PL141876B1 - Process for preparing novel derivatives of 2/1h,3h/-indolones - Google Patents

Process for preparing novel derivatives of 2/1h,3h/-indolones Download PDF

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Publication number
PL141876B1
PL141876B1 PL1983250769A PL25076983A PL141876B1 PL 141876 B1 PL141876 B1 PL 141876B1 PL 1983250769 A PL1983250769 A PL 1983250769A PL 25076983 A PL25076983 A PL 25076983A PL 141876 B1 PL141876 B1 PL 141876B1
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PL
Poland
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groups
formula
group
phenyl
alkyl
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Application number
PL1983250769A
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English (en)
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PL250769A1 (en
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Pfizer
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Application filed by Pfizer filed Critical Pfizer
Publication of PL250769A1 publication Critical patent/PL250769A1/xx
Publication of PL141876B1 publication Critical patent/PL141876B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (4)

1. Zastrzezenia patentowe 1. Sposób wytwarzania podstawionych 1-fenylo-3-/aminoalkilideno/-2/lH,3H/-indolonów 2 11 o wzorze 1, w którym w pierwszym przypadku A oznacza atom wodoru lub grupe metylowa, a B i C , niezaleznie od siebie, oznaczaja grupy /0.-C2/alkilowe, grupy fenylowe lub grupy benzylowe, w drugim przypadku A oznacza atom wodoru lub grupe metylowa, a B i C tworza wraz z atomem azotu, do którego sa przylaczone, pierscien piperydynowy, pierscien pirolidynowy, pierscien14 141 876 morfolinowy lub pierscien imidazolowy, a w trzecim przypadku A i B tworza razem grupe 1,3- propylenowa, grupe 1,4-butylenowa lub grupe 1,5-pentylenowa, a C oznacza grupe /Oi-Co/alki- lowa, grupe fenylowa lub grupe benzylowa, a ponadto W oznacza atom wodoru, grupe /(L-Cp/alki- lowa, grupe /c1-C2/alkoksylowa, atom chloru lub atom fluoru, a Vr, X* i Y niezaleznie od siebie, oznaczaja atomy wodoru, grupy I Z^-Z^alkilowe, grupy /(L-C2/alkoksylowe, grupy /(L-C^/ alkilotio, atomy bromu, chloru lub fluoru, grupy trójfluorometylowe*' grupy hydroksylowe, grupy formylowe, grupy karboksyamidowe, grupy /Oi-^/alkilokarboksyamidowe, grupy dwu-ZCL-CU/ alkilokarboksyamidowe, grupy cyjanowe, grupy nitrowe, grupy aminowe, grupy /(X|-C2/alkiloami- nowe lub grupy dwu-ZCL-C^/alkiloaminowe, pod warunkiem, ze /i/ gdy A oznacza atom wodoru lub grupe metylowa, B1 i C oznaczaja niezaleznie od siebie atomy wodoru, grupy /G--C2/alkilowe, grupy fenylowe lub grupy benzylowe, to grupa o wzorze 2 ma inne znaczenie niz 4-chlorofenyl, oraz /ii/ gdy A oznacza atom wodoru lub grupe metylowa, a B i C sa takie same i oznaczaja atomy wodoru lub grupy Iz^-Z^lAlkilowe, to grupa o wzorze 2 ma inne znaczenie niz grupa fenylowa lub 3-metoksyfenylowa, znamienny tym, ze zwiazek o wzorze 3f w którym A , B , C 1 R maja wyzej podane znaczenie, poddaje sie reakcji ze zwiazkiem o wzorze 4, w którym W, 111 W , X i Y maja wyzej podane znaczenie, w rozpuszczalniku obojetnym w warunkach reakcji, w temperaturze od 50 do 100°C.
2. Sposób wedlug zastrz. 1, znamienny 2 1 1 rze 3$ w którym A , B i C oznaczaja grupy metylowe,
3. * Sposób wedlug zastrz* 1, znamienny tym. rze 3, w którym A i B tworza razem grupe 1,3-propylenowa, a C tym, t y
4. Sposób wedlug zastrz. 3, tym, ze stosuje sie zwiazek o wzo- ze stosuje sie zwiazek o wzo- oznacza grupe metylowa. ze stosuje sie zwiazek o wzo- znamienny 11^ 1 rze 4, w którym W, W i X oznaczaja atomy wodoru, a Y oznacza grupe 4-metoksylowa« Wzór 1 Wzór 6141 876 Ó Wzór 7 C\OR\ NR, Wzór 8 A kJtwA0 Ó Wzór 9 W ^Prf< (R°)m Wzór 10 Wzór 11 N^O Wzór 7 C(OR1)z NR2 Wzór 8 A - ^ -NRz ó Wzór 9 Schemat PL PL PL
PL1983250769A 1982-09-20 1983-09-20 Process for preparing novel derivatives of 2/1h,3h/-indolones PL141876B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/420,544 US4476307A (en) 1982-09-20 1982-09-20 Heteroylidene indolone compounds

Publications (2)

Publication Number Publication Date
PL250769A1 PL250769A1 (en) 1985-07-02
PL141876B1 true PL141876B1 (en) 1987-09-30

Family

ID=23666904

Family Applications (3)

Application Number Title Priority Date Filing Date
PL1983250768A PL141370B1 (en) 1982-09-20 1983-09-20 Process for preparing novel derivatives of 2/1h,3h/-indolones
PL1983243826A PL141609B1 (en) 1982-09-20 1983-09-20 Process for preparing novel derivatives of 2/1h,3h/indolones
PL1983250769A PL141876B1 (en) 1982-09-20 1983-09-20 Process for preparing novel derivatives of 2/1h,3h/-indolones

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL1983250768A PL141370B1 (en) 1982-09-20 1983-09-20 Process for preparing novel derivatives of 2/1h,3h/-indolones
PL1983243826A PL141609B1 (en) 1982-09-20 1983-09-20 Process for preparing novel derivatives of 2/1h,3h/indolones

Country Status (24)

Country Link
US (1) US4476307A (pl)
EP (1) EP0104860B1 (pl)
JP (1) JPS5976058A (pl)
KR (1) KR860001270B1 (pl)
AT (1) ATE25972T1 (pl)
AU (1) AU543115B2 (pl)
CA (1) CA1194871A (pl)
DD (1) DD213211A5 (pl)
DE (1) DE3370325D1 (pl)
DK (1) DK157010C (pl)
ES (3) ES525737A0 (pl)
FI (1) FI77446C (pl)
GR (1) GR79732B (pl)
HU (1) HU189747B (pl)
IE (1) IE55923B1 (pl)
IL (1) IL69758A (pl)
NO (1) NO161557C (pl)
NZ (1) NZ205638A (pl)
PH (1) PH18297A (pl)
PL (3) PL141370B1 (pl)
PT (1) PT77360B (pl)
SU (1) SU1272983A3 (pl)
YU (4) YU189283A (pl)
ZA (1) ZA836933B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
WO1990008146A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5078756A (en) * 1990-01-12 1992-01-07 Major Thomas O Apparatus and method for purification and recovery of refrigerant
US5158969A (en) * 1991-08-21 1992-10-27 Neurosearch A/S Indole derivatives as potassium channel blockers
US5760250A (en) * 1991-11-05 1998-06-02 Zeneca Limited Process for the preparation of 3-(α-methoxy)methylenebenzofuranones and intermediates therefor
DE19949209A1 (de) * 1999-10-13 2001-04-19 Boehringer Ingelheim Pharma In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
WO2003027102A1 (en) * 2001-09-27 2003-04-03 Allergan, Inc. 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
IL163992A0 (en) * 2002-03-27 2005-12-18 Lundbeck & Co As H Method for manufacture of sertindole
FR2847811B1 (fr) * 2002-11-29 2005-01-07 Oreal Composition filtrante contenant au moins un derive du dibenzoylmethane et au moins un derive de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one;procede de photostabilisation
FR2847813A1 (fr) * 2002-11-29 2004-06-04 Oreal Compositions cosmetiques photoprotectrices contenant des derives de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one et utilisations
EP2591784B1 (en) 2005-05-10 2016-09-14 Intermune, Inc. Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
EP2380876B1 (en) 2008-12-19 2014-10-29 Nippon Soda Co., Ltd. 1-heterodiene derivative and harmful organism control agent
KR101376443B1 (ko) 2009-11-12 2014-03-19 닛뽕소다 가부시키가이샤 1-헤테로디엔 유도체 및 유해 생물 방제제
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CA2943363A1 (en) 2014-04-02 2015-10-08 Intermune, Inc. Anti-fibrotic pyridinones

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506683A (en) * 1963-10-07 1970-04-14 Upjohn Co 3-(2-pyrrolidinylidene)-3h-indoles
GB1237008A (en) * 1968-12-18 1971-06-30 Pfizer Ltd Novel indoline derivatives
US3723457A (en) * 1969-09-30 1973-03-27 Eisai Co Ltd Indoline-2-one derivatives and preparation thereof
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
DE2557342A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI77446B (fi) 1988-11-30
PT77360A (en) 1983-10-01
ES8503328A1 (es) 1985-02-16
ES525737A0 (es) 1985-02-16
US4476307A (en) 1984-10-09
SU1272983A3 (ru) 1986-11-23
NZ205638A (en) 1986-12-05
PL141370B1 (en) 1987-07-31
YU169286A (en) 1987-10-31
AU543115B2 (en) 1985-04-04
PL250768A1 (en) 1985-07-02
IL69758A0 (en) 1983-12-30
EP0104860A1 (en) 1984-04-04
NO161557B (no) 1989-05-22
PH18297A (en) 1985-05-24
IE832193L (en) 1984-03-20
DD213211A5 (de) 1984-09-05
ES531907A0 (es) 1985-06-01
DK425383A (da) 1984-05-03
IL69758A (en) 1986-12-31
ATE25972T1 (de) 1987-04-15
HU189747B (en) 1986-07-28
GR79732B (pl) 1984-10-31
PL243826A1 (en) 1985-04-24
KR860001270B1 (ko) 1986-09-04
JPS5976058A (ja) 1984-04-28
YU189283A (en) 1987-10-31
KR840006239A (ko) 1984-11-22
NO161557C (no) 1989-08-30
YU169186A (en) 1987-10-31
YU169386A (en) 1987-10-31
IE55923B1 (en) 1991-02-27
NO833367L (no) 1984-03-21
EP0104860B1 (en) 1987-03-18
FI833335A (fi) 1984-03-21
DK425383D0 (da) 1983-09-19
PL141609B1 (en) 1987-08-31
PL250769A1 (en) 1985-07-02
CA1194871A (en) 1985-10-08
DK157010B (da) 1989-10-30
AU1925283A (en) 1984-03-29
PT77360B (en) 1986-05-19
DE3370325D1 (en) 1987-04-23
ES531908A0 (es) 1985-06-01
FI833335A0 (fi) 1983-09-19
ES8505951A1 (es) 1985-06-01
FI77446C (fi) 1989-03-10
ZA836933B (en) 1985-05-29
DK157010C (da) 1990-03-26
JPS6241711B2 (pl) 1987-09-04
ES8505950A1 (es) 1985-06-01

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