RO82358B - Procedeu de preparare a 1-(p-metoxibenzoil)-3-hidroxi-2-pirolidinonei - Google Patents
Procedeu de preparare a 1-(p-metoxibenzoil)-3-hidroxi-2-pirolidinoneiInfo
- Publication number
- RO82358B RO82358B RO101940A RO10194080A RO82358B RO 82358 B RO82358 B RO 82358B RO 101940 A RO101940 A RO 101940A RO 10194080 A RO10194080 A RO 10194080A RO 82358 B RO82358 B RO 82358B
- Authority
- RO
- Romania
- Prior art keywords
- methoxybenzoyl
- hydroxy
- formula
- pyrolidinone
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedeu de preparare a 1-(p-metoxi-benzoil)-3-hidroxi-2-pirolidionei cu formula I: (vezi form. în desc.) caracterizat prin aceea ca o 1-(p-metoxi-benzoil)-2-pirolidinona cu formula generala II : (vezi form. în desc.) în care R reprezinta o grupa cloracetil sau trifluoracetil, se tInventia se refera la un procedeu pentru prepararea 1-(p-metoxibenzoil)-3-hidroxi-2-pirolidinonei cu formula I: (vezi formula) compus utilizat în combustie sau profilaxia insuficientei cerebrale, pentru ameliorarea capacitatii intelectuale. Procedeul consta în faptul ca se elimina o grupa protectoare din pozitia 3 pentru a pune în libertate grupa hidroxi si anume trifluoracetilul prin încalzire cu piridina si tiouree în etanol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH730879 | 1979-08-09 | ||
CH475580 | 1980-06-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
RO82358A RO82358A (ro) | 1984-03-15 |
RO82358B true RO82358B (ro) | 1984-03-30 |
Family
ID=25696222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO101940A RO82358B (ro) | 1979-08-09 | 1980-08-08 | Procedeu de preparare a 1-(p-metoxibenzoil)-3-hidroxi-2-pirolidinonei |
Country Status (38)
Country | Link |
---|---|
US (1) | US4461906A (ro) |
EP (1) | EP0024030B1 (ro) |
KR (2) | KR850000845B1 (ro) |
AR (1) | AR230625A1 (ro) |
AT (1) | ATE2894T1 (ro) |
AU (1) | AU538686B2 (ro) |
BG (1) | BG34612A3 (ro) |
CA (1) | CA1124247A (ro) |
CS (1) | CS214837B2 (ro) |
CU (1) | CU35300A (ro) |
DD (1) | DD152337A5 (ro) |
DE (2) | DE3029671A1 (ro) |
DK (1) | DK159679C (ro) |
ES (2) | ES494091A0 (ro) |
FI (1) | FI70572C (ro) |
FR (1) | FR2463127A1 (ro) |
GB (1) | GB2055835B (ro) |
GR (1) | GR69911B (ro) |
HK (1) | HK18486A (ro) |
HU (1) | HU180596B (ro) |
IE (1) | IE50090B1 (ro) |
IL (1) | IL60733A (ro) |
IN (1) | IN153082B (ro) |
IT (1) | IT1131959B (ro) |
LU (1) | LU82692A1 (ro) |
MC (1) | MC1344A1 (ro) |
MY (1) | MY8500273A (ro) |
NL (1) | NL8004025A (ro) |
NO (1) | NO154632C (ro) |
NZ (1) | NZ194558A (ro) |
OA (1) | OA06624A (ro) |
PH (1) | PH16220A (ro) |
PL (1) | PL127472B1 (ro) |
PT (1) | PT71686B (ro) |
RO (1) | RO82358B (ro) |
SE (1) | SE8005607L (ro) |
YU (1) | YU42516B (ro) |
ZW (1) | ZW16680A1 (ro) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH646149A5 (de) * | 1981-02-05 | 1984-11-15 | Hoffmann La Roche | Pyrrolidin-derivat. |
FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
US4560700A (en) * | 1985-02-08 | 1985-12-24 | Merrell Dow Pharmaceuticals Inc. | Pyrrole-3-carboxylate cardiotonic agents |
IT1215587B (it) * | 1987-06-26 | 1990-02-14 | Roussel Maestretti Spa | Derivati della 1-benzoil2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro impiego come sostanza medicinale. |
US5049577A (en) * | 1990-01-29 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith |
US5049578A (en) * | 1990-03-09 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones |
WO1997039750A1 (en) * | 1996-04-19 | 1997-10-30 | The Regents Of The University Of California | Treatment of mood/affective disorders by glutamatergic upmodulators |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2413935A1 (de) * | 1974-03-20 | 1975-10-16 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone |
DE2541855A1 (de) * | 1975-09-18 | 1977-03-31 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone ii |
IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
CU21107A3 (es) * | 1978-02-10 | 1988-02-01 | Hoffmann La Roche | Pyrrolidines derivatives |
CA1115212A (en) * | 1978-02-10 | 1981-12-29 | Emilio Kyburz | Pyrrolidine derivatives |
-
1980
- 1980-07-11 IT IT23391/80A patent/IT1131959B/it active
- 1980-07-11 NL NL8004025A patent/NL8004025A/nl not_active Application Discontinuation
- 1980-07-11 CA CA356,013A patent/CA1124247A/en not_active Expired
- 1980-07-16 ZW ZW166/80A patent/ZW16680A1/xx unknown
- 1980-07-28 US US06/172,607 patent/US4461906A/en not_active Expired - Lifetime
- 1980-07-29 BG BG8048645A patent/BG34612A3/xx unknown
- 1980-08-01 FI FI802417A patent/FI70572C/fi not_active IP Right Cessation
- 1980-08-01 AU AU60996/80A patent/AU538686B2/en not_active Ceased
- 1980-08-01 IL IL60733A patent/IL60733A/xx unknown
- 1980-08-01 AR AR282025A patent/AR230625A1/es active
- 1980-08-04 NZ NZ194558A patent/NZ194558A/en unknown
- 1980-08-04 CU CU8035300A patent/CU35300A/es unknown
- 1980-08-05 DD DD80223102A patent/DD152337A5/de unknown
- 1980-08-05 AT AT80104604T patent/ATE2894T1/de active
- 1980-08-05 DE DE19803029671 patent/DE3029671A1/de not_active Withdrawn
- 1980-08-05 DE DE8080104604T patent/DE3062531D1/de not_active Expired
- 1980-08-05 EP EP80104604A patent/EP0024030B1/de not_active Expired
- 1980-08-05 PH PH24407A patent/PH16220A/en unknown
- 1980-08-05 HU HU80801943A patent/HU180596B/hu not_active IP Right Cessation
- 1980-08-06 LU LU82692A patent/LU82692A1/de unknown
- 1980-08-06 DK DK338480A patent/DK159679C/da active
- 1980-08-07 SE SE8005607A patent/SE8005607L/xx not_active Application Discontinuation
- 1980-08-07 MC MC801462A patent/MC1344A1/xx unknown
- 1980-08-07 GR GR62625A patent/GR69911B/el unknown
- 1980-08-07 FR FR8017448A patent/FR2463127A1/fr active Granted
- 1980-08-08 GB GB8025938A patent/GB2055835B/en not_active Expired
- 1980-08-08 CS CS805497A patent/CS214837B2/cs unknown
- 1980-08-08 IN IN908/CAL/80A patent/IN153082B/en unknown
- 1980-08-08 YU YU2006/80A patent/YU42516B/xx unknown
- 1980-08-08 IE IE1676/80A patent/IE50090B1/en not_active IP Right Cessation
- 1980-08-08 RO RO101940A patent/RO82358B/ro unknown
- 1980-08-08 NO NO802370A patent/NO154632C/no unknown
- 1980-08-08 ES ES494091A patent/ES494091A0/es active Granted
- 1980-08-08 PT PT71686A patent/PT71686B/pt unknown
- 1980-08-08 KR KR1019800003148A patent/KR850000845B1/ko active
- 1980-08-09 OA OA57192A patent/OA06624A/xx unknown
- 1980-08-09 PL PL1980226164A patent/PL127472B1/pl unknown
-
1981
- 1981-03-16 ES ES500381A patent/ES500381A0/es active Granted
-
1984
- 1984-07-21 KR KR1019840004335A patent/KR850000843B1/ko not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY273/85A patent/MY8500273A/xx unknown
-
1986
- 1986-03-20 HK HK184/86A patent/HK18486A/xx unknown
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