KR20170088360A - 알츠하이머 질환의 치료 방법 - Google Patents
알츠하이머 질환의 치료 방법 Download PDFInfo
- Publication number
- KR20170088360A KR20170088360A KR1020177015204A KR20177015204A KR20170088360A KR 20170088360 A KR20170088360 A KR 20170088360A KR 1020177015204 A KR1020177015204 A KR 1020177015204A KR 20177015204 A KR20177015204 A KR 20177015204A KR 20170088360 A KR20170088360 A KR 20170088360A
- Authority
- KR
- South Korea
- Prior art keywords
- patient
- antibody
- dose
- body weight
- weeks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020227010447A KR20220044874A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086674P | 2014-12-02 | 2014-12-02 | |
| US62/086,674 | 2014-12-02 | ||
| US201562111874P | 2015-02-04 | 2015-02-04 | |
| US62/111,874 | 2015-02-04 | ||
| US201562149133P | 2015-04-17 | 2015-04-17 | |
| US62/149,133 | 2015-04-17 | ||
| US201562195119P | 2015-07-21 | 2015-07-21 | |
| US62/195,119 | 2015-07-21 | ||
| PCT/IB2015/002465 WO2016087944A2 (en) | 2014-12-02 | 2015-12-02 | Method for treating alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227010447A Division KR20220044874A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20170088360A true KR20170088360A (ko) | 2017-08-01 |
Family
ID=55358010
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227010447A Ceased KR20220044874A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
| KR1020247033653A Pending KR20240152957A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
| KR1020177015204A Ceased KR20170088360A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227010447A Ceased KR20220044874A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
| KR1020247033653A Pending KR20240152957A (ko) | 2014-12-02 | 2015-12-02 | 알츠하이머 질환의 치료 방법 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10842871B2 (enExample) |
| EP (1) | EP3227329A2 (enExample) |
| JP (5) | JP2017537905A (enExample) |
| KR (3) | KR20220044874A (enExample) |
| AU (3) | AU2015356773B2 (enExample) |
| CA (1) | CA2967897A1 (enExample) |
| EA (1) | EA201791199A1 (enExample) |
| IL (3) | IL285722B2 (enExample) |
| MA (1) | MA41115A (enExample) |
| MX (2) | MX385045B (enExample) |
| WO (1) | WO2016087944A2 (enExample) |
| ZA (1) | ZA202107358B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025517623A (ja) * | 2022-05-03 | 2025-06-10 | エフ. ホフマン-ラ ロシュ アーゲー | アミロイド関連画像異常のインシリコ予測 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| MA45149A (fr) * | 2016-06-07 | 2019-04-10 | Biogen Int Neuroscience Gmbh | Méthodes de traitement de la maladie d'alzheimer |
| TWI798751B (zh) * | 2016-07-01 | 2023-04-11 | 美商美國禮來大藥廠 | 抗-N3pGlu類澱粉β肽抗體及其用途 |
| US20190167611A1 (en) * | 2016-07-29 | 2019-06-06 | Biogen Chesapeake Llc | Methods of treating or preventing amyloid related imaging abnormalities associated with alzheimer's disease treatment |
| IL316169A (en) * | 2016-10-27 | 2024-12-01 | Eisai R&D Man Co Ltd | Composition comprising an anti-abeta protofibril antibody and a beta-secretase bace1 inhibitor for the treatment of alzheimer's disease |
| US10662226B2 (en) | 2016-10-28 | 2020-05-26 | The Regents of the University of Caiifomia | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
| US12227567B2 (en) | 2017-07-25 | 2025-02-18 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| KR20250053967A (ko) | 2017-08-22 | 2025-04-22 | 바이오젠 엠에이 인코포레이티드 | 항-베타 아밀로이드 항체를 함유하는 약제학적 조성물 |
