KR20230116948A - 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법 - Google Patents

오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법 Download PDF

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Publication number
KR20230116948A
KR20230116948A KR1020237025023A KR20237025023A KR20230116948A KR 20230116948 A KR20230116948 A KR 20230116948A KR 1020237025023 A KR1020237025023 A KR 1020237025023A KR 20237025023 A KR20237025023 A KR 20237025023A KR 20230116948 A KR20230116948 A KR 20230116948A
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South Korea
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compound
depression
acid
hours
subject
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Korean (ko)
Inventor
저스틴 엠. 켄트
웨인 씨. 드레베츠
뵈르 페터 데
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얀센 파마슈티카 엔.브이.
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Priority to KR1020257016875A priority Critical patent/KR20250083571A/ko
Publication of KR20230116948A publication Critical patent/KR20230116948A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020237025023A 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법 Ceased KR20230116948A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257016875A KR20250083571A (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662306487P 2016-03-10 2016-03-10
US62/306,487 2016-03-10
PCT/US2017/021565 WO2017156266A1 (en) 2016-03-10 2017-03-09 Methods of treating depression using orexin-2 receptor antagonists
KR1020227033141A KR102559922B1 (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법

Related Parent Applications (1)

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KR1020227033141A Division KR102559922B1 (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법

Related Child Applications (1)

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KR1020257016875A Division KR20250083571A (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법

Publications (1)

Publication Number Publication Date
KR20230116948A true KR20230116948A (ko) 2023-08-04

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Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020187026455A Active KR102448342B1 (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
KR1020257016875A Pending KR20250083571A (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
KR1020237025023A Ceased KR20230116948A (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
KR1020227033141A Active KR102559922B1 (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법

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KR1020187026455A Active KR102448342B1 (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
KR1020257016875A Pending KR20250083571A (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법

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Country Status (35)

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US (4) US10828302B2 (enExample)
EP (2) EP4091634A1 (enExample)
JP (4) JP7066622B2 (enExample)
KR (4) KR102448342B1 (enExample)
CN (2) CN108883110B (enExample)
AU (3) AU2017231828B2 (enExample)
BR (1) BR112018067906A2 (enExample)
CA (2) CA2960253A1 (enExample)
CL (1) CL2018002533A1 (enExample)
CO (1) CO2018009561A2 (enExample)
CR (1) CR20180433A (enExample)
CY (1) CY1125247T1 (enExample)
DK (1) DK3426251T3 (enExample)
DO (1) DOP2018000196A (enExample)
EA (1) EA201891930A1 (enExample)
ES (1) ES2913469T3 (enExample)
HR (1) HRP20220642T1 (enExample)
HU (1) HUE058759T2 (enExample)
IL (3) IL288321B2 (enExample)
LT (1) LT3426251T (enExample)
MA (2) MA43468B1 (enExample)
MD (1) MD3426251T2 (enExample)
MX (1) MX2018010852A (enExample)
MY (1) MY197558A (enExample)
NI (1) NI201800086A (enExample)
PH (1) PH12018501903B1 (enExample)
PL (1) PL3426251T3 (enExample)
PT (1) PT3426251T (enExample)
RS (1) RS63296B1 (enExample)
SG (1) SG11201807597UA (enExample)
SI (1) SI3426251T1 (enExample)
SM (1) SMT202200239T1 (enExample)
SV (1) SV2018005740A (enExample)
UA (1) UA125873C2 (enExample)
WO (1) WO2017156266A1 (enExample)

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JP7398452B2 (ja) 2018-11-14 2023-12-14 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての縮合複素環式化合物を作製する改良された合成方法
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KR102119231B1 (ko) 2019-09-05 2020-06-04 정소진 코르크칩을 이용한 신발용 밑창의 제조방법 및 그 제조방법에 의해 제조되는 신발용 밑창, 이를 포함하는 신발
WO2022122009A1 (zh) * 2020-12-11 2022-06-16 苏州晶云药物科技股份有限公司 吡咯类衍生化合物的晶型及其制备方法
TW202246274A (zh) * 2021-03-16 2022-12-01 大陸商上海翰森生物醫藥科技有限公司 含氮雜環的多環化合物及其製備方法和應用
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KR20230074653A (ko) 2021-11-19 2023-05-31 고려대학교 세종산학협력단 신규 우레아계 또는 카바메이트계 p2x7 수용체 길항제 및 이를 유효성분으로 포함하는 주요 우울 장애의 예방 또는 치료용 약학 조성물
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JP7626487B2 (ja) * 2022-12-16 2025-02-04 株式会社エフアンドエフ 認知症及び／又はうつ病推定ａｉシステム並びに教師データ作成方法
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