ES8604180A1 - Procedimiento para la obtencion de azoles 2, 4, 5-trisustituidos - Google Patents
Procedimiento para la obtencion de azoles 2, 4, 5-trisustituidosInfo
- Publication number
- ES8604180A1 ES8604180A1 ES537342A ES537342A ES8604180A1 ES 8604180 A1 ES8604180 A1 ES 8604180A1 ES 537342 A ES537342 A ES 537342A ES 537342 A ES537342 A ES 537342A ES 8604180 A1 ES8604180 A1 ES 8604180A1
- Authority
- ES
- Spain
- Prior art keywords
- etherified
- hydroxy
- oxidised
- substituted
- substd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE AZOLES 2,4,5-SUSTITUIDOS, DE FORMULA GENERAL (I), EN LA QUE R1 Y R2 SIGNIFICAN, INDEPENDIENTEMENTE ENTRE SI, RESTOS ARILO INSUSTITUIDOS O SUSTITUIDOS POR RESTOS HIDROCARBURO ALIFATICOS; N ES 0, 1 O 2; Y R3 SIGNIFICA UN RESTO HIDROCARBURO ALIFATICO, Y SUS SALES DE ADICION DE ACIDO, FARMACEUTICAMENTE UTILIZABLES, CON ACIDOS FUERTES. CONSISTE EN TRANSFORMAR EN UN COMPUESTO DE FORMULA GENERAL (I), EL RESTO R3 EN UN RESTO R3, MEDIANTE HIDROLIZACION DE DICHO RESTO R3 EN PRESENCIA DE UN AGENTE ACIDO O BASICO DE HIDROLISIS Y, EN CASO DADO, DE UN DISOLVENTE O DILUYENTE MISCIBLE CON AGUA. DE APLICACION EN LA OBTENCION DE PREPARADOS FARMACEUTICOS UTILIZADOS EN EL TRATAMIENTO DE ENFERMEDADES DOLOROSAS-INFLAMATORIAS, TALES COMO LA ARTRITIS CRONICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH183881 | 1981-03-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604180A1 true ES8604180A1 (es) | 1986-01-16 |
ES537342A0 ES537342A0 (es) | 1986-01-16 |
Family
ID=4219779
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES510504A Expired ES8400102A1 (es) | 1981-03-18 | 1982-03-17 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. |
ES522868A Granted ES522868A0 (es) | 1981-03-18 | 1983-05-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. (como desglose y con prioridad de la patente espanola no.510.504, presentada el 17 de marzo de 1.982) |
ES522869A Expired ES8503677A1 (es) | 1981-03-18 | 1983-05-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. (como desglose y con prioridad de la patente espanola no.510.504, presentada el 17 de marzo de 1.982). |
ES522867A Granted ES522867A0 (es) | 1981-03-18 | 1983-05-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. (como desglose y con prioridad de la patente espanola no.510.504, presentada el 17 de marzo de 1.982) |
ES537278A Expired ES8603499A1 (es) | 1981-03-18 | 1984-10-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. |
ES537277A Expired ES8603847A1 (es) | 1981-03-18 | 1984-10-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. |
ES537342A Expired ES8604180A1 (es) | 1981-03-18 | 1984-11-02 | Procedimiento para la obtencion de azoles 2, 4, 5-trisustituidos |
ES537343A Expired ES8601171A1 (es) | 1981-03-18 | 1984-11-02 | Procedimiento para la obtencion de azoles 2, 4, 5-trisustituidos |
Family Applications Before (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES510504A Expired ES8400102A1 (es) | 1981-03-18 | 1982-03-17 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. |
ES522868A Granted ES522868A0 (es) | 1981-03-18 | 1983-05-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. (como desglose y con prioridad de la patente espanola no.510.504, presentada el 17 de marzo de 1.982) |
ES522869A Expired ES8503677A1 (es) | 1981-03-18 | 1983-05-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. (como desglose y con prioridad de la patente espanola no.510.504, presentada el 17 de marzo de 1.982). |
ES522867A Granted ES522867A0 (es) | 1981-03-18 | 1983-05-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. (como desglose y con prioridad de la patente espanola no.510.504, presentada el 17 de marzo de 1.982) |
ES537278A Expired ES8603499A1 (es) | 1981-03-18 | 1984-10-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. |
ES537277A Expired ES8603847A1 (es) | 1981-03-18 | 1984-10-31 | Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537343A Expired ES8601171A1 (es) | 1981-03-18 | 1984-11-02 | Procedimiento para la obtencion de azoles 2, 4, 5-trisustituidos |
Country Status (16)
Country | Link |
---|---|
US (1) | US4451471A (es) |
EP (1) | EP0061425A3 (es) |
JP (1) | JPS57183767A (es) |
KR (1) | KR830009066A (es) |
AU (1) | AU8166782A (es) |
DK (1) | DK118482A (es) |
ES (8) | ES8400102A1 (es) |
FI (1) | FI820877L (es) |
GB (1) | GB2098203B (es) |
GR (1) | GR78347B (es) |
HU (1) | HU187684B (es) |
IL (1) | IL65285A (es) |
NO (1) | NO820881L (es) |
NZ (1) | NZ200038A (es) |
PT (1) | PT74593B (es) |
