KR830009066A - 티아졸 유도체의 제조방법 - Google Patents

티아졸 유도체의 제조방법 Download PDF

Info

Publication number
KR830009066A
KR830009066A KR1019820001200A KR820001200A KR830009066A KR 830009066 A KR830009066 A KR 830009066A KR 1019820001200 A KR1019820001200 A KR 1019820001200A KR 820001200 A KR820001200 A KR 820001200A KR 830009066 A KR830009066 A KR 830009066A
Authority
KR
South Korea
Prior art keywords
salt
lower alkyl
prepared
process according
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019820001200A
Other languages
English (en)
Korean (ko)
Inventor
기오르기오 페트리니 피에르
괴쉬케 리카르드
Original Assignee
아놀드 자일러, 에른스트 알테르
시바-가이기 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아놀드 자일러, 에른스트 알테르, 시바-가이기 에이지 filed Critical 아놀드 자일러, 에른스트 알테르
Publication of KR830009066A publication Critical patent/KR830009066A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019820001200A 1981-03-18 1982-03-18 티아졸 유도체의 제조방법 Withdrawn KR830009066A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1838/81 1981-03-18
CH183881 1981-03-18

Publications (1)

Publication Number Publication Date
KR830009066A true KR830009066A (ko) 1983-12-17

Family

ID=4219779

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820001200A Withdrawn KR830009066A (ko) 1981-03-18 1982-03-18 티아졸 유도체의 제조방법

Country Status (16)

Country Link
US (1) US4451471A (enExample)
EP (1) EP0061425A3 (enExample)
JP (1) JPS57183767A (enExample)
KR (1) KR830009066A (enExample)
AU (1) AU8166782A (enExample)
DK (1) DK118482A (enExample)
ES (8) ES8400102A1 (enExample)
FI (1) FI820877L (enExample)
GB (1) GB2098203B (enExample)
GR (1) GR78347B (enExample)
HU (1) HU187684B (enExample)
IL (1) IL65285A (enExample)
NO (1) NO820881L (enExample)
NZ (1) NZ200038A (enExample)
PT (1) PT74593B (enExample)
ZA (1) ZA821790B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4632930A (en) * 1984-11-30 1986-12-30 E. I. Du Pont De Nemours And Company Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives
DE3508665A1 (de) * 1985-03-12 1986-09-18 Hoechst Ag, 6230 Frankfurt Heterocyclische sulfide und ihre anwendung als immunmodulatoren
DE3508666A1 (de) * 1985-03-12 1986-09-18 Hoechst Ag, 6230 Frankfurt Heterocyclische disulfide und ihre anwendung als immunmodulatoren
JPS6339868A (ja) * 1986-08-04 1988-02-20 Otsuka Pharmaceut Factory Inc ジ低級アルキルフエノ−ル誘導体
EP0301613B1 (en) * 1987-07-27 1991-07-10 Duphar International Research B.V Thiazole compounds having fungicidal activity
AT392788B (de) * 1988-02-03 1991-06-10 Fisons Plc Neue benzimidazolverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE3807232A1 (de) * 1988-03-05 1989-09-14 Bayer Ag Substituierte acrylsaeureester
JP2933739B2 (ja) * 1990-04-09 1999-08-16 明治製菓株式会社 チアゾールまたはイミダゾール誘導体および抗潰瘍剤
US5255697A (en) * 1991-10-23 1993-10-26 Working Inc. Walking support apparatus
WO1995024400A1 (en) * 1994-03-08 1995-09-14 American Home Products Corporation Thiazolidinedione derivatives as anti-hyperglycemic agents
JP2636819B2 (ja) 1994-12-20 1997-07-30 日本たばこ産業株式会社 オキサゾール系複素環式芳香族化合物
CA2381215A1 (en) * 1999-08-06 2001-02-15 Takeda Chemical Industries, Ltd. P38map kinase inhibitors
EP1981884B1 (en) * 2006-01-18 2012-06-13 Amgen, Inc Thiazole compounds as protein kinase b (pkb) inhibitors
WO2009011871A2 (en) * 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of pkb
WO2014009425A1 (en) 2012-07-12 2014-01-16 Chiesi Farmaceutici S.P.A. Inhibition of enzymes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2129012A1 (de) * 1971-06-11 1973-01-04 Merck Patent Gmbh Azol-derivate
FR2146161A1 (en) * 1971-07-22 1973-03-02 Roussel Uclaf Thiazolyl thiolacetic acids - analgesics antiinflammatories and antipyretics
US3888870A (en) * 1974-03-08 1975-06-10 Sandoz Ag 2-sulfinyl-thiazoles and oxazoles
US4022607A (en) * 1975-06-09 1977-05-10 Sandoz, Inc. Substituted oxazoles and thiazoles as herbicides

