PE20231103A1 - Compuestos de piperidina sustituida y su uso - Google Patents
Compuestos de piperidina sustituida y su usoInfo
- Publication number
- PE20231103A1 PE20231103A1 PE2022003006A PE2022003006A PE20231103A1 PE 20231103 A1 PE20231103 A1 PE 20231103A1 PE 2022003006 A PE2022003006 A PE 2022003006A PE 2022003006 A PE2022003006 A PE 2022003006A PE 20231103 A1 PE20231103 A1 PE 20231103A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- piperidine compounds
- octan
- substituted piperidine
- methoxypiperidin
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 2
- 108050000742 Orexin Receptor Proteins 0.000 abstract 1
- 102000008834 Orexin receptor Human genes 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
Abstract
SE REFIERE A LOS COMPUESTOS DE PIPERIDINA A) (2R)-2-CICLOPROPIL-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-FLUOROPIRIMIDIN-2-IL)-3-METOXIPIPERIDIN-4-IL]-8-AZABICICLO[3.2.1]OCTAN-8-IL}ACETAMIDA DE FORMULA (I), B) (R)-2-((1R,3S,5S)-3-((3S,4R)-1-(5-FLUOROPIRIMIDIN-2-IL)-3-METOXIPIPERIDIN-4-IL)-8-AZABICICLO[3.2.1]OCTAN-8-IL)-3-METILBUTANAMIDA DE FORMULA (II), C) (R)-2-((1R,3S,5S)-3-((3S,4R)-1-(5-CLOROPIRIMIDIN-2-IL)-3-ETOXIPIPERIDIN-4-IL)-8-AZABICICLO[3.2.1]OCTAN-8-IL)-2-CICLOPROPILACETAMIDA DE FORMULA (III), Y D) (R)-2-CICLOPROPIL-2-((1R,3S,5S)-3-((2S,4S)-1-(5-FLUOROPIRIMIDIN-2-IL)-2-METILPIPERIDIN-4-IL)-8-AZABICICLO[3.2.1]OCTAN-8-IL)ACETAMIDA DE FORMULA (IV). TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE OREXINA TIPO 2 SIENDO UTILES EN EL TRATAMIENTO DE NARCOLEPSIA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020122864 | 2020-07-17 | ||
| PCT/JP2021/026649 WO2022014680A1 (ja) | 2020-07-17 | 2021-07-15 | 置換ピペリジン化合物及びその用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20231103A1 true PE20231103A1 (es) | 2023-07-19 |
Family
ID=79291962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2022003006A PE20231103A1 (es) | 2020-07-17 | 2021-07-15 | Compuestos de piperidina sustituida y su uso |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11479552B2 (es) |
| EP (1) | EP4151277A4 (es) |
| JP (1) | JP7190612B2 (es) |
| KR (1) | KR20230040953A (es) |
| AR (1) | AR122973A1 (es) |
| AU (1) | AU2021308053A1 (es) |
| BR (1) | BR112022026161A2 (es) |
| CA (1) | CA3187835A1 (es) |
| CL (1) | CL2022003666A1 (es) |
| CO (1) | CO2022018446A2 (es) |
| IL (1) | IL299125A (es) |
| MX (1) | MX2022016388A (es) |
| PE (1) | PE20231103A1 (es) |
| TW (1) | TW202216705A (es) |
| WO (1) | WO2022014680A1 (es) |
| ZA (1) | ZA202213562B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112022009938A2 (pt) | 2019-11-25 | 2022-09-13 | Alkermes Inc | Compostos macrocíclicos substituídos e métodos de tratamento relacionados |
| US12006330B2 (en) | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| KR20240134870A (ko) * | 2022-01-14 | 2024-09-10 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 치환된 피페리딘 화합물의 결정, 치환된 피페리딘 화합물의 염, 및 이의 결정 |
| WO2024075825A1 (ja) * | 2022-10-07 | 2024-04-11 | キッセイ薬品工業株式会社 | シクロペンタン化合物 |
| WO2024095158A1 (en) * | 2022-10-31 | 2024-05-10 | Takeda Pharmaceutical Company Limited | Dosing of orexin type 2 receptor agonists |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG34208A1 (en) | 1995-03-01 | 1996-12-06 | Guy Andrew Vaz | Blast and fragment resistant polyurethane boot sole for safety footwear |
| CA2220036A1 (en) | 1995-05-05 | 1996-11-07 | Human Genome Sciences, Inc. | Human neuropeptide receptor |
| US6309854B1 (en) | 1996-12-17 | 2001-10-30 | Smithkline Beecham Corporation | Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 |
| US6159605A (en) | 1997-02-18 | 2000-12-12 | Dainichiseika Color & Chemicals Mfg. Co., Ltd. | Ink-jet recording sheet |
| US5935814A (en) | 1997-04-30 | 1999-08-10 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72Y receptor |
| US6020157A (en) | 1997-04-30 | 2000-02-01 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72X receptor |
| US6166193A (en) | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
| KR100327888B1 (ko) | 1999-07-14 | 2002-03-09 | 정숭렬 | 도로포장 파손촉진 시험장치의 무선제어 시스템 |
| AU2004274309B2 (en) | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
| CA2584838A1 (en) | 2004-10-20 | 2006-05-04 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| TW201444849A (zh) | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途 |
-
2021
- 2021-07-15 AU AU2021308053A patent/AU2021308053A1/en active Pending
- 2021-07-15 US US17/376,452 patent/US11479552B2/en active Active
