KR830003420A - 피롤리딘 유도체 - Google Patents

피롤리딘 유도체 Download PDF

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Publication number
KR830003420A
KR830003420A KR1019800003148A KR800003148A KR830003420A KR 830003420 A KR830003420 A KR 830003420A KR 1019800003148 A KR1019800003148 A KR 1019800003148A KR 800003148 A KR800003148 A KR 800003148A KR 830003420 A KR830003420 A KR 830003420A
Authority
KR
South Korea
Prior art keywords
hydrogen
following formula
group
protecting group
pyrrolidine derivative
Prior art date
Application number
KR1019800003148A
Other languages
English (en)
Other versions
KR850000845B1 (ko
Inventor
아쉬반덴 베르너
키부르츠 에밀리오
Original Assignee
쿠르트 네젤 보쉬, 한스 스튀클린
에프. 호프만 라 롯슈 앤드 캄파니 아크티엔 게젤샤프트
한스 스튀클린
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쿠르트 네젤 보쉬, 한스 스튀클린, 에프. 호프만 라 롯슈 앤드 캄파니 아크티엔 게젤샤프트, 한스 스튀클린 filed Critical 쿠르트 네젤 보쉬, 한스 스튀클린
Publication of KR830003420A publication Critical patent/KR830003420A/ko
Priority to KR1019840004335A priority Critical patent/KR850000843B1/ko
Priority to KR1019850000256A priority patent/KR850000844B1/ko
Application granted granted Critical
Publication of KR850000845B1 publication Critical patent/KR850000845B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

피롤리딘 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 다음 구조식(II)의 피롤리딘 유도체로 부터 보호그룹을 제거하거나 다음 구조식(II)의 피롤리딘 유도체를 환원시켜 다음 구조식(I)의 피롤리딘 유도체를 제조하는 방법.
  4. 상기 구조식에서
  5. R1, R2및 R3중 하나는 하이드록시이고 나머지 둘은 수소이며
  6. R11,R21및 R31중 하나는 보호 하이드록시 그룹이고 나머지 둘은 수소이며
  7. (단 R11이 보호 하이드록시 그룹일 경우 보호그룹은 아실 그룹은 아니다)
  8. R4및 R6중 하나는 수소이고 다른 하나는 R5와 함께 탄소탄소 이중결합을 나타내고
  9. R32는 수소 또는 환원적으로 제거 가능한 보호그룹을 나타낸다.
  10. * 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800003148A 1979-08-09 1980-08-08 피롤리딘 유도체의 제조방법 KR850000845B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019840004335A KR850000843B1 (ko) 1979-08-09 1984-07-21 피롤리딘 유도체의 제조방법
KR1019850000256A KR850000844B1 (ko) 1979-08-09 1985-01-17 피롤리딘 유도체의 제조방법

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH730879 1979-08-09
CH7308 1979-08-09
CH7308/79 1979-08-09
CH475580 1980-06-20
CH4755 1980-06-20

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1019840004335A Division KR850000843B1 (ko) 1979-08-09 1984-07-21 피롤리딘 유도체의 제조방법
KR1019850000256A Division KR850000844B1 (ko) 1979-08-09 1985-01-17 피롤리딘 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR830003420A true KR830003420A (ko) 1983-06-20
KR850000845B1 KR850000845B1 (ko) 1985-06-17

Family

ID=25696222

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019800003148A KR850000845B1 (ko) 1979-08-09 1980-08-08 피롤리딘 유도체의 제조방법
KR1019840004335A KR850000843B1 (ko) 1979-08-09 1984-07-21 피롤리딘 유도체의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019840004335A KR850000843B1 (ko) 1979-08-09 1984-07-21 피롤리딘 유도체의 제조방법

Country Status (38)