| CN118924896A (zh) * | 2018-07-24 | 2024-11-12 | 卫材R&D管理有限公司 | 阿尔茨海默病的治疗及预防方法 |
| CN116063520A (zh) | 2019-01-30 | 2023-05-05 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| US20220372123A1 (en) * | 2019-10-22 | 2022-11-24 | Biogen Ma Inc. | Anti-beta-amyloid antibody for treating alzheimer's disease |
| CN116157151A (zh) | 2020-05-26 | 2023-05-23 | 真和制药有限公司 | 通过阻断半乳凝素-3治疗炎性疾病的方法 |
| EP4185612A4 (en) | 2020-07-23 | 2024-12-25 | Othair Prothena Limited | Anti-abeta antibodies |
| EP4351643A4 (en) * | 2021-06-07 | 2025-08-06 | Biogen Ma Inc | METHODS OF TREATMENT OF ALZHEIMER'S DISEASE |
| CA3223179A1 (en) | 2021-06-11 | 2022-12-15 | Sage Therapeutics, Inc. | Neuroactive steroid for the treatment of alzheimer's disease |
| KR102753583B1 (ko) | 2021-11-11 | 2025-01-10 | 의료법인 명지의료재단 | Kras 특이적 활성화 t 세포 유도용 항원 조성물 |
| US20250213727A1 (en) | 2022-03-25 | 2025-07-03 | Regenxbio Inc. | Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy |
| JPWO2023210405A1 (enExample) | 2022-04-25 | 2023-11-02 | ||
| AR132567A1 (es) | 2023-05-02 | 2025-07-16 | Sage Therapeutics Inc | Formulaciones de esteroides neuroactivos y métodos de uso de estas |
Family Cites Families (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| FR2686087A1 (fr) | 1992-01-13 | 1993-07-16 | Inst Nat Sante Rech Med | Nouvel antigene lymphocytaire, anticorps correspondant et leurs applications. |
| JPH09507746A (ja) | 1993-10-27 | 1997-08-12 | アテナ ニューロサイエンシズ,インコーポレイティド | Swedish変異を有するAPP対立遺伝子を含有するトランスジェニック動物 |
| US5876950A (en) | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
| US8173127B2 (en) | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
| CA2286305A1 (en) | 1997-04-09 | 1998-10-15 | Mindset Ltd. | Recombinant antibodies specific for beta-amyloid ends, dna encoding and methods of use thereof |
| US20020086847A1 (en) | 1997-04-09 | 2002-07-04 | Mindset Biopharmaceuticals (Usa) | Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof |
| US6703015B1 (en) | 1999-09-03 | 2004-03-09 | Ramot At Tel-Aviv University Ltd. | Filamentous bacteriophage displaying an β-amyloid epitope |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6710226B1 (en) | 1997-12-02 | 2004-03-23 | Neuralab Limited | Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics |
| US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| WO1999050300A1 (en) | 1998-03-30 | 1999-10-07 | The Trustees Of The University Of Pennsylvania | Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| CA2349434A1 (en) | 1999-09-03 | 2001-03-15 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases |
| US6713058B2 (en) | 1999-09-14 | 2004-03-30 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with neuropathic conditions comprising administration of low levels of antibodies |
| US6294171B2 (en) | 1999-09-14 | 2001-09-25 | Milkhaus Laboratory, Inc. | Methods for treating disease states comprising administration of low levels of antibodies |
| US6187309B1 (en) | 1999-09-14 | 2001-02-13 | Milkaus Laboratory, Inc. | Method for treatment of symptoms of central nervous system disorders |
| US6436401B1 (en) | 1999-09-14 | 2002-08-20 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with diabetes and diabetic neuropathy comprising administration of low levels of antibodies |
| ATE327346T1 (de) | 1999-10-27 | 2006-06-15 | Univ Liege | Immuno-real-time-pcr unter verwendung eines dna- chimers als amplifikationsmarker |
