KR830008681A - 흡수량을 조절하는 엘라스타제 함유 조성물 - Google Patents
흡수량을 조절하는 엘라스타제 함유 조성물 Download PDFInfo
- Publication number
- KR830008681A KR830008681A KR1019820000436A KR820000436A KR830008681A KR 830008681 A KR830008681 A KR 830008681A KR 1019820000436 A KR1019820000436 A KR 1019820000436A KR 820000436 A KR820000436 A KR 820000436A KR 830008681 A KR830008681 A KR 830008681A
- Authority
- KR
- South Korea
- Prior art keywords
- fatty acid
- elastase
- sucrose fatty
- containing composition
- sucrose
- Prior art date
Links
- 102000016387 Pancreatic elastase Human genes 0.000 title claims description 10
- 108010067372 Pancreatic elastase Proteins 0.000 title claims description 10
- 239000000203 mixture Substances 0.000 title claims 10
- 238000010521 absorption reaction Methods 0.000 title 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 12
- 229930195729 fatty acid Natural products 0.000 claims 12
- 239000000194 fatty acid Substances 0.000 claims 12
- 229930006000 Sucrose Natural products 0.000 claims 11
- 239000005720 sucrose Substances 0.000 claims 11
- -1 sucrose fatty acid ester Chemical class 0.000 claims 10
- 150000004665 fatty acids Chemical class 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 2
- 241000700159 Rattus Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 위스터계 래트의 혈청엘라스타제 레벨곡선을 나타내고, 제2도는 비글개의 혈청엘라스타제 레벨 곡선을 나타낸다.
Claims (6)
- 순수 엘라스타제 1부당 슈크로스지방산 에스테르 0.5 내지 50부(중량) 함유한 엘라스타제 함유 조성물.
- 슈크로스 지방산 에스테르가 슈크로스 지방산 모노에스테르, 슈크로스 지방산 디에스테르, 슈크로서지방산 트리에스테르의 혼합물인 제1항의 엘라스타제 함유 조성물.
- 슈크로스지방산 에스테르 혼합물이 슈크로스 지방산 모노에스테르를 50%이상 함유하는 제2항의 엘라스타제 함유 조성물.
- 슈크로스 지방산에스테르 혼합물이 슈크로스 지방산 모노에스테르를 70%이상 함유하는 제3항의 엘라스타제 함유 조성물.
- 슈크로스지방산 에스테르가 탄소수 12-18의 지방산과 슈크로스를 함유하는 제1, 2, 3, 4, 5항의 엘라스타제 함유 조성물.
- 지방산이 스테아린산, 팔미틴산, 로린산, 올레인산으로 이루어지는 그룹에서 선택되는 제1, 2, 3, 4, 5항의 엘라스타제 함유 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56013754A JPS57128634A (en) | 1981-02-03 | 1981-02-03 | Elastase-containing compound increasing absorption |
JP56-13754 | 1981-02-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830008681A true KR830008681A (ko) | 1983-12-14 |
KR880001808B1 KR880001808B1 (ko) | 1988-09-19 |
Family
ID=11842034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8200436A KR880001808B1 (ko) | 1981-02-03 | 1982-02-03 | 엘라스타제 함유조성물의 제조방법 |
Country Status (8)
Country | Link |
---|---|
US (1) | US4397951A (ko) |
EP (1) | EP0057462B1 (ko) |
JP (1) | JPS57128634A (ko) |
KR (1) | KR880001808B1 (ko) |
CA (1) | CA1182747A (ko) |
DE (1) | DE3260589D1 (ko) |
ES (1) | ES509221A0 (ko) |
PH (1) | PH17715A (ko) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58208236A (ja) * | 1982-05-28 | 1983-12-03 | Eisai Co Ltd | 糖尿病性腎症治療剤 |
JPS5951221A (ja) * | 1982-09-17 | 1984-03-24 | Eisai Co Ltd | 変形性関節症治療剤 |
JPS61191610A (ja) * | 1985-02-20 | 1986-08-26 | Dai Ichi Kogyo Seiyaku Co Ltd | 胃液中で速やかに溶解する錠剤 |
NL8701143A (nl) * | 1986-05-27 | 1987-12-16 | Sandoz Ag | Farmaceutische preparaten. |
JPS6485660A (en) * | 1987-02-19 | 1989-03-30 | Nippon Medical Supply | Suture coated with sugar fatty acid ester |
US4865848A (en) * | 1987-02-26 | 1989-09-12 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
US4940586A (en) * | 1987-02-26 | 1990-07-10 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
HU205010B (en) * | 1987-09-15 | 1992-03-30 | Sandoz Ag | Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity |
JPH02292226A (ja) * | 1989-05-08 | 1990-12-03 | Shigemi Fujisaki | 障害された神経細胞賦活予防治療剤 |
