KR20220152316A - 신규한 항-lilrb4 항체 및 유도체 생성물 - Google Patents

신규한 항-lilrb4 항체 및 유도체 생성물 Download PDF

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KR20220152316A
KR20220152316A KR1020227035314A KR20227035314A KR20220152316A KR 20220152316 A KR20220152316 A KR 20220152316A KR 1020227035314 A KR1020227035314 A KR 1020227035314A KR 20227035314 A KR20227035314 A KR 20227035314A KR 20220152316 A KR20220152316 A KR 20220152316A
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South Korea
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antibody
domain
antigen
cell
cancer
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Korean (ko)
Inventor
안 송
타오 후앙
라이언 스태포드
마리아 호세 코스타
규 희 홍
캐롤린 보난스
지안후이 죠우
리 죠우
지 리
제이 폴 우드아드
엑스 샤를렌 리아오
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이뮨-온크 테라퓨틱스, 인코포레이티드
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Publication of KR20220152316A publication Critical patent/KR20220152316A/ko
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • G—PHYSICS
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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KR1020227035314A 2020-03-12 2021-03-12 신규한 항-lilrb4 항체 및 유도체 생성물 Pending KR20220152316A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062988892P 2020-03-12 2020-03-12
US62/988,892 2020-03-12
PCT/US2021/022029 WO2021183839A2 (en) 2020-03-12 2021-03-12 Novel anti-lilrb4 antibodies and derivative products

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Publication Number Publication Date
KR20220152316A true KR20220152316A (ko) 2022-11-15

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KR1020227035314A Pending KR20220152316A (ko) 2020-03-12 2021-03-12 신규한 항-lilrb4 항체 및 유도체 생성물

Country Status (9)

Country Link
US (1) US12559555B2 (https=)
EP (1) EP4118120A4 (https=)
JP (2) JP7765397B2 (https=)
KR (1) KR20220152316A (https=)
CN (1) CN115551894A (https=)
AU (1) AU2021236302A1 (https=)
BR (1) BR112022018088A2 (https=)
CA (1) CA3175140A1 (https=)
WO (1) WO2021183839A2 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020232247A1 (en) 2019-05-14 2020-11-19 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
IL298999A (en) 2020-06-11 2023-02-01 Provention Bio Inc Methods and compositions for the prevention of type 1 diabetes
JP2024520444A (ja) 2021-05-24 2024-05-24 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を治療するための方法
WO2023159152A2 (en) * 2022-02-17 2023-08-24 Immune-Onc Therapeutics, Inc. Combination therapy of lilrb antagonist and pd-1/pd-l1 axis inhibitor
EP4499683A1 (en) 2022-03-29 2025-02-05 NGM Biopharmaceuticals, Inc. Ilt3 and cd3 binding agents and methods of use thereof
AU2023258644A1 (en) * 2022-04-25 2024-12-05 Biond Biologics Ltd. Anti-ilt3 antibodies and use thereof
WO2023235699A1 (en) * 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Antibodies to lilrb4 and uses thereof
WO2023236891A1 (en) * 2022-06-06 2023-12-14 Antengene (Hangzhou) Biologics Co., Ltd. Novel anti-lilrb4 antibodies and uses thereof
CN114716554B (zh) * 2022-06-08 2022-08-26 尚健单抗（北京）生物技术有限公司 抗原结合蛋白及其应用
CN115925941B (zh) * 2022-06-08 2026-04-03 北京科诺信诚科技有限公司 靶向人lilrb4的纳米抗体及其应用
CN117362433A (zh) * 2022-06-30 2024-01-09 杭州尚健生物技术有限公司 分离的抗原结合蛋白及其用途
EP4606823A1 (en) * 2022-12-26 2025-08-27 Bristar Immunotech Limited Synthetic t cell receptor antigen receptor specifically binding to lilrb4 and use thereof
CN115873119B (zh) * 2022-12-30 2026-01-23 北京东方百泰生物科技股份有限公司 一种抗lilrb4单克隆抗体的纯化方法
EP4694900A1 (en) * 2023-04-13 2026-02-18 The Johns Hopkins University Engineered t-cell receptors and methods of making and using the same
WO2024235317A1 (zh) 2023-05-18 2024-11-21 南京维立志博生物科技有限公司 结合lilrb4和cd3的抗体及其用途
CN118580352A (zh) * 2023-05-20 2024-09-03 四川大学 抗lilrb4抗体及其用途
WO2024251242A1 (en) * 2023-06-09 2024-12-12 Antengene (Hangzhou) Biologics Co., Ltd. Novel antibodies targeting cd3 and another target and uses thereof
CN119855835A (zh) * 2023-06-13 2025-04-18 南京维立志博生物科技股份有限公司 基于共同轻链产生双特异性抗体的方法
WO2025119253A1 (en) * 2023-12-06 2025-06-12 Antengene (Hangzhou) Biologics Co., Ltd. Novel antibodies that bind to cd3 and lilrb4, and uses thereof
WO2025188047A1 (en) * 2024-03-04 2025-09-12 Abl Bio, Inc. Anti-lilrb4 antibodies and anti-lilrb4/anti-4-1bb bispecific antibodies and uses thereof
WO2025207653A1 (en) * 2024-03-25 2025-10-02 Bectas Therapeutics, Inc. Antibodies against lilrb4 and lilrb2 and uses thereof
CN119985985B (zh) * 2025-04-16 2025-07-15 南昌大学第一附属医院 急性髓系白血病易感或预后不良人群的筛选试剂盒

