KR830009023A - 피롤리딘 유도체의 제조방법 - Google Patents
피롤리딘 유도체의 제조방법 Download PDFInfo
- Publication number
- KR830009023A KR830009023A KR1019820000475A KR820000475A KR830009023A KR 830009023 A KR830009023 A KR 830009023A KR 1019820000475 A KR1019820000475 A KR 1019820000475A KR 820000475 A KR820000475 A KR 820000475A KR 830009023 A KR830009023 A KR 830009023A
- Authority
- KR
- South Korea
- Prior art keywords
- hydroxy
- pyrrolidine derivative
- methoxybenzoyl
- preparing pyrrolidine
- preparing
- Prior art date
Links
- FKCMADOPPWWGNZ-YUMQZZPRSA-N [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O FKCMADOPPWWGNZ-YUMQZZPRSA-N 0.000 title 1
- 125000006239 protecting group Chemical group 0.000 claims 3
- VUOZPAGAAMBEGM-MRVPVSSYSA-N (3r)-3-hydroxy-1-(3-hydroxy-4-methoxybenzoyl)pyrrolidin-2-one Chemical compound C1=C(O)C(OC)=CC=C1C(=O)N1C(=O)[C@H](O)CC1 VUOZPAGAAMBEGM-MRVPVSSYSA-N 0.000 claims 1
- VUOZPAGAAMBEGM-QMMMGPOBSA-N (3s)-3-hydroxy-1-(3-hydroxy-4-methoxybenzoyl)pyrrolidin-2-one Chemical compound C1=C(O)C(OC)=CC=C1C(=O)N1C(=O)[C@@H](O)CC1 VUOZPAGAAMBEGM-QMMMGPOBSA-N 0.000 claims 1
- -1 3-hydroxy-4-methoxybenzoyl Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 다음 일반식(II)의 피롤리딘 유도체로부터 보호그룹을 제거함을 특징으로 하여 다음 일반식(I)의 1-(3-하이드록시-4-메톡시벤조일)-3-하이드록시-2-피롤리디논을 제조하는 방법.상기 일반식에서,R1및 R2중 하나는 보호그룹이고 다른 하나는 수소 또는 보호그룹이다.
- 제1항에 있어서, (R,S)-1-(3-하이드록시-4-메톡시벤조일)-3-하이드록시-2-피롤리디논을 제조하는 방법.
- 제1항에 있어서, (R)-1-(3-하이드록시-4-메톡시벤조일)-3-하이드록시-2-피롤리디논을 제조하는 방법.
- 제1항에 있어서, (S)-1-(3-하이드록시-4-메톡시벤조일)-3-하이드록시-2-피롤리디논을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH770/81 | 1981-02-05 | ||
| CH77081A CH646149A5 (de) | 1981-02-05 | 1981-02-05 | Pyrrolidin-derivat. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830009023A true KR830009023A (ko) | 1983-12-17 |
Family
ID=4194769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820000475A KR830009023A (ko) | 1981-02-05 | 1982-02-04 | 피롤리딘 유도체의 제조방법 |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US4452807A (ko) |
| EP (1) | EP0057846B1 (ko) |
| JP (1) | JPS57146753A (ko) |
| KR (1) | KR830009023A (ko) |
| AR (1) | AR231127A1 (ko) |
| AT (2) | ATE13668T1 (ko) |
| AU (1) | AU552063B2 (ko) |
| BG (1) | BG36932A3 (ko) |
| BR (1) | BR8200615A (ko) |
| CA (1) | CA1158250A (ko) |
| CH (1) | CH646149A5 (ko) |
| CS (1) | CS227035B2 (ko) |
| DD (1) | DD202539A5 (ko) |
| DE (2) | DE3202281A1 (ko) |
| DK (1) | DK20682A (ko) |
| ES (1) | ES8304545A1 (ko) |
| FI (1) | FI820192L (ko) |
| FR (1) | FR2499075A1 (ko) |
| GB (1) | GB2092584B (ko) |
| GR (1) | GR76052B (ko) |
| HU (1) | HU184988B (ko) |
| IE (1) | IE52439B1 (ko) |
| IL (1) | IL64896A (ko) |
| IS (1) | IS2700A7 (ko) |
| IT (1) | IT1153402B (ko) |
| LU (1) | LU83923A1 (ko) |
| MC (1) | MC1440A1 (ko) |
| NL (1) | NL8200337A (ko) |
| NO (1) | NO820346L (ko) |
| NZ (1) | NZ199624A (ko) |
| OA (1) | OA07002A (ko) |
| PH (1) | PH18267A (ko) |
| PL (1) | PL135221B1 (ko) |
| PT (1) | PT74387B (ko) |
| RO (1) | RO83099B (ko) |
| SE (1) | SE8200647L (ko) |
| SU (1) | SU1143315A3 (ko) |
| YU (1) | YU23982A (ko) |
| ZA (1) | ZA82608B (ko) |
| ZW (1) | ZW1982A1 (ko) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
