KR20240152957A - 알츠하이머 질환의 치료 방법 - Google Patents
알츠하이머 질환의 치료 방법 Download PDFInfo
- Publication number
- KR20240152957A KR20240152957A KR1020247033653A KR20247033653A KR20240152957A KR 20240152957 A KR20240152957 A KR 20240152957A KR 1020247033653 A KR1020247033653 A KR 1020247033653A KR 20247033653 A KR20247033653 A KR 20247033653A KR 20240152957 A KR20240152957 A KR 20240152957A
- Authority
- KR
- South Korea
- Prior art keywords
- patient
- body weight
- antibody
- dose
- administering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000024827 Alzheimer disease Diseases 0.000 title claims abstract description 171
- 238000000034 method Methods 0.000 title claims abstract description 117
- 206010072599 Amyloid related imaging abnormalities Diseases 0.000 claims abstract description 100
- 241000282414 Homo sapiens Species 0.000 claims abstract description 57
- 230000002829 reductive effect Effects 0.000 claims abstract description 46
- 230000001965 increasing effect Effects 0.000 claims abstract description 13
- 230000037396 body weight Effects 0.000 claims description 206
- 238000011282 treatment Methods 0.000 claims description 82
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 52
- 108010060159 Apolipoprotein E4 Proteins 0.000 claims description 35
- 208000024891 symptom Diseases 0.000 claims description 33
- 230000000737 periodic effect Effects 0.000 claims description 16
- 230000001225 therapeutic effect Effects 0.000 claims description 15
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 13
- 206010030113 Oedema Diseases 0.000 claims description 13
- 230000000982 vasogenic effect Effects 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
- 230000000069 prophylactic effect Effects 0.000 claims description 5
- 206010067277 Cerebral microhaemorrhage Diseases 0.000 claims description 4
- 230000003442 weekly effect Effects 0.000 claims description 4
- 239000000902 placebo Substances 0.000 description 34
- 229940068196 placebo Drugs 0.000 description 34
- 230000009467 reduction Effects 0.000 description 34
- 239000000969 carrier Substances 0.000 description 32
- 229950008995 aducanumab Drugs 0.000 description 28
- 210000004556 brain Anatomy 0.000 description 28
- 108010025628 Apolipoproteins E Proteins 0.000 description 27
- 102000013918 Apolipoproteins E Human genes 0.000 description 27
- 238000002600 positron emission tomography Methods 0.000 description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 21
- 230000000694 effects Effects 0.000 description 21
- 201000010099 disease Diseases 0.000 description 20
- 206010012289 Dementia Diseases 0.000 description 19
- 208000032843 Hemorrhage Diseases 0.000 description 19
- 238000002595 magnetic resonance imaging Methods 0.000 description 19
- 231100000673 dose–response relationship Toxicity 0.000 description 17
- 241000699670 Mus sp. Species 0.000 description 15
- 230000008859 change Effects 0.000 description 15
- 238000004448 titration Methods 0.000 description 14
- YNDIAUKFXKEXSV-CRYLGTRXSA-N florbetapir F-18 Chemical compound C1=CC(NC)=CC=C1\C=C\C1=CC=C(OCCOCCOCC[18F])N=C1 YNDIAUKFXKEXSV-CRYLGTRXSA-N 0.000 description 13
- 238000005259 measurement Methods 0.000 description 11
- 208000037259 Amyloid Plaque Diseases 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- 238000003384 imaging method Methods 0.000 description 10
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 9
- 230000001149 cognitive effect Effects 0.000 description 9
- 239000002131 composite material Substances 0.000 description 9
- 231100000062 no-observed-adverse-effect level Toxicity 0.000 description 9
- 208000031856 Haemosiderosis Diseases 0.000 description 8
- 208000010877 cognitive disease Diseases 0.000 description 8
- 230000006735 deficit Effects 0.000 description 8
- 108010090849 Amyloid beta-Peptides Proteins 0.000 description 7
- 102000013455 Amyloid beta-Peptides Human genes 0.000 description 7
- 238000012879 PET imaging Methods 0.000 description 7
- 230000015654 memory Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 description 6
- 208000035868 Vascular inflammations Diseases 0.000 description 6
- 239000000090 biomarker Substances 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 102000013498 tau Proteins Human genes 0.000 description 6
- 108010026424 tau Proteins Proteins 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 230000005856 abnormality Effects 0.000 description 5
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 description 5
