NZ222608A - Substituted aminomethane diphosphonic acids, preparation thereof and pharmaceutical compositions - Google Patents
Substituted aminomethane diphosphonic acids, preparation thereof and pharmaceutical compositionsInfo
- Publication number
- NZ222608A NZ222608A NZ222608A NZ22260887A NZ222608A NZ 222608 A NZ222608 A NZ 222608A NZ 222608 A NZ222608 A NZ 222608A NZ 22260887 A NZ22260887 A NZ 22260887A NZ 222608 A NZ222608 A NZ 222608A
- Authority
- NZ
- New Zealand
- Prior art keywords
- substituted
- phosphono
- denotes
- lower alkyl
- preparation
- Prior art date
Links
- SANTWJLQQOEKLI-UHFFFAOYSA-N NC.OP(=O)OP(O)=O Chemical class NC.OP(=O)OP(O)=O SANTWJLQQOEKLI-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
- C07F9/65324—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/65392—Five-membered rings containing two nitrogen atoms
- C07F9/65397—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Heteroarylaminomethanediphosphonic acids of the formula <IMAGE> in which R1 represents an optionally benzo- or cyclohexeno-fused 5-membered heteroaryl radical having 2 to 4 N atoms or 1 or 2 N atoms and 1 O or S atom as hetero atom(s) and which is unsubstituted or substituted by lower alkyl, phenyl which is unsubstituted or substituted by lower alkyl, lower alkoxy and/or halogen, lower alkoxy, hydroxyl, di-lower alkylamino, lower alkylthio and/or halogen and R2 denotes hydrogen or lower alkyl, and their salts have an action regulating the metabolism of calcium and can be used as pharmaceutical active compounds for the treatment of diseases which can be traced back to disorders thereof. They are prepared, for example, by converting the group(s) X into free phosphono in a compound of the formula <IMAGE> in which X1 denotes a functionally modified phosphono group X and X2 denotes phosphono or likewise a functionally modified phosphono group X.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH466586 | 1986-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ222608A true NZ222608A (en) | 1990-09-26 |
Family
ID=4280333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ222608A NZ222608A (en) | 1986-11-21 | 1987-11-19 | Substituted aminomethane diphosphonic acids, preparation thereof and pharmaceutical compositions |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0274346B1 (en) |
| JP (1) | JPS63150290A (en) |
| KR (1) | KR880006217A (en) |
| AT (1) | ATE61371T1 (en) |
| AU (1) | AU605203B2 (en) |
| CA (1) | CA1324383C (en) |
| DD (1) | DD265900A5 (en) |
| DE (1) | DE3768463D1 (en) |
| DK (1) | DK168869B1 (en) |
| ES (1) | ES2038693T3 (en) |
| FI (1) | FI87653C (en) |
| GR (1) | GR3001611T3 (en) |
| HU (1) | HU201087B (en) |
| IE (1) | IE60148B1 (en) |
| IL (1) | IL84494A (en) |
| MY (1) | MY103191A (en) |
| NO (1) | NO170283C (en) |
| NZ (1) | NZ222608A (en) |
| PH (1) | PH23959A (en) |
| PT (1) | PT86166B (en) |
| ZA (1) | ZA878656B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR880011136A (en) * | 1987-03-11 | 1988-10-26 | 모리오까 시게오 | Azole-aminomethylene bisphosphonic acid derivatives |
| US5270365A (en) * | 1991-12-17 | 1993-12-14 | Merck & Co., Inc. | Prevention and treatment of periodontal disease with alendronate |
| TW237386B (en) * | 1992-04-15 | 1995-01-01 | Ciba Geigy | |
| EP0600834A1 (en) * | 1992-11-30 | 1994-06-08 | Ciba-Geigy Ag | Use of methanebisphosphonic acid derivatives for the manufacture of a medicament for fracture healing |
