KR20250093593A - 골수증식성 장애를 치료하기 위한 방법 - Google Patents

골수증식성 장애를 치료하기 위한 방법 Download PDF

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KR20250093593A
KR20250093593A KR1020257020329A KR20257020329A KR20250093593A KR 20250093593 A KR20250093593 A KR 20250093593A KR 1020257020329 A KR1020257020329 A KR 1020257020329A KR 20257020329 A KR20257020329 A KR 20257020329A KR 20250093593 A KR20250093593 A KR 20250093593A
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tβrii
antagonist
myelofibrosis
antibody
patient
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Korean (ko)
Inventor
라빈드라 쿠마르
나가 벤카타 사이 라자세카르 수라가니
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악셀레론 파마 인코포레이티드
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Publication of KR20250093593A publication Critical patent/KR20250093593A/ko
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
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  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
KR1020257020329A 2015-08-04 2016-08-04 골수증식성 장애를 치료하기 위한 방법 Pending KR20250093593A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562201058P 2015-08-04 2015-08-04
US62/201,058 2015-08-04
US201562263603P 2015-12-04 2015-12-04
US62/263,603 2015-12-04
PCT/US2016/045631 WO2017024171A1 (en) 2015-08-04 2016-08-04 Methods for treating myeloproliferative disorders
KR1020187006105A KR102824235B1 (ko) 2015-08-04 2016-08-04 골수증식성 장애를 치료하기 위한 방법

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KR20250093593A true KR20250093593A (ko) 2025-06-24

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KR1020187006105A Active KR102824235B1 (ko) 2015-08-04 2016-08-04 골수증식성 장애를 치료하기 위한 방법

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US (4) US9884900B2 (enExample)
EP (2) EP3331550B1 (enExample)
JP (3) JP7320350B2 (enExample)
KR (2) KR20250093593A (enExample)
CN (2) CN116327952A (enExample)
AU (2) AU2016301380B2 (enExample)
CA (1) CA2994413A1 (enExample)
HK (1) HK1256638A1 (enExample)
WO (1) WO2017024171A1 (enExample)

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US20210113524A1 (en) * 2018-05-31 2021-04-22 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods of treating myeloproliferative disorders
WO2020068755A1 (en) * 2018-09-25 2020-04-02 Impact Biomedicines, Inc. Methods of treating myeloproliferative disorders
WO2021021528A1 (en) * 2019-07-26 2021-02-04 Board Of Trustees Of Michigan State University Methods of preventing or treating fatty degeneration of skeletal muscle
KR20220088699A (ko) 2019-09-27 2022-06-28 디스크 메디슨, 인크. 골수섬유증 및 관련 상태의 치료 방법
US20220347182A1 (en) * 2019-10-02 2022-11-03 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for the treatment of osteoarthritis
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JP2023528223A (ja) 2020-05-13 2023-07-04 ディスク・メディシン・インコーポレイテッド 骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体
CN116635036B (zh) * 2020-12-18 2025-06-17 努瓦米德股份有限公司 烟酰胺单核苷酸衍生物及其在治疗和预防红细胞病症中的用途
KR102794148B1 (ko) * 2021-08-18 2025-04-11 주식회사 삼양홀딩스 룩소리티닙의 경구용 정제 조성물 및 이의 제조 방법

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