,3-프로필렌 또는 1,4-부틸렌이고, C1은 메틸, 에틸, 페닐 또는 벤질이거나, 또는 A2는 수소이고, B1및 C1은 각기 독립적으로 메틸 또는 페닐이며, W는 수소 또는 클로로이고, W1,X1및 Y1은 각기 독립적으로 수소, 클로로, 플루오로 또는 메톡시이다.
  2. 제1항에 있어서, A2는 수소이고, B1및 C1은 각기 독립적이고 메틸 또는 페닐인 방법.
  3. 제2항에 있어서, W1및 Y1이 수소이고, X1이 3-클로로인 방법.
  4. 제1항에 있어서, A2와 B1이 함께 1,3-프로필렌 또는 1,4-부틸렌이고, C1이 메틸, 에틸, 페닐 또는 벤질인 방법.
  5. 제4항에 있어서, A2와 B1이 함께 1,3-프로필렌 이고, C1이 메틸인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830004396A 1982-09-20 1983-09-19 1-페닐-2(1h, 3h)-인돌온유도체의 제조방법 KR860001270B1 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019860005907A KR860001272B1 (ko) 1982-09-20 1986-07-19 1-페닐-2(1h, 3h)-인돌온 유도체의 제조방법
KR1019860005906A KR860001271B1 (ko) 1982-09-20 1986-07-19 1-페닐 -2(1h, 3h)-인돌온유도체의 제조방법
KR1019860005908A KR860001297B1 (ko) 1982-09-20 1986-07-19 1-페닐-2(1h, 3h)-인돌온 유도체의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US420544 1982-09-20
US06/420,544 US4476307A (en) 1982-09-20 1982-09-20 Heteroylidene indolone compounds

Related Child Applications (3)

Application Number Title Priority Date Filing Date
KR1019860005907A Division KR860001272B1 (ko) 1982-09-20 1986-07-19 1-페닐-2(1h, 3h)-인돌온 유도체의 제조방법
KR1019860005908A Division KR860001297B1 (ko) 1982-09-20 1986-07-19 1-페닐-2(1h, 3h)-인돌온 유도체의 제조방법
KR1019860005906A Division KR860001271B1 (ko) 1982-09-20 1986-07-19 1-페닐 -2(1h, 3h)-인돌온유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR840006239A true KR840006239A (ko) 1984-11-22
KR860001270B1 KR860001270B1 (ko) 1986-09-04

Family

ID=23666904

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830004396A KR860001270B1 (ko) 1982-09-20 1983-09-19 1-페닐-2(1h, 3h)-인돌온유도체의 제조방법

Country Status (24)