| US5880111A (en) * | 1995-06-07 | 1999-03-09 | Farcasiu; Dan | Therapeutic derivations of diphosphonates |
| EP0854724B1 (en) * | 1995-09-29 | 2005-03-16 | Novartis AG | Method of treating the navicular disease in horses |
| DE10226420A1 (en) * | 2002-06-13 | 2004-01-15 | Eucro European Contract Research Gmbh & Co Kg | Procedure for the treatment of atherosclerosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54135724A (en) * | 1978-04-11 | 1979-10-22 | Nissan Chem Ind Ltd | Preparation of amino-methylenedisulfonic acid derivative |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
-
1987
- 1987-11-16 IL IL84494A patent/IL84494A/en not_active IP Right Cessation
- 1987-11-16 DE DE8787810665T patent/DE3768463D1/en not_active Expired - Lifetime
- 1987-11-16 ES ES198787810665T patent/ES2038693T3/en not_active Expired - Lifetime
- 1987-11-16 EP EP87810665A patent/EP0274346B1/en not_active Expired - Lifetime
- 1987-11-16 AT AT87810665T patent/ATE61371T1/en not_active IP Right Cessation
- 1987-11-18 CA CA000552085A patent/CA1324383C/en not_active Expired - Fee Related
- 1987-11-18 FI FI875095A patent/FI87653C/en not_active IP Right Cessation
- 1987-11-18 PH PH36078A patent/PH23959A/en unknown
- 1987-11-19 DD DD87309213A patent/DD265900A5/en not_active IP Right Cessation
- 1987-11-19 ZA ZA878656A patent/ZA878656B/en unknown
- 1987-11-19 NZ NZ222608A patent/NZ222608A/en unknown
- 1987-11-19 PT PT86166A patent/PT86166B/en not_active IP Right Cessation
- 1987-11-20 IE IE314787A patent/IE60148B1/en not_active IP Right Cessation
- 1987-11-20 HU HU875159A patent/HU201087B/en not_active IP Right Cessation
- 1987-11-20 NO NO874855A patent/NO170283C/en unknown
- 1987-11-20 AU AU81452/87A patent/AU605203B2/en not_active Ceased
- 1987-11-20 JP JP62292196A patent/JPS63150290A/en active Pending
- 1987-11-20 KR KR1019870013062A patent/KR880006217A/en not_active Application Discontinuation
- 1987-11-20 MY MYPI87003074A patent/MY103191A/en unknown
- 1987-11-20 DK DK609387A patent/DK168869B1/en not_active IP Right Cessation
-
1991
- 1991-03-15 GR GR90401110T patent/GR3001611T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE873147L (en) | 1988-05-21 |
| AU605203B2 (en) | 1991-01-10 |
| HUT46329A (en) | 1988-10-28 |
| FI875095A (en) | 1988-05-22 |
| PT86166B (en) | 1990-11-20 |
| DD265900A5 (en) | 1989-03-15 |
| MY103191A (en) | 1993-05-29 |
| KR880006217A (en) | 1988-07-22 |
| DK609387D0 (en) | 1987-11-20 |
| DK609387A (en) | 1988-05-22 |
| NO170283C (en) | 1992-09-30 |
| AU8145287A (en) | 1988-05-26 |
| ZA878656B (en) | 1988-08-31 |
| IL84494A0 (en) | 1988-04-29 |
| ES2038693T3 (en) | 1993-08-01 |
| PH23959A (en) | 1990-01-23 |
| NO874855L (en) | 1988-05-24 |
| EP0274346B1 (en) | 1991-03-06 |
| CA1324383C (en) | 1993-11-16 |
| EP0274346A1 (en) | 1988-07-13 |
| NO874855D0 (en) | 1987-11-20 |
| HU201087B (en) | 1990-09-28 |
| ATE61371T1 (en) | 1991-03-15 |
| GR3001611T3 (en) | 1992-11-23 |
| IL84494A (en) | 1992-08-18 |
| FI87653B (en) | 1992-10-30 |
| IE60148B1 (en) | 1994-06-01 |
| JPS63150290A (en) | 1988-06-22 |
| FI875095A0 (en) | 1987-11-18 |
| NO170283B (en) | 1992-06-22 |
| PT86166A (en) | 1987-12-01 |
| FI87653C (en) | 1993-02-10 |
| DK168869B1 (en) | 1994-06-27 |
| DE3768463D1 (en) | 1991-04-11 |
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