KR840000543A - 1,4,9,10-테트라하이드로-피라졸로[4,3-e]-피리도[3,2-b][1,4]디아제핀-10-온의 제조방법 - Google Patents

1,4,9,10-테트라하이드로-피라졸로[4,3-e]-피리도[3,2-b][1,4]디아제핀-10-온의 제조방법 Download PDF

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KR840000543A
KR840000543A KR1019820002494A KR820002494A KR840000543A KR 840000543 A KR840000543 A KR 840000543A KR 1019820002494 A KR1019820002494 A KR 1019820002494A KR 820002494 A KR820002494 A KR 820002494A KR 840000543 A KR840000543 A KR 840000543A
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carbon atoms
alkyl group
formula
compound
hydrogen atom
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KR1019820002494A
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KR880001719B1 (ko
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슈미트 귄테르 (외 4)
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라우디엔, 좀머
닥터. 칼 토매 게젤샤프트 미트 베슈랭크터 하프퉁
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

1,4,9,10-테트라하이드로-피라졸로〔4,3-e〕-피리도〔3,2-b〕〔1,4〕디아제핀-10-온의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 다음 일반식(Ⅱ)의 N-(2-할로 겐-3-피리디닐)-4-아미노-1H-피라졸-5-카복스 아미드를 80내지 200℃, 유기용매 중에서, 임의로 촉매량의 무기산 존재하에 폐환시키고, 필요한 경우 R1는 후술하는 바와 같고 R4은 수소원자인 수득된 일반식(Ⅰ)의 화합물을 알킬화시켜 R4가 후술하는 바와같고 R1이 탄
  3. 소수 1내지 6의 알킬그룹인 상응하는 일반식(Ⅰ)의 화합물로 전환시키거나, 또는 R1이 탄소수 1내지 6의 알킬그룹이고, R4가 수소원자인 일반식(Ⅰ)의 화합물을 알킬화시켜 R1이 탄소수 1내지 6의 알킬그룹이고, R4가 탄소수 1내지 4의 알킬그룹인 상응하는 일반식(Ⅰ)의 화합물로 전환시키거나, 또는 R1및 R4가 각각 수소인 일반식(Ⅰ)의 화합물을 알킬화시켜 R1및 R4가 각각 탄소수 1내지 4의 알킬그룹인 상응하는 일반식(Ⅰ)의 화합물로 전환시킴을 포함하여 일반식(Ⅰ)의 1,4,9,10-테트라하이드로-피라졸로〔4,3-e〕피리도〔3,2-b〕〔1,4〕디아제핀-10-온을 제조하는 방법.
  4. 상기식에서,
  5. R1은 수소원자 또는 탄소수 1내지 6의 알킬그룹이고,
  6. R2는 탄소수 1내지 3의 알킬그룹이고,
  7. R3는 수소원자 또는 탄소수 1내지 3의 알킬그룹이고,
  8. R4는 수소원자 또는 탄소수 1내지 4의 알킬그룹이다.
  9. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8202494A 1981-06-06 1982-06-03 1,4,9,10-테트라하이드로-피라졸로[4,3-e]-피리도[3,2-b][1,4]디아제핀-10-온의 제조 방법 KR880001719B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE?3,122,670.1? 1981-06-06
DEP3122670.1 1981-06-06
DE19813122670 DE3122670A1 (de) 1981-06-06 1981-06-06 "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"

Publications (2)

Publication Number Publication Date
KR840000543A true KR840000543A (ko) 1984-02-25
KR880001719B1 KR880001719B1 (ko) 1988-09-08

Family

ID=6134176

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8202494A KR880001719B1 (ko) 1981-06-06 1982-06-03 1,4,9,10-테트라하이드로-피라졸로[4,3-e]-피리도[3,2-b][1,4]디아제핀-10-온의 제조 방법

Country Status (27)

Country Link
US (1) US4381303A (ko)
EP (1) EP0066774B1 (ko)
JP (1) JPS57212182A (ko)
KR (1) KR880001719B1 (ko)
AR (1) AR229124A1 (ko)
AT (1) ATE10744T1 (ko)
AU (1) AU552765B2 (ko)
CA (1) CA1167440A (ko)
CS (1) CS226743B2 (ko)
DD (1) DD202574A5 (ko)
DE (2) DE3122670A1 (ko)
DK (1) DK253382A (ko)
ES (1) ES512846A0 (ko)
FI (1) FI71560C (ko)
GB (1) GB2117755B (ko)
GR (1) GR76438B (ko)
HU (1) HU186067B (ko)
IE (1) IE53067B1 (ko)
IL (1) IL65977A (ko)
NO (1) NO158063C (ko)
NZ (1) NZ200859A (ko)
PH (1) PH17719A (ko)
PL (1) PL135845B1 (ko)
PT (1) PT75016B (ko)
SU (1) SU1103795A3 (ko)
YU (1) YU118282A (ko)
ZA (1) ZA823919B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3643666A1 (de) * 1986-12-20 1988-06-30 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4749788A (en) * 1987-04-13 1988-06-07 A. H. Robins Company, Incorporated Process for the preparation of aryl-pyrido(1,4) benzodiazepines
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
CA2019812C (en) * 1989-06-28 2000-11-21 Gunther Schmidt (Deceased) Novel 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones and their use in the prevention or treatment of aids
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
ES2137113B1 (es) 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450694A (en) * 1966-02-23 1969-06-17 Abbott Lab Substituted benzoxazepines and benzothiazepines
DE2707269A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung
NZ194529A (en) * 1979-08-03 1983-05-10 Byk Gulden Lomberg Chem Fab 9,10-dihydro-1h, 4h-pyrazolo (4,3-b)(1,5)benzodiazepin-10-ones

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Publication number Publication date
AU552765B2 (en) 1986-06-19
DE3122670A1 (de) 1982-12-23
DK253382A (da) 1982-12-07
ES8304571A1 (es) 1983-03-01
CA1167440A (en) 1984-05-15
DE3261530D1 (en) 1985-01-24
NZ200859A (en) 1985-08-16
HU186067B (en) 1985-05-28
IL65977A0 (en) 1982-09-30
NO158063C (no) 1988-07-06
AU8460582A (en) 1982-12-16
DD202574A5 (de) 1983-09-21
KR880001719B1 (ko) 1988-09-08
AR229124A1 (es) 1983-06-15
FI71560B (fi) 1986-10-10
ATE10744T1 (de) 1984-12-15
IE821350L (en) 1982-12-06
FI71560C (fi) 1987-01-19
US4381303A (en) 1983-04-26
FI821992A0 (fi) 1982-06-04
IE53067B1 (en) 1988-05-25
JPS57212182A (en) 1982-12-27
NO158063B (no) 1988-03-28
GB2117755B (en) 1985-01-30
GR76438B (ko) 1984-08-10
ZA823919B (en) 1984-02-29
PH17719A (en) 1984-11-21
ES512846A0 (es) 1983-03-01
CS226743B2 (en) 1984-04-16
PT75016B (de) 1985-05-17
GB2117755A (en) 1983-10-19
EP0066774B1 (de) 1984-12-12
SU1103795A3 (ru) 1984-07-15
EP0066774A1 (de) 1982-12-15
PT75016A (de) 1982-07-01
YU118282A (en) 1986-04-30
PL236742A1 (en) 1984-03-26
PL135845B1 (en) 1985-12-31
NO821882L (no) 1982-12-07
IL65977A (en) 1984-12-31

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