PE20231103A1 - Compuestos de piperidina sustituida y su uso - Google Patents
Compuestos de piperidina sustituida y su usoInfo
- Publication number
- PE20231103A1 PE20231103A1 PE2022003006A PE2022003006A PE20231103A1 PE 20231103 A1 PE20231103 A1 PE 20231103A1 PE 2022003006 A PE2022003006 A PE 2022003006A PE 2022003006 A PE2022003006 A PE 2022003006A PE 20231103 A1 PE20231103 A1 PE 20231103A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- piperidine compounds
- octan
- substituted piperidine
- methoxypiperidin
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 2
- 108050000742 Orexin Receptor Proteins 0.000 abstract 1
- 102000008834 Orexin receptor Human genes 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
Abstract
SE REFIERE A LOS COMPUESTOS DE PIPERIDINA A) (2R)-2-CICLOPROPIL-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-FLUOROPIRIMIDIN-2-IL)-3-METOXIPIPERIDIN-4-IL]-8-AZABICICLO[3.2.1]OCTAN-8-IL}ACETAMIDA DE FORMULA (I), B) (R)-2-((1R,3S,5S)-3-((3S,4R)-1-(5-FLUOROPIRIMIDIN-2-IL)-3-METOXIPIPERIDIN-4-IL)-8-AZABICICLO[3.2.1]OCTAN-8-IL)-3-METILBUTANAMIDA DE FORMULA (II), C) (R)-2-((1R,3S,5S)-3-((3S,4R)-1-(5-CLOROPIRIMIDIN-2-IL)-3-ETOXIPIPERIDIN-4-IL)-8-AZABICICLO[3.2.1]OCTAN-8-IL)-2-CICLOPROPILACETAMIDA DE FORMULA (III), Y D) (R)-2-CICLOPROPIL-2-((1R,3S,5S)-3-((2S,4S)-1-(5-FLUOROPIRIMIDIN-2-IL)-2-METILPIPERIDIN-4-IL)-8-AZABICICLO[3.2.1]OCTAN-8-IL)ACETAMIDA DE FORMULA (IV). TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE OREXINA TIPO 2 SIENDO UTILES EN EL TRATAMIENTO DE NARCOLEPSIA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020122864 | 2020-07-17 | ||
| PCT/JP2021/026649 WO2022014680A1 (ja) | 2020-07-17 | 2021-07-15 | 置換ピペリジン化合物及びその用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20231103A1 true PE20231103A1 (es) | 2023-07-19 |
Family
ID=79291962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2022003006A PE20231103A1 (es) | 2020-07-17 | 2021-07-15 | Compuestos de piperidina sustituida y su uso |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11479552B2 (es) |
| EP (1) | EP4151277A1 (es) |
| JP (1) | JP7190612B2 (es) |
| KR (1) | KR20230040953A (es) |
| CN (1) | CN115884971A (es) |
| AR (1) | AR122973A1 (es) |
| AU (1) | AU2021308053A1 (es) |
| BR (1) | BR112022026161A2 (es) |
| CA (1) | CA3187835A1 (es) |
| CL (1) | CL2022003666A1 (es) |
| CO (1) | CO2022018446A2 (es) |
| IL (1) | IL299125A (es) |
| MX (1) | MX2022016388A (es) |
| PE (1) | PE20231103A1 (es) |
| TW (1) | TW202216705A (es) |
| WO (1) | WO2022014680A1 (es) |
| ZA (1) | ZA202213562B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112022009938A2 (pt) | 2019-11-25 | 2022-09-13 | Alkermes Inc | Compostos macrocíclicos substituídos e métodos de tratamento relacionados |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| WO2023136279A1 (ja) * | 2022-01-14 | 2023-07-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物の結晶並びに置換ピペリジン化合物の塩及びそれらの結晶 |
| WO2024075825A1 (ja) * | 2022-10-07 | 2024-04-11 | キッセイ薬品工業株式会社 | シクロペンタン化合物 |
| WO2024095158A1 (en) | 2022-10-31 | 2024-05-10 | Takeda Pharmaceutical Company Limited | Dosing of orexin type 2 receptor agonists |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG34208A1 (en) | 1995-03-01 | 1996-12-06 | Guy Andrew Vaz | Blast and fragment resistant polyurethane boot sole for safety footwear |