- 230000027455 binding Effects 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 239000003446 ligand Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000004770 neurodegeneration Effects 0.000 description 5
- 210000002682 neurofibrillary tangle Anatomy 0.000 description 5
- 230000007170 pathology Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 208000028698 Cognitive impairment Diseases 0.000 description 4
- 206010061818 Disease progression Diseases 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 4
- 230000001174 ascending effect Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000002490 cerebral effect Effects 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 230000001054 cortical effect Effects 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- JXSJBGJIGXNWCI-UHFFFAOYSA-N diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate Chemical compound CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC JXSJBGJIGXNWCI-UHFFFAOYSA-N 0.000 description 4
- 230000005750 disease progression Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000000700 radioactive tracer Substances 0.000 description 4
- 238000011287 therapeutic dose Methods 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- ZCXUVYAZINUVJD-AHXZWLDOSA-N 2-deoxy-2-((18)F)fluoro-alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H]([18F])[C@@H](O)[C@@H]1O ZCXUVYAZINUVJD-AHXZWLDOSA-N 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 108010064397 amyloid beta-protein (1-40) Proteins 0.000 description 3
- 230000006399 behavior Effects 0.000 description 3
- 230000003542 behavioural effect Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000003759 clinical diagnosis Methods 0.000 description 3
- 230000019771 cognition Effects 0.000 description 3
- 230000009760 functional impairment Effects 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000006996 mental state Effects 0.000 description 3
- 230000003557 neuropsychological effect Effects 0.000 description 3
- 230000001936 parietal effect Effects 0.000 description 3
- 230000001575 pathological effect Effects 0.000 description 3
- 230000008289 pathophysiological mechanism Effects 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 230000000750 progressive effect Effects 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 208000023366 superficial siderosis Diseases 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 230000036962 time dependent Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 231100000041 toxicology testing Toxicity 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 208000032862 Clinical Deterioration Diseases 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010072810 Vascular wall hypertrophy Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000007792 alzheimer disease pathology Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000006736 behavioral deficit Effects 0.000 description 2
- 230000013629 beta-amyloid clearance Effects 0.000 description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 231100000876 cognitive deterioration Toxicity 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 229940000406 drug candidate Drugs 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 2
- 230000000971 hippocampal effect Effects 0.000 description 2
- 230000003118 histopathologic effect Effects 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 231100000682 maximum tolerated dose Toxicity 0.000 description 2
- 208000027061 mild cognitive impairment Diseases 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 230000002981 neuropathic effect Effects 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 238000011830 transgenic mouse model Methods 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 238000002562 urinalysis Methods 0.000 description 2
- 230000001755 vocal effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
- 238000010176 18-FDG-positron emission tomography Methods 0.000 description 1
- YNDIAUKFXKEXSV-NSCUHMNNSA-N 4-[(e)-2-[6-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]pyridin-3-yl]ethenyl]-n-methylaniline Chemical compound C1=CC(NC)=CC=C1\C=C\C1=CC=C(OCCOCCOCCF)N=C1 YNDIAUKFXKEXSV-NSCUHMNNSA-N 0.000 description 1
- 208000006888 Agnosia Diseases 0.000 description 1
- 241001047040 Agnosia Species 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 241000270491 Ameiva Species 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 description 1
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 1
