KR840001512B1 - 백일해 톡소이드의 제조방법 - Google Patents

백일해 톡소이드의 제조방법 Download PDF

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Publication number
KR840001512B1
KR840001512B1 KR1019810000199A KR810000199A KR840001512B1 KR 840001512 B1 KR840001512 B1 KR 840001512B1 KR 1019810000199 A KR1019810000199 A KR 1019810000199A KR 810000199 A KR810000199 A KR 810000199A KR 840001512 B1 KR840001512 B1 KR 840001512B1
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KR
South Korea
Prior art keywords
pertussis
toxoid
solution
added
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019810000199A
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English (en)
Korean (ko)
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KR830004851A (ko
Inventor
유끼오 슈우구다
히데오 와다나베
시게오 마쯔야마
Original Assignee
다께다 야꾸힝 고오교오 가부시기가이샤
고니시 신베이
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Application filed by 다께다 야꾸힝 고오교오 가부시기가이샤, 고니시 신베이 filed Critical 다께다 야꾸힝 고오교오 가부시기가이샤
Publication of KR830004851A publication Critical patent/KR830004851A/ko
Application granted granted Critical
Publication of KR840001512B1 publication Critical patent/KR840001512B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1019810000199A 1980-09-12 1981-01-23 백일해 톡소이드의 제조방법 Expired KR840001512B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP55127825A JPS5750925A (en) 1980-09-12 1980-09-12 Preparation of pertussis toxoid
JP127825 1983-07-15

Publications (2)

Publication Number Publication Date
KR830004851A KR830004851A (ko) 1983-07-20
KR840001512B1 true KR840001512B1 (ko) 1984-09-29

Family

ID=14969595

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000199A Expired KR840001512B1 (ko) 1980-09-12 1981-01-23 백일해 톡소이드의 제조방법

Country Status (12)

Country Link
US (1) US4455297A (enExample)
EP (1) EP0047802B1 (enExample)
JP (1) JPS5750925A (enExample)
KR (1) KR840001512B1 (enExample)
CA (1) CA1152001A (enExample)
DE (1) DE3069433D1 (enExample)
DK (1) DK155915C (enExample)
ES (1) ES8202058A1 (enExample)
GB (1) GB2083358B (enExample)
HU (1) HU185404B (enExample)
NO (1) NO159667C (enExample)
SU (1) SU1297712A3 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59206316A (ja) * 1983-05-11 1984-11-22 Kaken Pharmaceut Co Ltd インシユリン分泌増強活性物質誘導体およびその製法
US4551429A (en) * 1983-09-15 1985-11-05 American Home Products Corporation Stimulation of antigen production by Bordetella pertussis
US4563303A (en) * 1984-04-14 1986-01-07 Judicial Foundation The Chemosero-Therapeutic Research Institute Method for purification of filamentous hemagglutinin
GB8412207D0 (en) 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
JPS60155127A (ja) * 1984-12-10 1985-08-15 Teijin Ltd 生物学的活性物質の製法
GB8512972D0 (en) * 1985-05-22 1985-06-26 Univ Glasgow Vaccine production
GB8601279D0 (en) * 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
FR2597344B1 (fr) * 1986-04-16 1989-06-23 Merieux Inst Perfectionnement au procede de purification d'antigenes proteiques de bacteries appartenant au genre bordetella, en vue de l'obtention d'un vaccin acellulaire.
US4705686A (en) * 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
US5165927A (en) * 1986-08-01 1992-11-24 University Of Southern California Composition with modified pertussis toxin
US5032398A (en) * 1986-08-01 1991-07-16 Kaslow Harvey R Selective modification of the catalytic subunit of pertussis toxin
CA1337859C (en) * 1987-04-24 1996-01-02 Masashi Chazono Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine
US5139776A (en) * 1987-04-24 1992-08-18 The Research Foundation For Microbial Diseases Of Osaka University Method for culturing Bordetella pertussis, a pertussis toxoid and a pertussis vaccine
US5101019A (en) * 1987-05-22 1992-03-31 Takeda Chemical Industries, Ltd. Method for removing pertussis endotoxin, a pertussis toxoid and its production
JPS6485926A (en) * 1987-06-24 1989-03-30 Teijin Ltd Mutant of bordetella pertussis
GB8807860D0 (en) * 1988-04-05 1988-05-05 Connaught Lab Pertussis vaccine
JP2706792B2 (ja) * 1988-11-29 1998-01-28 財団法人化学及血清療法研究所 百日咳毒素のトキソイド化法
EP0396964B1 (en) * 1989-04-28 1995-09-06 SCLAVO S.p.A. Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines
GB8910570D0 (en) 1989-05-08 1989-06-21 Wellcome Found Acellular vaccine
ES2080941T3 (es) * 1990-02-12 1996-02-16 Smithkline Beecham Biolog Nueva vacuna y procedimiento para la misma.
US5578308A (en) * 1990-02-12 1996-11-26 Capiau; Carine Glutaraldehyde and formalin detoxified bordetella toxin vaccine
JPH0432188U (enExample) * 1990-07-10 1992-03-16
DK0669971T3 (da) * 1991-11-15 2003-04-22 Pfizer Fremgangsmåde til fremstilling af Gram-negative bakterielle vacciner
JP2634545B2 (ja) * 1992-10-27 1997-07-30 日本全薬工業株式会社 Ｒｔｘトキシンファミリーに属する細菌毒素ワクチンの製造法
CN1147259A (zh) * 1994-04-28 1997-04-09 武田药品工业株式会社 分离百日咳杆菌保护性组分的方法
RU2227746C1 (ru) * 2003-02-13 2004-04-27 Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН Способ получения анатоксина bordetella pertussis
BRPI0402630B8 (pt) * 2004-07-05 2021-05-25 Fund Butantan processo de obtenção de vacina pertussis celular menos reatogênica
RU2285540C2 (ru) * 2005-01-20 2006-10-20 Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова СПОСОБ ПОЛУЧЕНИЯ АНАТОКСИНА Bordetella pertussis
RU2332231C2 (ru) * 2006-07-31 2008-08-27 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации Способ получения бесклеточной вакцины для иммунопрофилактики коклюша
RU2504399C1 (ru) * 2012-12-06 2014-01-20 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским и иммунопрофилактическим препаратам "Микроген" Министерства здравоохранения Российской Федерации (ФГУП "НПО "Микроген" Минздрава России) Способ получения бесклеточной вакцины для иммунопрофилактики коклюша