| DK1292680T3 (da) | 2000-06-22 | 2010-03-08 | Genentech Inc | Agonist-anti-TrkC monoklonale antistoffer |
| JP5362164B2 (ja) | 2000-07-07 | 2013-12-11 | バイオアークティック ニューロサイエンス アーベー | アルツハイマー病の予防及び治療 |
| EP1172378A1 (en) | 2000-07-12 | 2002-01-16 | Richard Dr. Dodel | Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| PE20020574A1 (es) | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
| US20030028904A1 (en) | 2001-04-19 | 2003-02-06 | Gumienny Tina L. | Genes involved in engulfment of dying cells and cell migration |
| US7771722B2 (en) | 2001-08-17 | 2010-08-10 | Eli Lilly And Company | Assay method for alzheimer's disease |
| US7414111B2 (en) | 2001-09-19 | 2008-08-19 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
| GB0203446D0 (en) | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| WO2003089460A1 (en) | 2002-04-19 | 2003-10-30 | The Governing Council Of The University Of Toronto | Immunological methods and compositions for the treatment of alzheimer's disease |
| US20110200609A1 (en) | 2002-09-12 | 2011-08-18 | The Regents Of The University Of California | Monoclonal antibodies specific for pathological amyloid aggregates common to amyloids formed from proteins of differing sequence |
| BR0315157A (pt) | 2002-10-09 | 2005-08-09 | Rinat Neuroscience Corp | Métodos de tratar doença de alzheimer empregando-se anticorpos direcionados contra peptìdeo beta amilóide e composições deste |
| TW200509968A (en) | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
| US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| JP4690046B2 (ja) | 2002-11-22 | 2011-06-01 | 中外製薬株式会社 | 病巣組織に対する抗体 |
| DK2335725T3 (en) | 2003-04-04 | 2017-01-23 | Genentech Inc | Highly concentrated antibody and protein formulations |
| US20060240485A1 (en) | 2003-04-24 | 2006-10-26 | Universitat Zurich | Method of monitoring immunotherapy |
| TWI374893B (en) | 2003-05-30 | 2012-10-21 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| WO2005018424A2 (en) | 2003-08-18 | 2005-03-03 | Research Foundation For Mental Hygiene, Inc. | Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits |
| CA2538220A1 (en) | 2003-09-09 | 2005-03-24 | Takeda Pharmaceutical Company Limited | Use of antibody |
| WO2005047860A2 (en) | 2003-11-08 | 2005-05-26 | Elan Pharmaceuticals, Inc. | Antibodies to alpha-synuclein |
| US20060094064A1 (en) | 2003-11-19 | 2006-05-04 | Sandip Ray | Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids |
| PL1720909T3 (pl) | 2004-02-23 | 2012-04-30 | Lilly Co Eli | Przeciwciało anty-abeta |
| EP1747282B1 (en) | 2004-04-15 | 2011-06-08 | University of Florida Research Foundation, Inc. | Map-2 proteolytic breakdown products as diagnostic biomarkers for neural injury |
| US7763249B2 (en) | 2004-04-27 | 2010-07-27 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Human anti-amyloid β peptide antibody and fragment of said antibody |
| US20110142858A1 (en) | 2004-06-07 | 2011-06-16 | Ramot At Tel Aviv University Ltd. | Method of Passsive Immunization Against Disease or Disorder Charcterized by Amyloid Aggregation with Diminished Risk of Neuroinflammation |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| US20060062859A1 (en) | 2004-08-05 | 2006-03-23 | Kenneth Blum | Composition and method to optimize and customize nutritional supplement formulations by measuring genetic and metabolomic contributing factors to disease diagnosis, stratification, prognosis, metabolism, and therapeutic outcomes |
