KR840005660A - 퍼플로로탄소 유제조성물의 제법 - Google Patents

퍼플로로탄소 유제조성물의 제법 Download PDF

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Publication number
KR840005660A
KR840005660A KR1019830003805A KR830003805A KR840005660A KR 840005660 A KR840005660 A KR 840005660A KR 1019830003805 A KR1019830003805 A KR 1019830003805A KR 830003805 A KR830003805 A KR 830003805A KR 840005660 A KR840005660 A KR 840005660A
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South Korea
Prior art keywords
pharmaceutical composition
aqueous pharmaceutical
agent
composition according
emulsion
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KR1019830003805A
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English (en)
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KR890002204B1 (ko
Inventor
엠 유하스 죤
엠 유하스 죤 (외 2)
엘 군맨 로버어트
이이 무어 로버어트
Original Assignee
애더맨테크 인코포레이팃드
원본미기재
선 테크 인코포레이팃드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27020315&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR840005660(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 애더맨테크 인코포레이팃드, 원본미기재, 선 테크 인코포레이팃드 filed Critical 애더맨테크 인코포레이팃드
Publication of KR840005660A publication Critical patent/KR840005660A/ko
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Publication of KR890002204B1 publication Critical patent/KR890002204B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A61M2202/0476—Oxygenated solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

퍼플로로탄소 유제조성물의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 유화 퍼플로로탄소 및 친유성 약제, 화학요법제, 화학요법 보호제 또는 방사선 보호제 또는 이들 둘 또는 그 이상의 혼합물로 구성된 수성 약제 조성물.
  2. 제1항에 있어서, 상기 퍼플로로 탄소 화합물이 퍼플롤 사이클탄화숫소인 수성 약제 조성물.
  3. 제2항에 있어서, 상기 퍼플로로 사이클 탄화수소가 비방향, 성플리사이클 화합물로서 적어도 하나의 탄소원자를 함유하는 수성 약제 조성물.
  4. 제1항 내지 3항중 어느 하나에서 유화 퍼플로로 탄소의 평균 미셀 크기가 0.05-0.2미크론 범위인 수성 약제 조성물.
  5. 제1항 내지 4항중 어느 하나에서 화학요법제ㅏ 존재하며,이것이 메토트렉세이트인 수성 약제 조성물.
  6. 제1항 내지 5항중 어느 하나에서 화학 욥ㅂ제가 존재하며 상기 화학요법제가 사이클로포스파미드인 수성 약제 조성물.
  7. 제1항 내지 5항중 어느 하나에서 친유성 약제로 구성하며, 이 약제가다우놔이신인 수성 약제 조성물.
  8. 제1항 내지 5항중 어느 하나에서 친유성 약제로 구성되며, 이 약제가 빈크리스틴인 수성 약제 조성물.
  9. 제1항 내지 8항중 어느 하나에서 분산제를 더 함유하는 수성 약제 조성물.
  10. 제7항에 있어서, 상기 분산제가 산화에틸렌의 축합물 및 산화프로필렌과 프로필렌글리콜의 부가물 및 불화 아미도 아민 옥사이드로부터 선택되는 수성 약제 조성물.
  11. 제1항 내지 10항중 어느 하나에서 방사선 불투과성 약제를 더 함유하는 수성 약제 조성물.
  12. 친유성 약제, 화학요법제의 활성 또는 암의 화학요법적 또는 방사선 요법적 치료를 증진시키는데 사용되는 퍼플로로탄소의 수성유제.
  13. 퍼플로로탄소를 우선 분산제 수용액에 분산시켜 미셀크기 0.5-1미크론의 유제를 형성한 다음 이렇게 형성된 유제를 분산단계를 더 받게 하여 미셀크기 0.05-0.2미크론의 유제를 생성시크는 2단계 분산법으로 구성된 제1항 내지 11항중 어느 하나의 조성물에 사용되는 퍼플로로탄소의 수성 유제를 제조하는 방법.
  14. 제13항에 있어서, 사용되는 분산제를산화에틸렌의 축합물, 산화프로필렌과 프로필렌글리콜의 부가물, 불화 아미도 아민 옥사이드로부터 선택하는 방법.
  15. 제13항 또는 14항에 있어서, 퍼플로로탄소를 이산화탄소로 미리 포화시키는 방법.
  16. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830003805A 1982-08-17 1983-08-16 퍼플로로탄소 유제, 그의 제법 및 그 유제를 포함하는 수성 약제 조성물 KR890002204B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40858982A 1982-08-17 1982-08-17
US408.589 1982-08-17
US408589 1982-08-17
US51715083A 1983-07-25 1983-07-25
US517.150 1983-07-25

