EP2587917A4 - Anti-fibroblastic fluorochemical emulsion therapies - Google Patents

Anti-fibroblastic fluorochemical emulsion therapies

Info

Publication number
EP2587917A4
EP2587917A4 EP11801499.2A EP11801499A EP2587917A4 EP 2587917 A4 EP2587917 A4 EP 2587917A4 EP 11801499 A EP11801499 A EP 11801499A EP 2587917 A4 EP2587917 A4 EP 2587917A4
Authority
EP
European Patent Office
Prior art keywords
fibroblastic
therapies
fluorochemical emulsion
fluorochemical
emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11801499.2A
Other languages
German (de)
French (fr)
Other versions
EP2587917A1 (en
Inventor
Matthew T Mcleay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MTM Research LLC
Original Assignee
MTM Research LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MTM Research LLC filed Critical MTM Research LLC
Priority claimed from PCT/US2011/042815 external-priority patent/WO2012003457A1/en
Publication of EP2587917A1 publication Critical patent/EP2587917A1/en
Publication of EP2587917A4 publication Critical patent/EP2587917A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP11801499.2A 2010-07-01 2011-07-01 Anti-fibroblastic fluorochemical emulsion therapies Withdrawn EP2587917A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39882410P 2010-07-01 2010-07-01
PCT/US2011/042815 WO2012003457A1 (en) 2010-07-01 2011-07-01 Anti-fibroblastic fluorochemical emulsion therapies

Publications (2)

Publication Number Publication Date
EP2587917A1 EP2587917A1 (en) 2013-05-08
EP2587917A4 true EP2587917A4 (en) 2015-05-06

Family

ID=47998013

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11801499.2A Withdrawn EP2587917A4 (en) 2010-07-01 2011-07-01 Anti-fibroblastic fluorochemical emulsion therapies

Country Status (1)

Country Link
EP (1) EP2587917A4 (en)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366169A (en) * 1979-06-25 1982-12-28 Sun Tech, Inc. Use of perfluorocarbons as wound treatment
WO1984000686A1 (en) * 1982-08-17 1984-03-01 Sun Tech Inc Perfluorocarbon emulsions and their preparation and use in therapy
US4452818A (en) * 1982-03-19 1984-06-05 Haidt Sterling J Extraocular method of treating the eye with liquid perfluorocarbons
WO1996040057A2 (en) * 1995-06-07 1996-12-19 Alliance Pharmaceutical Corp. Reverse fluorocarbon emulsion compositions for drug delivery
US5733939A (en) * 1993-09-29 1998-03-31 Alliance Pharmaceutical Corp. Fluorocarbons as anti-inflammatory agents
US5874481A (en) * 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
WO1999024016A1 (en) * 1997-11-10 1999-05-20 Sonus Pharmaceuticals, Inc. Emulsions for aerosolization and drug delivery
US5980936A (en) * 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
US20050119330A1 (en) * 2003-03-17 2005-06-02 Kao Peter N. Use of antiproliferative agents in the treatment and prevention of pulmonary proliferative vascular diseases
US20070190183A1 (en) * 2005-12-21 2007-08-16 Uti Limited Partnership Treatment of respiratory diseases
US20080019926A1 (en) * 2004-04-19 2008-01-24 Marie-Pierre Krafft Lung Surfactant Supplements
US20100144861A1 (en) * 2008-11-25 2010-06-10 Gary Huvard Perfluorocarbon gel formulations

