IL64896A - 1-(3-hydroxy-4-methoxybenzoyl)-3-hydroxy-2-pyrrolidinone,a process and intermediates for its manufacture and pharmaceutical compositions containing it - Google Patents
1-(3-hydroxy-4-methoxybenzoyl)-3-hydroxy-2-pyrrolidinone,a process and intermediates for its manufacture and pharmaceutical compositions containing itInfo
- Publication number
- IL64896A IL64896A IL64896A IL6489682A IL64896A IL 64896 A IL64896 A IL 64896A IL 64896 A IL64896 A IL 64896A IL 6489682 A IL6489682 A IL 6489682A IL 64896 A IL64896 A IL 64896A
- Authority
- IL
- Israel
- Prior art keywords
- hydroxy
- methoxybenzoyl
- pyrrolidinone
- intermediates
- manufacture
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH77081A CH646149A5 (de) | 1981-02-05 | 1981-02-05 | Pyrrolidin-derivat. |
Publications (2)
Publication Number | Publication Date |
---|---|
IL64896A0 IL64896A0 (en) | 1982-03-31 |
IL64896A true IL64896A (en) | 1985-07-31 |
Family
ID=4194769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL64896A IL64896A (en) | 1981-02-05 | 1982-01-29 | 1-(3-hydroxy-4-methoxybenzoyl)-3-hydroxy-2-pyrrolidinone,a process and intermediates for its manufacture and pharmaceutical compositions containing it |
Country Status (40)
Country | Link |
---|---|
US (1) | US4452807A (xx) |
EP (1) | EP0057846B1 (xx) |
JP (1) | JPS57146753A (xx) |
KR (1) | KR830009023A (xx) |
AR (1) | AR231127A1 (xx) |
AT (2) | ATE13668T1 (xx) |
AU (1) | AU552063B2 (xx) |
BG (1) | BG36932A3 (xx) |
BR (1) | BR8200615A (xx) |
CA (1) | CA1158250A (xx) |
CH (1) | CH646149A5 (xx) |
CS (1) | CS227035B2 (xx) |
DD (1) | DD202539A5 (xx) |
DE (2) | DE3263960D1 (xx) |
DK (1) | DK20682A (xx) |
ES (1) | ES509312A0 (xx) |
FI (1) | FI820192L (xx) |
FR (1) | FR2499075A1 (xx) |
GB (1) | GB2092584B (xx) |
GR (1) | GR76052B (xx) |
HU (1) | HU184988B (xx) |
IE (1) | IE52439B1 (xx) |
IL (1) | IL64896A (xx) |
IS (1) | IS2700A7 (xx) |
IT (1) | IT1153402B (xx) |
LU (1) | LU83923A1 (xx) |
MC (1) | MC1440A1 (xx) |
NL (1) | NL8200337A (xx) |
NO (1) | NO820346L (xx) |
NZ (1) | NZ199624A (xx) |
OA (1) | OA07002A (xx) |
PH (1) | PH18267A (xx) |
PL (1) | PL135221B1 (xx) |
PT (1) | PT74387B (xx) |
RO (1) | RO83099B (xx) |
SE (1) | SE8200647L (xx) |
SU (1) | SU1143315A3 (xx) |
YU (1) | YU23982A (xx) |
ZA (1) | ZA82608B (xx) |
ZW (1) | ZW1982A1 (xx) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
FR2551751B1 (fr) * | 1983-09-12 | 1986-04-25 | Serobiologiques Lab Sa | Nouveau procede de preparation d'un derive pyroglutamique, nouveaux derives pyroglutamiques, nouveaux intermediaires de synthese de preparation de ceux-ci et utilisation ou application des derives pyroglutamiques comme agents antibacteriens ou antifongiques |
DE3336024A1 (de) * | 1983-10-04 | 1985-04-18 | Boehringer Ingelheim KG, 6507 Ingelheim | 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel |
DE3632589A1 (de) * | 1985-10-18 | 1987-04-23 | Bayer Ag | Verfahren zur herstellung von (gamma)-butyrolactamen |
DE3537075A1 (de) * | 1985-10-18 | 1987-04-23 | Bayer Ag | Verfahren zur herstellung von clausenamid |
US4677114A (en) * | 1985-11-22 | 1987-06-30 | Warner-Lambert Company | Pyrrolidone-2 derivatives and pharmaceutical compositions thereof |
IT1215587B (it) * | 1987-06-26 | 1990-02-14 | Roussel Maestretti Spa | Derivati della 1-benzoil2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro impiego come sostanza medicinale. |
JPH0720930B2 (ja) * | 1988-07-09 | 1995-03-08 | 明治製菓株式会社 | ピロリジノン化合物及び脳機能障害改善剤 |
US5049577A (en) * | 1990-01-29 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith |
US5049578A (en) * | 1990-03-09 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones |
PT1156043E (pt) * | 1992-07-24 | 2004-03-31 | Univ California | Drogas que aumentam as respostas sinapticas mediadas por receptores de ampa |
US5852008A (en) * | 1995-01-24 | 1998-12-22 | The Regents Of The University Of California | Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES433723A1 (es) * | 1975-01-10 | 1976-11-16 | Lafarquim S A Lab | Procedimiento de obtencion de un derivado de 2-pirrolidi- nona. |
IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
CA1115212A (en) * | 1978-02-10 | 1981-12-29 | Emilio Kyburz | Pyrrolidine derivatives |
CU21107A3 (es) * | 1978-02-10 | 1988-02-01 | Hoffmann La Roche | Pyrrolidines derivatives |
IT1131959B (it) * | 1979-08-09 | 1986-06-25 | Hoffmann La Roche | Derivati pirrolidinici |
-
1981
- 1981-02-05 CH CH77081A patent/CH646149A5/de not_active IP Right Cessation
-
1982
- 1982-01-08 CA CA000393829A patent/CA1158250A/en not_active Expired
- 1982-01-14 IT IT19115/82A patent/IT1153402B/it active
- 1982-01-18 DK DK20682A patent/DK20682A/da not_active Application Discontinuation
- 1982-01-20 US US06/340,920 patent/US4452807A/en not_active Expired - Fee Related
- 1982-01-21 FI FI820192A patent/FI820192L/fi not_active Application Discontinuation
- 1982-01-25 AT AT82100494T patent/ATE13668T1/de not_active IP Right Cessation
- 1982-01-25 DE DE8282100494T patent/DE3263960D1/de not_active Expired
- 1982-01-25 EP EP82100494A patent/EP0057846B1/de not_active Expired
- 1982-01-25 DE DE19823202281 patent/DE3202281A1/de not_active Withdrawn
- 1982-01-28 OA OA57598A patent/OA07002A/xx unknown
- 1982-01-29 CS CS82629A patent/CS227035B2/cs unknown
- 1982-01-29 ZW ZW19/82A patent/ZW1982A1/xx unknown
- 1982-01-29 ZA ZA82608A patent/ZA82608B/xx unknown
- 1982-01-29 PH PH26797A patent/PH18267A/en unknown
- 1982-01-29 NL NL8200337A patent/NL8200337A/nl not_active Application Discontinuation
- 1982-01-29 IL IL64896A patent/IL64896A/xx unknown
- 1982-01-30 RO RO106487A patent/RO83099B/ro unknown
- 1982-02-01 HU HU82285A patent/HU184988B/hu unknown
- 1982-02-01 NZ NZ199624A patent/NZ199624A/en unknown
- 1982-02-02 AR AR288323A patent/AR231127A1/es active
- 1982-02-02 JP JP57014411A patent/JPS57146753A/ja active Granted
- 1982-02-02 AU AU80104/82A patent/AU552063B2/en not_active Ceased
- 1982-02-03 GR GR67187A patent/GR76052B/el unknown
- 1982-02-03 MC MC821572A patent/MC1440A1/xx unknown
- 1982-02-03 SU SU823381951A patent/SU1143315A3/ru active
- 1982-02-03 DD DD82237159A patent/DD202539A5/de not_active IP Right Cessation
- 1982-02-03 FR FR8201714A patent/FR2499075A1/fr not_active Withdrawn
- 1982-02-04 KR KR1019820000475A patent/KR830009023A/ko unknown
- 1982-02-04 SE SE8200647A patent/SE8200647L/xx not_active Application Discontinuation
- 1982-02-04 GB GB8203264A patent/GB2092584B/en not_active Expired
- 1982-02-04 IS IS2700A patent/IS2700A7/is unknown
- 1982-02-04 LU LU83923A patent/LU83923A1/de unknown
- 1982-02-04 YU YU00239/82A patent/YU23982A/xx unknown
- 1982-02-04 IE IE249/82A patent/IE52439B1/en unknown
- 1982-02-04 NO NO820346A patent/NO820346L/no unknown
- 1982-02-04 ES ES509312A patent/ES509312A0/es active Granted
- 1982-02-04 AT AT0041882A patent/AT377982B/de not_active IP Right Cessation
- 1982-02-04 PT PT74387A patent/PT74387B/pt unknown
- 1982-02-04 BR BR8200615A patent/BR8200615A/pt unknown
- 1982-02-05 BG BG055269A patent/BG36932A3/xx unknown
- 1982-02-05 PL PL1982234962A patent/PL135221B1/pl unknown
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