KR20240043794A - Cdp-콜린의 제조에 이용하는 재조합 미생물 및 상기 재조합 미생물을 이용하는 cdp-콜린의 제조 방법 - Google Patents

Cdp-콜린의 제조에 이용하는 재조합 미생물 및 상기 재조합 미생물을 이용하는 cdp-콜린의 제조 방법 Download PDF

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Publication number
KR20240043794A
KR20240043794A KR1020247007949A KR20247007949A KR20240043794A KR 20240043794 A KR20240043794 A KR 20240043794A KR 1020247007949 A KR1020247007949 A KR 1020247007949A KR 20247007949 A KR20247007949 A KR 20247007949A KR 20240043794 A KR20240043794 A KR 20240043794A
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Prior art keywords
ctp
dna
choline
amino acid
acid sequence
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Pending
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Korean (ko)
Inventor
가즈마사 호리
도시히코 모리타
츠네요 니시노
데츠로 우지하라
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교와 핫꼬 바이오 가부시키가이샤
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Publication of KR20240043794A publication Critical patent/KR20240043794A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07015—Choline-phosphate cytidylyltransferase (2.7.7.15)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020247007949A 2021-09-10 2022-09-09 Cdp-콜린의 제조에 이용하는 재조합 미생물 및 상기 재조합 미생물을 이용하는 cdp-콜린의 제조 방법 Pending KR20240043794A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021147985 2021-09-10
JPJP-P-2021-147985 2021-09-10
PCT/JP2022/033972 WO2023038128A1 (ja) 2021-09-10 2022-09-09 Ｃｄｐ－コリンの製造に用いる組換え微生物及び該組換え微生物を用いるｃｄｐ－コリンの製造方法

Publications (1)

Publication Number Publication Date
KR20240043794A true KR20240043794A (ko) 2024-04-03

Family

ID=85506465

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247007949A Pending KR20240043794A (ko) 2021-09-10 2022-09-09 Cdp-콜린의 제조에 이용하는 재조합 미생물 및 상기 재조합 미생물을 이용하는 cdp-콜린의 제조 방법

Country Status (8)

Country Link
US (1) US20250043255A1 (https=)
EP (1) EP4400588A4 (https=)
JP (1) JPWO2023038128A1 (https=)
KR (1) KR20240043794A (https=)
CN (1) CN117916378A (https=)
AU (1) AU2022344719B2 (https=)
CA (1) CA3231307A1 (https=)
WO (1) WO2023038128A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095660A1 (en) 2002-05-08 2003-11-20 Kyowa Hakko Kogyo Co., Ltd. Process for producing cytidine 5’-diphocphate choline
KR20070023830A (ko) 2005-08-23 2007-03-02 주식회사 엘티아이 발광다이오드를 광원으로 사용하는 백라이트 유닛 및 그의결선 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58110600A (ja) 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
JP2545078B2 (ja) 1987-04-06 1996-10-16 協和醗酵工業株式会社 核酸関連物質の製造法
JP3369236B2 (ja) 1992-01-30 2003-01-20 協和醗酵工業株式会社 シチジンジリン酸コリンの製造法
KR100555161B1 (ko) 1996-09-17 2006-11-30 교와 핫꼬 고교 가부시끼가이샤 당뉴클레오티드류및복합당질의제조법
JP5112869B2 (ja) 2005-08-23 2013-01-09 協和発酵バイオ株式会社 シチジンジリン酸コリンの製造法
CN104774799B (zh) * 2015-04-17 2018-01-30 南京工业大学 一株表达胆碱激酶及磷酰胆碱胞苷转移酶的基因工程菌及其构建方法与应用
CN109207415B (zh) * 2017-07-07 2022-09-16 苏州华赛生物工程技术有限公司 一种生产胞二磷胆碱的重组微生物及生产胞二磷胆碱的方法
JP7401368B2 (ja) 2020-03-24 2023-12-19 フルテック株式会社 自動ドア

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095660A1 (en) 2002-05-08 2003-11-20 Kyowa Hakko Kogyo Co., Ltd. Process for producing cytidine 5’-diphocphate choline
KR20070023830A (ko) 2005-08-23 2007-03-02 주식회사 엘티아이 발광다이오드를 광원으로 사용하는 백라이트 유닛 및 그의결선 방법

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
[비특허문헌 1] Nutrients (2020) Vol. 12(3), 793, p. 1-17
[비특허문헌 2] Bull. Inst. Chem. Res. Kyoto U. (1976) Vol. 53, p. 546-562
[비특허문헌 3] Appl. Microbiol. Biotechnol. (2017) Vol. 101, p. 1409-1417
[비특허문헌 4] J. Bio. Chem. (1998) Vol. 273, p. 14022-14029
[비특허문헌 5] Eur. J. Biochem. (1987) Vol. 169, p. 477-486
[비특허문헌 6] J. Bio. Chem.(2002) Vol. 277, p. 4343-4350
[비특허문헌 7] Eur. J. Biochem. (1983) Vol. 131, p. 223-229

Also Published As

Publication number Publication date
WO2023038128A1 (ja) 2023-03-16
CA3231307A1 (en) 2023-03-16
EP4400588A4 (en) 2025-10-08
US20250043255A1 (en) 2025-02-06
AU2022344719A1 (en) 2024-03-28
CN117916378A (zh) 2024-04-19
EP4400588A1 (en) 2024-07-17
AU2022344719B2 (en) 2025-12-11
JPWO2023038128A1 (https=) 2023-03-16

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