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 1
- 206010059245 Angiopathy Diseases 0.000 description 1
- 102100029470 Apolipoprotein E Human genes 0.000 description 1
- 101710095339 Apolipoprotein E Proteins 0.000 description 1
- 206010003062 Apraxia Diseases 0.000 description 1
- 230000007082 Aβ accumulation Effects 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000031124 Dementia Alzheimer type Diseases 0.000 description 1
- 206010048554 Endothelial dysfunction Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 108010017480 Hemosiderin Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 238000012307 MRI technique Methods 0.000 description 1
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 208000034819 Mobility Limitation Diseases 0.000 description 1
- 206010027951 Mood swings Diseases 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 206010037180 Psychiatric symptoms Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 208000012759 altered mental status Diseases 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 1
- 230000003941 amyloidogenesis Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 238000011952 auditory verbal learning test Methods 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 229950001863 bapineuzumab Drugs 0.000 description 1
- 208000013404 behavioral symptom Diseases 0.000 description 1
- 238000001815 biotherapy Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000001638 cerebellum Anatomy 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000007213 cerebrovascular event Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 230000007278 cognition impairment Effects 0.000 description 1
- 230000003930 cognitive ability Effects 0.000 description 1
- 208000004209 confusion Diseases 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000005786 degenerative changes Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 206010013395 disorientation Diseases 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- -1 e.g. Substances 0.000 description 1
- 230000005584 early death Effects 0.000 description 1
- 230000001490 effect on brain Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000008694 endothelial dysfunction Effects 0.000 description 1
- 230000001073 episodic memory Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000035557 fibrillogenesis Effects 0.000 description 1
- 210000001652 frontal lobe Anatomy 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 208000018914 glucose metabolism disease Diseases 0.000 description 1
- 210000004884 grey matter Anatomy 0.000 description 1
- 210000004124 hock Anatomy 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000012623 in vivo measurement Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000002075 inversion recovery Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 210000002418 meninge Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000051 modifying effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000003562 morphometric effect Effects 0.000 description 1
- 238000013425 morphometry Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 230000001423 neocortical effect Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000003961 neuronal insult Effects 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 210000000869 occipital lobe Anatomy 0.000 description 1
- 210000001152 parietal lobe Anatomy 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 239000000092 prognostic biomarker Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 238000013102 re-test Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000003976 synaptic dysfunction Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000440 toxicity profile Toxicity 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086674P | 2014-12-02 | 2014-12-02 | |
| US62/086,674 | 2014-12-02 | ||
| US201562111874P | 2015-02-04 | 2015-02-04 | |
| US62/111,874 | 2015-02-04 | ||
| US201562149133P | 2015-04-17 | 2015-04-17 | |
| US62/149,133 | 2015-04-17 | ||
| US201562195119P | 2015-07-21 | 2015-07-21 | |
| US62/195,119 | 2015-07-21 | ||
| PCT/IB2015/002465 WO2016087944A2 (en) | 2014-12-02 | 2015-12-02 | Method for treating alzheimer's disease |
| KR1020227010447A KR20220044874A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227010447A Division KR20220044874A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240152957A true KR20240152957A (ko) | 2024-10-22 |
Family
ID=55358010
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177015204A Ceased KR20170088360A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
