TWI888599B - 取代哌啶化合物及其用途 - Google Patents
取代哌啶化合物及其用途 Download PDFInfo
- Publication number
- TWI888599B TWI888599B TW110126031A TW110126031A TWI888599B TW I888599 B TWI888599 B TW I888599B TW 110126031 A TW110126031 A TW 110126031A TW 110126031 A TW110126031 A TW 110126031A TW I888599 B TWI888599 B TW I888599B
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- mmol
- azabicyclo
- added
- solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020-122864 | 2020-07-17 | ||
| JP2020122864 | 2020-07-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202216705A TW202216705A (zh) | 2022-05-01 |
| TWI888599B true TWI888599B (zh) | 2025-07-01 |
Family
ID=79291962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110126031A TWI888599B (zh) | 2020-07-17 | 2021-07-15 | 取代哌啶化合物及其用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11479552B2 (enExample) |
| EP (1) | EP4151277A4 (enExample) |
| JP (1) | JP7190612B2 (enExample) |
| KR (1) | KR20230040953A (enExample) |
| CN (3) | CN115884971B (enExample) |
| AR (1) | AR122973A1 (enExample) |
| AU (1) | AU2021308053A1 (enExample) |
| BR (1) | BR112022026161A2 (enExample) |
| CA (1) | CA3187835A1 (enExample) |
| CL (1) | CL2022003666A1 (enExample) |
| CO (1) | CO2022018446A2 (enExample) |
| IL (1) | IL299125B1 (enExample) |
| MX (1) | MX2022016388A (enExample) |
| PE (1) | PE20231103A1 (enExample) |
| PH (1) | PH12022553488A1 (enExample) |
| TW (1) | TWI888599B (enExample) |
| UA (1) | UA129636C2 (enExample) |
| WO (1) | WO2022014680A1 (enExample) |
| ZA (1) | ZA202213562B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI4065585T1 (sl) | 2019-11-25 | 2025-11-28 | Alkermes, Inc. | Substituirane makrociklične spojine ter z njimi povezani postopki zdravljenja |
| US12006330B2 (en) | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| US20250051322A1 (en) * | 2022-01-14 | 2025-02-13 | Eisai R&D Management Co., Ltd. | Crystal of substituted piperidine compound, salts of substituted piperidine compound, and crystals thereof |
| JP7591592B2 (ja) * | 2022-01-14 | 2024-11-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物を含有する医薬 |
| IL319940A (en) * | 2022-10-07 | 2025-05-01 | Kissei Pharmaceutical | Cyclopentane compound |
| CN120129521A (zh) * | 2022-10-31 | 2025-06-10 | 武田药品工业株式会社 | 食欲素2型受体激动剂的给药 |
| JPWO2024128305A1 (enExample) | 2022-12-16 | 2024-06-20 | ||
| TW202502342A (zh) | 2023-06-02 | 2025-01-16 | 日商武田藥品工業股份有限公司 | 食慾素２受體促效劑用於改善睡眠期間之呼吸功能的用途 |
| WO2025124698A1 (en) | 2023-12-12 | 2025-06-19 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
| WO2025132542A1 (en) | 2023-12-19 | 2025-06-26 | Idorsia Pharmaceuticals Ltd | Macrocyclic orexin agonists |
| WO2025137359A1 (en) | 2023-12-20 | 2025-06-26 | Eisai R&D Management Co., Ltd. | Assay methods to identify a disease |
| WO2025229493A1 (en) | 2024-04-29 | 2025-11-06 | Takeda Pharmaceutical Company Limited | Dosing of orexin type 2 receptor agonists |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008517032A (ja) * | 2004-10-20 | 2008-05-22 | ノイロサーチ アクティーゼルスカブ | 新規なジアザ二環式アリール誘導体及びその医薬用途 |
| JP4765627B2 (ja) * | 2003-09-22 | 2011-09-07 | Ｍｓｄ株式会社 | 新規ピペリジン誘導体 |
| JP2016512536A (ja) * | 2013-03-13 | 2016-04-28 | ヤンセン ファーマシューティカ エヌ．ベー． | 置換した７−アザビシクル及びオレキシン受容体調節因子としてのそれらの使用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG34208A1 (en) | 1995-03-01 | 1996-12-06 | Guy Andrew Vaz | Blast and fragment resistant polyurethane boot sole for safety footwear |
| WO1996034877A1 (en) | 1995-05-05 | 1996-11-07 | Human Genome Sciences, Inc. | Human neuropeptide receptor |
