IL60357A - Pyrazoloquinolines,their manufacture and pharmaceutical compositions containing them - Google Patents
Pyrazoloquinolines,their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL60357A IL60357A IL60357A IL6035780A IL60357A IL 60357 A IL60357 A IL 60357A IL 60357 A IL60357 A IL 60357A IL 6035780 A IL6035780 A IL 6035780A IL 60357 A IL60357 A IL 60357A
- Authority
- IL
- Israel
- Prior art keywords
- hydroxy
- alkyl
- see diagramm
- hydrogen
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/28—Two oxygen or sulfur atoms
- C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
- C07D231/32—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Electrophonic Musical Instruments (AREA)
- Golf Clubs (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A compound of the general formulae I and II see diagramm : EP0022078,P19,F1 and see diagramm : EP0022078,P19,F2 wherein R3 is hydrogen or not more than 3 identical or different members selected from C1 -C7-alkyl, C1 -C7 -alkoxy, C1 -C7 -alkylthio, hydroxy, halogen, trifluoromethyl, nitro, amino, mono- or di-C1 -C7 -alkylamino, cyano, carbamoyl and carboxyl ; R is phenyl or phenyl substituted by not more than 3 of the radicals as defined for R3 , pyridyl, C1 -C7 -alkylpyridyl, or halopyridyl ; R1 is hydrogen, C1 -C7 -alkyl or (hydroxy, di-C1 -C7 -alkyl-mino or R3 -phenyl)-C1 -C7 -alkyl, wherein the hydroxy or amino group is separated from the ring nitrogen atom by at least 2 carbon atoms, and R2 is hydrogen or C1 -C7 -alkyl ; their 3-hydroxy-tautomers ; C1 -C7 -alkanoyl, carbamoyl, mono- or di-C1 -C7 alkylcarbomoyl derivatives of said (hydroxy or amino)-(phenyl or phenylene) compounds ; or salts thereof. For the Contracting State AT 1. A process for the preparation of a 2-aryl-pyrazolo [4,3-c] quinolin-3-(1 or 5H)-one of the general formulae I and II see diagramm : EP0022078,P21,F1 and see diagramm : EP0022078,P21,F2 wherein R3 is hydrogen or not more than 3 identical or different members selected from C1 -C7 -alkyl, C1 -C7 -alkoxy, C1 -C7 -alkylthio, hydroxy, halogen, trifluoromethyl, nitro, amino, mono- or di-C1 -C7 -alkylamino, cyano, carbamoyl and carboxy ; R is phenyl or phenyl substituted by not more than 3 of the radicals as defined for R3 , pyridyl, C1 -C7 -alkylpyridyl, or halopyridyl ; R1 is hydrogen, C1 -C7 -alkyl or (hydroxy, di-C1 -C7 -alkylamino or R3 -phenyl)-C1 -C7 -alkyl, wherein the hydroxy or amino group is separated from the ring nitrogen atom by at least 2 carbon atoms, and R2 is hydrogen or C1 -C7 -alkyl ; their 3-hydroxy-tautomers ; C1 -C7 -alkanoyl, carbamoyl, mono- or di-C1 -C7 -alkylcarbamoyl derivatives of said (hydroxy or amino)-(phenyl or phenylene) compounds ; or a salts thereof, which comprises a) cyclising a compound of the formula IV see diagramm : EP0022078,P21,F3 wherein X is -NH-NH-R and Y is hydroxy or C1 -C7 -alkoxy ; or X is halogen and Y is see diagramm : EP0022078,P21,F4 ; or X is C1 -C7 -alkoxyamino or azido, and Y is NH-R, and, if desired, reacting a resulting compound, or an alkali metal salt thereof, with a reactive ester of the alcohol R1 -OH, or b) condensing a compound of the formula V see diagramm : EP0022078,P21,F5 wherein W and R1 are both hydrogen, Z is see diagramm : EP0022078,P21,F6 and R1 ' is C1 -C7 -alkyl ; or W is see diagramm : EP0022078,P22,F7 and Z is hydrogen ; or W is see diagramm : EP0022078,P22,F8 and Z is R2 -CO, or see diagramm : EP0022078,P22,F9 together is isocyano ; and, if desired, converting a resulting compound into another compound of the invention, and/or, if desired, converting a resulting compound into a salt thereof, or a resulting salt into the corresponding free compound or into another salt, and/or, if desired, separating a mixture of isomers obtained into the individual isomers.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5071679A | 1979-06-21 | 1979-06-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL60357A0 IL60357A0 (en) | 1980-09-16 |