| KR1020247033653A Pending KR20240152957A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
| KR1020227010447A Ceased KR20220044874A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177015204A Ceased KR20170088360A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227010447A Ceased KR20220044874A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10842871B2 (enExample) |
| EP (1) | EP3227329A2 (enExample) |
| JP (5) | JP2017537905A (enExample) |
| KR (3) | KR20170088360A (enExample) |
| AU (3) | AU2015356773B2 (enExample) |
| CA (1) | CA2967897A1 (enExample) |
| EA (1) | EA201791199A1 (enExample) |
| IL (3) | IL311405A (enExample) |
| MA (1) | MA41115A (enExample) |
| MX (2) | MX385045B (enExample) |
| WO (1) | WO2016087944A2 (enExample) |
| ZA (1) | ZA202107358B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| IL263433B2 (en) * | 2016-06-07 | 2024-03-01 | Biogen Int Neuroscience Gmbh | Methods for treating alzheimer's disease |
| TWI735600B (zh) * | 2016-07-01 | 2021-08-11 | 美商美國禮來大藥廠 | 抗－N3pGlu類澱粉β肽抗體及其用途 |
| CA3032289A1 (en) * | 2016-07-29 | 2018-02-01 | Biogen Chesapeake Llc | Methods of treating or preventing amyloid related imaging abnormalities associated with alzheimer's disease treatment |
| AU2017347838B2 (en) * | 2016-10-27 | 2023-04-27 | Eisai R&D Management Co., Ltd. | Composition comprising an anti-Αβ protofibril antibody and a beta-secretase BACE1 inhibitor for the treatment of Alzheimer's disease |
| US10662226B2 (en) | 2016-10-28 | 2020-05-26 | The Regents of the University of Caiifomia | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
| WO2019023247A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND |
| SMT202300129T1 (it) | 2017-08-22 | 2023-05-12 | Biogen Ma Inc | Composizioni farmaceutiche contenenti anticorpi anti-beta amiloide |
| IL280315B2 (en) * | 2018-07-24 | 2024-06-01 | Eisai R&D Man Co Ltd | Methods for treating and preventing Alzheimer's disease |
| EP3918323A4 (en) | 2019-01-30 | 2022-12-28 | TrueBinding, Inc. | ANTI-GAL3 ANTIBODIES AND USES THEREOF |
| KR20220084095A (ko) * | 2019-10-22 | 2022-06-21 | 바이오젠 엠에이 인코포레이티드 | 알츠하이머병의 치료를 위한 항-베타-아밀로이드 항체 |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| MX2023000949A (es) | 2020-07-23 | 2023-02-22 | Othair Prothena Ltd | Anticuerpos anti-beta-amiloide (abeta). |
| TW202313111A (zh) * | 2021-06-07 | 2023-04-01 | 美商百健Ｍａ公司 | 治療阿茲海默症之方法 |
| AU2022291395A1 (en) | 2021-06-11 | 2024-01-04 | Sage Therapeutics, Inc. | Neuroactive steroid for the treatment of alzheimer's disease |
| KR102753583B1 (ko) | 2021-11-11 | 2025-01-10 | 의료법인 명지의료재단 | Kras 특이적 활성화 t 세포 유도용 항원 조성물 |
| EP4499154A1 (en) | 2022-03-25 | 2025-02-05 | REGENXBIO Inc. | Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy |
| WO2023210405A1 (ja) | 2022-04-25 | 2023-11-02 | 公益財団法人東京都医学総合研究所 | 変異型の神経変性疾患関連タンパク質 |
| US20230360721A1 (en) * | 2022-05-03 | 2023-11-09 | Hoffmann-La Roche Inc. | In silico predictions of amyloid-related imaging abnormalities |
| TW202508603A (zh) | 2023-05-02 | 2025-03-01 | 美商賽吉醫療公司 | 神經活性類固醇調配物及其使用方法 |
Family Cites Families (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| FR2686087A1 (fr) | 1992-01-13 | 1993-07-16 | Inst Nat Sante Rech Med | Nouvel antigene lymphocytaire, anticorps correspondant et leurs applications. |
| EP1001019A1 (en) | 1993-10-27 | 2000-05-17 | Athena Neurosciences, Inc. | Transgenic animals harboring APP Allele having Swedish mutation |
| US5876950A (en) | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
| US8173127B2 (en) | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
| WO1998044955A1 (en) | 1997-04-09 | 1998-10-15 | Mindset Ltd. | Recombinant antibodies specific for beta-amyloid ends, dna encoding and methods of use thereof |
| US20020086847A1 (en) | 1997-04-09 | 2002-07-04 | Mindset Biopharmaceuticals (Usa) | Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof |
| US6703015B1 (en) | 1999-09-03 | 2004-03-09 | Ramot At Tel-Aviv University Ltd. | Filamentous bacteriophage displaying an β-amyloid epitope |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6710226B1 (en) | 1997-12-02 | 2004-03-23 | Neuralab Limited | Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics |
| US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| WO1999050300A1 (en) | 1998-03-30 | 1999-10-07 | The Trustees Of The University Of Pennsylvania | Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| CA2349434A1 (en) | 1999-09-03 | 2001-03-15 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases |
| US6713058B2 (en) | 1999-09-14 | 2004-03-30 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with neuropathic conditions comprising administration of low levels of antibodies |
| US6187309B1 (en) | 1999-09-14 | 2001-02-13 | Milkaus Laboratory, Inc. | Method for treatment of symptoms of central nervous system disorders |
| US6294171B2 (en) | 1999-09-14 | 2001-09-25 | Milkhaus Laboratory, Inc. | Methods for treating disease states comprising administration of low levels of antibodies |
| US6436401B1 (en) | 1999-09-14 | 2002-08-20 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with diabetes and diabetic neuropathy comprising administration of low levels of antibodies |
| EP1232283B1 (fr) | 1999-10-27 | 2006-05-24 | Université de Liège | Immuno PCR en temps réel utilisant un ADN-chimère comme marqueur d'amplification |
| PL208113B1 (pl) | 2000-06-22 | 2011-03-31 | Genentech Inc | Agonistyczne przeciwciało monoklonalne anty-trkC, mysie agonistyczne przeciwciało monoklonalne, ludzkie agonistyczne przeciwciało monoklonalne, wyizolowana cząsteczka kwasu nukleinowego kodująca mysie agonistyczne przeciwciało monoklonalne, wyizolowana cząsteczka kwasu nukleinowego kodująca ludzkie przeciwciało anty-trkC, cząsteczka kwasu nukleinowego, linia komórek gospodarza, linia komórek hybrydomy, przeciwciało wytwarzane przez tę linię komórek hybrydomy, wyizolowana cząsteczka kwasu nukleinowego i wektor zawierający tę cząsteczkę kwasu nukleinowego, przeciwciało, polipeptyd, kompozycja |
| EP1309341A2 (en) | 2000-07-07 | 2003-05-14 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| EP1172378A1 (en) | 2000-07-12 | 2002-01-16 | Richard Dr. Dodel | Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US20030028904A1 (en) | 2001-04-19 | 2003-02-06 | Gumienny Tina L. | Genes involved in engulfment of dying cells and cell migration |
| EP1944040B1 (en) | 2001-08-17 | 2012-08-01 | Washington University | Assay method for Alzheimer's disease |
| US7414111B2 (en) | 2001-09-19 | 2008-08-19 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
| GB0203446D0 (en) | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| ES2368907T3 (es) | 2002-04-19 | 2011-11-23 | The Governing Council Of The University Of Toronto | Procedimientos y composiciones inmunológicas para el tratamiento de la enfermedad de alzheimer. |
| US20110200609A1 (en) | 2002-09-12 | 2011-08-18 | The Regents Of The University Of California | Monoclonal antibodies specific for pathological amyloid aggregates common to amyloids formed from proteins of differing sequence |
| CA2501945A1 (en) | 2002-10-09 | 2004-04-22 | Rinat Neuroscience Corp. | Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof |
| US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| TW200509968A (en) | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
| ATE455853T1 (de) | 2002-11-22 | 2010-02-15 | Chugai Pharmaceutical Co Ltd | Antikörper gegen geschädigtes gewebe |
| HRP20050934B1 (hr) | 2003-04-04 | 2014-09-26 | Genentech, Inc. | Formulacije s visokom koncentracijom antitijela i proteina |
| AU2003276107A1 (en) | 2003-04-24 | 2004-11-19 | Universitat Zurich | Method of monitoring immunotherapy |
| TWI306458B (en) | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
| WO2005018424A2 (en) | 2003-08-18 | 2005-03-03 | Research Foundation For Mental Hygiene, Inc. | Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits |
| WO2005025616A1 (ja) | 2003-09-09 | 2005-03-24 | Takeda Pharmaceutical Company Limited | 抗体の用途 |
| US7674599B2 (en) | 2003-11-08 | 2010-03-09 | Elan Pharmaceuticals, Inc. | Methods of using antibodies to detect alpha-synuclein in fluid samples |
| US20060094064A1 (en) | 2003-11-19 | 2006-05-04 | Sandip Ray | Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids |
| ES2375627T3 (es) | 2004-02-23 | 2012-03-02 | Eli Lilly And Company | Anticuerpos anti-abeta. |
| JP4885122B2 (ja) | 2004-04-15 | 2012-02-29 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 癌、器官傷害、および筋肉リハビリテーション／運動過剰訓練についての診断の生物マーカーとしてのタンパク質分解マーカー |
| CA2564432A1 (en) | 2004-04-27 | 2005-11-10 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Human anti-amyloid .beta. peptide antibody and fragment of said antibody |
