KR880011099A - 피리딘 유도체, 이의 제조방법, 이 유도체를 함유하는 간 손상치료 및 예방제, 및 이 약제를 사용하여 간 손상을 치료 및 예방하는 방법 - Google Patents

피리딘 유도체, 이의 제조방법, 이 유도체를 함유하는 간 손상치료 및 예방제, 및 이 약제를 사용하여 간 손상을 치료 및 예방하는 방법 Download PDF

Info

Publication number
KR880011099A
KR880011099A KR1019880002245A KR880002245A KR880011099A KR 880011099 A KR880011099 A KR 880011099A KR 1019880002245 A KR1019880002245 A KR 1019880002245A KR 880002245 A KR880002245 A KR 880002245A KR 880011099 A KR880011099 A KR 880011099A
Authority
KR
South Korea
Prior art keywords
compound
hydrogen
treating
liver damage
agents
Prior art date
Application number
KR1019880002245A
Other languages
English (en)
Inventor
히데노리 이와모또
마사또 사또
노리아끼 나가노
도꾸오 고이데
히로유끼 이까다이
Original Assignee
모리오까 시게오
야마노우찌 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 모리오까 시게오, 야마노우찌 세이야꾸 가부시끼가이샤 filed Critical 모리오까 시게오
Publication of KR880011099A publication Critical patent/KR880011099A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음

Description

피리딘 유도체, 이의 제조방법, 이 유도체를 함유하는 간 손상치료 및 예방제, 및 이 약제를 사용하여 간 손상을 치료 및 예방하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 일반식 (Ⅰ)의 피리딘 유도체.
    상기 식에서, R1및 R2는 동일하거나 상이하고 저급 알킬그룹, 및(여기에서 A는 저급 알킬렌이고, R9는 저급 알킬이며 R10은 저급 알킬 또는 아르알킬이거나 ; R9및 R10은 함께 5- 또는 6-원 환을 형성한다)로 나타내는 그룹중에서 선택되고 ; R3및 R4는 동일하거나 상이하며 저급 알킬 그룹으로 부터 선택되고 ; R5및 R6는 동일하거나 상이하며 수소 및 할로겐 원자 및 저급알콕시, 저급 알콕시카보닐 및 니트로 그룹으로부터 선택되고 ; R7및 R8은 함께 저급 알킬렌디옥시(즉,저급 알킬렌디옥시이다)를 형성하며 ;은 벤젠환, 또는 2,3-위치 이중결합 및/또는 5,6-위치 이중결합을 갖는 모노사이클릭 환을 나타내고 ; R0은 수소원자, 또는 저급 알콕시카보닐 또는 저급알콕시로 치환될 수 있는 저급 알킬 그룹이며 ; ( )는 R0가 피리딘 환 구조에 따라서 존재하지 않을 수 있음을 나타낸다.
  2. 제1항에 있어서, R5및 R6가 상이하고 수소 및 할로겐원자 및 저급 알콕시, 저급 알콕시카보닐 및 니트로 그룹으로부터 선택되는 화합물.
  3. 제1항의 화합물을 함유하는 약제학적 조성물.
  4. 제2항의 화합물을 함유하는 약제학적 조성물.
  5. 제3항 또는 4항의 조성물을 투여함으로써 간 손상을 치료 및 예방하는 방법.
  6. 제1항에 있어서, 디메틸 4-(2-메톡시카보닐-3,4-메틸렌디옥시)페닐-2,6-디메틸-1,4-디하이드로피리딘-3,5-디카복실레이트 또는 이의 염인 화합물.
  7. 제1항에 있어서, 디메틸 4-(2-메톡시카보닐-3,4-메틸렌디옥시-5-메톡시) -2, 6-디메틸피리딘-3,5-디카복실레이트 또는 이의 염인 화합물.
  8. 제1항에 있어서, R10이 저급 알킬 또는 아르알킬이거나, R9및 R10이 함께 5- 또는 6-원환을 형성하는 화합물.
  9. 일반식 (Ⅰ-B)의 화합물을 함유하는 약제학적 조성물.
    상기 식에서 R1, R2, R3, R4는 상기 제1항에서 정의한 바와 같고 : R9및 R10은 둘다 수소원자이거나, 서로 상이하게는 수소, 할로겐, 저급 알콕시, 저급 알콕시카보닐, 또는 니트로이며 : R11, R12는 둘다 수소원자이거나, 또는 함께 저급 알킬렌디옥시를 형성하고(단, R11및 R12가 둘다 수소인 경우, R9및 R12은 둘다 수소가 아니다) : R0및 ( )은 상기 제1항에서 정의한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880002245A 1987-03-05 1988-03-04 피리딘 유도체, 이의 제조방법, 이 유도체를 함유하는 간 손상치료 및 예방제, 및 이 약제를 사용하여 간 손상을 치료 및 예방하는 방법 KR880011099A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5174487 1987-03-05
JP62-51744 1987-03-05
JP27143287 1987-10-26
JP62-271432 1987-10-26

