KR20230040953A - 치환된 피페리딘 화합물 및 이의 적용례 - Google Patents

치환된 피페리딘 화합물 및 이의 적용례 Download PDF

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Publication number
KR20230040953A
KR20230040953A KR1020227044679A KR20227044679A KR20230040953A KR 20230040953 A KR20230040953 A KR 20230040953A KR 1020227044679 A KR1020227044679 A KR 1020227044679A KR 20227044679 A KR20227044679 A KR 20227044679A KR 20230040953 A KR20230040953 A KR 20230040953A
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KR
South Korea
Prior art keywords
pharmaceutically acceptable
acceptable salt
mmol
azabicyclo
compound
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Pending
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KR1020227044679A
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English (en)
Korean (ko)
Inventor
유 요시다
요이치 기타
마코토 고타케
게이이치 소리마치
도시유키 오후사
다카후미 모토키
다로 아사바
Original Assignee
에자이 알앤드디 매니지먼트 가부시키가이샤
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Application filed by 에자이 알앤드디 매니지먼트 가부시키가이샤 filed Critical 에자이 알앤드디 매니지먼트 가부시키가이샤
Publication of KR20230040953A publication Critical patent/KR20230040953A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pain & Pain Management (AREA)
KR1020227044679A 2020-07-17 2021-07-15 치환된 피페리딘 화합물 및 이의 적용례 Pending KR20230040953A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2020-122864 2020-07-17
JP2020122864 2020-07-17
PCT/JP2021/026649 WO2022014680A1 (ja) 2020-07-17 2021-07-15 置換ピペリジン化合物及びその用途

Publications (1)

Publication Number Publication Date
KR20230040953A true KR20230040953A (ko) 2023-03-23

Family

ID=79291962

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227044679A Pending KR20230040953A (ko) 2020-07-17 2021-07-15 치환된 피페리딘 화합물 및 이의 적용례

Country Status (19)

Country Link
US (1) US11479552B2 (enExample)
EP (1) EP4151277A4 (enExample)
JP (1) JP7190612B2 (enExample)
KR (1) KR20230040953A (enExample)
CN (3) CN119235864A (enExample)
AR (1) AR122973A1 (enExample)
AU (1) AU2021308053A1 (enExample)
BR (1) BR112022026161A2 (enExample)
CA (1) CA3187835A1 (enExample)
CL (1) CL2022003666A1 (enExample)
CO (1) CO2022018446A2 (enExample)
IL (1) IL299125B1 (enExample)
MX (1) MX2022016388A (enExample)
PE (1) PE20231103A1 (enExample)
PH (1) PH12022553488A1 (enExample)
TW (1) TWI888599B (enExample)
UA (1) UA129636C2 (enExample)
WO (1) WO2022014680A1 (enExample)
ZA (1) ZA202213562B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ787541A (en) 2019-11-25 2025-10-31 Alkermes Inc Substituted macrocyclic compounds and related methods of treatment
US11760747B2 (en) 2020-12-21 2023-09-19 Alkermes, Inc. Substituted piperidino compounds and related methods of treatment
US12006330B2 (en) 2020-12-21 2024-06-11 Alkermes, Inc. Substituted macrocyclic compounds and related methods of treatment
JP7591592B2 (ja) * 2022-01-14 2024-11-28 エーザイ・アール・アンド・ディー・マネジメント株式会社 置換ピペリジン化合物を含有する医薬
MX2024008024A (es) * 2022-01-14 2024-07-15 Eisai R&D Man Co Ltd Cristal de compuesto de piperidina sustituida, sales de compuesto de piperidina sustituida y cristales de estas.
TW202423404A (zh) * 2022-10-07 2024-06-16 日商橘生藥品工業股份有限公司 環戊烷化合物
EP4611745A1 (en) * 2022-10-31 2025-09-10 Takeda Pharmaceutical Company Limited Dosing of orexin type 2 receptor agonists
AU2023395547A1 (en) 2022-12-16 2025-06-26 Daiichi Sankyo Company, Limited 2-azabicyclo[3.1.1]heptane compound
TW202502342A (zh) 2023-06-02 2025-01-16 日商武田藥品工業股份有限公司 食慾素２受體促效劑用於改善睡眠期間之呼吸功能的用途
WO2025124698A1 (en) 2023-12-12 2025-06-19 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators
WO2025132542A1 (en) 2023-12-19 2025-06-26 Idorsia Pharmaceuticals Ltd Macrocyclic orexin agonists
WO2025137359A1 (en) 2023-12-20 2025-06-26 Eisai R&D Management Co., Ltd. Assay methods to identify a disease
WO2025229493A1 (en) 2024-04-29 2025-11-06 Takeda Pharmaceutical Company Limited Dosing of orexin type 2 receptor agonists

