KR870008022A - L- 트레오닌의 제조방법 - Google Patents

L- 트레오닌의 제조방법 Download PDF

Info

Publication number
KR870008022A
KR870008022A KR870001376A KR870001376A KR870008022A KR 870008022 A KR870008022 A KR 870008022A KR 870001376 A KR870001376 A KR 870001376A KR 870001376 A KR870001376 A KR 870001376A KR 870008022 A KR870008022 A KR 870008022A
Authority
KR
South Korea
Prior art keywords
ferm
threonine
preparing
producing
escherichia coli
Prior art date
Application number
KR870001376A
Other languages
English (en)
Other versions
KR910008634B1 (ko
Inventor
사또루 후루까와
아끼오 오자끼
도시히데 나까니시
유끼노부 고따니
마사히로 스기모또
Original Assignee
가또 미끼오
교오와학꼬 고오교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가또 미끼오, 교오와학꼬 고오교 가부시끼가이샤 filed Critical 가또 미끼오
Publication of KR870008022A publication Critical patent/KR870008022A/ko
Application granted granted Critical
Publication of KR910008634B1 publication Critical patent/KR910008634B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

L-트레오닌의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
첨부하는 도면은 트레오닌, 글리신 및 이소로이신의 에스케리키아 콜리 ATCC 21530을 이용한 분해반응 수행시, 이들의 상대 몰농도를 나타내는 그래프이다. 도면내에서 -●-는 트레오닌(thr)의 상대몰농도, -△-는 트레오닌의 분해로 인해 생성된 글리신(Gly)의 상대 몰농도, …△…는 글리신(Gly)의 상대몰농도, 및-●-□-●는 이소로이신(Ile)의 상대 몰농도를 나타낸다.

Claims (5)

  1. L-트레오닌을 제조하는데 있어서, L-트레오닌을 생산할 수 있으며, 동시에 리팜피신, 리신, 메티오닌, 아스파르트산 및 호모세린중 최소한 1가지 물질에 대한 내성을 갖거나 또는 저하된 L-트레오닌 분해능을 갖는 에스케리키아(Escherichia) 속에 속하는 미생물을 배지에서 배양하여 배양액내에 L-트레오닌을 축적시킨 후, 그로부터 L-트레오닌을 회수함을 특징으로 하는 L-트레오닌의 제조방법.
  2. 제 1 항에 있어서, 상술한 미생물이 에스케리키아 콜리(Escherichia coli)종에 속하는 것임을 특징으로 하는 L-트레오닌의 제조방법.
  3. 제 1 항에 있어서, 상술한 미생물이 에스케리키아 콜리 H-4258(FERM BP-985), H-4435(FERM BP-1094), H-4436(FERM BP-1095), H-4225(FERM BP-1236), H-4226(FERM BP-1237) 또는 H-4257(FERM BP-984)임을 특징으로 하는 L-트레오닌의 제조방법.
  4. 제 1 항에 있어서, 상술한 배양공정을 20-4℃에서 2-7일 동안 수행함을 특징으로 하는 L-트레오닌의 제조방법.
  5. FERM BP-985. FERM BP-1094. FERM BP-1095. FERM BP-1236, FERM BP-1237 및 FERM BP-984로 구성된 군으로부터 선택되는 확인 특성을 갖으며, 그의 배양물이 L-트레오닌 생산능을 갖는 미생물 에스케리키아 콜리의 생물학적으로 순수한 배양물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870001376A 1986-02-20 1987-02-19 L-트레오닌의 제조방법 KR910008634B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP36165 1986-02-20
JP3616586 1986-02-20
JP36164 1986-02-20
JP3616486 1986-02-20
JP16256986 1986-07-10
JP162569 1986-07-10
JP30313886 1986-12-19
JP303138 1986-12-19

Publications (2)

Publication Number Publication Date
KR870008022A true KR870008022A (ko) 1987-09-23
KR910008634B1 KR910008634B1 (ko) 1991-10-19

Family

ID=27460215

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870001376A KR910008634B1 (ko) 1986-02-20 1987-02-19 L-트레오닌의 제조방법

Country Status (4)

Country Link
US (1) US5017483A (ko)
EP (1) EP0237819B1 (ko)
KR (1) KR910008634B1 (ko)
DE (1) DE3788583T2 (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6437295A (en) * 1987-07-31 1989-02-07 Kyowa Hakko Kogyo Kk Production of l-threonine by fermentation
JP2578492B2 (ja) * 1988-11-10 1997-02-05 協和醗酵工業株式会社 発酵法によるｌ−スレオニンの製造法
JP2971089B2 (ja) * 1990-03-09 1999-11-02 協和醗酵工業株式会社 発酵法によるｌ―スレオニンの製造法
JP3006926B2 (ja) * 1991-09-04 2000-02-07 協和醗酵工業株式会社 発酵法によるｌ−スレオニンの製造法
JP3036930B2 (ja) * 1991-11-11 2000-04-24 協和醗酵工業株式会社 発酵法によるｌ−イソロイシンの製造法
JP3151073B2 (ja) * 1992-02-25 2001-04-03 協和醗酵工業株式会社 発酵法によるアミノ酸の製造法
US5939307A (en) * 1996-07-30 1999-08-17 The Archer-Daniels-Midland Company Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
JP3966583B2 (ja) * 1997-06-23 2007-08-29 協和醗酵工業株式会社 発酵法によるｌ−アミノ酸の製造法
US20060040364A1 (en) * 1998-10-13 2006-02-23 Livshits Vitaly A DNA coding for a protein which imparts L-homoserine resistance to Escherichia coli bacterium, and a method for producing L-amino acids
RU2144564C1 (ru) * 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
JP4245746B2 (ja) 1999-09-20 2009-04-02 協和発酵バイオ株式会社 発酵法によるアミノ酸の製造法
CA2319283A1 (en) 1999-09-20 2001-03-20 Kuniki Kino Method for producing l-amino acids by fermentation
US7220571B2 (en) * 2000-09-28 2007-05-22 Archer-Daniels-Midland Company Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation
DE60219969T2 (de) * 2001-02-13 2008-01-17 Ajinomoto Co., Inc. Methode zur Production von L-Aminosäuren mittels Bakterien der Gattung Escherichia
DE10116518A1 (de) * 2001-04-03 2002-10-17 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
US7052883B2 (en) 2001-04-03 2006-05-30 Degussa Ag Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated fruR gene
EP1407025B1 (en) * 2001-07-18 2008-04-23 Evonik Degussa GmbH Process for the preparation of l-threonine using strains of the enterobacteriaceae family which contain an enhanced male gene
KR100596372B1 (ko) * 2004-12-06 2006-07-04 씨제이 주식회사 염색체 상의 ｌｙｓＲ유전자가 불활성화된 Ｌ-쓰레오닌생성 미생물, 그를 제조하는 방법 및 상기 미생물을이용한 Ｌ-쓰레오닌의 제조방법
US7723097B2 (en) * 2005-03-11 2010-05-25 Archer-Daniels-Midland Company Escherichia coli strains that over-produce L-threonine and processes for their production
CN103497979B (zh) * 2005-06-20 2018-09-11 阿彻-丹尼尔斯-米德兰公司 用于改良生产天冬氨酸衍生的氨基酸及化学品的改变的乙醛酸支路