| EA013752B1 (ru) | 2004-08-09 | 2010-06-30 | Элан Фармасьютикалз, Инк. | Предупреждение и лечение синуклеинопатических и амилоидогенных заболеваний |
| WO2006050041A2 (en) | 2004-10-28 | 2006-05-11 | Ramot At Tel Aviv University Ltd. | Methods for reducing or inhibiting brain inflammation or for promoting neurogenesis |
| TW200636066A (en) | 2004-12-15 | 2006-10-16 | Elan Pharm Inc | Humanized antibodies that recognize beta amyloid peptide |
| TW200635608A (en) | 2004-12-15 | 2006-10-16 | Neuralab Ltd | Aβ antibodies for use in improving cognition |
| ATE458754T1 (de) | 2005-03-05 | 2010-03-15 | Abbott Gmbh & Co Kg | Screening-verfahren, verfahren zur aufreinigung nichtdiffundierbarer a-beta-oligomere, selektive antikörper gegen diese nichtdiffundierbaren a- beta-oligomere und verfahren zur herstellung dieser antikörper |
| JP2006265189A (ja) | 2005-03-24 | 2006-10-05 | Kyoto Univ | βアミロイドペプチド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法 |
| ES2318918B1 (es) | 2005-04-01 | 2010-02-16 | Biotherapix Molecular Medicines, S.L.U. | Anticuerpos humanos con capacidad de union al peptido beta-amiloide y sus aplicaciones. |
| WO2006116192A2 (en) | 2005-04-21 | 2006-11-02 | Medarex, Inc. | Irta-1 antibodies and their uses |
| MY148086A (en) | 2005-04-29 | 2013-02-28 | Rinat Neuroscience Corp | Antibodies directed against amyloid-beta peptide and methods using same |
| WO2007011907A2 (en) | 2005-07-19 | 2007-01-25 | University Of Rochester | Alpha-synuclein antibodies and methods related thereto |
| WO2007021255A1 (en) | 2005-08-09 | 2007-02-22 | Elan Pharmaceuticals, Inc. | Antibodies to alpha-synuclein |
| US20090246145A1 (en) | 2005-11-14 | 2009-10-01 | Small Scott A | Imaging Correlates of Neurogenesis With MRI |
| WO2007062088A1 (en) | 2005-11-22 | 2007-05-31 | The Trustees Of The University Of Pennsylvania | Antibody treatment of alzheimer's and related diseases |
| CN101506236B (zh) | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
| EP1963363A2 (en) | 2005-11-30 | 2008-09-03 | Abbott Laboratories | Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| WO2007067959A2 (en) * | 2005-12-07 | 2007-06-14 | Medarex, Inc. | Ctla-4 antibody dosage escalation regimens |
| RU2551782C2 (ru) | 2005-12-12 | 2015-05-27 | Ац Иммуне Са | Специфические в отношении амилоида бета (а бета) 1-42 моноклональные антитела, обладающие терапевтическими свойствами |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| WO2008022349A2 (en) | 2006-08-18 | 2008-02-21 | Armagen Technologies, Inc. | Agents for blood-brain barrier delivery |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| ES2439490T3 (es) | 2007-01-05 | 2014-01-23 | University Of Zurich | Anticuerpo anti-beta amiloide y usos del mismo |
| CL2008000058A1 (es) | 2007-01-09 | 2008-05-23 | Wyeth Corp | Formulacion que comprende un anticuerpo anti-il13, un criprotector, y una solucion amortiguadora; composicion farmaceutica que la comprende; metodo para tratar un trastorno relacionado con il13; y formas farmaceuticas que la comprenden. |
| JP5558834B2 (ja) | 2007-02-23 | 2014-07-23 | ヤンセン アルツハイマー イミュノセラピー | シヌクレイノパチーおよびアミロイド形成疾患(amyloidogenicdisease)の予防および処置 |
| DK2457928T3 (en) | 2007-03-13 | 2017-08-28 | Univ Zuerich | Monoclonal human tumor-specific antibody |
| WO2008131298A2 (en) | 2007-04-18 | 2008-10-30 | Elan Pharma International Limited | Prevention and treatment of cerebral amyloid angiopathy |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| JP2008309778A (ja) | 2007-05-11 | 2008-12-25 | Daiichi Sankyo Co Ltd | ポリペプチドの検出又は定量方法、及び装置 |
| EP2162471A1 (en) | 2007-06-08 | 2010-03-17 | Université de la Méditerranée | Compositions and methods for treating pancreatic tumors |
| US8022268B2 (en) | 2007-06-11 | 2011-09-20 | The University Of Zurich | Transgenic animal model for alzheimer's disease |
| ES2498040T3 (es) | 2007-07-27 | 2014-09-24 | Janssen Alzheimer Immunotherapy | Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados |
| JP2010536907A (ja) | 2007-08-31 | 2010-12-02 | ニューリミューン セラピューティクス エイジー | 患者にアミロイドーシスおよびタンパク質凝集性障害における特異的免疫応答をもたらす方法 |
| US20100239570A1 (en) | 2007-09-13 | 2010-09-23 | Roger Nitsch | Moncolonal amyloid beta (abeta) - specific antibody and uses thereof |
| TW200927761A (en) | 2007-09-26 | 2009-07-01 | U3 Pharma Ag | Heparin-binding epidermal growth factor-like growth factor antigen binding proteins |
| WO2009043103A1 (en) | 2007-10-02 | 2009-04-09 | Csl Limited | Therapeutic antibody purification method and method of use |
| CN101965365A (zh) | 2007-10-19 | 2011-02-02 | 伊缪纳斯制药株式会社 | 能够特异性结合Aβ寡聚体的抗体及其应用 |
| US7771957B2 (en) | 2007-10-19 | 2010-08-10 | The Regents Of The University Of California | Method for diagnosing alzheimer's disease |
| GB0720912D0 (en) | 2007-10-25 | 2007-12-05 | Univ Cardiff | Monoclonal Anitbody for APP |
| WO2009056490A1 (en) | 2007-10-29 | 2009-05-07 | Innogenetics Nv | NEW ANTIBODIES SPECIFIC OF THE β-AMYLOID PEPTIDES AND THEIR USES AS DIAGNOSTIC AGENTS OR DRUGS |
| BRPI0819312A2 (pt) | 2007-11-16 | 2020-09-15 | The Rockefeller University | específico anticorpo para a forma protofibril de proteínas amilóide beta |
| AU2008343855B2 (en) | 2007-12-21 | 2013-08-15 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
| WO2009094592A2 (en) | 2008-01-23 | 2009-07-30 | Perlegen Sciences, Inc. | Genetic basis of alzheimer's disease and diagnosis and treatment thereof |
| PL2246427T3 (pl) | 2008-02-08 | 2017-06-30 | Immunas Pharma, Inc. | Przeciwciała zdolne do wiązania się swoiście do oligomerów amyloidu beta i ich stosowanie |
| LT2282758T (lt) | 2008-04-29 | 2019-03-12 | Bioarctic Ab | Antikūnai ir vakcinos, skirti su alfa sinukleinu susijusių sutrikimų gydymo ir diagnostiniams metodams |
| US20110182809A1 (en) | 2008-07-09 | 2011-07-28 | University Of Zurich | Method of Promoting Neurogenesis |
| KR20110057245A (ko) | 2008-09-19 | 2011-05-31 | 메디뮨 엘엘씨 | Cd105에 대해 지시된 항체 및 그의 용도 |
| AU2009313851A1 (en) | 2008-11-13 | 2010-05-20 | Modgene, Llc | Modification of amyloid-beta load in non-brain tissue |
| CA2746778C (en) | 2008-12-19 | 2019-04-23 | University Of Zurich | Human anti-alpha-synuclein autoantibodies |
| WO2010119704A1 (en) | 2009-04-17 | 2010-10-21 | Immunas Pharma, Inc. | Antibodies that specifically bind to a beta oligomers and use thereof |
| US20110237537A1 (en) | 2009-05-29 | 2011-09-29 | Lombard Jay L | Methods for assessment and treatment of mood disorders via single nucleotide polymorphisms analysis |
| US8613924B2 (en) | 2009-08-06 | 2013-12-24 | Immunas Pharma, Inc. | Antibodies that specifically bind to A beta oligomers and use thereof |