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034877A1 (en) 1995-05-05 1996-11-07 Human Genome Sciences, Inc. Human neuropeptide receptor
JPH11178588A (ja) 1997-07-25 1999-07-06 Smithkline Beecham Corp 新規なヒト７−トランスメンブランレセプターをコードするｃＤＮＡクローンＭＹ１
KR100229887B1 (ko) 1995-03-01 1999-11-15 구이 앤드류 바즈 폭발 및 파편화에 저항성을 갖는 안전화용의 폴리우레탄 신발창
KR100327888B1 (ko) 1999-07-14 2002-03-09 정숭렬 도로포장 파손촉진 시험장치의 무선제어 시스템
KR100327889B1 (ko) 1997-02-18 2002-08-21 다이니치 세이카 고교 가부시키가이샤 잉크젯용기록시트

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309854B1 (en) 1996-12-17 2001-10-30 Smithkline Beecham Corporation Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72
US5935814A (en) 1997-04-30 1999-08-10 Smithkline Beecham Corporation Polynucleotides encoding HFGAN72Y receptor
US6020157A (en) 1997-04-30 2000-02-01 Smithkline Beecham Corporation Polynucleotides encoding HFGAN72X receptor
JP4765627B2 (ja) 2003-09-22 2011-09-07 Ｍｓｄ株式会社 新規ピペリジン誘導体
CA2584838A1 (en) 2004-10-20 2006-05-04 Neurosearch A/S Novel diazabicyclic aryl derivatives and their medical use
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
TW201444849A (zh) * 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100229887B1 (ko) 1995-03-01 1999-11-15 구이 앤드류 바즈 폭발 및 파편화에 저항성을 갖는 안전화용의 폴리우레탄 신발창
WO1996034877A1 (en) 1995-05-05 1996-11-07 Human Genome Sciences, Inc. Human neuropeptide receptor
KR100327889B1 (ko) 1997-02-18 2002-08-21 다이니치 세이카 고교 가부시키가이샤 잉크젯용기록시트
JPH11178588A (ja) 1997-07-25 1999-07-06 Smithkline Beecham Corp 新規なヒト７−トランスメンブランレセプターをコードするｃＤＮＡクローンＭＹ１
KR100327888B1 (ko) 1999-07-14 2002-03-09 정숭렬 도로포장 파손촉진 시험장치의 무선제어 시스템

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Busquets X. et al, Respiration, 2004, 71, 575-579
Chemelli R.M. et al, Cell, 1999, 98, 437-451
Lin L. et al, Cell, 1999, 98, 365-376
Mieda M. et al, CNS Drugs, 2013, 27, 83-90
Mieda M. et al, Proc. Natl. Acad. Sci. USA, 2004, 101, 4649-4654
Sakurai T. et al, Cell, 1998, 92, 573-585
Thannickal T.C. et al, Brain. 2007, 130, 1586-1595
Willie J.T. et al, Neuron, 2003, 38, 715-730

Also Published As

Publication number Publication date
BR112022026161A2 (pt) 2023-01-31
US20220017517A1 (en) 2022-01-20
IL299125A (en) 2023-02-01
TWI888599B (zh) 2025-07-01
PE20231103A1 (es) 2023-07-19
ZA202213562B (en) 2023-10-25
CA3187835A1 (en) 2022-01-20
CN119235864A (zh) 2025-01-03
EP4151277A4 (en) 2024-06-26
JP7190612B2 (ja) 2022-12-15
CO2022018446A2 (es) 2023-03-07
TW202216705A (zh) 2022-05-01
AR122973A1 (es) 2022-10-19
MX2022016388A (es) 2023-01-30
CL2022003666A1 (es) 2023-05-26
EP4151277A1 (en) 2023-03-22
CN119258067A (zh) 2025-01-07
JPWO2022014680A1 (enExample) 2022-01-20
US11479552B2 (en) 2022-10-25
CN115884971B (zh) 2024-11-05
WO2022014680A1 (ja) 2022-01-20
CN115884971A (zh) 2023-03-31
IL299125B1 (en) 2025-11-01
PH12022553488A1 (en) 2024-04-22
UA129636C2 (uk) 2025-06-18
AU2021308053A1 (en) 2023-02-02

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PA0105 International application

Patent event date: 20221220

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20240625

Comment text: Request for Examination of Application