ZA (1) | ZA821790B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4632930A (en) * | 1984-11-30 | 1986-12-30 | E. I. Du Pont De Nemours And Company | Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives |
DE3508665A1 (de) * | 1985-03-12 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Heterocyclische sulfide und ihre anwendung als immunmodulatoren |
DE3508666A1 (de) * | 1985-03-12 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Heterocyclische disulfide und ihre anwendung als immunmodulatoren |
JPS6339868A (ja) * | 1986-08-04 | 1988-02-20 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
DE3863603D1 (de) * | 1987-07-27 | 1991-08-14 | Duphar Int Res | Thiazol-verbindungen mit fungizider aktivitaet. |
AT392788B (de) * | 1988-02-03 | 1991-06-10 | Fisons Plc | Neue benzimidazolverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen |
DE3807232A1 (de) * | 1988-03-05 | 1989-09-14 | Bayer Ag | Substituierte acrylsaeureester |
JP2933739B2 (ja) * | 1990-04-09 | 1999-08-16 | 明治製菓株式会社 | チアゾールまたはイミダゾール誘導体および抗潰瘍剤 |
US5255697A (en) * | 1991-10-23 | 1993-10-26 | Working Inc. | Walking support apparatus |
JP2636819B2 (ja) | 1994-12-20 | 1997-07-30 | 日本たばこ産業株式会社 | オキサゾール系複素環式芳香族化合物 |
WO2001010865A1 (fr) * | 1999-08-06 | 2001-02-15 | Takeda Chemical Industries, Ltd. | INHIBITEURS DE p38MAP KINASE |
KR20080091369A (ko) * | 2006-01-18 | 2008-10-10 | 암젠 인크 | 단백질 키나제 b (pkb) 억제제로서 티아졸 화합물 |
CA2693473A1 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
BR112015000507A2 (pt) | 2012-07-12 | 2017-06-27 | Chiesi Farm Spa | inibição de enzimas |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2129012A1 (de) * | 1971-06-11 | 1973-01-04 | Merck Patent Gmbh | Azol-derivate |
FR2146161A1 (en) * | 1971-07-22 | 1973-03-02 | Roussel Uclaf | Thiazolyl thiolacetic acids - analgesics antiinflammatories and antipyretics |
US3888870A (en) * | 1974-03-08 | 1975-06-10 | Sandoz Ag | 2-sulfinyl-thiazoles and oxazoles |
US4022607A (en) * | 1975-06-09 | 1977-05-10 | Sandoz, Inc. | Substituted oxazoles and thiazoles as herbicides |
-
1982
- 1982-03-08 US US06/355,989 patent/US4451471A/en not_active Expired - Fee Related
- 1982-03-12 EP EP82810111A patent/EP0061425A3/de not_active Withdrawn
- 1982-03-15 FI FI820877A patent/FI820877L/fi not_active Application Discontinuation
- 1982-03-17 PT PT74593A patent/PT74593B/pt unknown
- 1982-03-17 HU HU82811A patent/HU187684B/hu unknown
- 1982-03-17 NO NO820881A patent/NO820881L/no unknown
- 1982-03-17 DK DK118482A patent/DK118482A/da not_active Application Discontinuation
- 1982-03-17 GB GB8207759A patent/GB2098203B/en not_active Expired
- 1982-03-17 ES ES510504A patent/ES8400102A1/es not_active Expired
- 1982-03-17 NZ NZ200038A patent/NZ200038A/en unknown
- 1982-03-17 ZA ZA821790A patent/ZA821790B/xx unknown
- 1982-03-18 JP JP57041809A patent/JPS57183767A/ja active Pending
- 1982-03-18 AU AU81667/82A patent/AU8166782A/en not_active Abandoned
- 1982-03-18 IL IL65285A patent/IL65285A/xx unknown
- 1982-03-18 KR KR1019820001200A patent/KR830009066A/ko unknown
-
1983
- 1983-05-30 GR GR67611A patent/GR78347B/el unknown
- 1983-05-31 ES ES522868A patent/ES522868A0/es active Granted
- 1983-05-31 ES ES522869A patent/ES8503677A1/es not_active Expired
- 1983-05-31 ES ES522867A patent/ES522867A0/es active Granted
-
1984
- 1984-10-31 ES ES537278A patent/ES8603499A1/es not_active Expired
- 1984-10-31 ES ES537277A patent/ES8603847A1/es not_active Expired
- 1984-11-02 ES ES537342A patent/ES8604180A1/es not_active Expired
- 1984-11-02 ES ES537343A patent/ES8601171A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
US4451471A (en) | 1984-05-29 |
ES537343A0 (es) | 1985-10-16 |
ES522869A0 (es) | 1985-03-16 |
ES8601171A1 (es) | 1985-10-16 |
ES537277A0 (es) | 1986-01-01 |
GB2098203A (en) | 1982-11-17 |
ES510504A0 (es) | 1983-10-16 |
ES8502980A1 (es) | 1985-02-01 |
FI820877L (fi) | 1982-09-19 |
JPS57183767A (en) | 1982-11-12 |
ES522868A0 (es) | 1985-02-01 |
HU187684B (en) | 1986-02-28 |
EP0061425A3 (de) | 1982-12-15 |
NZ200038A (en) | 1985-05-31 |
GB2098203B (en) | 1985-05-09 |
KR830009066A (ko) | 1983-12-17 |
EP0061425A2 (de) | 1982-09-29 |
ES8603498A1 (es) | 1985-12-16 |
NO820881L (no) | 1982-09-20 |
ES8400102A1 (es) | 1983-10-16 |
ES537342A0 (es) | 1986-01-16 |
PT74593B (de) | 1984-11-27 |
IL65285A (en) | 1985-11-29 |
ES537278A0 (es) | 1985-12-16 |
ES8603499A1 (es) | 1985-12-16 |
ES522867A0 (es) | 1985-12-16 |
DK118482A (da) | 1982-09-19 |
AU8166782A (en) | 1982-09-23 |
ES8603847A1 (es) | 1986-01-01 |
GR78347B (es) | 1984-09-26 |
ZA821790B (en) | 1983-01-26 |
IL65285A0 (en) | 1982-05-31 |
PT74593A (de) | 1982-04-01 |
ES8503677A1 (es) | 1985-03-16 |
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