Publications (2)

Publication Number Publication Date
KR840005660A true KR840005660A (ko) 1984-11-15
KR890002204B1 KR890002204B1 (ko) 1989-06-23

Family

ID=27020315

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830003805A KR890002204B1 (ko) 1982-08-17 1983-08-16 퍼플로로탄소 유제, 그의 제법 및 그 유제를 포함하는 수성 약제 조성물

Country Status (19)

Country Link
EP (1) EP0105584B1 (ko)
JP (1) JPS59501665A (ko)
KR (1) KR890002204B1 (ko)
AU (1) AU559559B2 (ko)
CA (1) CA1225027A (ko)
CH (1) CH665952A5 (ko)
DE (2) DE3378954D1 (ko)
ES (1) ES8502405A1 (ko)
FI (1) FI841513A (ko)
GB (1) GB2134787A (ko)
GR (1) GR79383B (ko)
IE (1) IE55618B1 (ko)
IL (1) IL69505A (ko)
NL (1) NL8320264A (ko)
NO (1) NO841519L (ko)
PH (2) PH25492A (ko)
PT (1) PT77204B (ko)
SE (1) SE8402098L (ko)
WO (1) WO1984000686A1 (ko)

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JP2935519B2 (ja) * 1989-08-28 1999-08-16 シーキンス，ケイ・マイケル 超音波および／またはペルフルオロカーボン液での対流を介する肺癌高熱治療
US6458376B1 (en) 1990-09-27 2002-10-01 Allergan, Inc. Nonaqueous fluorinated drug delivery suspensions
US5518731A (en) * 1990-09-27 1996-05-21 Allergan, Inc. Nonaqueous fluorinated drug delivery vehicle suspensions
FR2679150A1 (fr) * 1991-07-17 1993-01-22 Atta Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations.
AU3924193A (en) * 1992-03-19 1993-10-21 Allergan, Inc. Compositions comprising a drug delivery vehicle suspended in a nonaqueous fluorinated liquid
DE4221268C2 (de) * 1992-06-26 1997-06-12 Lancaster Group Ag Verwendung eines Dermatikums zur Unterstützung des Sauerstofftransportes in der Haut
DE4221256C2 (de) * 1992-06-26 1997-07-10 Lancaster Group Ag Galenische Zusammensetzung für die topische Anwendung
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Also Published As

Publication number Publication date
FI841513A0 (fi) 1984-04-16
GR79383B (ko) 1984-10-22
AU1941383A (en) 1984-03-07
PH25027A (en) 1991-01-28
EP0105584B1 (en) 1989-01-18
SE8402098D0 (sv) 1984-04-16
PT77204B (en) 1986-02-04
PT77204A (en) 1983-09-01
ES524972A0 (es) 1985-01-01
SE8402098L (sv) 1984-04-16
IE55618B1 (en) 1990-11-21
CA1225027A (en) 1987-08-04
IE831925L (en) 1984-02-17
IL69505A (en) 1990-03-19
GB2134787A (en) 1984-08-22
JPS59501665A (ja) 1984-10-04
PH25492A (en) 1991-07-24
NO841519L (no) 1984-04-16
IL69505A0 (en) 1983-11-30
EP0105584A1 (en) 1984-04-18
ES8502405A1 (es) 1985-01-01
KR890002204B1 (ko) 1989-06-23
NL8320264A (nl) 1984-07-02
DE3390172T1 (de) 1984-11-29
WO1984000686A1 (en) 1984-03-01
CH665952A5 (de) 1988-06-30
DE3378954D1 (en) 1989-02-23
AU559559B2 (en) 1987-03-12
FI841513A (fi) 1984-04-16

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