| ATE476993T1 (de) | 2004-06-07 | 2010-08-15 | Univ Ramot | Verfahren zur passiven immunisierung gegen eine durch amyloidaggregation gekennzeichnete krankheit oder erkrankung mit vermindertem nervenentzündungsrisiko |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| US20060062859A1 (en) | 2004-08-05 | 2006-03-23 | Kenneth Blum | Composition and method to optimize and customize nutritional supplement formulations by measuring genetic and metabolomic contributing factors to disease diagnosis, stratification, prognosis, metabolism, and therapeutic outcomes |
| MX2007001679A (es) | 2004-08-09 | 2007-05-23 | Elan Pharm Inc | Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica. |
| WO2006050041A2 (en) | 2004-10-28 | 2006-05-11 | Ramot At Tel Aviv University Ltd. | Methods for reducing or inhibiting brain inflammation or for promoting neurogenesis |
| ES2396555T3 (es) | 2004-12-15 | 2013-02-22 | Janssen Alzheimer Immunotherapy | Anticuerpos que reconocen péptido beta amiloide |
| PE20061401A1 (es) | 2004-12-15 | 2006-12-23 | Neuralab Ltd | ANTICUERPOS Aß PARA MEJORAR LA COGNICION |
| EP2204381A1 (en) | 2005-03-05 | 2010-07-07 | Abbott GmbH & Co. KG | Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies |
| JP2006265189A (ja) | 2005-03-24 | 2006-10-05 | Kyoto Univ | βアミロイドペプチド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法 |
| ES2318918B1 (es) | 2005-04-01 | 2010-02-16 | Biotherapix Molecular Medicines, S.L.U. | Anticuerpos humanos con capacidad de union al peptido beta-amiloide y sus aplicaciones. |
| WO2006116192A2 (en) | 2005-04-21 | 2006-11-02 | Medarex, Inc. | Irta-1 antibodies and their uses |
| UY29504A1 (es) | 2005-04-29 | 2006-10-31 | Rinat Neuroscience Corp | Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos. |
| CA2657953A1 (en) | 2005-07-19 | 2007-01-25 | University Of Rochester | Alpha-synuclein antibodies and methods related thereto |
| WO2007021255A1 (en) | 2005-08-09 | 2007-02-22 | Elan Pharmaceuticals, Inc. | Antibodies to alpha-synuclein |
| JP2009521403A (ja) | 2005-11-14 | 2009-06-04 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | Ｍｒｉによる神経発生の相関の画像法 |
| WO2007062088A1 (en) | 2005-11-22 | 2007-05-31 | The Trustees Of The University Of Pennsylvania | Antibody treatment of alzheimer's and related diseases |
| DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
| CA2628703C (en) | 2005-11-30 | 2019-10-29 | Abbott Laboratories | Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| CN101528770A (zh) | 2005-11-30 | 2009-09-09 | 艾博特公司 | 制备重组形式的人β-淀粉样蛋白的方法和这些蛋白质的应用 |
| NZ568016A (en) * | 2005-12-07 | 2011-12-22 | Medarex Inc | CTLA-4 antibody dosage escalation regimens |
| MX358175B (es) | 2005-12-12 | 2018-08-08 | Ac Immune Sa | Anticuerpos monoclonales especificos 1-42 beta con propiedades terapeuticas. |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| US8497246B2 (en) | 2006-08-18 | 2013-07-30 | Armagen Technologies, Inc. | Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| DK2099826T3 (da) | 2007-01-05 | 2014-01-20 | Univ Zuerich | Anti-beta-amyloid-antistof og anvendelser deraf |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| TW200837080A (en) | 2007-01-09 | 2008-09-16 | Wyeth Corp | Anti-IL-13 antibody formulations and uses thereof |
| JP5558834B2 (ja) | 2007-02-23 | 2014-07-23 | ヤンセン アルツハイマー イミュノセラピー | シヌクレイノパチーおよびアミロイド形成疾患（ａｍｙｌｏｉｄｏｇｅｎｉｃｄｉｓｅａｓｅ）の予防および処置 |
| MX2009009926A (es) | 2007-03-13 | 2010-03-15 | Univ Zuerich | Anticuerpo tumor-especifico humano monoclonal. |
| US20080292625A1 (en) | 2007-04-18 | 2008-11-27 | Sally Schroeter | Prevention and treatment of cerebral amyloid angiopathy |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| JP2008309778A (ja) | 2007-05-11 | 2008-12-25 | Daiichi Sankyo Co Ltd | ポリペプチドの検出又は定量方法、及び装置 |
| EP2162471A1 (en) | 2007-06-08 | 2010-03-17 | Université de la Méditerranée | Compositions and methods for treating pancreatic tumors |
| US8022268B2 (en) | 2007-06-11 | 2011-09-20 | The University Of Zurich | Transgenic animal model for alzheimer's disease |
| SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
| JP2010536907A (ja) | 2007-08-31 | 2010-12-02 | ニューリミューン セラピューティクス エイジー | 患者にアミロイドーシスおよびタンパク質凝集性障害における特異的免疫応答をもたらす方法 |
| WO2009033743A1 (en) | 2007-09-13 | 2009-03-19 | University Of Zurich Prorektorat Forschung | Monoclonal amyloid beta (abeta)-specific antibody and uses thereof |
| CA2700723A1 (en) | 2007-09-26 | 2009-04-02 | Amgen Inc. | Heparin-binding epidermal growth factor-like growth factor antigen binding proteins |
| AU2008307144B2 (en) | 2007-10-02 | 2012-12-20 | Csl Limited | Therapeutic antibody purification method and method of use |
| US7771957B2 (en) | 2007-10-19 | 2010-08-10 | The Regents Of The University Of California | Method for diagnosing alzheimer's disease |