CA2070061C (en) * | 1991-06-07 | 2004-02-10 | Shigeyuki Takama | Physiologically active polypeptide-containing pharmaceutical composition |
WO2004052405A1 (en) * | 2002-12-11 | 2004-06-24 | Chong Kun Dang Pharmaceutical Corp. | Oral formulations for poorly absorptive hydrophilic drugs |
WO2006025882A2 (en) * | 2004-08-25 | 2006-03-09 | The Uab Research Foundation | Absorption enhancers for drug administration |
US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
US20060046969A1 (en) * | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Antibacterial compositions for drug administration |
US20060046962A1 (en) | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Absorption enhancers for drug administration |
US9114069B2 (en) * | 2004-08-25 | 2015-08-25 | Aegis Therapeutics, Llc | Antibacterial compositions for drug administration |
US20140162965A1 (en) | 2004-08-25 | 2014-06-12 | Aegis Therapeutics, Inc. | Compositions for oral drug administration |
US8642564B2 (en) * | 2004-08-25 | 2014-02-04 | Aegis Therapeutics, Llc | Compositions for drug administration |
US8268791B2 (en) * | 2004-08-25 | 2012-09-18 | Aegis Therapeutics, Llc. | Alkylglycoside compositions for drug administration |
US20090047347A1 (en) * | 2005-07-29 | 2009-02-19 | Aegis Therapeutics, Inc. | Compositions for Drug Administration |
US8226949B2 (en) | 2006-06-23 | 2012-07-24 | Aegis Therapeutics Llc | Stabilizing alkylglycoside compositions and methods thereof |
TWI395593B (zh) * | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
AU2009228093B2 (en) * | 2008-03-28 | 2014-08-07 | Neurelis, Inc. | Administration of benzodiazepine compositions |
US8440631B2 (en) | 2008-12-22 | 2013-05-14 | Aegis Therapeutics, Llc | Compositions for drug administration |
PL3415139T3 (pl) | 2011-06-14 | 2022-07-11 | Neurelis, Inc. | Podawanie benzodiazepiny |
CN105775051B (zh) * | 2016-03-03 | 2017-08-11 | 上海船舶研究设计院 | 多功能油田增产作业支持船 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB837444A (en) * | 1956-10-26 | 1960-06-15 | Armour & Co | Improvements in and relating to the preparation of elastase |
GB1076776A (en) * | 1963-10-10 | 1967-07-19 | Rolland Lab A | Process for the extraction of elastase |
GB1448276A (en) * | 1973-09-15 | 1976-09-02 | Eisai Co Ltd | Elastase and methods for using same |
JPS5261287A (en) * | 1975-11-08 | 1977-05-20 | Eisai Co Ltd | Preparation of pancreatic elastase |
-
1981
- 1981-02-03 JP JP56013754A patent/JPS57128634A/ja active Granted
-
1982
- 1982-01-27 US US06/343,333 patent/US4397951A/en not_active Expired - Lifetime
- 1982-02-01 ES ES509221A patent/ES509221A0/es active Granted
- 1982-02-01 CA CA000395311A patent/CA1182747A/en not_active Expired
- 1982-02-02 DE DE8282100730T patent/DE3260589D1/de not_active Expired
- 1982-02-02 EP EP82100730A patent/EP0057462B1/en not_active Expired
- 1982-02-03 KR KR8200436A patent/KR880001808B1/ko active
- 1982-02-03 PH PH26824A patent/PH17715A/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES8502334A1 (es) | 1985-01-01 |
KR880001808B1 (ko) | 1988-09-19 |
EP0057462B1 (en) | 1984-08-22 |
US4397951A (en) | 1983-08-09 |
JPH0150686B2 (ko) | 1989-10-31 |
EP0057462A3 (en) | 1982-12-29 |
EP0057462A2 (en) | 1982-08-11 |
PH17715A (en) | 1984-11-19 |
CA1182747A (en) | 1985-02-19 |
ES509221A0 (es) | 1985-01-01 |
JPS57128634A (en) | 1982-08-10 |
DE3260589D1 (en) | 1984-09-27 |
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