| FR2551751B1 (fr) * | 1983-09-12 | 1986-04-25 | Serobiologiques Lab Sa | Nouveau procede de preparation d'un derive pyroglutamique, nouveaux derives pyroglutamiques, nouveaux intermediaires de synthese de preparation de ceux-ci et utilisation ou application des derives pyroglutamiques comme agents antibacteriens ou antifongiques |
| DE3336024A1 (de) * | 1983-10-04 | 1985-04-18 | Boehringer Ingelheim KG, 6507 Ingelheim | 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel |
| DE3632589A1 (de) * | 1985-10-18 | 1987-04-23 | Bayer Ag | Verfahren zur herstellung von (gamma)-butyrolactamen |
| DE3537075A1 (de) * | 1985-10-18 | 1987-04-23 | Bayer Ag | Verfahren zur herstellung von clausenamid |
| US4677114A (en) * | 1985-11-22 | 1987-06-30 | Warner-Lambert Company | Pyrrolidone-2 derivatives and pharmaceutical compositions thereof |
| IT1215587B (it) * | 1987-06-26 | 1990-02-14 | Roussel Maestretti Spa | Derivati della 1-benzoil2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro impiego come sostanza medicinale. |
| JPH0720930B2 (ja) * | 1988-07-09 | 1995-03-08 | 明治製菓株式会社 | ピロリジノン化合物及び脳機能障害改善剤 |
| US5049577A (en) * | 1990-01-29 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith |
| US5049578A (en) * | 1990-03-09 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones |
| AU688271B2 (en) * | 1992-07-24 | 1998-03-12 | Regents Of The University Of California, The | Drugs that enhance synaptic responses mediated by ampa receptors |
| US5852008A (en) * | 1995-01-24 | 1998-12-22 | The Regents Of The University Of California | Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES433723A1 (es) * | 1975-01-10 | 1976-11-16 | Lafarquim S A Lab | Procedimiento de obtencion de un derivado de 2-pirrolidi- nona. |
| IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
| CA1115212A (en) * | 1978-02-10 | 1981-12-29 | Emilio Kyburz | Pyrrolidine derivatives |
| CU21107A3 (es) * | 1978-02-10 | 1988-02-01 | Hoffmann La Roche | Pyrrolidines derivatives |
| NL8004025A (nl) * | 1979-08-09 | 1981-02-11 | Hoffmann La Roche | Pyrrolidinederivaten en werkwijze voor het bereiden daarvan alsmede geneesmiddel. |
-
1981
- 1981-02-05 CH CH77081A patent/CH646149A5/de not_active IP Right Cessation
-
1982
- 1982-01-08 CA CA000393829A patent/CA1158250A/en not_active Expired
- 1982-01-14 IT IT19115/82A patent/IT1153402B/it active
- 1982-01-18 DK DK20682A patent/DK20682A/da not_active Application Discontinuation
- 1982-01-20 US US06/340,920 patent/US4452807A/en not_active Expired - Fee Related
- 1982-01-21 FI FI820192A patent/FI820192L/fi not_active Application Discontinuation
- 1982-01-25 DE DE19823202281 patent/DE3202281A1/de not_active Withdrawn
- 1982-01-25 AT AT82100494T patent/ATE13668T1/de not_active IP Right Cessation
- 1982-01-25 DE DE8282100494T patent/DE3263960D1/de not_active Expired
- 1982-01-25 EP EP82100494A patent/EP0057846B1/de not_active Expired
- 1982-01-28 OA OA57598A patent/OA07002A/xx unknown
- 1982-01-29 ZA ZA82608A patent/ZA82608B/xx unknown
- 1982-01-29 IL IL64896A patent/IL64896A/xx unknown
- 1982-01-29 PH PH26797A patent/PH18267A/en unknown
