KR900007836A - 티아졸 유도체 - Google Patents

티아졸 유도체 Download PDF

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Publication number
KR900007836A
KR900007836A KR1019890016061A KR890016061A KR900007836A KR 900007836 A KR900007836 A KR 900007836A KR 1019890016061 A KR1019890016061 A KR 1019890016061A KR 890016061 A KR890016061 A KR 890016061A KR 900007836 A KR900007836 A KR 900007836A
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KR
South Korea
Prior art keywords
group
compound
alkyl
pharmaceutically acceptable
thiazole
Prior art date
Application number
KR1019890016061A
Other languages
English (en)
Inventor
로버트슨 래 던칸
조오지 깁슨 사무엘
Original Assignee
에이. 쥐. 제이. 베르메렌 에프. 쥐. 헤르만스
악조 엔. 브이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에이. 쥐. 제이. 베르메렌 에프. 쥐. 헤르만스, 악조 엔. 브이 filed Critical 에이. 쥐. 제이. 베르메렌 에프. 쥐. 헤르만스
Publication of KR900007836A publication Critical patent/KR900007836A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

티아졸 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 일반식(Ⅰ)의 티아졸 유도체 및 이들의 약학적 허용 산부가염.
    식중, R1은 할로겐, CF3,CN,NO2OH 또는 C1-C6알콕시이고, R2는 수소, C1-C6알킬, C1-C6알콕시, 아릴, C6-C13아르알킬, 비치환 아미노기, 치환아미노기, 또는 5- 또는 6-원고리의 일부인 아미노기이고, R3는 C1-C6탄화수소, C6-C13아르알킬, C2-C7알콜시알킬 또는 C1-C13아실이다.
  2. 제1항에 있어서, R1이 할로겐 또는 CN이고, R2가 비치환 또는 치환아미노기이고, R3가 C1-C4알킬 또는 아릴에틸인 화합물.
  3. 제2항에 있어서, R1이 Cl이고 티아졸이 테트라히드로 피리딘의 3위치에 결합된 화합물.
  4. 제2항에 있어서, R1이 CN이고 티아졸이 테트라히드로 피리딘의 3위치에 결합된 화합물.
  5. 하기일반식(Ⅱ)화합물의 피리딘기를 R3기를 첨가하여 4차화시킨 후 환원시키고, R3기를 다른 R3기로 치환시키거나, 아미노 보호기가 존재하는 경우 이것을 분리한 후, 알킬, 아릴 또는 아릴알킬기로 선택적 치환시키고 수득된 생성물을 약학적 허용염으로 전환시키는 것을 특징으로 하는 제1항 제4항의 화합물의 제조방법.
    식중, R1및 R2는 제1항에서의 정의와 같고 A는 3- 또는 4-피리딜기이다.
  6. 제1항 내지 제4항중 어느 한 항의 화합물의 약학적 허용 담체와 혼합한 약학조성물.
  7. 제6항에 있어서, 상기 조성물이 우울증, 불안장해 또는 인식장해의 치료용 약제로서 사용되는 약학조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890016061A 1988-11-08 1989-11-07 티아졸 유도체 KR900007836A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP88310471.3 1988-11-08
EP88310471A EP0372125A1 (en) 1988-11-08 1988-11-08 Oxazole and thiazole derivatives

Publications (1)

Publication Number Publication Date
KR900007836A true KR900007836A (ko) 1990-06-02

Family

ID=8200282

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890016061A KR900007836A (ko) 1988-11-08 1989-11-07 티아졸 유도체

Country Status (11)

Country Link
US (1) US5128340A (ko)
EP (2) EP0372125A1 (ko)
JP (1) JPH02180881A (ko)
KR (1) KR900007836A (ko)
AU (1) AU623942B2 (ko)
CA (1) CA2001867A1 (ko)
DK (1) DK552989A (ko)
FI (1) FI895263A0 (ko)
NZ (1) NZ231275A (ko)
PT (1) PT92222A (ko)
ZA (1) ZA898292B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
IL95548A0 (en) * 1989-09-15 1991-06-30 Fujisawa Pharmaceutical Co Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
US5807872A (en) * 1992-12-16 1998-09-15 Schering Corporation Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring
DE69212164T2 (de) * 1991-12-18 1996-12-05 Schering Corp Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring
US5932596A (en) * 1991-12-18 1999-08-03 Schering Corporation Imidazoylalkyl substituted with a six membered nitrogen containing nitrogen containing heterocyclic ring
SI3002283T1 (en) * 2003-12-26 2018-06-29 Kyowa Hakko Kirin Co., Ltd. Thiazole derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650805A (en) * 1985-12-02 1987-03-17 Warner-Lambert Company 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
DE3703435A1 (de) * 1987-02-05 1988-08-18 Thomae Gmbh Dr K Neue thiazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JP3003148B2 (ja) * 1989-01-05 2000-01-24 藤沢薬品工業株式会社 チアゾール化合物、その製造法およびそれを含有する医薬組成物
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use

Also Published As

Publication number Publication date
EP0372125A1 (en) 1990-06-13
DK552989A (da) 1990-05-09
JPH02180881A (ja) 1990-07-13
FI895263A0 (fi) 1989-11-06
PT92222A (pt) 1990-05-31
NZ231275A (en) 1991-04-26
US5128340A (en) 1992-07-07
AU4440689A (en) 1990-05-17
DK552989D0 (da) 1989-11-06
EP0368384A1 (en) 1990-05-16
ZA898292B (en) 1990-07-25
CA2001867A1 (en) 1990-05-08
AU623942B2 (en) 1992-05-28

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