ES531908A0 - Un procedimiento para la preparacion de nuevas indolonas. - Google Patents

Un procedimiento para la preparacion de nuevas indolonas.

Info

Publication number
ES531908A0
ES531908A0 ES531908A ES531908A ES531908A0 ES 531908 A0 ES531908 A0 ES 531908A0 ES 531908 A ES531908 A ES 531908A ES 531908 A ES531908 A ES 531908A ES 531908 A0 ES531908 A0 ES 531908A0
Authority
ES
Spain
Prior art keywords
indolones
phenyl
treatment
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES531908A
Other languages
English (en)
Other versions
ES8505951A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of ES8505951A1 publication Critical patent/ES8505951A1/es
Publication of ES531908A0 publication Critical patent/ES531908A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES531908A 1982-09-20 1984-04-25 Un procedimiento para la preparacion de nuevas indolonas. Granted ES531908A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/420,544 US4476307A (en) 1982-09-20 1982-09-20 Heteroylidene indolone compounds

Publications (2)

Publication Number Publication Date
ES8505951A1 ES8505951A1 (es) 1985-06-01
ES531908A0 true ES531908A0 (es) 1985-06-01

Family

ID=23666904

Family Applications (3)

Application Number Title Priority Date Filing Date
ES525737A Expired ES8503328A1 (es) 1982-09-20 1983-09-19 Un procedimiento para la preparacion de nuevas idolonas.
ES531907A Granted ES531907A0 (es) 1982-09-20 1984-04-25 Un procedimiento para la preparacion de nuevas indolonas.
ES531908A Granted ES531908A0 (es) 1982-09-20 1984-04-25 Un procedimiento para la preparacion de nuevas indolonas.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES525737A Expired ES8503328A1 (es) 1982-09-20 1983-09-19 Un procedimiento para la preparacion de nuevas idolonas.
ES531907A Granted ES531907A0 (es) 1982-09-20 1984-04-25 Un procedimiento para la preparacion de nuevas indolonas.

Country Status (24)

Country Link
US (1) US4476307A (es)
EP (1) EP0104860B1 (es)
JP (1) JPS5976058A (es)
KR (1) KR860001270B1 (es)
AT (1) ATE25972T1 (es)
AU (1) AU543115B2 (es)
CA (1) CA1194871A (es)
DD (1) DD213211A5 (es)
DE (1) DE3370325D1 (es)
DK (1) DK157010C (es)
ES (3) ES8503328A1 (es)
FI (1) FI77446C (es)
GR (1) GR79732B (es)
HU (1) HU189747B (es)
IE (1) IE55923B1 (es)
IL (1) IL69758A (es)
NO (1) NO161557C (es)
NZ (1) NZ205638A (es)
PH (1) PH18297A (es)
PL (3) PL141370B1 (es)
PT (1) PT77360B (es)
SU (1) SU1272983A3 (es)
YU (4) YU189283A (es)
ZA (1) ZA836933B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
WO1990008146A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5078756A (en) * 1990-01-12 1992-01-07 Major Thomas O Apparatus and method for purification and recovery of refrigerant
US5158969A (en) * 1991-08-21 1992-10-27 Neurosearch A/S Indole derivatives as potassium channel blockers
US5760250A (en) * 1991-11-05 1998-06-02 Zeneca Limited Process for the preparation of 3-(α-methoxy)methylenebenzofuranones and intermediates therefor
DE19949209A1 (de) * 1999-10-13 2001-04-19 Boehringer Ingelheim Pharma In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6765012B2 (en) * 2001-09-27 2004-07-20 Allergan, Inc. 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
IL163992A0 (en) * 2002-03-27 2005-12-18 Lundbeck & Co As H Method for manufacture of sertindole
FR2847811B1 (fr) * 2002-11-29 2005-01-07 Oreal Composition filtrante contenant au moins un derive du dibenzoylmethane et au moins un derive de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one;procede de photostabilisation
FR2847813A1 (fr) * 2002-11-29 2004-06-04 Oreal Compositions cosmetiques photoprotectrices contenant des derives de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one et utilisations
PT1928454E (pt) 2005-05-10 2014-12-04 Intermune Inc Derivativos da piridona para modulação do sistema de proteína quinase ativada pelo stress
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
KR20130136591A (ko) 2008-12-19 2013-12-12 닛뽕소다 가부시키가이샤 １-헤테로디엔 유도체 및 유해 생물 방제제
KR101376443B1 (ko) 2009-11-12 2014-03-19 닛뽕소다 가부시키가이샤 1-헤테로디엔 유도체 및 유해 생물 방제제
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506683A (en) * 1963-10-07 1970-04-14 Upjohn Co 3-(2-pyrrolidinylidene)-3h-indoles
GB1237008A (en) * 1968-12-18 1971-06-30 Pfizer Ltd Novel indoline derivatives
US3723457A (en) * 1969-09-30 1973-03-27 Eisai Co Ltd Indoline-2-one derivatives and preparation thereof
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
DE2557342A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DK425383D0 (da) 1983-09-19
JPS5976058A (ja) 1984-04-28
FI77446C (fi) 1989-03-10
YU169186A (en) 1987-10-31
IE55923B1 (en) 1991-02-27
DK157010B (da) 1989-10-30
KR860001270B1 (ko) 1986-09-04
ES8505950A1 (es) 1985-06-01
ES8505951A1 (es) 1985-06-01
PL250768A1 (en) 1985-07-02
YU169386A (en) 1987-10-31
AU1925283A (en) 1984-03-29
SU1272983A3 (ru) 1986-11-23
AU543115B2 (en) 1985-04-04
HU189747B (en) 1986-07-28
ES525737A0 (es) 1985-02-16
PL141609B1 (en) 1987-08-31
FI833335A7 (fi) 1984-03-21
PT77360A (en) 1983-10-01
ES8503328A1 (es) 1985-02-16
NO833367L (no) 1984-03-21
DK157010C (da) 1990-03-26
FI833335A0 (fi) 1983-09-19
JPS6241711B2 (es) 1987-09-04
CA1194871A (en) 1985-10-08
PT77360B (en) 1986-05-19
PL141876B1 (en) 1987-09-30
YU189283A (en) 1987-10-31
FI77446B (fi) 1988-11-30
US4476307A (en) 1984-10-09
IL69758A (en) 1986-12-31
PL250769A1 (en) 1985-07-02
NZ205638A (en) 1986-12-05
ZA836933B (en) 1985-05-29
IL69758A0 (en) 1983-12-30
NO161557B (no) 1989-05-22
PH18297A (en) 1985-05-24
KR840006239A (ko) 1984-11-22
NO161557C (no) 1989-08-30
EP0104860B1 (en) 1987-03-18
EP0104860A1 (en) 1984-04-04
ES531907A0 (es) 1985-06-01
DK425383A (da) 1984-05-03
IE832193L (en) 1984-03-20
ATE25972T1 (de) 1987-04-15
PL243826A1 (en) 1985-04-24
DD213211A5 (de) 1984-09-05
GR79732B (es) 1984-10-31
PL141370B1 (en) 1987-07-31
YU169286A (en) 1987-10-31
DE3370325D1 (en) 1987-04-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401