KR840005484A - 항종양 항생물질의 제조방법 - Google Patents

항종양 항생물질의 제조방법 Download PDF

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KR840005484A
KR840005484A KR1019830003458A KR830003458A KR840005484A KR 840005484 A KR840005484 A KR 840005484A KR 1019830003458 A KR1019830003458 A KR 1019830003458A KR 830003458 A KR830003458 A KR 830003458A KR 840005484 A KR840005484 A KR 840005484A
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bbm
microorganism
producing
solution
inhibits
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KR1019830003458A
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고니시 마사따까 (외 3)
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고오이찌 이와다레
브리스톨-반유 리서치 인스티튜트 리미티드
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Publication of KR840005484A publication Critical patent/KR840005484A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/03—Actinomadura
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/825—Actinomadura

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

항종양 항생물질의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 BBM-1644의 적외선 흡수 스펙트럼이고
제2도는 BBM-1644의 자외선 흡수 스펙트럼이다.

Claims (7)

  1. Actionmadura 속의 BBM-1644 생산균주를 호기조건하에 동화시킬 수 있는 탄소원 및 질소원이 함유된 배지용액에 본 배양배지에 있는 본 미생물에 의해 생성되는 BBM-1644가 다량 산출될 때까지 액내배양시켜, 하기 특징 즉, 그람 양성 및 항산성 박테리아의 성장을 억제하고, 생쥐에서 p388 백혈병의 성장을 억제하고, 용해성 박테리아에서 프로파지(prophage)를 유도하고, 수용성이며, 0.25% 수용액에서 [α] D26=-75.6°의 광학적 선광도를 갖으며, pH8.6의 0.5M바르비탈 완충액을 이용하는 4500V종이 전기영동을 1시간 실시하면 음극으로 8.7em 이동하고, 원소분석 결과 C : 46.60%, H : 6.45%, N : 13.43%, S : 0.20%, O : 3.341%를 나타내고, 분자량 22,000정도의 고분자량 펩티드이며, 과망간산 칼륨용액에서 탈색되고 폴린-로우리, 크산토프로테인, 뷰렛 및 닌히드린 반응에서 양성을 나타내고 안트론 및 사까구찌반응에서 음성을 나타내고, 가수분해하면 루신함량을 1.0으로 간주할 때 알라닌(8.0), 아스파라긴산(6.0), 시스틴 분자의 절반(1.0), 글루탐산(5.7), 글리신(8.7), 이소루신(2.3), 루신(1.0), 페닐알라닌(1.4), 프롤린(4.1), 세린(1.6), 트레오닌(7.2), 티로신(0.6) 및 발린(11.1)의 아미노산 조성을 갖는 항생물질 BBM-1644의 제조방법.
  2. 제1항에 있어서, BMM-1644가 배양배지로 부터 회수되는 제조방법.
  3. 제1항 또는 제2항에 있어서, BBM-1644 생산 미생물이 Actinomadura sp. H 710-49(ATCC39144)의 검정특성을 갖는 생산방법.
  4. 동화시킬 수 있는 탄소원 및 질소원이 포함된 영양배지액에서 배양에 의해 항생물질 BBM-1644를 회수가능한 양만큼 생산할 수 있는 미생물 Actinomadura sp ATCC 39144의 생물학적 순수 배양체.
  5. BBM-1644의 항박테리아 유효량과 약리적담체 또는 희석제가 함유된 제약조성물.
  6. BBM-1644의 종양억제 유효량과 약리적 담체 도는 희석제가 함유된 제약조성물.
  7. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830003458A 1982-07-26 1983-07-26 항종양 항생물질의 제조방법 KR840005484A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40146882A 1982-07-26 1982-07-26
US401468 1982-07-26

Publications (1)

Publication Number Publication Date
KR840005484A true KR840005484A (ko) 1984-11-14

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ID=23587892

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KR1019830003458A KR840005484A (ko) 1982-07-26 1983-07-26 항종양 항생물질의 제조방법

Country Status (29)

