KR840000421B1 - 피라졸로 퀴놀린의 제조방법 - Google Patents
피라졸로 퀴놀린의 제조방법 Download PDFInfo
- Publication number
- KR840000421B1 KR840000421B1 KR1019800002438A KR800002438A KR840000421B1 KR 840000421 B1 KR840000421 B1 KR 840000421B1 KR 1019800002438 A KR1019800002438 A KR 1019800002438A KR 800002438 A KR800002438 A KR 800002438A KR 840000421 B1 KR840000421 B1 KR 840000421B1
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- compounds
- mixture
- solution
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/28—Two oxygen or sulfur atoms
- C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
- C07D231/32—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5071679A | 1979-06-21 | 1979-06-21 | |
| US50716 | 1987-05-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830002763A KR830002763A (ko) | 1983-05-30 |
| KR840000421B1 true KR840000421B1 (ko) | 1984-04-02 |
Family
ID=21966959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800002438A Expired KR840000421B1 (ko) | 1979-06-21 | 1980-06-20 | 피라졸로 퀴놀린의 제조방법 |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0022078B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS5618980A (cg-RX-API-DMAC7.html) |
| KR (1) | KR840000421B1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE8629T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU538890B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1148159A (cg-RX-API-DMAC7.html) |
| CY (1) | CY1357A (cg-RX-API-DMAC7.html) |
| DD (1) | DD151754A5 (cg-RX-API-DMAC7.html) |
| DE (1) | DE3068673D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK160762C (cg-RX-API-DMAC7.html) |
| FI (1) | FI68827C (cg-RX-API-DMAC7.html) |
| GR (1) | GR69282B (cg-RX-API-DMAC7.html) |
| HK (1) | HK47387A (cg-RX-API-DMAC7.html) |
| HU (1) | HU183156B (cg-RX-API-DMAC7.html) |
| IE (1) | IE49993B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL60357A (cg-RX-API-DMAC7.html) |
| MY (1) | MY8700556A (cg-RX-API-DMAC7.html) |
| NO (1) | NO153430C (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ194102A (cg-RX-API-DMAC7.html) |
| PT (1) | PT71420A (cg-RX-API-DMAC7.html) |
| SG (1) | SG14387G (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA803714B (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459298A (en) * | 1982-09-28 | 1984-07-10 | Ciba-Geigy Corporation | Method of suppressing appetite |
| US4524146A (en) * | 1982-12-08 | 1985-06-18 | Ciba-Geigy Corporation | Certain -2-heterocycle substituted pyrazoloquinolines |
| US4479955A (en) * | 1983-01-10 | 1984-10-30 | Ciba-Geigy Corporation | Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators |
| EP0126970A3 (en) * | 1983-04-27 | 1985-11-06 | Beecham Group Plc | Anxiolytic and anti-depressant thienopyridine derivatives |
| FR2549833B1 (fr) * | 1983-07-26 | 1985-11-08 | Roussel Uclaf | Derives de la pyrazolo /4,3-c/ cinnolin-3-one, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et produits intermediaires |
| CA1263651A (en) * | 1984-07-09 | 1989-12-05 | Ciba-Geigy Ag | Certain ring-fused pyrazolo ¬3,4-d|-pyridin-3-one derivatives |
| PH21213A (en) * | 1984-10-26 | 1987-08-21 | Fujisawa Pharmaceutical Co | Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same |
| JPS61112075A (ja) * | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | チエニルピラゾロキノリン誘導体 |
| DE3728278A1 (de) * | 1986-12-17 | 1988-06-23 | Bayer Ag | Herbizide und fungizide mittel auf basis von substituierten pyrazolin-5-on derivaten |
| US5243049A (en) * | 1992-01-22 | 1993-09-07 | Neurogen Corporation | Certain pyrroloquinolinones: a new class of GABA brain receptor ligands |
| GB9625398D0 (en) * | 1996-12-06 | 1997-01-22 | Merck Sharp & Dohme | Method of treatment,manufacture,compositions and compounds |
| US6835707B1 (en) | 1998-10-13 | 2004-12-28 | The Procter & Gamble Company | Laundry detergent compositions with a combination of cyclic amine based polymers and hydrophobically modified carboxy methyl cellulose |