| AU2008312802A1 (en) | 2007-10-19 | 2009-04-23 | Immunas Pharma, Inc. | Antibody capable of specifically binding to abeta oligomer, and use thereof |
| GB0720912D0 (en) | 2007-10-25 | 2007-12-05 | Univ Cardiff | Monoclonal Anitbody for APP |
| UA103602C2 (ru) | 2007-10-29 | 2013-11-11 | Енсерм (Енстітю Насьональ Де Ля Санте Е Де Ля Решер Медікалє) | АНТИТЕЛО, СПЕЦИФИЧНОЕ К β-АМИЛОИДНЫМ ПЕПТИДАМ, И ЕГО ПРИМЕНЕНИЕ В КАЧЕСТВЕ ДИАГНОСТИЧЕСКОГО ИЛИ ЛЕКАРСТВЕННОГО СРЕДСТВА |
| SI2207568T1 (sl) | 2007-11-16 | 2017-11-30 | The Rockefeller University | Protitelesa specifična za protifibrilno obliko beta-amiloidnega proteina |
| EP2261254A3 (en) | 2007-12-21 | 2011-04-13 | Amgen, Inc | Anti-amyloid antibodies and uses thereof |
| WO2009094592A2 (en) | 2008-01-23 | 2009-07-30 | Perlegen Sciences, Inc. | Genetic basis of alzheimer's disease and diagnosis and treatment thereof |
| WO2009099176A1 (ja) | 2008-02-08 | 2009-08-13 | Immunas Pharma, Inc. | Aβオリゴマーに特異的に結合する抗体およびその利用 |
| LT2282758T (lt) | 2008-04-29 | 2019-03-12 | Bioarctic Ab | Antikūnai ir vakcinos, skirti su alfa sinukleinu susijusių sutrikimų gydymo ir diagnostiniams metodams |
| EP2321348A2 (en) | 2008-07-09 | 2011-05-18 | University of Zürich | Method of promoting neurogenesis |
| CN102388067A (zh) | 2008-09-19 | 2012-03-21 | 米迪缪尼有限公司 | 定向于cd105的抗体及其用途 |
| DK2365804T3 (en) | 2008-11-13 | 2015-07-27 | Modgene Llc | The reduction of amyloid-beta burden in tissues that are not derived from brain |
| CA2746778C (en) | 2008-12-19 | 2019-04-23 | University Of Zurich | Human anti-alpha-synuclein autoantibodies |
| ES2641612T3 (es) | 2009-04-17 | 2017-11-10 | Immunas Pharma, Inc. | Anticuerpos que se unen específicamente a oligómeros de beta A y uso de los mismos |
| US20110237537A1 (en) | 2009-05-29 | 2011-09-29 | Lombard Jay L | Methods for assessment and treatment of mood disorders via single nucleotide polymorphisms analysis |
| ES2614949T3 (es) | 2009-08-06 | 2017-06-02 | Immunas Pharma, Inc. | Anticuerpos que se unen específicamente a oligómeros beta A y uso de los mismos |
| JP5769316B2 (ja) | 2009-08-06 | 2015-08-26 | イムナス・ファーマ株式会社 | Ａβオリゴマーに特異的に結合する抗体およびその利用 |
| CN102666577A (zh) | 2009-11-24 | 2012-09-12 | 前体生物药物股份公司 | 诊断阿尔茨海默病或轻度认知损害的新的诊断方法 |
| EP2862929B1 (en) | 2009-12-09 | 2017-09-06 | Quark Pharmaceuticals, Inc. | Compositions and methods for treating diseases, disorders or injury of the CNS |
| US20110152341A1 (en) | 2009-12-22 | 2011-06-23 | Probiodrug Ag | Cleavage of b-amyloid precursor protein |
| US9297808B2 (en) | 2010-07-07 | 2016-03-29 | Thermo Fisher Scientific Gmbh | Analyte mass spectrometry quantitation using a universal reporter |
| PT3042917T (pt) | 2010-08-12 | 2018-05-02 | Lilly Co Eli | Anticorpos do péptido beta amilóide anti-n3pglu e seus usos |
| CN103339146B (zh) | 2010-10-11 | 2017-09-01 | 比奥根国际神经科学公司 | 人抗tau抗体 |
| JP6067575B2 (ja) | 2010-12-17 | 2017-01-25 | ニューリミューン ホールディング エイジー | ヒト抗ｓｏｄ１抗体 |
| WO2012174262A2 (en) | 2011-06-14 | 2012-12-20 | Cenestra Llc | Formulations and methods of treating subjects having central nervous system, endocrine, inflammatory or cardiovascular disorders or at-risk thereof with highly purified omega-3 fatty acid formulations |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| MY167795A (en) | 2011-10-28 | 2018-09-26 | Biogen Int Neuroscience Gmbh | Tdp-43 specefic binding molecules |
| US20130164367A1 (en) | 2011-12-08 | 2013-06-27 | The Board Of Regents Of The University Of Texas System | Treatment of neurodegenerative disease with creb-binding protein |
| ITRM20120383A1 (it) | 2012-03-20 | 2013-09-21 | Uni Degli Studi Di Milano B Icocca | Metodo e kit per la rivelazione di anticorpi. |
| KR102117969B1 (ko) | 2012-09-12 | 2020-06-04 | 뉴리뮨 홀딩 아게 | 인간 섬 아밀로이드 폴리펩티드(hiapp) 특이적 항체 및 이들의 용도 |
| EP2928494A4 (en) | 2012-12-07 | 2016-11-02 | Biogen Internat Neuroscience Gmbh | METHOD FOR REDUCING AMYLOIDER PLAQUE OF BRAIN WITH ANTI-ASS ANTIBODIES |
| US20140274764A1 (en) | 2013-03-15 | 2014-09-18 | Pathway Genomics Corporation | Method and system to predict response to treatments for mental disorders |
| US20140272950A1 (en) | 2013-03-15 | 2014-09-18 | Pathway Genomics Corporation | Method and system to predict ssri response |
| PT2994160T (pt) | 2013-05-06 | 2019-08-07 | Baxalta Inc | Tratamento de sub-populações com doença de alzheimer com imunoglobulina g combinada |
