KR830008680A - 아자스피로알칸디온의 제조방법 - Google Patents

아자스피로알칸디온의 제조방법 Download PDF

Info

Publication number
KR830008680A
KR830008680A KR1019820001128A KR820001128A KR830008680A KR 830008680 A KR830008680 A KR 830008680A KR 1019820001128 A KR1019820001128 A KR 1019820001128A KR 820001128 A KR820001128 A KR 820001128A KR 830008680 A KR830008680 A KR 830008680A
Authority
KR
South Korea
Prior art keywords
structural formula
hydrogen
carbon atoms
following structural
azaspiroalkanedione
Prior art date
Application number
KR1019820001128A
Other languages
English (en)
Other versions
KR880001557B1 (ko
Inventor
엘.템플 쥬니어 데비스
피.예비취 조세프
지. 로베크 쥬니어 월터
Original Assignee
도미니크 엠. 페자펠
브리스톨-마이어스 컴페니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 도미니크 엠. 페자펠, 브리스톨-마이어스 컴페니 filed Critical 도미니크 엠. 페자펠
Publication of KR830008680A publication Critical patent/KR830008680A/ko
Application granted granted Critical
Publication of KR880001557B1 publication Critical patent/KR880001557B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

내용 없음

Description

아자스피로알칸디온의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 포유동물숙주의 몸무게 kg당 0.01-0.4mg의 무독성 효과적인 복용량을 제공하도록 본 발명의 화합물과 제약학적 매개물로 구성하는 단계적 투여용의 단위복용 성태의 제약학적 조성물.
  2. 하기 구조식(2)의 테트라히드로피리딘 혹은 그 전구물질과 하기 구조식(3)의 스피로글루타릭산 유도체와 불활성 유기액체 미디엄에서 상승된 온도로 반응시키거나, 구조식(2)의 중간체가 반응체로 사용되는 경우 탈수소단계를 포괄하는 것으로 구성되는 아자스피로알간디온을 제조하는 방법.
    상기식에서 n은 4 혹은 5인 기수, A는 2-5탄소원자를 지닌 이가 직쇄알킬렌, B는 구조식의 기(단 R은 수소, 1-4 탄소원자의 저급알킬, 혹은 할로겐임),
    Y는 수소, H2NA-일 때 0 혹은 Y가 XA-일 때 NH, 혹은 (CH2)n=이거나, 혹은 Y가 수소일 때 NAX임.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8201128A 1981-03-16 1982-03-16 아자스피로알칸디온 및 그의 제조방법 KR880001557B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US244,426 1981-03-16
US06/244,426 US4320131A (en) 1981-03-16 1981-03-16 N-[(4-Phenyl-1,2,3,6-tetrahydropyridin-1-yl)alkylene]azaspiroalkanediones and N-[(4-hydroxy-4-phenylpiperidin-1-yl)alkylene]azaspiroalkanediones

Publications (2)

Publication Number Publication Date
KR830008680A true KR830008680A (ko) 1983-12-14
KR880001557B1 KR880001557B1 (ko) 1988-08-22

Family

ID=22922718

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8201128A KR880001557B1 (ko) 1981-03-16 1982-03-16 아자스피로알칸디온 및 그의 제조방법

Country Status (31)

Country Link
US (1) US4320131A (ko)
JP (1) JPS57165384A (ko)
KR (1) KR880001557B1 (ko)
AT (1) AT381939B (ko)
AU (1) AU535385B2 (ko)
BE (1) BE892502A (ko)
CA (1) CA1192556A (ko)
CH (2) CH652123A5 (ko)
CY (1) CY1372A (ko)
DE (1) DE3209534A1 (ko)
DK (1) DK161322C (ko)
ES (1) ES8305753A1 (ko)
FI (1) FI71317C (ko)
FR (1) FR2501689B1 (ko)
GB (1) GB2094801B (ko)
GR (1) GR76113B (ko)
HK (1) HK4688A (ko)
HU (2) HU193379B (ko)
IE (1) IE52789B1 (ko)
IL (1) IL65254A0 (ko)
IT (1) IT1148145B (ko)
KE (1) KE3710A (ko)
LU (1) LU84012A1 (ko)
NL (1) NL8201022A (ko)
NZ (1) NZ199944A (ko)
PH (1) PH18182A (ko)
PT (1) PT74584B (ko)
SE (2) SE449100B (ko)
SG (1) SG30887G (ko)
YU (1) YU43789B (ko)
ZA (1) ZA821541B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
HU207310B (en) * 1988-12-02 1993-03-29 Pfizer Process for producing aryl-piperidine derivatives
US5137894A (en) * 1991-12-05 1992-08-11 New James S 4-(4-Piperidinyl-thieno[3,2-c]pyridine derivatives of n-alkylglutarimides

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US355877A (en) * 1887-01-11 Waltee n
FR3013E (fr) * 1902-04-03 1904-08-12 William Henry Hoyle Perfectionnements au procédé et aux machines pour la fabrication de matières fibreuses connues sous le nom de fils "frottés"
US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US3432499A (en) * 1965-04-02 1969-03-11 Geschickter Fund Med Res Trifluoromethylazaspiranes and azaspirane diones
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
US3558777A (en) * 1968-06-21 1971-01-26 Mead Johnson & Co Pharmacologic processes and compositions containing azaspirodecanediones and azaspiroundecanediones
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
CH547802A (de) * 1970-06-19 1974-04-11 Hoffmann La Roche Verfahren zur herstellung von tetrahydropyridinderivaten.
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
US4250175A (en) * 1977-10-31 1981-02-10 Mccall John M Methods of treating psychosis
US4179510A (en) * 1977-10-31 1979-12-18 The Upjohn Company Methods of treating psychosis
US4218456A (en) * 1978-07-10 1980-08-19 Warner-Lambert Company 1-(4-Fluorophenyl)-4-(1,2,3,6-tetrahydro-4-phenoxy-1-pyridinyl)-butanones
US4261990A (en) * 1979-03-09 1981-04-14 Ciba-Geigy Corporation N-alkyleneiminoalkyl-dicarboximides as antiallergics and antiasthmatics
US4221714A (en) * 1979-08-03 1980-09-09 American Cyanamid Company 11-(1,2,3,6-Tetrahydro-substituted-4-pyridyl)-dibenz[b,f][1,4]oxazepines
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones

Also Published As

Publication number Publication date
CA1192556A (en) 1985-08-27
DK161322C (da) 1991-12-09
IL65254A0 (en) 1982-05-31
LU84012A1 (fr) 1983-02-22
PH18182A (en) 1985-04-12
PT74584A (en) 1982-04-01
GB2094801B (en) 1985-04-24
ES510448A0 (es) 1983-04-16
US4320131A (en) 1982-03-16
CH652123A5 (de) 1985-10-31
AT381939B (de) 1986-12-10
HU190793B (en) 1986-11-28
NL8201022A (nl) 1982-10-18
FI820855L (fi) 1982-09-17
KR880001557B1 (ko) 1988-08-22
DE3209534A1 (de) 1982-09-23
PT74584B (pt) 1984-11-27
IE820590L (en) 1982-09-16
CY1372A (en) 1987-08-07
HK4688A (en) 1988-01-29
SE8201630L (sv) 1982-09-17
YU55882A (en) 1984-10-31
FI71317B (fi) 1986-09-09
GB2094801A (en) 1982-09-22
CH657365A5 (de) 1986-08-29
FR2501689B1 (fr) 1985-07-19
SE460606B (sv) 1989-10-30
IE52789B1 (en) 1988-03-02
SG30887G (en) 1987-07-17
AU8133582A (en) 1982-11-04
HU193379B (en) 1987-09-28
YU43789B (en) 1989-12-31
JPH0345072B2 (ko) 1991-07-09
DK112682A (da) 1982-09-17
ES8305753A1 (es) 1983-04-16
HUT40797A (en) 1987-02-27
NZ199944A (en) 1986-06-11
BE892502A (fr) 1982-09-15
AU535385B2 (en) 1984-03-15
IT1148145B (it) 1986-11-26
DE3209534C2 (ko) 1993-03-11
SE449100B (sv) 1987-04-06
FR2501689A1 (fr) 1982-09-17
SE8603177D0 (sv) 1986-07-21
ZA821541B (en) 1983-01-26
ATA104682A (de) 1986-05-15
JPS57165384A (en) 1982-10-12
IT8247992A0 (it) 1982-03-15
KE3710A (en) 1987-04-16
FI71317C (fi) 1986-12-19
GR76113B (ko) 1984-08-03
SE8603177L (sv) 1986-07-21
DK161322B (da) 1991-06-24

Similar Documents

Publication Publication Date Title
KR880013888A (ko) 신규 디티오아세탈 화합물, 그의 제조방법 및 이 화합물로 되는 제약 조성물
KR880006206A (ko) 퀴나졸리논 유도체 및 이의 제조방법
KR850004463A (ko) 디히드로피리딘 유도체의 제조방법
KR870006039A (ko) 신규 티아졸 화합물, 그 제조방법 및 이 화합물을 함유하는 약학적 조성물
KR870002056A (ko) 치환된 프로파르길옥시아세토니트릴 유도체의 제조 방법
KR860700250A (ko) 신규 아미딘 화합물
KR830006198A (ko) 시클로헥산 유도체의 제조방법
KR840000486A (ko) 치환된 피롤리딘의 제조방법
KR830008680A (ko) 아자스피로알칸디온의 제조방법
KR900016178A (ko) 2-치환 n,n'-디트리메톡시벤조일 피페라진, 그의 제조 방법 및 그를 함유하는 치료 조성물
KR890008110A (ko) 피리미딘 유도체
KR890009901A (ko) 3-히드록시-2-(4-메톡시페닐)-5-(2-메틸아미노에틸)-2,3-디히드로-5h-1,5- 벤조티아제핀-4-온 유도체, 그의 제조 및 치료에의 이용
KR910015537A (ko) 신규 1-아릴술포닐-2-피페리디논 유도체, 이의 제조방법, 제조용 중간체, 의약품으로서의 용도 및 이 화합물을 함유하는 조성물
ATE97404T1 (de) Prostazyklin-(pgi2)-analoge.
AU539348B2 (en) 5,6,8,9-tetrahydro-7h-dibenz(d,f)azonine derivatives
KR850002478A (ko) 2-(n-피롤리디노)-3-이소부톡시-n-치환된 페닐-n-벤질-프로필아민의 제조방법
KR900006309A (ko) 신규 2-카르보닐 치환 n, n'-디-(트리메톡시벤조일)피페라진, 이들의 제조방법 및 이들을 함유한 치료 조성물
KR880012544A (ko) 벤젠설폰아미드 유도체 및 그의 제조방법
KR830001900A (ko) 페닐모르판과 그의 중간물질및 제조방법
KR840004747A (ko) 강심제 퀸아졸린의 제조방법
KR870002110A (ko) 구아니디노티아졸 유도체의 제조방법
KR860008987A (ko) 2- 카르복시피라진 4-옥시드의 제조방법
KR880001635A (ko) 5-플루오로우라실 유도체, 그의 제조방법 및 용도
KR890002011A (ko) 5-할로 게노-6-아미노-니코틴산 할라이드. 이의 제조방법 및 용도
HU905000D0 (en) Process for producing compounds suitable for treatment of gastric ulcer