IL60357A true IL60357A (en) | 1984-05-31 |
Family
ID=21966959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL60357A IL60357A (en) | 1979-06-21 | 1980-06-19 | Pyrazoloquinolines,their manufacture and pharmaceutical compositions containing them |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0022078B1 (en) |
JP (1) | JPS5618980A (en) |
KR (1) | KR840000421B1 (en) |
AT (1) | ATE8629T1 (en) |
AU (1) | AU538890B2 (en) |
CA (1) | CA1148159A (en) |
CY (1) | CY1357A (en) |
DD (1) | DD151754A5 (en) |
DE (1) | DE3068673D1 (en) |
DK (1) | DK160762C (en) |
FI (1) | FI68827C (en) |
GR (1) | GR69282B (en) |
HK (1) | HK47387A (en) |
HU (1) | HU183156B (en) |
IE (1) | IE49993B1 (en) |
IL (1) | IL60357A (en) |
MY (1) | MY8700556A (en) |
NO (1) | NO153430C (en) |
NZ (1) | NZ194102A (en) |
PT (1) | PT71420A (en) |
SG (1) | SG14387G (en) |
ZA (1) | ZA803714B (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4459298A (en) * | 1982-09-28 | 1984-07-10 | Ciba-Geigy Corporation | Method of suppressing appetite |
US4524146A (en) * | 1982-12-08 | 1985-06-18 | Ciba-Geigy Corporation | Certain -2-heterocycle substituted pyrazoloquinolines |
US4479955A (en) * | 1983-01-10 | 1984-10-30 | Ciba-Geigy Corporation | Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators |
EP0126970A3 (en) * | 1983-04-27 | 1985-11-06 | Beecham Group Plc | Anxiolytic and anti-depressant thienopyridine derivatives |
FR2549833B1 (en) * | 1983-07-26 | 1985-11-08 | Roussel Uclaf | PYRAZOLO / 4,3-C / CINNOLIN-3-ONE DERIVATIVES, SALTS THEREOF, PROCESS FOR PREPARATION, APPLICATION AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES |
CA1263651A (en) * | 1984-07-09 | 1989-12-05 | Ciba-Geigy Ag | Certain ring-fused pyrazolo ¬3,4-d|-pyridin-3-one derivatives |
PH21213A (en) * | 1984-10-26 | 1987-08-21 | Fujisawa Pharmaceutical Co | Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same |
JPS61112075A (en) * | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | Thienylpyrazoloquinoline derivative |
DE3728278A1 (en) * | 1986-12-17 | 1988-06-23 | Bayer Ag | HERBICIDES AND FUNGICIDES ON THE BASIS OF SUBSTITUTED PYRAZOLIN-5-ON DERIVATIVES |
US5243049A (en) * | 1992-01-22 | 1993-09-07 | Neurogen Corporation | Certain pyrroloquinolinones: a new class of GABA brain receptor ligands |
GB9625398D0 (en) * | 1996-12-06 | 1997-01-22 | Merck Sharp & Dohme | Method of treatment,manufacture,compositions and compounds |
US6835707B1 (en) | 1998-10-13 | 2004-12-28 | The Procter & Gamble Company | Laundry detergent compositions with a combination of cyclic amine based polymers and hydrophobically modified carboxy methyl cellulose |
GB0305876D0 (en) * | 2003-03-14 | 2003-04-16 | Avidex Ltd | Immuno inhibitory heterocyclic compounds |
CA2688405A1 (en) * | 2007-06-08 | 2008-12-18 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline urea derivatives |
EP2483275B1 (en) * | 2009-10-01 | 2014-10-15 | Merck Sharp & Dohme Corp. | HETEROCYCLIC-FUSED PYRAZOLO[4,3-c]PYRIDIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS |
WO2011049731A1 (en) * | 2009-10-21 | 2011-04-28 | Merck Sharp & Dohme Corp. | Quinolinone-pyrazolone m1 receptor positive allosteric modulators |
BR112013026744B1 (en) | 2011-04-21 | 2022-05-17 | Origenis Gmbh | HETEROCYCLIC COMPOUNDS, THEIR USES AND THEIR INTERMEDIATES, AND PHARMACEUTICAL COMPOSITION |
US10000482B2 (en) | 2012-10-19 | 2018-06-19 | Origenis Gmbh | Kinase inhibitors |
CN114891236B (en) * | 2022-06-09 | 2023-04-28 | 安庆师范大学 | Three-dimensional Co-MOF compound and preparation method and application thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3890324A (en) * | 1974-04-12 | 1975-06-17 | Lilly Co Eli | 1h-pyrazolo(4,3-)quinol-4(5h)-one-3-carboxylic acids |
EP0005745B1 (en) * | 1978-05-26 | 1982-07-14 | Gruppo Lepetit S.P.A. | Pyrazolo (3,4-c) and thiazolo (5,4-c) isoquinolines, methods for preparing them, these compounds for use as antiinflammatory, cns-depressant and anti-anxiety agents and pharmaceutical compositions thereof |
-
1980
- 1980-06-16 CY CY135780A patent/CY1357A/en unknown
- 1980-06-16 DE DE8080810200T patent/DE3068673D1/en not_active Expired
- 1980-06-16 EP EP80810200A patent/EP0022078B1/en not_active Expired
- 1980-06-16 AT AT80810200T patent/ATE8629T1/en not_active IP Right Cessation
- 1980-06-18 FI FI801964A patent/FI68827C/en not_active IP Right Cessation
- 1980-06-19 PT PT71420A patent/PT71420A/en unknown
- 1980-06-19 CA CA000354349A patent/CA1148159A/en not_active Expired
- 1980-06-19 GR GR62257A patent/GR69282B/el unknown
- 1980-06-19 IL IL60357A patent/IL60357A/en unknown
- 1980-06-20 DK DK264880A patent/DK160762C/en not_active IP Right Cessation
- 1980-06-20 NO NO801866A patent/NO153430C/en unknown
- 1980-06-20 NZ NZ194102A patent/NZ194102A/en unknown
- 1980-06-20 KR KR1019800002438A patent/KR840000421B1/en active
- 1980-06-20 IE IE1279/80A patent/IE49993B1/en not_active IP Right Cessation
- 1980-06-20 AU AU59455/80A patent/AU538890B2/en not_active Ceased
- 1980-06-20 ZA ZA00803714A patent/ZA803714B/en unknown
- 1980-06-21 JP JP8449380A patent/JPS5618980A/en active Granted
- 1980-06-23 DD DD80222091A patent/DD151754A5/en unknown
- 1980-08-21 HU HU801539A patent/HU183156B/en unknown
-
1987
- 1987-02-17 SG SG143/87A patent/SG14387G/en unknown
- 1987-06-18 HK HK473/87A patent/HK47387A/en unknown
- 1987-12-30 MY MY556/87A patent/MY8700556A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CY1357A (en) | 1987-08-07 |
GR69282B (en) | 1982-05-13 |
FI68827C (en) | 1985-11-11 |
NO801866L (en) | 1980-12-22 |
EP0022078B1 (en) | 1984-07-25 |
EP0022078A1 (en) | 1981-01-07 |
NO153430B (en) | 1985-12-09 |
DK264880A (en) | 1980-12-22 |
FI68827B (en) | 1985-07-31 |
CA1148159A (en) | 1983-06-14 |
DD151754A5 (en) | 1981-11-04 |
NZ194102A (en) | 1983-04-12 |
AU538890B2 (en) | 1984-08-30 |
AU5945580A (en) | 1981-01-08 |
NO153430C (en) | 1986-03-19 |
FI801964A (en) | 1980-12-22 |
MY8700556A (en) | 1987-12-31 |
IE49993B1 (en) | 1986-01-22 |
IL60357A0 (en) | 1980-09-16 |
KR830002763A (en) | 1983-05-30 |
HK47387A (en) | 1987-06-26 |
DK160762B (en) | 1991-04-15 |
KR840000421B1 (en) | 1984-04-02 |
IE801279L (en) | 1980-12-21 |
JPS5618980A (en) | 1981-02-23 |
ATE8629T1 (en) | 1984-08-15 |
HU183156B (en) | 1984-04-28 |
ZA803714B (en) | 1981-06-24 |
PT71420A (en) | 1980-07-01 |
DE3068673D1 (en) | 1984-08-30 |
DK160762C (en) | 1991-09-23 |
JPH039114B2 (en) | 1991-02-07 |
SG14387G (en) | 1987-07-10 |
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