| US20160177390A1 (en) | 2013-07-12 | 2016-06-23 | Biogen International Neuroscience Gmbh | Genetic and image biomarkets associated with decline in cognitive measures and brain glucose metabolism in populations with alzheimer's disease or those susceptible to developing alzheimer's disease |
| NZ721048A (en) | 2013-12-20 | 2020-08-28 | Neurimmune Holding Ag | Antibody-based therapy of transthyretin (ttr) amyloidosis and human-derived antibodies therefor |
| EP3718563A1 (en) | 2014-02-08 | 2020-10-07 | F. Hoffmann-La Roche AG | Methods of treating alzheimer's disease |
| WO2015175769A1 (en) | 2014-05-15 | 2015-11-19 | Biogen Ma Inc. | Methods for the detection of amyloid beta oligomers in biological samples |
| WO2015191825A1 (en) | 2014-06-13 | 2015-12-17 | Biogen Ma Inc. | Methods for the detection and measurement of amyloid beta in biological samples |
| EP4406549A3 (en) | 2014-07-29 | 2025-01-08 | Neurimmune Holding AG | Human-derived anti-huntingtin (htt) antibodies and uses thereof |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| MA43723A (fr) | 2016-03-14 | 2021-05-19 | Biogen Int Neuroscience Gmbh | Essai employant la phagocytose à médiation cellulaire initié par anticorps pour mesurer des protéines agrégées |
-
2015
- 2015-12-01 MA MA041115A patent/MA41115A/fr unknown
- 2015-12-02 IL IL311405A patent/IL311405A/en unknown
- 2015-12-02 AU AU2015356773A patent/AU2015356773B2/en active Active
- 2015-12-02 WO PCT/IB2015/002465 patent/WO2016087944A2/en not_active Ceased
- 2015-12-02 EA EA201791199A patent/EA201791199A1/ru unknown
- 2015-12-02 KR KR1020177015204A patent/KR20170088360A/ko not_active Ceased
- 2015-12-02 MX MX2017006789A patent/MX385045B/es unknown
- 2015-12-02 CA CA2967897A patent/CA2967897A1/en active Pending
- 2015-12-02 KR KR1020247033653A patent/KR20240152957A/ko active Pending
- 2015-12-02 US US15/531,960 patent/US10842871B2/en active Active
- 2015-12-02 KR KR1020227010447A patent/KR20220044874A/ko not_active Ceased
- 2015-12-02 IL IL285722A patent/IL285722B2/en unknown
- 2015-12-02 JP JP2017527872A patent/JP2017537905A/ja not_active Withdrawn
- 2015-12-02 EP EP15834670.0A patent/EP3227329A2/en active Pending
-
2017
- 2017-05-22 IL IL252433A patent/IL252433B/en unknown
- 2017-05-24 MX MX2021009053A patent/MX2021009053A/es unknown
-
2020
- 2020-01-15 JP JP2020004429A patent/JP2020055880A/ja not_active Withdrawn
-
2021
- 2021-08-04 JP JP2021127999A patent/JP2021169536A/ja not_active Withdrawn
- 2021-09-30 ZA ZA2021/07358A patent/ZA202107358B/en unknown
- 2021-12-08 AU AU2021282448A patent/AU2021282448A1/en not_active Abandoned
-
2022
- 2022-11-25 JP JP2022188107A patent/JP2023011002A/ja not_active Withdrawn
-
2025
- 2025-02-21 AU AU2025201237A patent/AU2025201237A1/en active Pending
- 2025-10-03 JP JP2025167679A patent/JP2025182058A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025182058A (ja) | 2025-12-11 |
| NZ731520A (en) | 2021-08-27 |
| EP3227329A2 (en) | 2017-10-11 |
| AU2021282448A1 (en) | 2022-01-06 |
| IL252433B (en) | 2021-09-30 |
| IL285722A (en) | 2021-09-30 |
| AU2015356773B2 (en) | 2021-09-09 |
| JP2023011002A (ja) | 2023-01-20 |
| WO2016087944A3 (en) | 2016-08-04 |
| JP2021169536A (ja) | 2021-10-28 |
| CA2967897A1 (en) | 2016-06-09 |
| IL285722B2 (en) | 2024-08-01 |
| AU2015356773A1 (en) | 2017-05-25 |
| IL252433A0 (en) | 2017-07-31 |
| IL285722B1 (en) | 2024-04-01 |
| ZA202107358B (en) | 2025-01-29 |
| KR20170088360A (ko) | 2017-08-01 |
| MX2021009053A (es) | 2021-09-21 |
| US10842871B2 (en) | 2020-11-24 |
| JP2017537905A (ja) | 2017-12-21 |
| NZ770434A (en) | 2024-10-25 |
| MA41115A (fr) | 2017-10-10 |
| MX2017006789A (es) | 2018-01-11 |
| AU2025201237A1 (en) | 2025-03-20 |
| EA201791199A1 (ru) | 2017-09-29 |
| KR20220044874A (ko) | 2022-04-11 |
| JP2020055880A (ja) | 2020-04-09 |
| WO2016087944A2 (en) | 2016-06-09 |
| US20180333487A1 (en) | 2018-11-22 |
| IL311405A (en) | 2024-05-01 |
| MX385045B (es) | 2025-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2015356773B2 (en) | Method for treating Alzheimer's disease | |
| US20220281963A1 (en) | Methods for treating alzheimer's disease | |
| US20220372123A1 (en) | Anti-beta-amyloid antibody for treating alzheimer's disease | |
| JP2024540294A (ja) | アルツハイマー病を治療するための方法 | |
| US20240270830A1 (en) | Methods for treating alzheimer's disease | |
| NZ788486A (en) | Methods for treating Alzheimer's disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20241008 Application number text: 1020227010447 Filing date: 20220329 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20241106 Comment text: Request for Examination of Application |