KR20230088630A - 항-vegf 엔티티 및 음성 보체 조절인자를 코딩하는 핵산 및 연령-관련 황반 변성의 치료를 위한 그의 용도 - Google Patents

항-vegf 엔티티 및 음성 보체 조절인자를 코딩하는 핵산 및 연령-관련 황반 변성의 치료를 위한 그의 용도 Download PDF

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KR20230088630A
KR20230088630A KR1020227041935A KR20227041935A KR20230088630A KR 20230088630 A KR20230088630 A KR 20230088630A KR 1020227041935 A KR1020227041935 A KR 1020227041935A KR 20227041935 A KR20227041935 A KR 20227041935A KR 20230088630 A KR20230088630 A KR 20230088630A
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ser
vector
complement
polynucleotide
vegf
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KR1020227041935A
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Korean (ko)
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조세핀 조엘
줄리안 에스테베-루드
로렌스 탐
스캇 엘리스
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자이로스코프 테라퓨틱스 리미티드
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Priority claimed from GBGB2104148.8A external-priority patent/GB202104148D0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1725—Complement proteins, e.g. anaphylatoxin, C3a or C5a
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C12N2750/14011—Parvoviridae
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KR1020227041935A 2020-10-16 2021-10-18 항-vegf 엔티티 및 음성 보체 조절인자를 코딩하는 핵산 및 연령-관련 황반 변성의 치료를 위한 그의 용도 Pending KR20230088630A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB2016463.8A GB202016463D0 (en) 2020-10-16 2020-10-16 Product
GB2016463.8 2020-10-16
GBGB2104148.8A GB202104148D0 (en) 2021-03-24 2021-03-24 Product
GB2104148.8 2021-03-24
PCT/GB2021/052689 WO2022079453A1 (en) 2020-10-16 2021-10-18 Nucleic acid encoding an anti-vegf entity and a negative complement regulator and uses thereof for the treatment of age-related macular degeneration

Publications (1)

Publication Number Publication Date
KR20230088630A true KR20230088630A (ko) 2023-06-20

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KR1020227041935A Pending KR20230088630A (ko) 2020-10-16 2021-10-18 항-vegf 엔티티 및 음성 보체 조절인자를 코딩하는 핵산 및 연령-관련 황반 변성의 치료를 위한 그의 용도

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US (1) US20230212275A1 (https=)
EP (1) EP4229076A1 (https=)
JP (1) JP2023545229A (https=)
KR (1) KR20230088630A (https=)
CN (1) CN119585299A (https=)
AU (1) AU2021362770A1 (https=)
CA (1) CA3182337A1 (https=)
CL (1) CL2023001072A1 (https=)
CO (1) CO2023005981A2 (https=)
CR (1) CR20230202A (https=)
DO (1) DOP2023000076A (https=)
EC (1) ECSP23034907A (https=)
IL (1) IL298527A (https=)
JO (1) JOP20230076A1 (https=)
MX (1) MX2023004377A (https=)
PE (1) PE20231747A1 (https=)
PH (1) PH12023551015A1 (https=)
WO (1) WO2022079453A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
GB201821089D0 (en) 2018-12-21 2019-02-06 Gyroscope Therapeutics Ltd Codon-optimised complement factor I
JP7842082B2 (ja) * 2020-07-21 2026-04-07 エフティージェン コーポレーション 眼疾患を処置するための組成物および方法
WO2025083169A1 (en) * 2023-10-17 2025-04-24 Tenpoint Therapeutics Limited Combination of a vegf inhibitor and a complement pathway inhibitor for treating ocular disorders
KR20260004635A (ko) * 2024-07-01 2026-01-09 삼성바이오에피스 주식회사 애플리버셉트를 암호화하는 코돈-최적화된 폴리뉴클레오티드를 포함하는 발현 카세트 및 이를 포함하는 rAAV 생산용 플라스미드

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
DK2191001T3 (en) 2007-04-09 2016-09-19 Univ Florida RAAV VECTOR COMPOSITIONS WITH TYROSIN MODIFIED CAPSIDE PROTEINS AND PROCEDURES FOR USE THEREOF
BR112014013205A2 (pt) * 2011-12-01 2020-10-27 Protevobio, Inc. proteína de fusão, seu uso e seu método de produção, composição farmacêutica, ácido nucleico, e kit
JP7046828B2 (ja) * 2016-04-15 2022-04-04 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 滲出型加齢性黄斑変性の治療のための組成物
AU2018350990A1 (en) * 2017-10-18 2020-05-21 Regenxbio Inc. Treatment of ocular diseases and metastatic colon cancer with human post-translationally modified VEGF-Trap
CN111788311A (zh) * 2017-10-20 2020-10-16 双子治疗公司 用于治疗年龄相关性黄斑变性的组合物和方法
US12558434B2 (en) 2018-02-20 2026-02-24 The Trustees Of The University Of Pennsylvania Compositions for treatment of wet age-related macular degeneration
GB201821089D0 (en) * 2018-12-21 2019-02-06 Gyroscope Therapeutics Ltd Codon-optimised complement factor I
GB201821082D0 (en) * 2018-12-21 2019-02-06 Gyroscope Therapeutics Ltd Combination of complement factors i and h, and vector encoding thereof
EP4048318A4 (en) * 2019-10-23 2023-11-22 Gemini Therapeutics Sub, Inc. METHOD FOR TREATING PATIENTS WITH CFH MUTATIONS USING RECOMBINANT CFH PROTEINS

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IL298527A (en) 2023-01-01
PH12023551015A1 (en) 2024-02-05
PE20231747A1 (es) 2023-11-06
CN119585299A (zh) 2025-03-07
JP2023545229A (ja) 2023-10-27
ECSP23034907A (es) 2023-06-30
CR20230202A (es) 2023-06-13
MX2023004377A (es) 2023-06-28
DOP2023000076A (es) 2023-06-15
JOP20230076A1 (ar) 2023-04-16
US20230212275A1 (en) 2023-07-06
CL2023001072A1 (es) 2023-12-01
WO2022079453A1 (en) 2022-04-21
CA3182337A1 (en) 2022-04-21
AU2021362770A1 (en) 2022-12-08
CO2023005981A2 (es) 2023-05-29
EP4229076A1 (en) 2023-08-23

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