KR820002098B1 - 요소 및 아미도 유도체의 제조방법 - Google Patents

요소 및 아미도 유도체의 제조방법 Download PDF

Info

Publication number
KR820002098B1
KR820002098B1 KR7900682A KR790000682A KR820002098B1 KR 820002098 B1 KR820002098 B1 KR 820002098B1 KR 7900682 A KR7900682 A KR 7900682A KR 790000682 A KR790000682 A KR 790000682A KR 820002098 B1 KR820002098 B1 KR 820002098B1
Authority
KR
South Korea
Prior art keywords
acid
ethyl
urea
imidazoline
melting point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR7900682A
Other languages
English (en)
Korean (ko)
Inventor
막서 아드리안
Original Assignee
아놀드 자일러
시바-가이기 에이지
에른스트 알테르
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아놀드 자일러, 시바-가이기 에이지, 에른스트 알테르 filed Critical 아놀드 자일러
Application granted granted Critical
Publication of KR820002098B1 publication Critical patent/KR820002098B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR7900682A 1978-03-08 1979-03-06 요소 및 아미도 유도체의 제조방법 Expired KR820002098B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH251978 1978-03-08
CH2519/78-0 1978-03-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019820004065A Division KR830000884B1 (ko) 1978-03-08 1982-09-08 요소 및 아미도 유도체의 제조방법

Publications (1)

Publication Number Publication Date
KR820002098B1 true KR820002098B1 (ko) 1982-11-05

Family

ID=4235609

Family Applications (2)

Application Number Title Priority Date Filing Date
KR7900682A Expired KR820002098B1 (ko) 1978-03-08 1979-03-06 요소 및 아미도 유도체의 제조방법
KR1019820004065A Expired KR830000884B1 (ko) 1978-03-08 1982-09-08 요소 및 아미도 유도체의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019820004065A Expired KR830000884B1 (ko) 1978-03-08 1982-09-08 요소 및 아미도 유도체의 제조방법

Country Status (28)

Country Link
US (2) US4292429A (https=)
EP (1) EP0004561B1 (https=)
JP (1) JPS54125668A (https=)
KR (2) KR820002098B1 (https=)
AR (2) AR225010A1 (https=)
AT (1) AT364375B (https=)
AU (1) AU531006B2 (https=)
CS (1) CS244656B2 (https=)
CY (1) CY1304A (https=)
DD (1) DD142336A5 (https=)
DE (1) DE2961198D1 (https=)
DK (1) DK95279A (https=)
ES (1) ES478342A1 (https=)
FI (1) FI70708C (https=)
GB (1) GB2016011B (https=)
GR (1) GR71998B (https=)
HK (1) HK80185A (https=)
HU (1) HU182940B (https=)
IL (1) IL56797A (https=)
MY (1) MY8700199A (https=)
NO (1) NO152606C (https=)
NZ (1) NZ189841A (https=)
OA (1) OA06201A (https=)
PH (1) PH16207A (https=)
PL (2) PL116762B1 (https=)
PT (1) PT69314A (https=)
SU (2) SU845779A3 (https=)
ZA (1) ZA791062B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338453A (en) 1980-09-17 1982-07-06 The Upjohn Company Aminoalkyl-1,2,4-triazoles
US4353921A (en) * 1981-06-19 1982-10-12 Berlex Laboratories, Inc. Antiarrythmic 1-arylcarbamoylalkyl-2-imidazoline derivatives, composition and method of use
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
JPS6133173A (ja) * 1984-07-25 1986-02-17 Torii Yakuhin Kk アミジン化合物
WO1986003539A1 (en) * 1984-12-12 1986-06-19 MTD-PRODUKTER I SMA^oLAND AB Method of preparing a hospital room or the like
GB8906198D0 (en) * 1989-03-17 1989-05-04 Ciba Geigy Ag Compounds
CN101171236A (zh) * 2005-05-03 2008-04-30 马尔药品公司 抗肿瘤的四氢嘧啶
FR2901273B1 (fr) * 2006-05-19 2010-12-24 Anaconda Pharma Inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant
US8215871B2 (en) 2008-09-17 2012-07-10 William Kingston Tideway anchor system
EP2543660A4 (en) 2010-03-04 2014-04-30 Ajinomoto Kk PROPHYLACTIC OR THERAPEUTIC ACTIVE AGAINST DIABETES OR ADIPOSITAS
PL2546231T3 (pl) * 2010-03-04 2019-05-31 Ea Pharma Co Ltd Pochodna alkiloaminy
CN102924380B (zh) * 2012-11-13 2014-12-31 齐鲁动物保健品有限公司 一种咪唑苯脲的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH234990A (de) * 1938-05-11 1944-10-31 Chem Ind Basel Verfahren zur Darstellung eines neuen therapeutisch wirksamen Amidins.
GB813525A (en) * 1956-07-09 1959-05-21 Socony Mobil Oil Co Inc Fuel oil composition
GB1082964A (en) * 1963-06-25 1967-09-13 Wellcome Found New substituted imidazolines and their preparation and use
US3455940A (en) * 1965-12-07 1969-07-15 Herbert C Stecker Certain halo and dihalo n-substituted salicylamides
GB1174349A (en) * 1966-08-25 1969-12-17 Boehringer Sohn Ingelheim Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof
US3846071A (en) * 1969-02-12 1974-11-05 Petrolite Corp Process of inhibiting corrosion by treatment with phosphate-cyclic amidine salts
NL7415845A (nl) * 1973-12-26 1975-06-30 Upjohn Co Werkwijze voor het bevorderen van de productie van endogene prostaglandinen door zoogdieren, alsmede werkwijze ter bereiding van daarbij te gebruiken preparaten.
US4088766A (en) * 1975-06-25 1978-05-09 The Upjohn Company Urea containing compositions and methods
US4233451A (en) * 1976-05-20 1980-11-11 The Procter & Gamble Company Process for making imidazolinium salts
US4353921A (en) * 1981-06-19 1982-10-12 Berlex Laboratories, Inc. Antiarrythmic 1-arylcarbamoylalkyl-2-imidazoline derivatives, composition and method of use