| GB0305876D0 (en) * | 2003-03-14 | 2003-04-16 | Avidex Ltd | Immuno inhibitory heterocyclic compounds |
| JP2010529144A (ja) * | 2007-06-08 | 2010-08-26 | ヘリコン・セラピューティクス・インコーポレーテッド | 治療用ピラゾロキノリン尿素誘導体 |
| WO2011041143A1 (en) * | 2009-10-01 | 2011-04-07 | Merck Sharp & Dohme Corp. | HETEROCYCLIC-FUSED PYRAZOLO[4,3-c]PYRIDIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS |
| US8895580B2 (en) * | 2009-10-21 | 2014-11-25 | Merck Sharp & Dohme Corp. | Quinolinone-pyrazolone M1 receptor positive allosteric modulators |
| TWI557121B (zh) | 2011-04-21 | 2016-11-11 | 原真股份有限公司 | 新穎激酶抑制劑 |
| WO2014060113A1 (en) | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Novel kinase inhibitors |
| CN114891236B (zh) * | 2022-06-09 | 2023-04-28 | 安庆师范大学 | 一种三维Co-MOF化合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3890324A (en) * | 1974-04-12 | 1975-06-17 | Lilly Co Eli | 1h-pyrazolo(4,3-)quinol-4(5h)-one-3-carboxylic acids |
| EP0005745B1 (en) * | 1978-05-26 | 1982-07-14 | Gruppo Lepetit S.P.A. | Pyrazolo (3,4-c) and thiazolo (5,4-c) isoquinolines, methods for preparing them, these compounds for use as antiinflammatory, cns-depressant and anti-anxiety agents and pharmaceutical compositions thereof |
-
1980
- 1980-06-16 EP EP80810200A patent/EP0022078B1/de not_active Expired
- 1980-06-16 CY CY135780A patent/CY1357A/xx unknown
- 1980-06-16 AT AT80810200T patent/ATE8629T1/de not_active IP Right Cessation
- 1980-06-16 DE DE8080810200T patent/DE3068673D1/de not_active Expired
- 1980-06-18 FI FI801964A patent/FI68827C/fi not_active IP Right Cessation
- 1980-06-19 IL IL60357A patent/IL60357A/xx unknown
- 1980-06-19 PT PT71420A patent/PT71420A/pt unknown
- 1980-06-19 CA CA000354349A patent/CA1148159A/en not_active Expired
- 1980-06-19 GR GR62257A patent/GR69282B/el unknown
- 1980-06-20 IE IE1279/80A patent/IE49993B1/en not_active IP Right Cessation
- 1980-06-20 NZ NZ194102A patent/NZ194102A/xx unknown
- 1980-06-20 KR KR1019800002438A patent/KR840000421B1/ko not_active Expired
- 1980-06-20 NO NO801866A patent/NO153430C/no unknown
- 1980-06-20 ZA ZA00803714A patent/ZA803714B/xx unknown
- 1980-06-20 AU AU59455/80A patent/AU538890B2/en not_active Ceased
- 1980-06-20 DK DK264880A patent/DK160762C/da not_active IP Right Cessation
- 1980-06-21 JP JP8449380A patent/JPS5618980A/ja active Granted
- 1980-06-23 DD DD80222091A patent/DD151754A5/de unknown
- 1980-08-21 HU HU801539A patent/HU183156B/hu unknown
-
1987
- 1987-02-17 SG SG143/87A patent/SG14387G/en unknown
- 1987-06-18 HK HK473/87A patent/HK47387A/xx unknown
- 1987-12-30 MY MY556/87A patent/MY8700556A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI68827C (fi) | 1985-11-11 |
| DE3068673D1 (en) | 1984-08-30 |
| FI801964A7 (fi) | 1980-12-22 |
| IE801279L (en) | 1980-12-21 |
| FI68827B (fi) | 1985-07-31 |
| CA1148159A (en) | 1983-06-14 |
| NO801866L (no) | 1980-12-22 |
| PT71420A (en) | 1980-07-01 |
| KR830002763A (ko) | 1983-05-30 |
| MY8700556A (en) | 1987-12-31 |
| DK264880A (da) | 1980-12-22 |
| AU538890B2 (en) | 1984-08-30 |
| IL60357A0 (en) | 1980-09-16 |
| HU183156B (en) | 1984-04-28 |
| ATE8629T1 (de) | 1984-08-15 |
| DK160762B (da) | 1991-04-15 |
| SG14387G (en) | 1987-07-10 |
| ZA803714B (en) | 1981-06-24 |
| IL60357A (en) | 1984-05-31 |
| EP0022078B1 (de) | 1984-07-25 |
| DK160762C (da) | 1991-09-23 |
| DD151754A5 (de) | 1981-11-04 |
| EP0022078A1 (de) | 1981-01-07 |
| GR69282B (cg-RX-API-DMAC7.html) | 1982-05-13 |
| IE49993B1 (en) | 1986-01-22 |
| HK47387A (en) | 1987-06-26 |
| JPH039114B2 (cg-RX-API-DMAC7.html) | 1991-02-07 |
| NO153430B (no) | 1985-12-09 |
| AU5945580A (en) | 1981-01-08 |
| NO153430C (no) | 1986-03-19 |
| JPS5618980A (en) | 1981-02-23 |
| NZ194102A (en) | 1983-04-12 |
| CY1357A (en) | 1987-08-07 |
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