KR20240115933A - T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 - Google Patents

T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 Download PDF

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KR20240115933A
KR20240115933A KR1020247024111A KR20247024111A KR20240115933A KR 20240115933 A KR20240115933 A KR 20240115933A KR 1020247024111 A KR1020247024111 A KR 1020247024111A KR 20247024111 A KR20247024111 A KR 20247024111A KR 20240115933 A KR20240115933 A KR 20240115933A
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lys
thr
ser
glu
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Inventor
에릭 앨런 버츠
크리스티 앤 톰슨
마르크 알라인 가빈
랜 네빈 폴츠
동 시아
디나 엔. 알콘
아이 칭 림
랜달 로버트 켓쳄
케시 만출렌코
로라 세키로브
켈리 앤 베리
시르 클로비스 추아 드 이무스
니라즈 자그디쉬 아그라왈
구나세카란 카난
리 리
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암젠 인크
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Priority to KR1020257029040A priority Critical patent/KR20250133490A/ko
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    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Transplantation (AREA)
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KR1020247024111A 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 Ceased KR20240115933A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257029040A KR20250133490A (ko) 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020177032587A KR102687530B1 (ko) 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인
PCT/US2016/030843 WO2016164937A2 (en) 2015-04-10 2016-05-04 Interleukin-2 muteins for the expansion of t-regulatory cells

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KR1020177032587A Division KR102687530B1 (ko) 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인

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KR1020257029040A Division KR20250133490A (ko) 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인

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KR20240115933A true KR20240115933A (ko) 2024-07-26

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KR1020177032587A Active KR102687530B1 (ko) 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인
KR1020247024111A Ceased KR20240115933A (ko) 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인
KR1020257029040A Pending KR20250133490A (ko) 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인

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KR1020177032587A Active KR102687530B1 (ko) 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인

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KR1020257029040A Pending KR20250133490A (ko) 2016-05-04 2016-05-04 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인

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EP (2) EP3280725B1 (enExample)
JP (3) JP7422480B2 (enExample)
KR (3) KR102687530B1 (enExample)
CN (2) CN115073581A (enExample)
NZ (1) NZ775714A (enExample)
WO (1) WO2016164937A2 (enExample)

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