ES8502405A1 - Un metodo para producir una emulsion acuosa de perfluorocarburo - Google Patents
Un metodo para producir una emulsion acuosa de perfluorocarburoInfo
- Publication number
- ES8502405A1 ES8502405A1 ES524972A ES524972A ES8502405A1 ES 8502405 A1 ES8502405 A1 ES 8502405A1 ES 524972 A ES524972 A ES 524972A ES 524972 A ES524972 A ES 524972A ES 8502405 A1 ES8502405 A1 ES 8502405A1
- Authority
- ES
- Spain
- Prior art keywords
- therapy
- preparation
- perfluorocarbon emulsions
- emulsion
- perfluorocarbon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000839 emulsion Substances 0.000 title abstract 4
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/0476—Oxygenated solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
METODO PARA PRODUCIR UNA EMULSION ACUOSA DE PERFLUOROCARBURO, QUE SE UTILIZA EN UNA COMPOSICION FARMACEUTICA ACUOSA.COMPRENDE UN PROCESO DE DISPERSION EN DOS ETAPAS, EN LA PRIMERA DE LAS CUALES SE DISPERSA EL PERFLUOROCARBURO EN UNA SOLUCION ACUOSA DE DISPERSANTE PARA PRODUCIR UNA EMULSION CON TAMAN/O DE 0,5 A UN MICRON, Y EN LA SEGUNDA ETAPA LA EMULSION ASI FORMADA ES SUBSECUENTEMENTE SOMETIDA A UN PROCESO DE MAYOR DISPERSION PARA PRODUCIR UNA EMULSION CON TAMAN/OS DE MICELA COMPRENDIDOS ENTRE 0,5 Y 0,2 MICRONES.DE APLICACION EN COMPOSICIONES Y SISTEMAS QUE SIRVEN PARA SENSIBILIZAR CELULAS TUMORALES HIPOXICAS A UNA RADIACION O A CIERTOS AGENTES QUIMIOTERAPEUTICOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40858982A | 1982-08-17 | 1982-08-17 | |
US51715083A | 1983-07-25 | 1983-07-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8502405A1 true ES8502405A1 (es) | 1985-01-01 |
ES524972A0 ES524972A0 (es) | 1985-01-01 |
Family
ID=27020315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524972A Granted ES524972A0 (es) | 1982-08-17 | 1983-08-16 | Un metodo para producir una emulsion acuosa de perfluorocarburo |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0105584B1 (es) |
JP (1) | JPS59501665A (es) |
KR (1) | KR890002204B1 (es) |
AU (1) | AU559559B2 (es) |
CA (1) | CA1225027A (es) |
CH (1) | CH665952A5 (es) |
DE (2) | DE3378954D1 (es) |
ES (1) | ES524972A0 (es) |
FI (1) | FI841513A (es) |
GB (1) | GB2134787A (es) |
GR (1) | GR79383B (es) |
IE (1) | IE55618B1 (es) |
IL (1) | IL69505A (es) |
NL (1) | NL8320264A (es) |
NO (1) | NO841519L (es) |
PH (2) | PH25492A (es) |
PT (1) | PT77204B (es) |
SE (1) | SE8402098L (es) |
WO (1) | WO1984000686A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59130813A (ja) * | 1983-01-14 | 1984-07-27 | Green Cross Corp:The | 癌化学療法補助剤 |
JPS59130812A (ja) * | 1983-01-14 | 1984-07-27 | Green Cross Corp:The | 癌化学療法補助剤 |
CA1257828A (en) * | 1984-04-16 | 1989-07-25 | William Mccormick | Perfluoro compound dispersions containing reduced amounts of surfactant and process of preparation |
US4815446A (en) * | 1985-05-09 | 1989-03-28 | Alpha Therapeutic Corporation | Process for treating metastasis of cancerous tumors |
US4781676A (en) * | 1987-02-20 | 1988-11-01 | Air Products And Chemicals, Inc. | Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells |
US4956390A (en) * | 1987-08-25 | 1990-09-11 | Air Products And Chemicals, Inc. | Gas transport employing perfluorobutyldecalin |
US5562608A (en) * | 1989-08-28 | 1996-10-08 | Biopulmonics, Inc. | Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation |
JP2935519B2 (ja) * | 1989-08-28 | 1999-08-16 | シーキンス,ケイ・マイケル | 超音波および/またはペルフルオロカーボン液での対流を介する肺癌高熱治療 |
US5518731A (en) * | 1990-09-27 | 1996-05-21 | Allergan, Inc. | Nonaqueous fluorinated drug delivery vehicle suspensions |
US6458376B1 (en) | 1990-09-27 | 2002-10-01 | Allergan, Inc. | Nonaqueous fluorinated drug delivery suspensions |
FR2679150A1 (fr) * | 1991-07-17 | 1993-01-22 | Atta | Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations. |
AU3924193A (en) * | 1992-03-19 | 1993-10-21 | Allergan, Inc. | Compositions comprising a drug delivery vehicle suspended in a nonaqueous fluorinated liquid |
DE4221268C2 (de) * | 1992-06-26 | 1997-06-12 | Lancaster Group Ag | Verwendung eines Dermatikums zur Unterstützung des Sauerstofftransportes in der Haut |
US5643601A (en) * | 1992-06-26 | 1997-07-01 | Lancaster Group Ag | Phospholipid-and fluorocarbon-containing cosmetic |
DE4221256C2 (de) * | 1992-06-26 | 1997-07-10 | Lancaster Group Ag | Galenische Zusammensetzung für die topische Anwendung |
US5480914A (en) * | 1994-05-06 | 1996-01-02 | Allergan, Inc. | Nonaqueous thixotropic drug delivery suspensions and methods of their use |
EP1100366B1 (en) * | 1998-07-09 | 2009-04-15 | Curelight Medical Ltd | Apparatus and method for efficient high energy photodynamic therapy of acne vulgaris and seborrhea |
US20040122492A1 (en) | 1999-07-07 | 2004-06-24 | Yoram Harth | Phototherapeutic treatment of skin conditions |
GB0200721D0 (en) * | 2002-01-14 | 2002-02-27 | Univ Bristol | Toxicity test |
EP2587917A4 (en) * | 2010-07-01 | 2015-05-06 | Mtm Res Llc | THERAPIES USING ANTIFIBROBLASTIC FLUOROCHEMICAL EMULSIONS |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3828085A (en) * | 1970-07-09 | 1974-08-06 | Allied Chem | Novel amidoamine oxides |
US3823091A (en) * | 1971-05-19 | 1974-07-09 | Green Cross Corp | Stable emulsion of fluorocarbon particles |
US4041086A (en) * | 1972-02-07 | 1977-08-09 | Sun Ventures, Inc. | Process of manufacture of flourinated alkyladamantanes |
US3911138B1 (en) * | 1973-02-26 | 1996-10-29 | Childrens Hosp Medical Center | Artificial blood and method for supporting oxygen transport in animals |
JPS5331209B2 (es) * | 1973-10-05 | 1978-09-01 | ||
DE2524363A1 (de) * | 1975-06-02 | 1976-12-16 | Boehringer Sohn Ingelheim | Neue pharmazeutische mittel |
US4105798A (en) * | 1976-07-19 | 1978-08-08 | Sun Ventures, Inc. | Perfluoro polycyclic compounds for use as synthetic blood and perfusion media |
JPS5331209A (en) * | 1976-09-03 | 1978-03-24 | Hitachi Ltd | Small compressor cylinder for refrigerating machine and production of same |
IE47132B1 (en) * | 1977-08-19 | 1983-12-28 | Roche Products Ltd | Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture |
JPS6033367B2 (ja) * | 1978-11-24 | 1985-08-02 | 株式会社ミドリ十字 | 酸素運搬輸液 |
US4282232A (en) * | 1979-04-26 | 1981-08-04 | Research Corporation | Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof |
US4252827A (en) * | 1979-05-23 | 1981-02-24 | The Green Cross Corporation | Oxygen-transferable fluorocarbon emulsion |
WO1981000002A1 (en) * | 1979-06-25 | 1981-01-08 | Suntech | Use of perfluorocarbon as burn treatment |
CA1181011A (en) * | 1980-05-27 | 1985-01-15 | Robert P. Geyer | Perfluorinated n,n-dimethyl cyclohexylmethylamine and emulsions containing the same |
GR78151B (es) * | 1982-04-05 | 1984-09-26 | Alcon Lab Inc |
-
1983
- 1983-08-10 DE DE8383304632T patent/DE3378954D1/de not_active Expired
- 1983-08-10 AU AU19413/83A patent/AU559559B2/en not_active Ceased
- 1983-08-10 DE DE19833390172 patent/DE3390172T1/de not_active Ceased
- 1983-08-10 WO PCT/US1983/001237 patent/WO1984000686A1/en active Application Filing
- 1983-08-10 JP JP58502857A patent/JPS59501665A/ja active Pending
- 1983-08-10 GB GB08409519A patent/GB2134787A/en not_active Withdrawn
- 1983-08-10 CH CH2020/84A patent/CH665952A5/de not_active IP Right Cessation
- 1983-08-10 EP EP83304632A patent/EP0105584B1/en not_active Expired
- 1983-08-10 NL NL8320264A patent/NL8320264A/nl unknown
- 1983-08-16 PT PT77204A patent/PT77204B/pt not_active IP Right Cessation
- 1983-08-16 IL IL69505A patent/IL69505A/xx unknown
- 1983-08-16 ES ES524972A patent/ES524972A0/es active Granted
- 1983-08-16 KR KR1019830003805A patent/KR890002204B1/ko not_active IP Right Cessation
- 1983-08-16 CA CA000434734A patent/CA1225027A/en not_active Expired
- 1983-08-17 GR GR72239A patent/GR79383B/el unknown
- 1983-08-17 IE IE1925/83A patent/IE55618B1/en unknown
- 1983-08-17 PH PH29411A patent/PH25492A/en unknown
-
1984
- 1984-04-16 SE SE8402098A patent/SE8402098L/xx not_active Application Discontinuation
- 1984-04-16 FI FI841513A patent/FI841513A/fi not_active Application Discontinuation
- 1984-04-16 NO NO841519A patent/NO841519L/no unknown
- 1984-05-16 PH PH30682A patent/PH25027A/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE3390172T1 (de) | 1984-11-29 |
IE831925L (en) | 1984-02-17 |
NO841519L (no) | 1984-04-16 |
DE3378954D1 (en) | 1989-02-23 |
SE8402098D0 (sv) | 1984-04-16 |
PT77204B (en) | 1986-02-04 |
WO1984000686A1 (en) | 1984-03-01 |
CA1225027A (en) | 1987-08-04 |
PT77204A (en) | 1983-09-01 |
AU1941383A (en) | 1984-03-07 |
IE55618B1 (en) | 1990-11-21 |
CH665952A5 (de) | 1988-06-30 |
JPS59501665A (ja) | 1984-10-04 |
EP0105584A1 (en) | 1984-04-18 |
IL69505A0 (en) | 1983-11-30 |
EP0105584B1 (en) | 1989-01-18 |
AU559559B2 (en) | 1987-03-12 |
GB2134787A (en) | 1984-08-22 |
FI841513A0 (fi) | 1984-04-16 |
IL69505A (en) | 1990-03-19 |
PH25492A (en) | 1991-07-24 |
NL8320264A (nl) | 1984-07-02 |
FI841513A (fi) | 1984-04-16 |
KR840005660A (ko) | 1984-11-15 |
GR79383B (es) | 1984-10-22 |
KR890002204B1 (ko) | 1989-06-23 |
PH25027A (en) | 1991-01-28 |
SE8402098L (sv) | 1984-04-16 |
ES524972A0 (es) | 1985-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19960603 |