Country Link
JP (1) JPS5948084A (ko)
KR (1) KR840005484A (ko)
AU (1) AU567105B2 (ko)
BE (1) BE897381A (ko)
CA (1) CA1215337A (ko)
CH (1) CH657778A5 (ko)
CS (1) CS251077B2 (ko)
DD (1) DD210075A5 (ko)
DE (1) DE3326917A1 (ko)
DK (1) DK339683A (ko)
ES (1) ES524405A0 (ko)
FI (1) FI832676A (ko)
FR (1) FR2530663A1 (ko)
GB (1) GB2124234B (ko)
GR (1) GR78648B (ko)
HU (1) HU192165B (ko)
IE (1) IE55800B1 (ko)
IL (1) IL69313A0 (ko)
IT (1) IT1163847B (ko)
LU (1) LU84930A1 (ko)
MY (1) MY8800125A (ko)
NL (1) NL8302610A (ko)
NO (1) NO832689L (ko)
NZ (1) NZ204965A (ko)
OA (1) OA07503A (ko)
PT (1) PT77091B (ko)
SE (1) SE8304132L (ko)
YU (1) YU158583A (ko)
ZA (1) ZA835337B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208013A (en) * 1983-05-16 1987-07-31 Bristol Myers Co Antitumour antibiotic bbm-1675 and production by cultivating actinomadura verrucosospora
JPS606194A (ja) * 1983-06-23 1985-01-12 Meiji Seika Kaisha Ltd 新規抗生物質ｓｆ−２２８８及びその製造法
GB8425685D0 (en) * 1984-10-11 1984-11-14 Lepetit Spa Antibiotic a 40926 complex
US5304373A (en) * 1991-10-22 1994-04-19 Bristol-Myers Squibb Co. Antitumor antibiotic

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148882A (en) * 1977-06-24 1979-04-10 Pfizer Inc. Polycyclic ether antibiotics produced by new species of actinomycete
JPS56113791A (en) * 1980-02-15 1981-09-07 Kaken Pharmaceut Co Ltd Novel antibiotic and its preparation
CA1198386A (en) * 1981-10-22 1985-12-24 Donald B. Borders ANTIBACTERIAL AGENTS LL-C23024.beta. AND IOTA AND MICROORGANISM ACTINOMADURA YUMAENSE NRRL 12515
US4578271A (en) * 1982-05-24 1986-03-25 Fujisawa Pharmaceutical Co., Ltd. Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions
NZ208013A (en) * 1983-05-16 1987-07-31 Bristol Myers Co Antitumour antibiotic bbm-1675 and production by cultivating actinomadura verrucosospora

Also Published As

Publication number Publication date
OA07503A (en) 1985-03-31
AU567105B2 (en) 1987-11-12
BE897381A (fr) 1984-01-26
GB2124234B (en) 1986-04-03
PT77091B (en) 1986-06-26
GR78648B (ko) 1984-09-27
MY8800125A (en) 1988-12-31
HU192165B (en) 1987-05-28
IE831740L (en) 1984-01-26
SE8304132D0 (sv) 1983-07-25
HUT37167A (en) 1985-11-28
PT77091A (en) 1983-08-01
CA1215337A (en) 1986-12-16
NZ204965A (en) 1986-09-10
CH657778A5 (de) 1986-09-30
FI832676A0 (fi) 1983-07-22
DK339683A (da) 1984-01-27
IT8322219A0 (it) 1983-07-25
SE8304132L (sv) 1984-01-27
IL69313A0 (en) 1983-11-30
ES8502161A1 (es) 1984-12-16
LU84930A1 (fr) 1984-03-22
DE3326917A1 (de) 1984-02-02
NO832689L (no) 1984-01-27
IT1163847B (it) 1987-04-08
DD210075A5 (de) 1984-05-30
YU158583A (en) 1985-12-31
FR2530663A1 (fr) 1984-01-27
NL8302610A (nl) 1984-02-16
GB8320026D0 (en) 1983-08-24
DK339683D0 (da) 1983-07-25
CS251077B2 (en) 1987-06-11
AU1720083A (en) 1984-02-02
IE55800B1 (en) 1991-01-16
ZA835337B (en) 1984-03-28
FI832676A (fi) 1984-01-27
JPH0526799B2 (ko) 1993-04-19
ES524405A0 (es) 1984-12-16
JPS5948084A (ja) 1984-03-19
GB2124234A (en) 1984-02-15

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