| ES2624835T3 (es) | 2009-08-06 | 2017-07-17 | Immunas Pharma, Inc. | Anticuerpos que se unen específicamente a los oligómeros A beta y uso de los mismos |
| WO2011064225A1 (en) | 2009-11-24 | 2011-06-03 | Probiodrug Ag | Novel diagnostic method for the diagnosis of alzheimer's disease or mild cgnitive impairment |
| EP2862929B1 (en) | 2009-12-09 | 2017-09-06 | Quark Pharmaceuticals, Inc. | Compositions and methods for treating diseases, disorders or injury of the CNS |
| WO2011076854A1 (en) | 2009-12-22 | 2011-06-30 | Probiodrug Ag | CLEAVAGE OF β-AMYLOID PRECURSOR PROTEIN |
| US9297808B2 (en) | 2010-07-07 | 2016-03-29 | Thermo Fisher Scientific Gmbh | Analyte mass spectrometry quantitation using a universal reporter |
| PL2603523T3 (pl) | 2010-08-12 | 2016-07-29 | Lilly Co Eli | Przeciwciała przeciwko peptydowi amyloidu beta N3pGlu i ich zastosowania |
| TR201812636T4 (tr) | 2010-10-11 | 2018-09-21 | Biogen Int Neuroscience Gmbh | İnsan anti-tau antikorları. |
| US9283271B2 (en) | 2010-12-17 | 2016-03-15 | Neurimmune Holding Ag | Human anti-SOD1 antibodies |
| WO2012174262A2 (en) | 2011-06-14 | 2012-12-20 | Cenestra Llc | Formulations and methods of treating subjects having central nervous system, endocrine, inflammatory or cardiovascular disorders or at-risk thereof with highly purified omega-3 fatty acid formulations |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| SG11201401735WA (en) | 2011-10-28 | 2014-05-29 | Biogen Idec Internat Neuroscience Gmbh | Tdp-43 specific binding molecules |
| US20130164367A1 (en) | 2011-12-08 | 2013-06-27 | The Board Of Regents Of The University Of Texas System | Treatment of neurodegenerative disease with creb-binding protein |
| ITRM20120383A1 (it) | 2012-03-20 | 2013-09-21 | Uni Degli Studi Di Milano B Icocca | Metodo e kit per la rivelazione di anticorpi. |
| KR102117969B1 (ko) | 2012-09-12 | 2020-06-04 | 뉴리뮨 홀딩 아게 | 인간 섬 아밀로이드 폴리펩티드(hiapp) 특이적 항체 및 이들의 용도 |
| WO2014089500A1 (en) * | 2012-12-07 | 2014-06-12 | Biogen Idec International Neuroscience Gmbh | A METHOD OF REDUCING BRAIN AMYLOID PLAQUES USING ANTI-Aß ANTIBODIES |
| US20140272950A1 (en) | 2013-03-15 | 2014-09-18 | Pathway Genomics Corporation | Method and system to predict ssri response |
| US20140274764A1 (en) | 2013-03-15 | 2014-09-18 | Pathway Genomics Corporation | Method and system to predict response to treatments for mental disorders |
| PT2994160T (pt) * | 2013-05-06 | 2019-08-07 | Baxalta Inc | Tratamento de sub-populações com doença de alzheimer com imunoglobulina g combinada |
| EP3019629A4 (en) | 2013-07-12 | 2017-01-18 | Biogen International Neuroscience GmbH | Genetic and image biomarkers associated with decline in cognitive measures and brain glucose metabolism in populations with alzheimer's disease or those susceptible to developing alzheimer's disease |
| SG11201604831QA (en) | 2013-12-20 | 2016-08-30 | Neurimmune Holding Ag | Antibody-based therapy of transthyretin (ttr) amyloidosis and human-derived antibodies therefor |
| KR20240094017A (ko) | 2014-02-08 | 2024-06-24 | 제넨테크, 인크. | 알츠하이머 질환을 치료하는 방법 |
| WO2015175769A1 (en) | 2014-05-15 | 2015-11-19 | Biogen Ma Inc. | Methods for the detection of amyloid beta oligomers in biological samples |
| WO2015191825A1 (en) | 2014-06-13 | 2015-12-17 | Biogen Ma Inc. | Methods for the detection and measurement of amyloid beta in biological samples |
| EP3174898A2 (en) | 2014-07-29 | 2017-06-07 | Neurimmune Holding AG | Human-derived anti-huntingtin (htt) antibodies and uses thereof |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| PL3430397T3 (pl) | 2016-03-14 | 2022-04-04 | Biogen International Neuroscience Gmbh | Oznaczenie fagocytozy zależnej od przeciwciał do wiarygodnych pomiarów wychwytu zagregowanych białek |
-
2015
- 2015-12-01 MA MA041115A patent/MA41115A/fr unknown
- 2015-12-02 KR KR1020227010447A patent/KR20220044874A/ko not_active Ceased
- 2015-12-02 AU AU2015356773A patent/AU2015356773B2/en active Active
- 2015-12-02 IL IL285722A patent/IL285722B2/en unknown
- 2015-12-02 MX MX2017006789A patent/MX385045B/es unknown
- 2015-12-02 KR KR1020247033653A patent/KR20240152957A/ko active Pending
- 2015-12-02 US US15/531,960 patent/US10842871B2/en active Active
- 2015-12-02 EA EA201791199A patent/EA201791199A1/ru unknown
- 2015-12-02 KR KR1020177015204A patent/KR20170088360A/ko not_active Ceased
- 2015-12-02 CA CA2967897A patent/CA2967897A1/en active Pending
- 2015-12-02 EP EP15834670.0A patent/EP3227329A2/en active Pending
- 2015-12-02 WO PCT/IB2015/002465 patent/WO2016087944A2/en not_active Ceased
- 2015-12-02 IL IL311405A patent/IL311405A/en unknown
- 2015-12-02 JP JP2017527872A patent/JP2017537905A/ja not_active Withdrawn
-
2017
- 2017-05-22 IL IL252433A patent/IL252433B/en unknown
- 2017-05-24 MX MX2021009053A patent/MX2021009053A/es unknown
-
2020
- 2020-01-15 JP JP2020004429A patent/JP2020055880A/ja not_active Withdrawn
-
2021
- 2021-08-04 JP JP2021127999A patent/JP2021169536A/ja not_active Withdrawn
- 2021-09-30 ZA ZA2021/07358A patent/ZA202107358B/en unknown
- 2021-12-08 AU AU2021282448A patent/AU2021282448A1/en not_active Abandoned
-
2022
- 2022-11-25 JP JP2022188107A patent/JP2023011002A/ja not_active Withdrawn
-
2025
- 2025-02-21 AU AU2025201237A patent/AU2025201237A1/en active Pending
- 2025-10-03 JP JP2025167679A patent/JP2025182058A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025517623A (ja) * | 2022-05-03 | 2025-06-10 | エフ. ホフマン-ラ ロシュ アーゲー | アミロイド関連画像異常のインシリコ予測 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL285722A (en) | 2021-09-30 |
| AU2015356773A1 (en) | 2017-05-25 |
| MX2021009053A (es) | 2021-09-21 |
| IL252433B (en) | 2021-09-30 |
| JP2017537905A (ja) | 2017-12-21 |
| JP2021169536A (ja) | 2021-10-28 |
| IL285722B1 (en) | 2024-04-01 |
| AU2015356773B2 (en) | 2021-09-09 |
| EA201791199A1 (ru) | 2017-09-29 |
| AU2025201237A1 (en) | 2025-03-20 |
| US20180333487A1 (en) | 2018-11-22 |
| ZA202107358B (en) | 2025-01-29 |
| JP2025182058A (ja) | 2025-12-11 |
| MX385045B (es) | 2025-03-14 |
| WO2016087944A3 (en) | 2016-08-04 |
| NZ731520A (en) | 2021-08-27 |
| CA2967897A1 (en) | 2016-06-09 |
| NZ770434A (en) | 2024-10-25 |
| MX2017006789A (es) | 2018-01-11 |
| MA41115A (fr) | 2017-10-10 |
| KR20220044874A (ko) | 2022-04-11 |
| IL285722B2 (en) | 2024-08-01 |
| US10842871B2 (en) | 2020-11-24 |
| JP2023011002A (ja) | 2023-01-20 |
| IL252433A0 (en) | 2017-07-31 |
| JP2020055880A (ja) | 2020-04-09 |
| WO2016087944A2 (en) | 2016-06-09 |
| AU2021282448A1 (en) | 2022-01-06 |
| EP3227329A2 (en) | 2017-10-11 |
| IL311405A (en) | 2024-05-01 |
| KR20240152957A (ko) | 2024-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2015356773B2 (en) | Method for treating Alzheimer's disease | |