| WO1996034877A1 (en) | 1995-05-05 | 1996-11-07 | Human Genome Sciences, Inc. | Human neuropeptide receptor |
| US6309854B1 (en) | 1996-12-17 | 2001-10-30 | Smithkline Beecham Corporation | Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 |
| US6159605A (en) | 1997-02-18 | 2000-12-12 | Dainichiseika Color & Chemicals Mfg. Co., Ltd. | Ink-jet recording sheet |
| US5935814A (en) | 1997-04-30 | 1999-08-10 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72Y receptor |
| US6020157A (en) | 1997-04-30 | 2000-02-01 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72X receptor |
| US6166193A (en) | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
| KR100327888B1 (ko) | 1999-07-14 | 2002-03-09 | 정숭렬 | 도로포장 파손촉진 시험장치의 무선제어 시스템 |
| CA2551037A1 (en) * | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
| NZ553622A (en) | 2004-10-20 | 2010-08-27 | Neurosearch As | Novel diazabicyclic aryl derivatives and their medical use |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| TW201444849A (zh) | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途 |
-
2021
- 2021-07-15 KR KR1020227044679A patent/KR20230040953A/ko unknown
- 2021-07-15 PE PE2022003006A patent/PE20231103A1/es unknown
- 2021-07-15 IL IL299125A patent/IL299125A/en unknown
- 2021-07-15 MX MX2022016388A patent/MX2022016388A/es unknown
- 2021-07-15 TW TW110126031A patent/TW202216705A/zh unknown
- 2021-07-15 AU AU2021308053A patent/AU2021308053A1/en active Pending
- 2021-07-15 US US17/376,452 patent/US11479552B2/en active Active
- 2021-07-15 AR ARP210101982A patent/AR122973A1/es unknown
- 2021-07-15 JP JP2022536446A patent/JP7190612B2/ja active Active
- 2021-07-15 EP EP21842047.9A patent/EP4151277A1/en active Pending
- 2021-07-15 WO PCT/JP2021/026649 patent/WO2022014680A1/ja active Application Filing
- 2021-07-15 CA CA3187835A patent/CA3187835A1/en active Pending
- 2021-07-15 CN CN202180044081.3A patent/CN115884971A/zh active Pending
- 2021-07-15 BR BR112022026161A patent/BR112022026161A2/pt unknown
-
2022
- 2022-12-14 ZA ZA2022/13562A patent/ZA202213562B/en unknown
- 2022-12-20 CL CL2022003666A patent/CL2022003666A1/es unknown
- 2022-12-20 CO CONC2022/0018446A patent/CO2022018446A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2022003666A1 (es) | 2023-05-26 |
| KR20230040953A (ko) | 2023-03-23 |
| ZA202213562B (en) | 2023-10-25 |
| CA3187835A1 (en) | 2022-01-20 |
| JPWO2022014680A1 (es) | 2022-01-20 |
| BR112022026161A2 (pt) | 2023-01-31 |
| US20220017517A1 (en) | 2022-01-20 |
| US11479552B2 (en) | 2022-10-25 |
| IL299125A (en) | 2023-02-01 |
| EP4151277A1 (en) | 2023-03-22 |
| AU2021308053A1 (en) | 2023-02-02 |
| AR122973A1 (es) | 2022-10-19 |
| JP7190612B2 (ja) | 2022-12-15 |
| TW202216705A (zh) | 2022-05-01 |
| WO2022014680A1 (ja) | 2022-01-20 |
| MX2022016388A (es) | 2023-01-30 |
| CN115884971A (zh) | 2023-03-31 |
| CO2022018446A2 (es) | 2023-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20231103A1 (es) | Compuestos de piperidina sustituida y su uso | |
| CL2009000394A1 (es) | Compuestos derivados de n-(1h-indazol-5-il)pirrolidin-3-carboxamida sustituida, inhibidores de erk; composicion farmaceutica; y su uso en el tratamiento del cancer. | |