- 2021-07-15 TW TW110126031A patent/TW202216705A/zh unknown
- 2021-07-15 JP JP2022536446A patent/JP7190612B2/ja active Active
- 2021-07-15 IL IL299125A patent/IL299125A/en unknown
- 2021-07-15 MX MX2022016388A patent/MX2022016388A/es unknown
- 2021-07-15 WO PCT/JP2021/026649 patent/WO2022014680A1/ja active Application Filing
- 2021-07-15 CA CA3187835A patent/CA3187835A1/en active Pending
- 2021-07-15 PE PE2022003006A patent/PE20231103A1/es unknown
- 2021-07-15 BR BR112022026161A patent/BR112022026161A2/pt unknown
- 2021-07-15 EP EP21842047.9A patent/EP4151277A4/en active Pending
- 2021-07-15 KR KR1020227044679A patent/KR20230040953A/ko unknown
- 2021-07-15 AR ARP210101982A patent/AR122973A1/es unknown
-
2022
- 2022-12-14 ZA ZA2022/13562A patent/ZA202213562B/en unknown
- 2022-12-20 CO CONC2022/0018446A patent/CO2022018446A2/es unknown
- 2022-12-20 CL CL2022003666A patent/CL2022003666A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230040953A (ko) | 2023-03-23 |
| CL2022003666A1 (es) | 2023-05-26 |
| WO2022014680A1 (ja) | 2022-01-20 |
| EP4151277A4 (en) | 2024-06-26 |
| CO2022018446A2 (es) | 2023-03-07 |
| AR122973A1 (es) | 2022-10-19 |
| US20220017517A1 (en) | 2022-01-20 |
| US11479552B2 (en) | 2022-10-25 |
| CA3187835A1 (en) | 2022-01-20 |
| IL299125A (en) | 2023-02-01 |
| BR112022026161A2 (pt) | 2023-01-31 |
| JP7190612B2 (ja) | 2022-12-15 |
| TW202216705A (zh) | 2022-05-01 |
| EP4151277A1 (en) | 2023-03-22 |
| AU2021308053A1 (en) | 2023-02-02 |
| ZA202213562B (en) | 2023-10-25 |
| MX2022016388A (es) | 2023-01-30 |
| JPWO2022014680A1 (es) | 2022-01-20 |
| CN115884971A (zh) | 2023-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20231103A1 (es) | Compuestos de piperidina sustituida y su uso | |
| PE20220569A1 (es) | Compuestos de 1-oxo-isoindolin-5-carboxamida sustituida, composiciones de estos y metodos de tratamiento con dichos compuestos | |
| CL2009000394A1 (es) | Compuestos derivados de n-(1h-indazol-5-il)pirrolidin-3-carboxamida sustituida, inhibidores de erk; composicion farmaceutica; y su uso en el tratamiento del cancer. | |
| PE20220766A1 (es) | Agonistas de receptor de melanocortina-4 | |
| PE20240050A1 (es) | Inhibidores de cdk2 y metodos de uso de los mismos | |
| AR106963A2 (es) | Compuestos de isoindolina y composiciones farmacéuticas de los mismos | |
| PE20090772A1 (es) | Derivados de bencimidazol | |
| BRPI0508622B8 (pt) | compostos de bifenil úteis como antagonistas do receptor muscarínico, composição farmacêutica, processo, medicamento e uso do composto. | |
| RS51963B (en) | 4- (2-AMINO-1-HYDROXYETHYL) PHENOL DERIVATIVES AS AGONISTS OF BETA-2 ADRENERGIC RECEPTORS | |
| DOP2009000124A (es) | Derivados de benzamida como receptores agonista ep4 | |
| UY28885A1 (es) | 4-fenilamino-quinazolin-6-il-amidas referencia cruzada a solicitud(es) relacionada(s) | |
| UY31672A1 (es) | "agonistas de receptores muscarínicos composiciones farmacéuticas métodos de tratamiento de los mismos, y procedimientos para su preparación" | |
| GT200600163A (es) | Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de la depresion | |
| PE20140302A1 (es) | Inhibidores del virus de la hepatitis c | |
| CO6501183A2 (es) | Piperidinas sustituidas como antagonistas de ccr3 | |
| UY30310A1 (es) | Derivados 2-azetidinona, sales, solvatos, composiciones farmacéuticas conteniéndolos, procesos de preparacion y aplicaciones | |
| AR108906A1 (es) | Heterociclos de biarilmetilo | |
| PE20090700A1 (es) | Compuestos heterociclicos como antagonistas del receptor opioide periferico | |
| AR083879A1 (es) | Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos | |
| UY28979A1 (es) | Derivados de hidrocloruros de 3-carboxamida, composiciones farmacéuticas que los contienen, procedimiento de preparación y su uso, útiles como inhibidores selectivos de gsk3 | |
| PE20080094A1 (es) | COMPUESTOS DE DIALQUILFENILO CON ACTIVIDAD AGONISTA DEL RECEPTOR ß2 ADRENERGICO Y ANTAGONISTA DEL RECEPTOR MUSCARINICO | |
| PE20071220A1 (es) | Sales de hidrocloruro de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decan-2-ona y su proceso de preparacion | |
| PE20150105A1 (es) | Inhibidores del virus de la hepatitis c | |
| UY31334A1 (es) | 3a,4,5,6,7,7a-hexahidro-3h-benzoimidazol y derivaods de 3a, 4,5,6,,7,7a-hexahidro-3-indol, enantiómeros, diastereoisómeros, sales farmacéuticamente aceptadas, mezclas, composiciones, preparaciones y aplicaciones de las mismas | |
| CO6430439A2 (es) | Agonistas del receptor de esfingosina -1- fosfato |