Also Published As

Publication number Publication date
DD142336A5 (de) 1980-06-18
CY1304A (en) 1985-12-06
GR71998B (https=) 1983-08-26
DE2961198D1 (en) 1982-01-14
ATA171079A (de) 1981-03-15
DK95279A (da) 1979-09-09
SU845779A3 (ru) 1981-07-07
EP0004561A2 (de) 1979-10-17
FI70708B (fi) 1986-06-26
OA06201A (fr) 1981-06-30
SU923367A3 (ru) 1982-04-23
AT364375B (de) 1981-10-12
NO152606C (no) 1985-10-23
PL213924A1 (https=) 1980-02-25
ES478342A1 (es) 1979-05-16
PT69314A (de) 1979-04-01
HU182940B (en) 1984-03-28
FI70708C (fi) 1986-10-06
ZA791062B (en) 1980-03-26
US4420619A (en) 1983-12-13
PH16207A (en) 1983-08-05
EP0004561B1 (de) 1981-11-04
IL56797A (en) 1982-09-30
US4292429A (en) 1981-09-29
NO790765L (no) 1979-09-11
NZ189841A (en) 1982-03-09
PL116762B1 (en) 1981-06-30
HK80185A (en) 1985-10-25
CS244656B2 (en) 1986-08-14
JPS54125668A (en) 1979-09-29
AU4490079A (en) 1979-09-13
JPS629109B2 (https=) 1987-02-26
NO152606B (no) 1985-07-15
GB2016011B (en) 1982-08-25
GB2016011A (en) 1979-09-19
AR227286A1 (es) 1982-10-15
PL123150B1 (en) 1982-09-30
AR225010A1 (es) 1982-02-15
AU531006B2 (en) 1983-08-04
KR830000884B1 (ko) 1983-04-26
FI790740A7 (fi) 1979-09-09
MY8700199A (en) 1987-12-31
EP0004561A3 (en) 1979-11-14

Similar Documents

Publication Publication Date Title
KR820002098B1 (ko) 요소 및 아미도 유도체의 제조방법
EP0097323A2 (en) 2-(4-Pyridyl)-thiazole derivatives
KR880000180B1 (ko) 디하이드로 피리딘의 제조방법
JPS6016976A (ja) 芳香族化合物およびその製法
US4005205A (en) Compositions and methods for inhibiting H2 histamine receptors
JPS58128384A (ja) ベンゾジオキシン化合物、その製造方法、および精神作用障害治療用医薬組成物
KR870000912B1 (ko) 디하이드로피리딘 유도체의 제조방법
EP0117345B1 (en) Aminopyrimidinones as histamine h2-antagonists
US4567176A (en) 4H-Imidazol-4-ones and their pharmaceutical use
CA1125759A (en) Process for the preparation of novel urea and amido compounds
IE47864B1 (en) Process for the preparation of novel urea and amido compounds
US3686178A (en) Preparation of 4-aryl-2(1h)-quinazolinones and thiones
EP0207651A2 (en) Anti-inflammatory 7-phenyl pyrazolo-[1,5A]-1,3,5-triazine derivatives
US4260744A (en) Pharmacologically active compounds
EP1098888A1 (fr) Derives de piperazinones et leurs applications
US4578459A (en) Heterocyclic alkylaminoheterocycles
JPS58208289A (ja) キナゾリン化合物とそれからなる強心剤
KR840001284B1 (ko) 2-이미다졸린 유도체류의 제조방법
US4470985A (en) Pharmacologically active compounds
KR850000766B1 (ko) 티아졸린 유도체의 제조방법
KR790001869B1 (ko) 피페리딘 유도체의 제조방법
KR800000411B1 (ko) 퀴나졸린 유도체의 제조방법
KR790001322B1 (ko) 1, 2, 3, 4-테트라하이드로이소퀴놀린 유도체의 제조법
US3910914A (en) 5-Heterocyclic-1,2,3,6-tetrahydro-4(5H)-pyrimidinethiones and pyrimidinone intermediates therefor
GB2038798A (en) (Hydroxymethyl imidazolyl) methylthioethyl guanidine derivatives

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19851106

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19851106