| PE20081736A1 (es) | Compuestos triciclicos, composiciones, y procedimientos | |
| AR106963A2 (es) | Compuestos de isoindolina y composiciones farmacéuticas de los mismos | |
| BRPI0508622B8 (pt) | compostos de bifenil úteis como antagonistas do receptor muscarínico, composição farmacêutica, processo, medicamento e uso do composto. | |
| RS51963B (en) | 4- (2-AMINO-1-HYDROXYETHYL) PHENOL DERIVATIVES AS AGONISTS OF BETA-2 ADRENERGIC RECEPTORS | |
| UY28885A1 (es) | 4-fenilamino-quinazolin-6-il-amidas referencia cruzada a solicitud(es) relacionada(s) | |
| AR045856A1 (es) | Derivados de tropano sustituidos con imidazopiridinas,procedimiento de preparacion,composiciones farmaceuticas que los contienen y usos, | |
| GT200600163A (es) | Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de la depresion | |
| PE20121820A1 (es) | (2s,3r)-n-(2-((3-piridinil)metil)-1-azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida, formas de sales novedosas de ella, y metodos de uso de ella | |
| CL2011000835A1 (es) | Compuestos derivados de espiro-oxindol; moduladores de los canales de sodio; composicion farmaceutica que comprende a dicho compuesto; y uso en el tratamiento del dolor, depresion, enfermedades cardiovasculares, respiratorias, psiquiatricas, entre otras. | |
| CR8759A (es) | 3-aminociclopentanocarboxamidas como moduladores de receptores quimioquinas | |
| UY30310A1 (es) | Derivados 2-azetidinona, sales, solvatos, composiciones farmacéuticas conteniéndolos, procesos de preparacion y aplicaciones | |
| CO6290644A2 (es) | Antagonista del receptor opioide selectivo kappa. | |
| PE20060937A1 (es) | Derivados de sulfonilbencimidazol como agonistas del receptor cannabinoide 2 (cb2) | |
| PE20090700A1 (es) | Compuestos heterociclicos como antagonistas del receptor opioide periferico | |
| CL2009000662A1 (es) | Compuestos derivados de 1,2,4-triazol trisustituidos, moduladores del receptor de acetilcolina nicotinicos; composicion farmaceutica; su proceso de preparacion; y uso para la prevencion o el tratamiento de trastornos psicoticos, trastornos o enfermedades de daño intelectual, o enfermedades o trastornos inflamatorios. | |
| PE20120545A1 (es) | Composicion farmaceutica que comprende la forma i cristalina de la sal clorhidrato monohidrato de (5s,8s)-8-[{(1r)-1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4,5]decan-2-ona | |
| AR083879A1 (es) | Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos | |
| UY31672A1 (es) | "agonistas de receptores muscarínicos composiciones farmacéuticas métodos de tratamiento de los mismos, y procedimientos para su preparación" | |
| UY28979A1 (es) | Derivados de hidrocloruros de 3-carboxamida, composiciones farmacéuticas que los contienen, procedimiento de preparación y su uso, útiles como inhibidores selectivos de gsk3 | |
| PE20231185A1 (es) | Moduladores del regulador de la conductancia transmembrana de la fibrosis quistica | |
| PE20240050A1 (es) | Inhibidores de cdk2 y metodos de uso de los mismos | |
| AR108906A1 (es) | Heterociclos de biarilmetilo | |
| PE20080094A1 (es) | COMPUESTOS DE DIALQUILFENILO CON ACTIVIDAD AGONISTA DEL RECEPTOR ß2 ADRENERGICO Y ANTAGONISTA DEL RECEPTOR MUSCARINICO |