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366169A (en) * 1979-06-25 1982-12-28 Sun Tech, Inc. Use of perfluorocarbons as wound treatment
US4452818A (en) * 1982-03-19 1984-06-05 Haidt Sterling J Extraocular method of treating the eye with liquid perfluorocarbons
WO1984000686A1 (en) * 1982-08-17 1984-03-01 Sun Tech Inc Perfluorocarbon emulsions and their preparation and use in therapy
US5733939A (en) * 1993-09-29 1998-03-31 Alliance Pharmaceutical Corp. Fluorocarbons as anti-inflammatory agents
WO1996040057A2 (en) * 1995-06-07 1996-12-19 Alliance Pharmaceutical Corp. Reverse fluorocarbon emulsion compositions for drug delivery
US5874481A (en) * 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
US5980936A (en) * 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
WO1999024016A1 (en) * 1997-11-10 1999-05-20 Sonus Pharmaceuticals, Inc. Emulsions for aerosolization and drug delivery
US20050119330A1 (en) * 2003-03-17 2005-06-02 Kao Peter N. Use of antiproliferative agents in the treatment and prevention of pulmonary proliferative vascular diseases
US20080019926A1 (en) * 2004-04-19 2008-01-24 Marie-Pierre Krafft Lung Surfactant Supplements
US20070190183A1 (en) * 2005-12-21 2007-08-16 Uti Limited Partnership Treatment of respiratory diseases
US20100144861A1 (en) * 2008-11-25 2010-06-10 Gary Huvard Perfluorocarbon gel formulations

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BARTUSIK D ET AL: "Detection of fluorine labeled Herceptin using cellular <19>F MRI ex vivo", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, NEW YORK, NY, US, vol. 51, no. 4, 11 March 2010 (2010-03-11), pages 894 - 900, XP026813980, ISSN: 0731-7085, [retrieved on 20091014] *
CENTIS CENTIS ET AL: "Perfluorocarbon Emulsions Cytotoxic Effects on Human Fibroblasts and Effect of Aging on Particle Size Distribution", ARTIFICIAL ORGANS, vol. 31, no. 8, August 2007 (2007-08-01), pages 649 - 653, XP055152542, ISSN: 0160-564X, DOI: 10.1111/j.1525-1594.2007.00437.x *
EJ WAKE ET AL: "Changes in human cultured cells exposed to a perfluorocarbon emulsion", TRANSFUSION, vol. 25, no. 1, January 1985 (1985-01-01), pages 73 - 77, XP055152534, ISSN: 0041-1132, DOI: 10.1046/j.1537-2995.1985.25185116510.x *
LANE T A: "Perfluorochemical-based artificial oxygen carrying red cell substitutes", TRANSFUSION SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 16, no. 1, March 1995 (1995-03-01), pages 19 - 31, XP004568651, ISSN: 0955-3886, DOI: 10.1016/0955-3886(94)00067-T *
LONGLEY D B ET AL: "5-FLUOROURACIL: MECHANISMS OF ACTION AND CLINICAL STRATEGIES", NATURE REVIEWS. CANCER, NATUR PUBLISHING GROUP, LONDON, GB, vol. 3, no. 5, May 2003 (2003-05-01), pages 330 - 338, XP008039669, ISSN: 1474-175X, DOI: 10.1038/NRC1074 *
RIESS J G ET AL: "ADVANCED FLUOROCARBON-BASED SYSTEMS FOR OXYGEN AND DRUG DELIVERY, AND DIAGNOSIS", ARTIFICIAL CELLS, BLOOD SUBSTITUTES, AND IMMOBILIZATION BIOTECHNOLOGY, MARCEL DEKKER INC, US, vol. 25, no. 1/02, January 1997 (1997-01-01), pages 43 - 52, XP001064197, ISSN: 1073-1199, DOI: 10.3109/10731199709118896 *
See also references of WO2012003457A1 *
TEICHER B A: "Combination of perfluorochemical emulsions and carbogen breathing with cancer chemotherapy.", ARTIFICIAL CELLS, BLOOD SUBSTITUTES, AND IMMOBILIZATION BIOTECHNOLOGY 1994, vol. 22, no. 4, 1994, pages 1109 - 1120, XP009181239, ISSN: 1073-1199 *
TEICHER BEVERLY A ET AL: "Effect of Fluosol-DA/O2 on tumor-cell and bone-marrow cytotoxicity of nitrosoureas in mice bearing FSA-II fibrosarcoma.", INTERNATIONAL JOURNAL OF CANCER, vol. 38, no. 2, 15 August 1986 (1986-08-15), pages 285 - 288, XP055152882, ISSN: 0020-7136 *

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Publication number Publication date
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DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/02 20060101AFI20141120BHEP

Ipc: A01N 29/12 20060101ALI20141120BHEP

Ipc: A61P 35/00 20060101ALI20141120BHEP

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RA4 Supplementary search report drawn up and despatched (corrected)

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