Also Published As

Publication number Publication date
GB2098203B (en) 1985-05-09
ES522869A0 (es) 1985-03-16
PT74593A (de) 1982-04-01
EP0061425A2 (de) 1982-09-29
FI820877A7 (fi) 1982-09-19
ES8604180A1 (es) 1986-01-16
AU8166782A (en) 1982-09-23
ES522868A0 (es) 1985-02-01
ES8601171A1 (es) 1985-10-16
ES8603499A1 (es) 1985-12-16
ES8502980A1 (es) 1985-02-01
PT74593B (de) 1984-11-27
ES537277A0 (es) 1986-01-01
ES8503677A1 (es) 1985-03-16
ES537278A0 (es) 1985-12-16
DK118482A (da) 1982-09-19
NO820881L (no) 1982-09-20
GB2098203A (en) 1982-11-17
ES510504A0 (es) 1983-10-16
NZ200038A (en) 1985-05-31
JPS57183767A (en) 1982-11-12
ZA821790B (en) 1983-01-26
IL65285A0 (en) 1982-05-31
EP0061425A3 (de) 1982-12-15
ES8400102A1 (es) 1983-10-16
GR78347B (enExample) 1984-09-26
FI820877L (fi) 1982-09-19
ES537342A0 (es) 1986-01-16
US4451471A (en) 1984-05-29
ES522867A0 (es) 1985-12-16
IL65285A (en) 1985-11-29
ES8603498A1 (es) 1985-12-16
ES8603847A1 (es) 1986-01-01
ES537343A0 (es) 1985-10-16
HU187684B (en) 1986-02-28

Similar Documents

Publication Publication Date Title
KR830009066A (ko) 티아졸 유도체의 제조방법
KR940019699A (ko) 옥사졸리딘디온 유도체, 그의 제조방법 및 용도
KR890014533A (ko) 혈당 감소제 티아졸리딘디온 유도체
KR880007471A (ko) 살균제 피리딜 이미데이트와 이를 이용한 살균제 조성물 및 억제방법
KR930002328A (ko) 신규 제초제
KR960017648A (ko) 옥사졸리딘디온 유도체, 그의 제법 및 용도
KR900006341A (ko) 이형고리 화합물
FI833794A0 (fi) Substituerade 2-merkapto-imidazoler
KR960702460A (ko) 티아졸리딘디온 및 이것을 함유하는 약제(new thiazolidindiones and drugs containing them)
KR860008157A (ko) 2.5-디아릴 테트라하이드로푸란 및 이의 동족체의 제조방법
KR890014534A (ko) 혈당 감소제로서 티아졸리딘디온 유도체
IE791949L (en) Substituted 1-thia-3-aza-4-ones
KR890000476A (ko) 벤조티아졸 또는 기타 헤테로시클릭 측쇄를 갖는 옥소프탈라지닐 아세트산의 제조
KR840005126A (ko) 디티오 화합물의 제조방법
KR890012989A (ko) 아크릴산 모르폴리드, 그의 제조방법 및 용도
KR900018113A (ko) 티에노-트리아졸로-디아제핀 유도체, 그의 제조 방법 및 그를 함유하는 치료 조성물
MX9202782A (es) Compuesto triciclos y composiciones farmaceuticas que lo contienen.
NZ236083A (en) Phenyl thioglyoxylic acid methyl ester o-methyloxime derivatives and fungicidal compositions
KR900016207A (ko) 치환된 1,8-나프티리딘
OA07308A (fr) Nouveaux dérivés de benzodioxine, leurs procédés de préparation et les compositions pharmaceutiques les renfermant .
KR840006342A (ko) 복소환식 화합물 및 그 제법
KR840007232A (ko) 헤테로싸이클릴 화합물의 제조방법
KR840006664A (ko) 헤테로사이클릴티오 화합물의 제조방법
NZ222608A (en) Substituted aminomethane diphosphonic acids, preparation thereof and pharmaceutical compositions
KR900016125A (ko) N-치환 n-아미노-피롤

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19820320

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination