KR20230154292A - 델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법 - Google Patents

델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법 Download PDF

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Publication number
KR20230154292A
KR20230154292A KR1020237037455A KR20237037455A KR20230154292A KR 20230154292 A KR20230154292 A KR 20230154292A KR 1020237037455 A KR1020237037455 A KR 1020237037455A KR 20237037455 A KR20237037455 A KR 20237037455A KR 20230154292 A KR20230154292 A KR 20230154292A
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South Korea
Prior art keywords
trifluoromethyl
tautomer
compound
pyrimidin
pyrazol
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Ceased
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KR1020237037455A
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English (en)
Korean (ko)
Inventor
제니퍼 알. 알렌
미켈라 벨트라니
매튜 피. 부르보
테오도라 피. 다미야노바
이언 린가드
아나 이. 미나띠
파올로 빈세티
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암젠 인크
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020237037455A 2019-11-25 2020-11-24 델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법 Ceased KR20230154292A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962939821P 2019-11-25 2019-11-25
US62/939,821 2019-11-25
PCT/US2020/062020 WO2021108408A1 (en) 2019-11-25 2020-11-24 Heterocyclic compounds as delta-5 desaturase inhibitors and methods of use
KR1020227021152A KR102598203B1 (ko) 2019-11-25 2020-11-24 델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법

Related Parent Applications (1)

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KR1020227021152A Division KR102598203B1 (ko) 2019-11-25 2020-11-24 델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법

Publications (1)

Publication Number Publication Date
KR20230154292A true KR20230154292A (ko) 2023-11-07

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Family Applications (2)

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KR1020237037455A Ceased KR20230154292A (ko) 2019-11-25 2020-11-24 델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법
KR1020227021152A Active KR102598203B1 (ko) 2019-11-25 2020-11-24 델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법

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Country Status (21)

Country Link
US (3) US11512097B2 (https=)
EP (1) EP4065223A1 (https=)
JP (2) JP7254246B2 (https=)
KR (2) KR20230154292A (https=)
CN (2) CN114728167B (https=)
AR (1) AR120556A1 (https=)
AU (1) AU2020392087B2 (https=)
BR (1) BR112022010054A2 (https=)
CA (1) CA3162281A1 (https=)
CL (2) CL2022001357A1 (https=)
CO (1) CO2022008690A2 (https=)
CR (1) CR20220308A (https=)
IL (1) IL293191B2 (https=)
JO (1) JOP20220125A1 (https=)
MX (1) MX2022006281A (https=)
PE (1) PE20231097A1 (https=)
PH (1) PH12022551282A1 (https=)
SA (1) SA522432710B1 (https=)
TW (2) TWI815061B (https=)
UY (1) UY38971A (https=)
WO (1) WO2021108408A1 (https=)

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CN115557903A (zh) * 2022-09-27 2023-01-03 山东潍坊润丰化工股份有限公司 一种特草定的制备方法
CN120435293A (zh) 2022-11-23 2025-08-05 安进公司 选择使用fads-1抑制剂治疗fads1介导的疾病或障碍的患者

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AU2020392087A1 (en) 2022-06-09
JP2022549739A (ja) 2022-11-28
JP7254246B2 (ja) 2023-04-07
TW202132317A (zh) 2021-09-01
TW202409042A (zh) 2024-03-01
CN114728167B (zh) 2024-03-19
IL293191A (en) 2022-07-01
US20210221824A1 (en) 2021-07-22
KR102598203B1 (ko) 2023-11-03
JOP20220125A1 (ar) 2023-01-30
JP7698676B2 (ja) 2025-06-25
CL2022001357A1 (es) 2023-03-10
US20230159560A1 (en) 2023-05-25
US20210188874A1 (en) 2021-06-24
IL293191B2 (en) 2025-09-01
CO2022008690A2 (es) 2022-06-30
CN118161500A (zh) 2024-06-11
PH12022551282A1 (en) 2023-11-29
AR120556A1 (es) 2022-02-23
EP4065223A1 (en) 2022-10-05
US12448396B2 (en) 2025-10-21
JP2023078418A (ja) 2023-06-06
SA522432710B1 (ar) 2025-05-29
WO2021108408A1 (en) 2021-06-03
BR112022010054A2 (pt) 2022-08-16
UY38971A (es) 2021-06-30
TWI815061B (zh) 2023-09-11
TWI867822B (zh) 2024-12-21
MX2022006281A (es) 2022-06-08
CN114728167A (zh) 2022-07-08
US11512097B2 (en) 2022-11-29
AU2020392087B2 (en) 2025-10-23
CR20220308A (es) 2022-08-04
CL2023002486A1 (es) 2024-01-12
CA3162281A1 (en) 2021-06-03
IL293191B1 (en) 2025-05-01
KR20220106159A (ko) 2022-07-28
PE20231097A1 (es) 2023-07-18

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