- 1982-01-29 CS CS82629A patent/CS227035B2/cs unknown
- 1982-01-29 NL NL8200337A patent/NL8200337A/nl not_active Application Discontinuation
- 1982-01-29 ZW ZW19/82A patent/ZW1982A1/xx unknown
- 1982-01-30 RO RO106487A patent/RO83099B/ro unknown
- 1982-02-01 HU HU82285A patent/HU184988B/hu unknown
- 1982-02-01 NZ NZ199624A patent/NZ199624A/en unknown
- 1982-02-02 AU AU80104/82A patent/AU552063B2/en not_active Ceased
- 1982-02-02 JP JP57014411A patent/JPS57146753A/ja active Granted
- 1982-02-02 AR AR288323A patent/AR231127A1/es active
- 1982-02-03 DD DD82237159A patent/DD202539A5/de not_active IP Right Cessation
- 1982-02-03 MC MC821572A patent/MC1440A1/xx unknown
- 1982-02-03 FR FR8201714A patent/FR2499075A1/fr not_active Withdrawn
- 1982-02-03 SU SU823381951A patent/SU1143315A3/ru active
- 1982-02-03 GR GR67187A patent/GR76052B/el unknown
- 1982-02-04 NO NO820346A patent/NO820346L/no unknown
- 1982-02-04 BR BR8200615A patent/BR8200615A/pt unknown
- 1982-02-04 LU LU83923A patent/LU83923A1/de unknown
- 1982-02-04 GB GB8203264A patent/GB2092584B/en not_active Expired
- 1982-02-04 YU YU00239/82A patent/YU23982A/xx unknown
- 1982-02-04 IS IS2700A patent/IS2700A7/is unknown
- 1982-02-04 SE SE8200647A patent/SE8200647L/xx not_active Application Discontinuation
- 1982-02-04 PT PT74387A patent/PT74387B/pt unknown
- 1982-02-04 KR KR1019820000475A patent/KR830009023A/ko unknown
- 1982-02-04 IE IE249/82A patent/IE52439B1/en unknown
- 1982-02-04 ES ES509312A patent/ES8304545A1/es not_active Expired
- 1982-02-04 AT AT0041882A patent/AT377982B/de not_active IP Right Cessation
- 1982-02-05 BG BG8255269A patent/BG36932A3/xx unknown
- 1982-02-05 PL PL1982234962A patent/PL135221B1/pl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR830007567A (ko) | 1, 2, 3, 4-테트라하이드로이소퀴놀린-3-카복실산의 치환아실 유도체의 제조방법. | |
| KR830000679A (ko) | N-알킬화 아미노알콜의 제조방법 | |
| KR830009089A (ko) | 2-펜옥시알킬-1,2,4-트리아졸-3-원 항우울제의 제조방법 | |
| KR830009023A (ko) | 피롤리딘 유도체의 제조방법 | |
| KR840008317A (ko) | 디할로겐화벤젠의 제조방법 | |
| KR830009084A (ko) | 퀴놀린 카복실산 유도체의 제조방법 | |
| ES472747A1 (es) | Procedimiento para la preparacion de derivados de aminopro- panol | |
| KR870002090A (ko) | 1-(2-옥시아미노 카보닐페닐설포닐)-3-헤테로아릴-우레아의 제조방법 | |
| KR830004292A (ko) | 벤조구아나민 유도체의 제조방법 | |
| KR830003420A (ko) | 피롤리딘 유도체 | |
| KR840008342A (ko) | 모르포린 유도체의 제조방법 | |
| KR830010078A (ko) | 이미다졸 화합물의 제조방법 | |
| KR830008990A (ko) | 2-아미노-3-(할로벤조일)-메틸페닐아세트산 유도체의 제조방법 | |
| KR830005168A (ko) | 5-(디하이드록시페녹시)테트라졸의 제조방법 | |
| KR870003097A (ko) | (+)-6-클로로-5,10-디하이드로-5-[(1-메틸-4-피페리디닐)아세틸]-11H-디벤조 [b,e][1,4] 디아제핀-11-온의 분리방법 | |
| KR870002094A (ko) | 1-(2-옥시아미노설포닐-페닐설포닐)-헤테로아릴 우레아의 제조방법 | |
| KR920009792A (ko) | 3-아미노-4-메틸렌피롤리딘 유도체의 제조방법 | |
| KR890009877A (ko) | 1-아실-2-피라졸린유도체의 제조방법 | |
| KR830010091A (ko) | 구연산 나프티드로푸릴의 제조방법 | |
| KR860007226A (ko) | 1-(하이드록시페닐)-3-메틸-4-디플루오로메틸-δ^2-1,2,4-트리아졸린-5-온 유도체의 제조방법 | |
| KR830009044A (ko) | 3,5-디-3급부틸-4-하이드록시페닐-치환 복소환 화합물의 제조방법 | |
| KR840003639A (ko) | 이속사졸로피리미딘 유도체의 제조방법 | |
| KR830004331A (ko) | 스테리일 글르코사이드 유도체의 제조 방법 | |
| KR840001144A (ko) | 5(6)-페닐설포닐옥시-벤즈이미다졸 유도체의 제조방법 | |
| KR830006215A (ko) | 4-저급알킬-3-페녹시피리딘-1-옥사이드의 제조방법 |