KR20240096884A - 조작된 기억-유사 nk 세포 및 이의 조성물을 생성하기 위한 방법 - Google Patents

조작된 기억-유사 nk 세포 및 이의 조성물을 생성하기 위한 방법 Download PDF

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KR20240096884A
KR20240096884A KR1020247019590A KR20247019590A KR20240096884A KR 20240096884 A KR20240096884 A KR 20240096884A KR 1020247019590 A KR1020247019590 A KR 1020247019590A KR 20247019590 A KR20247019590 A KR 20247019590A KR 20240096884 A KR20240096884 A KR 20240096884A
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cells
population
amino acids
cytokine
amino acid
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Korean (ko)
Inventor
지안주 첸
제롬 리츠
리즈완 로미
한 동
궈주 시에
제임스 동주 햄
Original Assignee
매사추세츠 인스티튜트 오브 테크놀로지
다나-파버 캔서 인스티튜트 인크.
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Priority claimed from US17/144,834 external-priority patent/US11896619B2/en
Application filed by 매사추세츠 인스티튜트 오브 테크놀로지, 다나-파버 캔서 인스티튜트 인크. filed Critical 매사추세츠 인스티튜트 오브 테크놀로지
Publication of KR20240096884A publication Critical patent/KR20240096884A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A61K39/4613—
    • A61K39/4631—
    • A61K39/4635—
    • A61K39/4644—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/35—Cytokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61P35/04—Antineoplastic agents specific for metastasis
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
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    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/17—Hinge-spacer domain
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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  • Developmental Biology & Embryology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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KR1020247019590A 2020-03-10 2021-03-10 조작된 기억-유사 nk 세포 및 이의 조성물을 생성하기 위한 방법 Pending KR20240096884A (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US202062987612P 2020-03-10 2020-03-10
US62/987,612 2020-03-10
US202063119959P 2020-12-01 2020-12-01
US63/119,959 2020-12-01
US202063121127P 2020-12-03 2020-12-03
US63/121,127 2020-12-03
US17/144,834 US11896619B2 (en) 2020-03-10 2021-01-08 Compositions and methods for immunotherapy of NPM1c-positive cancer
US17/144,834 2021-01-08
KR1020227034868A KR20220166282A (ko) 2020-03-10 2021-03-10 조작된 기억-유사 nk 세포 및 이의 조성물을 생성하기 위한 방법
PCT/US2021/021758 WO2021183675A2 (en) 2020-03-10 2021-03-10 Methods for generating engineered memory-like nk cells and compositions thereof

Related Parent Applications (1)

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KR1020227034868A Division KR20220166282A (ko) 2020-03-10 2021-03-10 조작된 기억-유사 nk 세포 및 이의 조성물을 생성하기 위한 방법

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KR20240096884A true KR20240096884A (ko) 2024-06-26

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KR1020247019590A Pending KR20240096884A (ko) 2020-03-10 2021-03-10 조작된 기억-유사 nk 세포 및 이의 조성물을 생성하기 위한 방법
KR1020227034868A Pending KR20220166282A (ko) 2020-03-10 2021-03-10 조작된 기억-유사 nk 세포 및 이의 조성물을 생성하기 위한 방법

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US (1) US20230149460A1 (https=)
EP (1) EP4117716A2 (https=)
JP (2) JP2023517063A (https=)
KR (2) KR20240096884A (https=)
CN (1) CN115768464A (https=)
AU (1) AU2021236145A1 (https=)
BR (1) BR112022018105A2 (https=)
CA (1) CA3173527A1 (https=)
IL (1) IL296242A (https=)
MX (1) MX2022011080A (https=)
WO (1) WO2021183675A2 (https=)

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CN113599395B (zh) * 2021-09-22 2022-08-12 郑州源创吉因实业有限公司 含有nk细胞的治疗癌症的药物组合物
MX2024003250A (es) * 2021-09-22 2024-05-28 Sonoma Biotherapeutics Inc Marcadores de superficie celular il5ra.
CN119256084A (zh) * 2022-05-13 2025-01-03 莱顿大学医学中心附属莱顿教学医院 血液系统恶性肿瘤的治疗
CN116478931A (zh) * 2023-05-16 2023-07-25 新乡医学院 一种高亲和型抗肿瘤nk细胞及其制备方法和应用
WO2025166096A1 (en) * 2024-02-01 2025-08-07 Inndura Therapeutics Inc. Method of induction of immune cells into a memory-like state
EP4600264A1 (en) * 2024-02-08 2025-08-13 Ecole Polytechnique Fédérale de Lausanne (EPFL) Engineered type 2 cytokine signalling to improve car-t cell effector functions
CN119776278B (zh) * 2025-03-12 2025-06-27 四川大学华西医院 一种增强型nk细胞及其制备方法和应用

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