KR102448342B1 - 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법 - Google Patents

오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법 Download PDF

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KR102448342B1
KR102448342B1 KR1020187026455A KR20187026455A KR102448342B1 KR 102448342 B1 KR102448342 B1 KR 102448342B1 KR 1020187026455 A KR1020187026455 A KR 1020187026455A KR 20187026455 A KR20187026455 A KR 20187026455A KR 102448342 B1 KR102448342 B1 KR 102448342B1
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compound
depression
administered
treatment
medicament
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KR20180116316A (ko
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저스틴 엠. 켄트
웨인 씨. 드레베츠
뵈르 페터 데
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얀센 파마슈티카 엔.브이.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
KR1020187026455A 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법 Active KR102448342B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227033141A KR102559922B1 (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662306487P 2016-03-10 2016-03-10
US62/306,487 2016-03-10
PCT/US2017/021565 WO2017156266A1 (en) 2016-03-10 2017-03-09 Methods of treating depression using orexin-2 receptor antagonists

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KR20180116316A KR20180116316A (ko) 2018-10-24
KR102448342B1 true KR102448342B1 (ko) 2022-09-27

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KR1020237025023A Ceased KR20230116948A (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
KR1020187026455A Active KR102448342B1 (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
KR1020257016875A Pending KR20250083571A (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
KR1020227033141A Active KR102559922B1 (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법

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KR1020227033141A Active KR102559922B1 (ko) 2016-03-10 2017-03-09 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법

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US (4) US10828302B2 (enExample)
EP (2) EP3426251B1 (enExample)
JP (4) JP7066622B2 (enExample)
KR (4) KR20230116948A (enExample)
CN (2) CN115154470B (enExample)
AU (3) AU2017231828B2 (enExample)
BR (1) BR112018067906A2 (enExample)
CA (2) CA2960253A1 (enExample)
CL (1) CL2018002533A1 (enExample)
CO (1) CO2018009561A2 (enExample)
CR (1) CR20180433A (enExample)
CY (1) CY1125247T1 (enExample)
DK (1) DK3426251T3 (enExample)
DO (1) DOP2018000196A (enExample)
EA (1) EA201891930A1 (enExample)
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HU (1) HUE058759T2 (enExample)
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MA (2) MA43817B1 (enExample)
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MX (1) MX2018010852A (enExample)
MY (1) MY197558A (enExample)
NI (1) NI201800086A (enExample)
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SI (1) SI3426251T1 (enExample)
SM (1) SMT202200239T1 (enExample)
SV (1) SV2018005740A (enExample)
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WO (1) WO2017156266A1 (enExample)

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KR101859409B1 (ko) 2009-10-23 2018-05-18 얀센 파마슈티카 엔.브이. 오렉신 수용체 조절제로서의 이치환된 옥타하이드로피롤로［3,4-ｃ］피롤
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CA3130580A1 (en) * 2019-02-17 2020-08-20 Neurawell Therapeutics Compositions and methods for treatment of depression and other disorders
KR102119231B1 (ko) 2019-09-05 2020-06-04 정소진 코르크칩을 이용한 신발용 밑창의 제조방법 및 그 제조방법에 의해 제조되는 신발용 밑창, 이를 포함하는 신발
WO2022122009A1 (zh) * 2020-12-11 2022-06-16 苏州晶云药物科技股份有限公司 吡咯类衍生化合物的晶型及其制备方法
CA3212319A1 (en) * 2021-03-16 2022-09-22 Hualing XIAO Nitrogen-containing heterocyclic polycyclic compound, preparation method therefor, and application thereof
CN113393944A (zh) * 2021-06-17 2021-09-14 中国科学院长春应用化学研究所 基于代谢组学的芪参颗粒治疗慢性心力衰竭的药代动力学-药效动力学分析方法
KR20230074653A (ko) 2021-11-19 2023-05-31 고려대학교 세종산학협력단 신규 우레아계 또는 카바메이트계 p2x7 수용체 길항제 및 이를 유효성분으로 포함하는 주요 우울 장애의 예방 또는 치료용 약학 조성물
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TW202440545A (zh) * 2022-12-12 2024-10-16 大陸商江蘇恩華藥業股份有限公司 取代四氫環戊基〔ｃ〕吡咯衍生物、製備方法、中間體及其用途
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