| US6309854B1 (en) | 1996-12-17 | 2001-10-30 | Smithkline Beecham Corporation | Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 |
| US6159605A (en) | 1997-02-18 | 2000-12-12 | Dainichiseika Color & Chemicals Mfg. Co., Ltd. | Ink-jet recording sheet |
| US6020157A (en) | 1997-04-30 | 2000-02-01 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72X receptor |
| US5935814A (en) | 1997-04-30 | 1999-08-10 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72Y receptor |
| US6166193A (en) | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
| KR100327888B1 (ko) | 1999-07-14 | 2002-03-09 | 정숭렬 | 도로포장 파손촉진 시험장치의 무선제어 시스템 |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
-
2021
- 2021-07-15 AU AU2021308053A patent/AU2021308053A1/en active Pending
- 2021-07-15 PH PH1/2022/553488A patent/PH12022553488A1/en unknown
- 2021-07-15 JP JP2022536446A patent/JP7190612B2/ja active Active
- 2021-07-15 AR ARP210101982A patent/AR122973A1/es unknown
- 2021-07-15 PE PE2022003006A patent/PE20231103A1/es unknown
- 2021-07-15 MX MX2022016388A patent/MX2022016388A/es unknown
- 2021-07-15 TW TW110126031A patent/TWI888599B/zh active
- 2021-07-15 EP EP21842047.9A patent/EP4151277A4/en active Pending
- 2021-07-15 CN CN202180044081.3A patent/CN115884971B/zh active Active
- 2021-07-15 BR BR112022026161A patent/BR112022026161A2/pt unknown
- 2021-07-15 US US17/376,452 patent/US11479552B2/en active Active
- 2021-07-15 UA UAA202204882A patent/UA129636C2/uk unknown
- 2021-07-15 CA CA3187835A patent/CA3187835A1/en active Pending
- 2021-07-15 KR KR1020227044679A patent/KR20230040953A/ko active Pending
- 2021-07-15 CN CN202411459551.4A patent/CN119235864A/zh active Pending
- 2021-07-15 CN CN202411462171.6A patent/CN119258067A/zh active Pending
- 2021-07-15 WO PCT/JP2021/026649 patent/WO2022014680A1/ja not_active Ceased
-
2022
- 2022-12-14 ZA ZA2022/13562A patent/ZA202213562B/en unknown
- 2022-12-14 IL IL299125A patent/IL299125B1/en unknown
- 2022-12-20 CO CONC2022/0018446A patent/CO2022018446A2/es unknown
- 2022-12-20 CL CL2022003666A patent/CL2022003666A1/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4765627B2 (ja) * | 2003-09-22 | 2011-09-07 | Ｍｓｄ株式会社 | 新規ピペリジン誘導体 |
| JP2008517032A (ja) * | 2004-10-20 | 2008-05-22 | ノイロサーチ アクティーゼルスカブ | 新規なジアザ二環式アリール誘導体及びその医薬用途 |
| JP2016512536A (ja) * | 2013-03-13 | 2016-04-28 | ヤンセン ファーマシューティカ エヌ．ベー． | 置換した７−アザビシクル及びオレキシン受容体調節因子としてのそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| PE20231103A1 (es) | 2023-07-19 |
| US20220017517A1 (en) | 2022-01-20 |
| CA3187835A1 (en) | 2022-01-20 |
| MX2022016388A (es) | 2023-01-30 |
| JP7190612B2 (ja) | 2022-12-15 |
| JPWO2022014680A1 (enExample) | 2022-01-20 |
| CL2022003666A1 (es) | 2023-05-26 |
| AR122973A1 (es) | 2022-10-19 |
| CN119258067A (zh) | 2025-01-07 |
| UA129636C2 (uk) | 2025-06-18 |
| CN115884971B (zh) | 2024-11-05 |
| AU2021308053A1 (en) | 2023-02-02 |
| ZA202213562B (en) | 2023-10-25 |
| IL299125A (en) | 2023-02-01 |
| CN119235864A (zh) | 2025-01-03 |
| PH12022553488A1 (en) | 2024-04-22 |
| KR20230040953A (ko) | 2023-03-23 |
| TW202216705A (zh) | 2022-05-01 |
| CN115884971A (zh) | 2023-03-31 |
| WO2022014680A1 (ja) | 2022-01-20 |
| EP4151277A1 (en) | 2023-03-22 |
| CO2022018446A2 (es) | 2023-03-07 |
| EP4151277A4 (en) | 2024-06-26 |
| IL299125B1 (en) | 2025-11-01 |
| US11479552B2 (en) | 2022-10-25 |
| BR112022026161A2 (pt) | 2023-01-31 |
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