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4680338A (en) 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・２・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
US5141648A (en) 1987-12-02 1992-08-25 Neorx Corporation Methods for isolating compounds using cleavable linker bound matrices
US5563250A (en) 1987-12-02 1996-10-08 Neorx Corporation Cleavable conjugates for the delivery and release of agents in native form
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
FI941572A7 (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
ATE207080T1 (de) 1991-11-25 2001-11-15 Enzon Inc Multivalente antigen-bindende proteine
CA2372813A1 (en) 1992-02-06 1993-08-19 L.L. Houston Biosynthetic binding protein for cancer marker
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
DK1621554T4 (da) 1992-08-21 2012-12-17 Univ Bruxelles Immunoglobuliner blottet for lette kæder
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
WO1994012520A1 (en) 1992-11-20 1994-06-09 Enzon, Inc. Linker for linked fusion polypeptides
ES2162863T3 (es) 1993-04-29 2002-01-16 Unilever Nv Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae.
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
WO1996040662A2 (en) 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
ATE375365T1 (de) 1998-04-02 2007-10-15 Genentech Inc Antikörper varianten und fragmente davon
DK1071700T3 (da) 1998-04-20 2010-06-07 Glycart Biotechnology Ag Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
DK1137789T3 (da) 1998-12-09 2010-11-08 Phyton Holdings Llc Fremgangsmåde til fremstilling af et glycoprotein med glycosylering af human type
PL209392B1 (pl) 1999-01-15 2011-08-31 Genentech Inc Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
CA2704600C (en) 1999-04-09 2016-10-25 Kyowa Kirin Co., Ltd. A method for producing antibodies with increased adcc activity
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
ES2252261T3 (es) 2000-06-28 2006-05-16 Glycofi, Inc. Metodos para producir glicoproteinas modificadas.
US7632983B2 (en) 2000-07-31 2009-12-15 Biolex Therapeutics, Inc. Expression of monoclonal antibodies in duckweed
US6555674B2 (en) 2000-08-09 2003-04-29 Nsgene A/S JeT promoter
CA2463879C (en) 2001-10-25 2012-12-04 Genentech, Inc. Glycoprotein compositions
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
BR0309145A (pt) 2002-04-09 2005-02-01 Kyowa Hakko Kogyo Kk Células das quais o genoma é modificado
AU2003226356A1 (en) 2002-04-12 2003-10-27 Ramot At Tel Aviv University Ltd. Prevention of brain inflammation as a result of induced autoimmune response
AU2004273791A1 (en) 2003-09-05 2005-03-31 Genentech, Inc. Antibodies with altered effector functions
EP1697520A2 (en) 2003-12-22 2006-09-06 Xencor, Inc. Fc polypeptides with novel fc ligand binding sites
EP2471813B1 (en) 2004-07-15 2014-12-31 Xencor, Inc. Optimized Fc variants
DK1791565T3 (en) 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
CN101160324B (zh) 2005-02-18 2013-04-24 米德列斯公司 缺乏岩藻糖残基的抗前列腺特异性膜抗原(psma)单克隆抗体
CA2655903A1 (en) * 2006-06-19 2008-08-07 Tolerx, Inc. Ilt3 binding molecules and uses therefor
AU2008227024A1 (en) 2007-03-07 2008-09-18 Glycofi, Inc. Production of glycoproteins with modified fucosylation
BRPI0914251B1 (pt) * 2008-06-25 2022-07-19 Novartis Ag Imunoligante recombinante, seu fragmento de ligação ao antígeno, uso dos mesmos, e composição
WO2013033734A1 (en) 2011-09-02 2013-03-07 The Trustees Of Columbia University In The City Of New York Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand
CA2977544C (en) 2015-03-06 2023-12-19 The Board Of Regents Of The University Of Texas System Anti-lilrb antibodies and their use in detecting and treating cancer
EP3538141A4 (en) 2016-11-10 2020-07-15 Merck Sharp & Dohme Corp. LIGAND ILT3
WO2018148494A1 (en) 2017-02-09 2018-08-16 Bluefin Biomedicine, Inc. Anti-ilt3 antibodies and antibody drug conjugates
EP3645738A4 (en) 2017-06-25 2021-08-18 Systimmune, Inc. ANTI-PD-L1 ANTIBODIES AND METHOD FOR MANUFACTURING AND USING THEREOF
CN115991777A (zh) 2017-09-21 2023-04-21 上海药明生物技术有限公司 新型抗CD3ε抗体
AU2018334886B2 (en) 2017-09-22 2025-06-26 WuXi Biologics Ireland Limited Novel bispecific polypeptide complexes
CA3109366A1 (en) * 2018-09-13 2020-03-19 The Board Of Regents Of The University Of Texas System Novel lilrb4 antibodies and uses thereof

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