Country Link
US (1) US4476307A (ko)
EP (1) EP0104860B1 (ko)
JP (1) JPS5976058A (ko)
KR (1) KR860001270B1 (ko)
AT (1) ATE25972T1 (ko)
AU (1) AU543115B2 (ko)
CA (1) CA1194871A (ko)
DD (1) DD213211A5 (ko)
DE (1) DE3370325D1 (ko)
DK (1) DK157010C (ko)
ES (3) ES525737A0 (ko)
FI (1) FI77446C (ko)
GR (1) GR79732B (ko)
HU (1) HU189747B (ko)
IE (1) IE55923B1 (ko)
IL (1) IL69758A (ko)
NO (1) NO161557C (ko)
NZ (1) NZ205638A (ko)
PH (1) PH18297A (ko)
PL (3) PL141609B1 (ko)
PT (1) PT77360B (ko)
SU (1) SU1272983A3 (ko)
YU (4) YU189283A (ko)
ZA (1) ZA836933B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
US5128352A (en) * 1989-01-10 1992-07-07 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5078756A (en) * 1990-01-12 1992-01-07 Major Thomas O Apparatus and method for purification and recovery of refrigerant
US5158969A (en) * 1991-08-21 1992-10-27 Neurosearch A/S Indole derivatives as potassium channel blockers
US5760250A (en) * 1991-11-05 1998-06-02 Zeneca Limited Process for the preparation of 3-(α-methoxy)methylenebenzofuranones and intermediates therefor
DE19949209A1 (de) * 1999-10-13 2001-04-19 Boehringer Ingelheim Pharma In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6765012B2 (en) * 2001-09-27 2004-07-20 Allergan, Inc. 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
IL163992A0 (en) * 2002-03-27 2005-12-18 Lundbeck & Co As H Method for manufacture of sertindole
FR2847811B1 (fr) * 2002-11-29 2005-01-07 Oreal Composition filtrante contenant au moins un derive du dibenzoylmethane et au moins un derive de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one;procede de photostabilisation
FR2847813A1 (fr) * 2002-11-29 2004-06-04 Oreal Compositions cosmetiques photoprotectrices contenant des derives de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one et utilisations
EA015252B1 (ru) 2005-05-10 2011-06-30 Интермьюн, Инк. Способ модуляции стресс-активированной протеинкиназной системы
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
ES2523741T3 (es) 2008-12-19 2014-12-01 Nippon Soda Co., Ltd. Derivado de 1-heterodieno y agente de represión de organismos dañinos
WO2011058963A1 (ja) 2009-11-12 2011-05-19 日本曹達株式会社 １－ヘテロジエン誘導体および有害生物防除剤
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506683A (en) * 1963-10-07 1970-04-14 Upjohn Co 3-(2-pyrrolidinylidene)-3h-indoles
GB1237008A (en) * 1968-12-18 1971-06-30 Pfizer Ltd Novel indoline derivatives
US3723457A (en) * 1969-09-30 1973-03-27 Eisai Co Ltd Indoline-2-one derivatives and preparation thereof
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
DE2557342A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung

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Publication number Publication date
DE3370325D1 (en) 1987-04-23
HU189747B (en) 1986-07-28
PT77360B (en) 1986-05-19
ES531907A0 (es) 1985-06-01
YU169286A (en) 1987-10-31
DK157010B (da) 1989-10-30
ES8503328A1 (es) 1985-02-16
NO161557B (no) 1989-05-22
PH18297A (en) 1985-05-24
GR79732B (ko) 1984-10-31
YU169186A (en) 1987-10-31
PL243826A1 (en) 1985-04-24
PT77360A (en) 1983-10-01
ES531908A0 (es) 1985-06-01
NO161557C (no) 1989-08-30
DK425383A (da) 1984-05-03
EP0104860B1 (en) 1987-03-18
EP0104860A1 (en) 1984-04-04
FI833335A (fi) 1984-03-21
DK157010C (da) 1990-03-26
DK425383D0 (da) 1983-09-19
FI77446B (fi) 1988-11-30
KR860001270B1 (ko) 1986-09-04
IE55923B1 (en) 1991-02-27
ES8505950A1 (es) 1985-06-01
ZA836933B (en) 1985-05-29
FI833335A0 (fi) 1983-09-19
PL250768A1 (en) 1985-07-02
IL69758A (en) 1986-12-31
YU169386A (en) 1987-10-31
IL69758A0 (en) 1983-12-30
YU189283A (en) 1987-10-31
JPS6241711B2 (ko) 1987-09-04
AU543115B2 (en) 1985-04-04
ATE25972T1 (de) 1987-04-15
CA1194871A (en) 1985-10-08
NZ205638A (en) 1986-12-05
PL141370B1 (en) 1987-07-31
JPS5976058A (ja) 1984-04-28
NO833367L (no) 1984-03-21
FI77446C (fi) 1989-03-10
US4476307A (en) 1984-10-09
ES525737A0 (es) 1985-02-16
PL250769A1 (en) 1985-07-02
PL141609B1 (en) 1987-08-31
SU1272983A3 (ru) 1986-11-23
AU1925283A (en) 1984-03-29
IE832193L (en) 1984-03-20
ES8505951A1 (es) 1985-06-01
PL141876B1 (en) 1987-09-30
DD213211A5 (de) 1984-09-05

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