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB512196A (en) * 1937-08-19 1939-08-30 Lederle Lab Inc Method of preparing pertussis toxin and toxoid
US2359388A (en) * 1941-02-13 1944-10-03 Lederle Lab Inc Method of preparing pertussis toxin and toxoid
US3135662A (en) * 1961-01-05 1964-06-02 Burroughs Wellcome Co Diphtheria toxoid preparation and its production
NL6600706A (enExample) * 1965-02-05 1966-08-08
US4070454A (en) * 1973-05-04 1978-01-24 Agence Nationale De Valorisation De La Recherche (Anvar) Vaccines, the process for preparing the same and the applications thereof
DE2448530C3 (de) * 1974-10-11 1980-03-27 Behringwerke Ag, 3550 Marburg Verfahren zum Herstellen von Derivaten des Diphtherietoxins und diese enthaltende Mittel
DE2457047C3 (de) * 1974-12-03 1979-10-31 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe
FR2393065A1 (fr) * 1977-05-31 1978-12-29 Merieux Inst Procede de separation de lipides d'endotoxines bacteriennes et notamment d'endotoxine de bordetella pertussis

Also Published As

Publication number Publication date
EP0047802B1 (en) 1984-10-10
NO810014L (no) 1982-03-15
US4455297A (en) 1984-06-19
NO159667C (no) 1989-02-01
DK9281A (da) 1982-03-13
EP0047802A3 (en) 1982-12-29
GB2083358B (en) 1984-06-13
CA1152001A (en) 1983-08-16
ES499112A0 (es) 1982-02-01
HU185404B (en) 1985-02-28
DK155915C (da) 1989-10-23
NO159667B (no) 1988-10-17
DE3069433D1 (en) 1984-11-15
ES8202058A1 (es) 1982-02-01
SU1297712A3 (ru) 1987-03-15
GB2083358A (en) 1982-03-24
EP0047802A2 (en) 1982-03-24
KR830004851A (ko) 1983-07-20
JPS64928B2 (enExample) 1989-01-10
JPS5750925A (en) 1982-03-25
DK155915B (da) 1989-06-05

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