Country Link
US (1) US4461906A (ko)
EP (1) EP0024030B1 (ko)
KR (2) KR850000845B1 (ko)
AR (1) AR230625A1 (ko)
AT (1) ATE2894T1 (ko)
AU (1) AU538686B2 (ko)
BG (1) BG34612A3 (ko)
CA (1) CA1124247A (ko)
CS (1) CS214837B2 (ko)
CU (1) CU35300A (ko)
DD (1) DD152337A5 (ko)
DE (2) DE3029671A1 (ko)
DK (1) DK159679C (ko)
ES (2) ES8106290A1 (ko)
FI (1) FI70572C (ko)
FR (1) FR2463127A1 (ko)
GB (1) GB2055835B (ko)
GR (1) GR69911B (ko)
HK (1) HK18486A (ko)
HU (1) HU180596B (ko)
IE (1) IE50090B1 (ko)
IL (1) IL60733A (ko)
IN (1) IN153082B (ko)
IT (1) IT1131959B (ko)
LU (1) LU82692A1 (ko)
MC (1) MC1344A1 (ko)
MY (1) MY8500273A (ko)
NL (1) NL8004025A (ko)
NO (1) NO154632C (ko)
NZ (1) NZ194558A (ko)
OA (1) OA06624A (ko)
PH (1) PH16220A (ko)
PL (1) PL127472B1 (ko)
PT (1) PT71686B (ko)
RO (1) RO82358B (ko)
SE (1) SE8005607L (ko)
YU (1) YU42516B (ko)
ZW (1) ZW16680A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH646149A5 (de) * 1981-02-05 1984-11-15 Hoffmann La Roche Pyrrolidin-derivat.
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
US4560700A (en) * 1985-02-08 1985-12-24 Merrell Dow Pharmaceuticals Inc. Pyrrole-3-carboxylate cardiotonic agents
IT1215587B (it) * 1987-06-26 1990-02-14 Roussel Maestretti Spa Derivati della 1-benzoil2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro impiego come sostanza medicinale.
US5049577A (en) * 1990-01-29 1991-09-17 E. R. Squibb & Sons, Inc. 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith
US5049578A (en) * 1990-03-09 1991-09-17 E. R. Squibb & Sons, Inc. 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones
WO1997039750A1 (en) * 1996-04-19 1997-10-30 The Regents Of The University Of California Treatment of mood/affective disorders by glutamatergic upmodulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2413935A1 (de) * 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
DE2541855A1 (de) * 1975-09-18 1977-03-31 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone ii
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
CA1115212A (en) * 1978-02-10 1981-12-29 Emilio Kyburz Pyrrolidine derivatives

Also Published As

Publication number Publication date
KR850000843B1 (ko) 1985-06-17
CU35300A (en) 1982-03-28
PT71686B (en) 1982-01-22
RO82358A (ro) 1984-03-15
HU180596B (en) 1983-03-28
SE8005607L (sv) 1981-02-10
ZW16680A1 (en) 1981-03-04
MY8500273A (en) 1985-12-31
AR230625A1 (es) 1984-05-31
MC1344A1 (fr) 1981-06-22
DE3029671A1 (de) 1981-02-26
LU82692A1 (de) 1982-05-10
IL60733A0 (en) 1980-10-26
PL226164A1 (ko) 1981-08-07
NO154632C (no) 1986-11-19
YU200680A (en) 1983-09-30
ES500381A0 (es) 1982-12-01
FI70572B (fi) 1986-06-06
NO802370L (no) 1981-02-10
DD152337A5 (de) 1981-11-25
KR850001457A (ko) 1985-03-18
ES8301209A1 (es) 1982-12-01
HK18486A (en) 1986-03-27
FR2463127B1 (ko) 1983-08-12
OA06624A (fr) 1981-08-31
RO82358B (ro) 1984-03-30
FI70572C (fi) 1986-09-24
PT71686A (en) 1980-09-01
DK159679B (da) 1990-11-19
FR2463127A1 (fr) 1981-02-20
YU42516B (en) 1988-10-31
NZ194558A (en) 1984-07-06
IN153082B (ko) 1984-05-26
US4461906A (en) 1984-07-24
ES494091A0 (es) 1981-08-01
IL60733A (en) 1984-03-30
IE801676L (en) 1981-02-09
GB2055835B (en) 1983-07-06
AU6099680A (en) 1981-02-12
PH16220A (en) 1983-08-09
NO154632B (no) 1986-08-11
GR69911B (ko) 1982-07-21
IT1131959B (it) 1986-06-25
GB2055835A (en) 1981-03-11
ATE2894T1 (de) 1983-04-15
FI802417A (fi) 1981-02-10
EP0024030B1 (de) 1983-03-30
AU538686B2 (en) 1984-08-23
BG34612A3 (en) 1983-10-15
EP0024030A1 (de) 1981-02-18
PL127472B1 (en) 1983-10-31
DE3062531D1 (en) 1983-05-05
IE50090B1 (en) 1986-02-05
KR850000845B1 (ko) 1985-06-17
DK338480A (da) 1981-02-10
DK159679C (da) 1991-04-15
ES8106290A1 (es) 1981-08-01
NL8004025A (nl) 1981-02-11
CS214837B2 (en) 1982-06-25
CA1124247A (en) 1982-05-25
IT8023391A0 (it) 1980-07-11

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