| US20220281963A1 (en) | Methods for treating alzheimer's disease | |
| US20220372123A1 (en) | Anti-beta-amyloid antibody for treating alzheimer's disease | |
| JP2025506389A (ja) | p-タウ181レベルを使用した治療方法 | |
| NZ788486A (en) | Methods for treating Alzheimer's disease | |
| US20240270830A1 (en) | Methods for treating alzheimer's disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20170602 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| A302 | Request for accelerated examination | ||
| AMND | Amendment | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20201201 Comment text: Request for Examination of Application |
|
| PA0302 | Request for accelerated examination |
Patent event date: 20201201 Patent event code: PA03022R01D Comment text: Request for Accelerated Examination |
|
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20210412 Patent event code: PE09021S01D |
|
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20210930 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20210412 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |
|
| AMND | Amendment | ||
| PX0901 | Re-examination |
Patent event code: PX09011S01I Patent event date: 20210930 Comment text: Decision to Refuse Application Patent event code: PX09012R01I Patent event date: 20210712 Comment text: Amendment to Specification, etc. Patent event code: PX09012R01I Patent event date: 20201201 Comment text: Amendment to Specification, etc. |
|
| PX0601 | Decision of rejection after re-examination |
Comment text: Decision to Refuse Application Patent event code: PX06014S01D Patent event date: 20220127 Comment text: Amendment to Specification, etc. Patent event code: PX06012R01I Patent event date: 20211230 Comment text: Decision to Refuse Application Patent event code: PX06011S01I Patent event date: 20210930 Comment text: Amendment to Specification, etc. Patent event code: PX06012R01I Patent event date: 20210712 Comment text: Notification of reason for refusal Patent event code: PX06013S01I Patent event date: 20210412 Comment text: Amendment to Specification, etc. Patent event code: PX06012R01I Patent event date: 20201201 |
|
| X601 | Decision of rejection after re-examination | ||
| J201 | Request for trial against refusal decision | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20220329 |
|
| PJ0201 | Trial against decision of rejection |
Patent event date: 20220329 Comment text: Request for Trial against Decision on Refusal Patent event code: PJ02012R01D Patent event date: 20220127 Comment text: Decision to Refuse Application Patent event code: PJ02011S01I Patent event date: 20210930 Comment text: Decision to Refuse Application Patent event code: PJ02011S01I Appeal kind category: Appeal against decision to decline refusal Decision date: 20220708 Appeal identifier: 2022101000707 Request date: 20220329 |
|
| PC1202 | Submission of document of withdrawal before decision of registration |
Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment) Patent event code: PC12021R01D Patent event date: 20220708 |
|
| PJ1201 | Withdrawal of trial |
Patent event code: PJ12011R01D Patent event date: 20220708 Comment text: Written Withdrawal of Request for Trial Appeal identifier: 2022101000707 Request date: 20220329 Appeal kind category: Appeal against decision to decline refusal Decision date: 20220708 |