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1126937A (en) * 1965-07-07 1968-09-11 Kyowa Hakko Kogyo Kk Process for producing l-threonine
FR1484846A (fr) * 1966-05-18 1967-06-16 Ajinomoto Kk Préparation de la thréonine par fermentation
FR1580549A (ko) * 1967-07-28 1969-09-05
GB1185130A (en) * 1967-09-12 1970-03-18 Kyowa Hakko Kogyo Kk Process for producing L-Threonine
GB1342308A (en) * 1970-01-22 1974-01-03 Kyowa Hakko Kogyo Kk Production of threonine and lysine by fermentation
JPS6051338B2 (ja) * 1979-06-30 1985-11-13 株式会社東芝 電力調整装置
JPS56134993A (en) * 1980-03-21 1981-10-22 Tanabe Seiyaku Co Ltd Preparation of l-threonine by fermentation method
JPS60180597A (ja) * 1984-02-27 1985-09-14 Toray Ind Inc 発酵法によるｌ−スレオニンの製法
JPS6410037A (en) * 1987-06-30 1989-01-13 Matsushita Seiko Kk Operation control device for hot water heating machine

Also Published As

Publication number Publication date
EP0237819A3 (en) 1988-07-06
US5017483A (en) 1991-05-21
DE3788583T2 (de) 1994-05-19
EP0237819B1 (en) 1993-12-29
DE3788583D1 (de) 1994-02-10
KR910008634B1 (ko) 1991-10-19
EP0237819A2 (en) 1987-09-23

Similar Documents

Publication Publication Date Title
KR870008022A (ko) L- 트레오닌의 제조방법
KR930006160A (ko) L-트레오닌의 제조방법
DE3878564D1 (de) Verfahren zur mikrobiologischen herstellung von 1,3-propandiol aus glycerin.
KR890002413A (ko) 발효에 의한 l-트레오닌의 제조방법
ATE29198T1 (de) Verfahren zur herstellung von zusammensetzungen auf basis von lysin zur tierfuetterung.
KR960700346A (ko) 면역억제제의 제조방법 및 이에 사용되는 신규 미생물(a process for producing immunosuppressives and a novel microbial species to be employed therein)
KR920006507A (ko) L-발린의 제조방법
DE69424658D1 (de) Verfahren zur herstellung von alkylpolyglykosiden
GB1444072A (en) Microbiological production of proteinaceous material
DE3367413D1 (en) Antibiotic compound
DE69130200D1 (de) Xyloseisomerase-Gen von Thermus Aquaticus, Xyloseisomerase und Verfahren zur Herstellung von Fructose
ATE124449T1 (de) Mikrobiologisches verfahren zur herstellung von hydroxylierten heterocyclen.
GB978593A (en) Method for producing l-homoserine by fermentation
KR890013190A (ko) L-리신의 제조방법
KR920004562A (ko) Phb-비함유 젤란 검 발효액
KR850006228A (ko) L-세린의 제조방법
KR910002457A (ko) 항 비루스 항생제 bu-3889v
KR850006451A (ko) 항생제 LL-D42067α 및 LL-D42067β의 제조방법
KR850005502A (ko) 세펨 화합물의 제조방법
AT234274B (de) Verfahren zur Züchtung von Bakterien zwecks Gewinnung von 6-Aminopenicillansäure aus Penicillinen
ATE152773T1 (de) Verfahren zur herstellung von 17-oxosteroiden
DE68908253T2 (de) Verfahren zur Herstellung von Itaconsäure.
KR900009966A (ko) 글루타민산을 생산하는 미생물 및 이를 이용한 글루타민산의 제조방법
KR840007106A (ko) 항종양성 항생 물질 투조펩틴 e₂의 제조방법
KR880001820A (ko) L-글루탐산을 제조하는 발효방법

Legal Events

Date Code Title Description
E902 Notification of reason for refusal
G160 Decision to publish patent application
O035 Opposition [patent]: request for opposition

Free format text: OPPOSITION NUMBER: 001991000744; OPPOSITION DATE: 19911219

E902 Notification of reason for refusal
E601 Decision to refuse application
O063 Decision on refusal after opposition [patent]: decision to refuse application