Publications (1)

Publication Number Publication Date
KR880011099A true KR880011099A (ko) 1988-10-26

Family

ID=26392308

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880002245A KR880011099A (ko) 1987-03-05 1988-03-04 피리딘 유도체, 이의 제조방법, 이 유도체를 함유하는 간 손상치료 및 예방제, 및 이 약제를 사용하여 간 손상을 치료 및 예방하는 방법

Country Status (5)

Country Link
EP (1) EP0285267A3 (ko)
KR (1) KR880011099A (ko)
AU (1) AU1275188A (ko)
FI (1) FI880990A (ko)
NO (1) NO880992L (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015484A1 (de) * 1990-04-10 1991-10-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyridine als arzneimittel
WO1991015485A1 (de) * 1990-04-10 1991-10-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue pyridinester
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
DE10115922A1 (de) * 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248548A1 (de) * 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS61227567A (ja) * 1985-04-01 1986-10-09 Eisai Co Ltd １，４−ジヒドロピリジン誘導体

Also Published As

Publication number Publication date
FI880990A0 (fi) 1988-03-03
AU1275188A (en) 1988-09-08
NO880992L (no) 1988-09-06
NO880992D0 (no) 1988-03-04
EP0285267A2 (en) 1988-10-05
FI880990A (fi) 1988-09-06
EP0285267A3 (en) 1989-12-20

Similar Documents

Publication Publication Date Title
KR920018026A (ko) 아미노피리딘 화합물
KR840004741A (ko) 디히드로피리딘 유도체의 제조방법
KR910019989A (ko) 비스-아릴 아미드 및 우레아 화합물들, 이들로 구성된 조성물 이들을 이용한 paf 억제 방법 및 이들의 생산 방법
KR910007525A (ko) 양모제
FI800047A (fi) Nya (piperidinylalkyl)kinazolinderivat
DK623586D0 (da) Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
KR850003890A (ko) 1H-이미다조[4,5c]-퀴놀린-4-아민의 제조방법
JPS57171968A (en) 1,4-dihydropyridine derivative
FI842911A (fi) Dihydropyridiner som motverkar lokal blodbrist och foerhoejt tryck.
PT81855B (pt) Processo de preparacao de arilciclobutilalquilaminas e de composicoes farmaceuticas que as contem
NO902111L (no) Cyklopropylalkyl- eller -alkenylforbindelser, fremgangsmaater for deres fremstilling og anvendelse derav i flytende krystallinske blandinger.
SE8400239D0 (sv) Nya arylettiksyraderivat
KR920703056A (ko) 항 바이러스제
KR880011099A (ko) 피리딘 유도체, 이의 제조방법, 이 유도체를 함유하는 간 손상치료 및 예방제, 및 이 약제를 사용하여 간 손상을 치료 및 예방하는 방법
KR900001691A (ko) 피리다지논 유도체
KR890014536A (ko) 축합 퀴놀린계 화합물, 축합 아크리딘계 화합물 및 그의 제조방법과 그것을 함유하는 항암제 조성물
KR880002828A (ko) 디하이드로피리딘 유도체 및 이것의 약학적 조성말
EP0191724A3 (de) 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
KR970703301A (ko) 신규 디아미노메틸리덴 유도체(novel diamincmethylidene derivative)
KR960703401A (ko) 약학적 활성을 갖는 피리다지논 유도체[pyridazinone derivatives with pharmaceutical activity]
KR860001789A (ko) 디히드로피리딘 유도체의 제조방법
DK157854C (da) Analogifremgangsmaade til fremstilling af alfa-aryl-alfa-(2-pyridyl)-alkansyrederivater
KR880005076A (ko) 2-아제티디논 유도체
KR880008995A (ko) 2-알킬설피닐-4(3h)-퀴나졸리논 유도체, 이의 제조방법 및 약학적 조성물
KR900007836A (ko) 티아졸 유도체

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid